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April 29, 2018
Dr. Stan Gerson
Stan Gerson, MD
Director, Case Comprehensive Cancer Center

Hill Day 2018
Hill Day 2018 We have had an incredible year, and I take every opportunity possible to educate others on the Case CCC and our  impact. I recently sent letters to our government delegates reminding them of the importance of our Center, and the exceptional work made possible by their support and NIH/NCI funding. These letters laid the groundwork for successful and effective in-person meetings with our delegates while I was in Washington, D.C. earlier this week.  While on Capitol Hill  I met with Senators Sherrod Brown, Rob Portman and Lamar Alexander, and staff for Senator Richard Shelby, to discuss the importance of further increases to the budgets of NIH and NCI. I also took the chance to thank them for the FY18 increase of $3B.  What a great day for cancer research! 

I encourage you to send your own messages to your delegates, including Senators Brown and Portman, and Representatives Marcia Fudge and David Joyce, to thank them for their support. 
CWRU Research Projects Selected for State of Ohio's Focused Commercialization Training
Four medical-technology research teams at Case Western Reserve University, three of which are led by Case CCC members, will participate in focused entrepreneurial training through  I-Corps@Ohio , an  Ohio Department of Higher Education  initiative created to advance their work from the lab to the commercial market. Each selected project has potential for a product or services for medical treatments or surgeries.  

Novel imaging agent for tumor detection and fluorescence-guided imaging during surgery Susann Brady-Kalnay

Susann  Brady-Kalnay, PhD, Professor of Molecular Biology and Microbiology, has developed an imaging peptide that binds to and fluorescently highlights cancer cells to aid in the surgical resection of the brain tumor glioblastoma. This imaging agent, which she calls SBK2, has translational significance for molecular imaging of tumors, guiding neurosurgeons to a more complete resection of tumors-including the removal of invasive tumor cells that have migrated away from the main tumor. That allows surgeons to make real-time decisions on tumor margins to improve patient outcomes.

Optical method for monitoring corneal crosslinking and corneal biomechanics 
Andrew Rollins
Andrew  Rollins, PhD, Professor of Biomedical Engineering and Medicine, and his research team have developed a new method, based on optical coherence tomography, to detect and map corneal mechanical properties that requires no contact or disturbance of the cornea. The potential advantages of this technique may make it readily translatable to clinical use because of existing hardware already in the clinician's office.

Point-of-care device (POC) for diagnosing and monitoring of oral cancer
Aaron Weinberg
Aaron  Weinberg, DMD, PhD, CWRU School of Dental Medicine Associate Dean for Research, and Professor and Chair of Biological Sciences, has developed a non-invasive oral cancer biomarker test that collects cells from questionable oral lesions and objectively determines if they are cancerous within 15 minutes. He is currently conducting a small clinical study to test the technology.
Michael Kattan, PhD, MBA, Chair of  Lerner Research Institute's Department of Quantitative Health Sciences and a joint appointee in the  Cleveland Clinic Glickman Urological and Kidney Institute, and member of the Case Comprehensive Cancer Center, has been elected a Fellow of the American Statistical Association (ASA). The formal induction ceremony will be in Vancouver this coming July. Dr. Kattan was nominated by an ASA-member peer for his excellent reputation and outstanding contributions to statistical science.

Dr. Kattan has created numerous nomograms-mathematical models sometimes called "risk calculators"-that clinicians use to help assess a patient's individual risk for cancers and other disorders and to inform targeted therapeutic strategy. The models, often called "Kattan nomograms", have already become part of the staging systems and decision-making guidelines for doctors at such prestigious institutions as Memorial Sloan-Kettering Cancer Center (where more than 100 nomograms are featured), as advocated by the American Joint Committee on Cancer. His online calculators are a valuable aspect of modern medicine's push toward more precise personalized care using "big data", primarily culled from electronic medical records. Dr. Kattan has long been a specialist in machine learning, analysis of health care data and computer modeling for medical decision making. more>

DNA Repair Symp Banner The Case Comprehensive Cancer Center and Case Western Reserve University will host the 20th Annual Midwest DNA Repair Symposium May 5-6, 2018 . This symposium is a great opportunity for people working on DNA damage and repair in the midwest area to gather together and discuss science! The agenda promises exciting science and opportunities for networking, poster presentations, and keynote presentations from field experts  Stephen Kowalczykowski and Lee Zou .

There is only one more week to register - secure your spot today, and encourage your students and trainees to attend as well! 

CSC 2018 - web banner
The Case Comprehensive Cancer Center (Case CCC) and National Center for Regenerative Medicine (NCRM) invite you to Cancer Stem Cell Conference (CSC 2018)! Now in it's third year, CSC 2018 will feature renowned thought leaders in the field of cancer stem cell research. This conference is guaranteed to offer cutting-edge keynote presentations from a variety of niches within the field. Join world-class investigators for this 3-day summit and network with scientists and clinicians advancing cancer stem cell research and therapeutic applications.

Conference Highlights
  • The agenda will integrate invited talks from thought leaders in the CSC field with short talks from early-stage investigators and trainees selected from submitted abstracts.
  • Pre-conference career development workshop for junior faculty and trainees
    • Meet the Editors: Natalie Cain, PhD (CellReports), Mark Landis, PhD (CancerDiscovery) and Teodoro Pulvirenti, PhD(JEM)
    • Discussion of NIH grants: Michael Espey, PhD (NCI) and Michelle McGuirl, PhD (NIH)
  • Young Investigator Awards available to support travel for senior trainees or junior faculty (less than 5 years from their first independent position). Submit your abstracts by May 15 to be eligible. 
  • Opportunity to share ideas with world-class investigators in stem cell research. 2016 CSC was attended by over 300 from 20 countries and 25 U.S. states. This year's conference is on track to attract a similar crowd of colleagues.
Keynote Speakers
  • Norman E. 'Ned' Sharpless, MD (NCI)
  • John S. Condeelis, PhD (Einstein)
  • Irving Weissman, MD (Stanford)
  • Zena Werb, PhD (UCSF)
Call for Abstracts Deadline: May 15

Discounts for early registration through May 31

Cancer Therapy Advisor - Apr 26, 2018
Patients with  resected high-risk stage III melanoma  had significantly longer recurrence-free survival (RFS) when given adjuvant pembrolizumab than those given placebo, according to results from the EORTC 1325/KEYNOTE-054 trial..." Melanoma has long been the immunotherapy poster child despite many years with a lack of benefit," said Brian Gastman, MD, Case Comprehensive Cancer Center, director of Cleveland Clinic Melanoma Program in Ohio. "Now that we are into the PD-1 and PD-L1-based immunotherapies, responses have gotten a lot better with fewer side effects."
Business Wire - Apr 24, 2018
PAVmed Inc. , a highly differentiated, multi-product medical device company, today announced that it has signed a letter of intent with Case Western Reserve University to commercialize its groundbreaking EsoCheck technology. EsoCheck combines a non-invasive, cell-sampling device with highly accurate DNA biomarkers to detect Barrett's Esophagus, the primary precursor of esophageal cancer. In a simple five-minute office-based test, the patient swallows a vitamin pill-sized capsule containing a small inflatable balloon attached to a thin catheter, which swabs the target area for cells as the catheter is withdrawn. The sample is then tested for the presence of DNA biomarkers recently shown to be highly accurate in detecting Barrett's Esophagus..."Our goal is to save lives through early detection," said EsoCheck co-inventor Amitabh Chak, MD, Case Comprehensive Cancer Center, professor of medicine at Case Western University School of Medicine, gastroenterologist at UH Digestive Health Institute, and director of the Advanced Technology & Innovation Center of Excellence at University Hospitals Division of Gastroenterology and editorial board chair of Gastrointestinal Endoscopy, the pre-eminent journal in the field... DNA is extracted from the cells and tested for a panel of DNA biomarkers developed by the laboratory of EsoCheck co-inventor Sanford Markowitz, MD, PhD, the Ingalls Professor of Cancer Genetics medical oncologist at University Hospitals Seidman Cancer Center, NCI Outstanding Investigator Awardee, and head of the NIH-Case GI Cancers Program of Research Excellence (GI SPORE) and co-Leader, GI Cancer Genetics Program at the Case Comprehensive Cancer Center.  The Science Translational Medicine paper showed that DNA methylation of the VIM and CCNA1 genes is diagnostic of Barrett's Esophagus and that EsoCheck, which combines the proprietary balloon sampling device with these biomarkers, was over 90% accurate at identifying patients without Barrett's Esophagus. The third EsoCheck co-inventor, Joseph Willis, MD, Case Comprehensive Cancer Center, professor of pathology and pathology vice-chair for clinical affairs, at University Hospitals Cleveland Medical Center, is leading an ongoing NIH-supported effort to create a CLIA-certified VIM/CCNA1 DNA methylation test suitable for commercialization. - Apr 23, 2018
Luckily, that pain in the few inches of space right below your right ribs isn't necessarily an indicator something is seriously wrong. " Sometimes a pain under the rib is nothing more than you slept wrong, or you exercised too hard," said Dr. Gregory Cooper, a gastroenterologist at the University Hospitals Cleveland Medical Center. But if the pain is severe enough - or you are stressing yourself out enough - that you're actually spending time  online self-diagnosing , it may be time to get checked out, he noted.
NIH BULLETIN- Notices and Funding Opportunities
Notice of Correction to Award Information in PAR-18-246 "Intervening with Cancer Caregivers to Improve Patient Health Outcomes and Optimize Health Care Utilization (R01 Clinical Trial Optional)" (NOT-CA-18-064)

Notice of Correction to Award Information in PAR-18-247 Intervening with Cancer Caregivers to Improve Patient Health Outcomes and Optimize Health Care Utilization (R21 Clinical Trial Optional)"(NOT-CA-18-065)

Notice of Change to the NIAID Specific Areas of Research Interest for PA-18-722 "Improving Patient Adherence to Treatment and Prevention Regimens to Promote Health (R01 Clinical Trial Optional"(NOT-AI-18-033l)

Notice of Change to the NIAID Specific Areas of Research Interest for PA-18-723 "Improving Patient Adherence to Treatment and Prevention Regimens to Promote Health (R21 Clinical Trial Optional)"(NOT-AI-18-034)

Notice of Change in Eligible Organizations in PA-18-748 "Research Supplements to Promote Data Sharing in Cancer Epidemiology Studies (Admin Supp Clinical Trial Not Allowed)" to Allow Foreign Institutions (NOT-CA-18-069)

Presolicitation Notice: Request for Proposals (RFP) N01CN77019-18 "PREVENT Cancer Preclinical Drug Development Program: Preclinical Services for Biopharmaceutical Product Development and Manufacturing, Toxicology and Pharmacology Testing"(NOT-CA-18-070)

Program Announcements
Improving the Reach and Quality of Cancer Care in Rural Populations (R01 Clinical Trial Required)(RFA-CA-18-026)
Deadline: Sep 19, 2018

Research Supplements to Promote Data Sharing in Cancer Epidemiology Studies (Admin Supp Clinical Trial Not Allowed)(PA-18-748)
Deadline: Jul 1, 2018
Mon, Apr 30
Genomic Medicine Institute
Fang Feng, PhD
Eng lab, Genomic Medicine Institute, Cleveland Clinic
"Exploring non-pump function of NIS in thyroid cancer through crosstalk with PTEN signaling"
12p NE1-205

Pathology Research Seminar Series
Sirui Jiang
Zhu lab, CWRU
"Mitochondrial dynamics and Alzheimer's Disease"
12p WRB 1-413

Cancer Center Research Chalk Talk
Liraz Levi, PhD
Case CCC
1p WRB 3-136
Tues, May 1
Radiation Oncology Grand Rounds
Tangel Chang, DO 
PGY5 Physician Resident, Radiation Oncology, UHCMC
"Decrease hospitalization for concurrent chemo-RT patients"
8:10a Lerner B-151

Special Physiology & Biophysics Seminar
Xinghong Dai, PhD Postdoctoral Scholar, Sun lab, Molecular and Medical Pharmacology, University of California - Los Angeles "Mechanisms of viral capsid assembly and genome packaging"

Enrique Ecker Lecture External Speaker
Irving Weissman, MD
Professor, Pathology and Developmental Biology, Stanford University
"Normal and neoplastic stem cells"
12p WRB 1-1413
Thurs, May 3
Developmental Therapeutics Journal Club
9a R4-013

CFAR Leaders Meeting
Jintanat Ananworanich, MD, PhD
Associate Director for Therapeutics Research, U.S. Military HIV Research Program
"Acute HIV infection and HIV remission research: experience from the RV254 study in Thailand"
1p SOM W203
Fri, May 4
Taussig Cancer Institute Grand Rounds
Rebecca Flyckt, MD "Fertility preservation in the female cancer Patient: Survivors, previvors, and the newly diagnosed"
8a CA5-120

Cellular and Molecular Medicine
Jeremy Chien, PhD
Endowed Professor, Cancer Genomics and Target Discovery,  University of New Mexico Comprehensive Cancer Center
"Targeting genetic vulnerabilities in ovarian cancer"
10a NC1-202

Cancer Center Seminar Series: Helen Moss Integrative Oncology Lecture
Donald I. Abrams, MD Professor, Medicine, University of California San Francisco Oncology, Zuckerberg San Francisco General Hospital Integrative Oncology, Osher Center for Integrative Medicine "Cannabis in cancer care"
12p WRB 1-413
Sat, May 5
Mid-West DNA Repair Symposium
10:45a - 10p Thwing Center
Sun, May 6
Mid-West DNA Repair Symposium
9a - 3:10p Thwing Center
Mon, May 7
Genomic Medicine Institute 
Angela Ting, PhD
Associate Professor, Genomic Medicine Institute, Cleveland Clinic
"The role of DNA methylation in modulating transcriptome diversity"
12p NE1-205 Cleveland Clinic

Pathology Research Seminar Series
Alex Gooding 
Schiemann Lab, Oncology, CWRU
"Elucidating the role of the lncRNA BORG during beast cancer metastasis"
12p WRB 1-413

Cancer Center Research Chalk Talk
Vinay Varadan, PhD
Assistant Professor, Oncology, CWRU
1p WRB 3-136

Tumor Immunology and Immunotherapy Meeting
4p CA5-124 Cleveland Clinic
Tues, May 8
Cancer Center Research in Progress Seminar
3p WRB 3-136
Wed, May 9
PRCHN Seminar
Anna Thornton, MPH
REACH Project Manager; Shari Bolen, MD, and Jonathan Lever, MPH, Better Health Partnership; and Samantha Smith, MA, Cuyahoga County Board of Health 
"Chronic disease self-management program: Innovations and partnerships to make a difference in self-reported outcomes"
12p PRCHN conference room
Thurs, May 10
Molecular Biology and Microbiology Seminar
1p SOM W203

Team Case CCC Velosano Happy Hour 
4-6p Washington Place Inn and Bistro
Fri, May 11
Taussig Cancer Institute Grand Rounds
Daniel Stover, MD
Ohio State University
"Cell-free DNA in breast cancer: Hype, hope, and reality"
8a CA5-120 Cleveland Clinic


Deadline: Open

Deadline: Open

Deadline: Open
Case Comprehensive Cancer Center 
11100 Euclid Avenue, Wearn152
Cleveland, OH 44106-5065