August 21, 2020
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Member/Center Highlights
Clinical trial studies use of genetically modified poliovirus as glioblastoma treatment
Andrew Sloan
A new clinical trial at University Hospitals Seidman Cancer Center, part of the NCI-designated Case Comprehensive Cancer Center (Case CCC) seeks to validate whether a modified version of poliovirus can impact survival of patients with a deadly brain cancer known as glioblastoma (GBM).

The study, initiated at Duke Cancer Institute and published in New England Journal of Medicine in 2018, uses the virus to evoke an anti-tumor immune response to expose and attack tumor cells in addition to the small number of tumor cells killed directly by the virus. UH Seidman is the only site in the US Midwest participating in the trial and recently treated its first patient for the trial, a 59-year-old man with recurrent glioblastoma following initial surgery and treatment.

“This trial uses a polio virus modified to specifically target a receptor (CD155) found only on tumor cells,” explained Andrew E. Sloan, MD, FAANS, FACS in a release earlier this year. Dr. Sloan is Director of the Brain Tumor and Neuro-Oncology Center and the Center of Excellence in Translational Neuro-Oncology at UH Seidman Cancer Center and the UH Neurological Institute. He is also a member of the Case CCC's Developmental Therapeutics and Cancer Imaging Programs.
Cancer Center Seminar Series returns Friday, September 11
Each Fall and Spring, the Case Comprehensive Cancer Center (Case CCC) hosts an interdisciplinary seminar series addressing cutting-edge clinical, translational and basic research topics in cancer, held weekly each Friday at 12 pm EST. As of March 2020, these weekly seminars are held virtually via Zoom.

This series returns this Fall, beginning Friday, September 11 with Jennifer Cullen, PhD, MPH presenting, "History, Evolution, and Modern Opportunities in Cancer Population Sciences" on behalf of the Cancer Prevention, Control & Population Research Program. Dr. Cullen holds the The James T. Pardee - Carl A. Gerstacker Professorship in Cancer Research and is Associate Director for Cancer Population Sciences at the Case CCC.
VeloSano Trainee Dream Experiment Awardee Symposium to be held virtually Thursday, September 17
In 2019, the Case Comprehensive Cancer Center granted 8 trainees with VeloSano Trainee Dream Experiment Fellowships. Awardees will present their projects and outcomes to the cancer research community on Thursday September 17, 2020 at 9 am via Zoom.

Please join us via Zoom to see a brief presentation of their research projects and to ask questions. A list of awardees and their projects is below.
Ashwin Kishtagari
Mentor: Yogen Saunthararajah, MD
"A first-in-class ISWI epigenetic therapy for acute myeloid leukemia"

Darcie Seachrist
Mentor, Ruth Keri, PhD
"Identification of the BCL11A-regulated secretome of triple-negative breast cancer cells"

Defne Bayik
Mentor: Justin Lathia, PhD
"Therapeutic targeting of communication between systemic immunity and gut microbiome in glioblastoma"

LC Stetson
Mentor: David Wald, MD, PhD
"Leukemic initiating cell heterogeneity and evolution in the progression of acute myeloid leukemia"
Nathaniel Robinson
Mentor: William Schiemann, PhD
"Characterizing the role of SLX4IP in breast cancer metastasis through telomere proteome dynamics"

Prabhani Atukorale
Mentor: Efstathios Karathanasis, MD
"Immuno-nanoparticles for ‘prime-pull’ cancer vaccination and the identification of the CD8+ neo-antigens"

Uriel Kim
Mentor: Johnie Rose, MD, PhD
"Bridging the clinical-community divide: Understanding how to better deliver lung cancer screenings at a community-scale"

Bhavuk Garg
Mentor: Seth Corey, MD, MPH
"Mutational cooperativity driven clonal advantage is a model for leukemic evolution"
VeloSano 7 fundraising continues through October 1
To-date, the 43 members that comprise Team Case Comprehensive Cancer Center have raised $19,797 and counting for lifesaving cancer research at Cleveland's top-tier hospitals and research institutions.

Despite the shift to Virtual VeloSano, our team pressed on and remained committed to participating in their chosen activities - biking, hiking, walking and yes, even gardening. Fundraising for this year's event will continue through October 1, 2020. Thank you to our committed team members, those who have donated to the cause and all who have cheered them on!
Review COVID-19 guidelines to help keep our CWRU community safe
As more students, staff and faculty are returning to campus to begin the Fall 2020 semester, please review resources that highlight university guidelines to keep our community as safe as possible during the pandemic.

Case CCC COVID-19 Resource Hub
As the COVID-19 outbreak progresses, the Case Comprehensive Cancer Center (Case CCC) has centralized COVID-19 related news, resources and funding opportunities for our cancer center community. Content is updated regularly.

To have a cancer-focused resource added to the page, please email cancer@case.edu.
What's Coming Up
Mark Your Calendar
Early Bird Registration Ending Soon: Artificial Intelligence in Oncology Virtual Symposium 2020
October 19-20, 2020

The second annual Artificial Intelligence in Oncology Symposium will bring together experts in AI and machine learning as well as clinical, industry and federal agency experts in pathology, radiology, drug discovery, and ethics and policy to speak on research developments, regulatory policy, reimbursement and ethics surrounding AI in oncology. For the health and safety of all attendees, this year's symposium will take place virtually.

The symposium will feature four focused sessions, with speakers and panel discussions providing unique perspectives on how AI and machine learning are impacting the major areas of radiology, pathology and -omics in the contexts of precision medicine approaches for characterizing tumors and predicting therapeutic response.

Beyond the science, attendees will be able to network and enjoy a special session highlighting some of the brightest rising stars in the field of AI in oncology, selected from abstract submissions. Submit your abstract by Friday, September 11!

Geraldine McGinty, MD, MBA, FACR will present the symposium plenary, "Fostering a Strong Ecosystem for AI in Medical Imaging." Dr. McGinty is an internationally recognized expert in imaging economics, Chair of the American College of Radiology Board of Chancellors and Chief Strategy and Contracting Officer at Weill Cornell Medicine in New York City.

Additional keynotes in drug discovery, ethics & policy and pathology will be delivered by Russ Altman, MD, PhD of Stanford University, Aashima Gupta, MS of Google, Vinay Prasad, MD, MPH of the University of California, San Francisco, and Yinyin Yuan, PhD of the Institute of Cancer Research, London. Learn more about AIO 2020 speakers.
Additional Upcoming Events
NCCN Oncology Policy Virtual Summit
September 9, 2020
The Summit will explore diverse perspectives related to emerging models to drive down healthcare costs in the United States and their potential impact on access to high-quality cancer care. Major themes of the summit will include an overview of legislative and regulatory efforts to reduce health costs, the current state of value-based payment models, and the impact of these models on providers and patients with cancer. The summit will also explore the unique implications of policies intended to curb costs for rural and other underserved populations.

If you have any questions, please contact Terrell Johnson, Manager, Policy and Advocacy, johnson@nccn.org.
NCCN 2020 Virtual Congress: Hematologic Malignancies
October 9-10, 2020
Attend this NCCN virtual congress to hear from world-renowned experts in the management of Hematologic Malignancies present the latest treatment advances, updates to the standard of care as recommended in the NCCN Guidelines®, and unique and challenging patient cases.

Co-chaired by Ranjana H. Advani, MD, Stanford Cancer Institute, and Andrew D. Zelenetz, MD, PhD, Memorial Sloan Kettering Cancer Center, this virtual program features presentations and interactive discussions highlighting the treatment options and supportive care for a variety of hematological malignancies.

This program is approved for AMA PRA Category 1 Credit™ for physicians and will award contact hours for nurses, pharmacists, and other health care professionals.
NCCN 2021 Annual Conference: Call for Abstracts
Abstract Deadline: November 11, 2020
NCCN is now accepting abstracts for consideration to be presented during the NCCN 2021 Annual Conference General Poster Session at the Rosen Shingle Creek in Orlando, Florida on Thursday, March 18 and Friday, March 19, 2021. NCCN welcomes original abstracts from investigators in the general oncology community. Submissions will be accepted from academic institutions, teaching and community hospitals, or industry. Both NCCN and non-NCCN institutions may participate.

Research may fall into the general areas below:

  • Clinical Oncology (all phases)
  • Pre-Clinical Oncology
  • Epidemiology/Risks/Prevention
  • Correlative/Genomic
  • Best Practices in Implementation and Use of Clinical Practice Guidelines
  • Quality Improvement
  • Outcomes and Health Services Research
  • Bioinformatics/Information Technology Sciences
Sixth Computational Approaches for Cancer Workshop (CAFCW20)
Abstract Deadline: September 6, 2020
Workshop: November 13, 2020
The National Cancer Institute Center for Biomedical Informatics and Information Technology and SC20 are seeking abstracts for presentations for the Sixth Computational Approaches for Cancer Workshop (CAFCW20). CAFCW20 is a workshop designed to bring together clinicians, cancer biologists, mathematicians, data scientists, computational scientists, engineers, developers, thought leaders, and anyone else interested in advancing computation to use in cancer care and research. This year’s topic is “AI and HPC: Overcoming Data Challenges in Cancer Research and Clinical Applications.”

A special emphasis for the CAFCW20 is the role of HPC and AI to address research challenges when data are limited by availability, variability and size. The workshop will be held in conjunction with SC20: The International Conference on High Performance Computing, Networking, Storage and Analysis in Atlanta, GA., on November 15.
SGO 2021 Annual Meeting
Abstract Deadline: October 23, 2020
Annual Meeting: March 20-23, 2021

The Society of Gynecologic Oncology (SGO) Annual Meeting on Women’s Cancer is a comprehensive forum for the subspecialty of gynecologic oncology. Whether you’re a physician, surgeon, researcher, allied health professional or a student in the field, you can join us to make the connections that will boost your career, see what’s new in gynecologic oncology science and research, and learn the best practices and techniques that can take your care to the next level.

The Call for Abstracts and Surgical Films for the SGO 2021 Annual Meeting on Women’s Cancer is open through October 23, 2020. Call for Late-breaking abstracts will be open December 1, 2020 through January 4, 2021.
Funding Opportunities
NCI will be announcing a Request for Applications for the Predoctoral to Postdoctoral Fellow Transition (F99/K00) Award for 2020, to support outstanding Ph.D. candidates as they complete their dissertation research training (F99 phase; 1-2 years) and transition to a mentored, cancer-focused postdoctoral career development research positions (K00 phase – up to 4 years).

The F99/K00 award is open to 3rd or 4th year PhD students, including F31 Fellowship applicants and current awardees (note that 3 rd or 4 th year students would have matriculated in 2017 or 2018). International students may also apply. Students Matriculated in a dual-degree program (e.g.) MD/PhD, DO/PhD, DDS/PhD, or DVM/PhD) are not eligible for the F99/K00 program. Projects must be clearly focused on cancer.

To apply for this award, an applicant must be nominated by their institution. As each institution is allocated only one nomination, the Case Comprehensive Cancer Center (Case CCC) requires potential applicants to assemble a pre-application.

Click here to download nomination application instructions. Contact Damian Junk at damian.junk@case.edu for additional information.
VeloSano logo
With the generous support from VeloSano Bike to Cure, the Case Comprehensive Cancer Center (Case CCC) is providing funding for Case CCC Trainee Associate Members to perform their “dream experiment.”

The experiment should catalyze highly innovative and impactful projects and help strengthen fellowship and career development grant applications. The intent of the award is to support a single or limited set of innovative experiments, not for general laboratory supplies/projects or maintenance of the trainee’s project.

Up to five (4) projects will be funded at $10,000/award. Research projects must be completed within one (1) year, with funds expended by June 30, 2021.

Deadline: August 31, 2020

The Case Comprehensive Cancer Center is now accepting applications for the Fall 2020 pilot funding opportunities:

  • Available award: $120,000 for one year

  • Available award: $75,000 for 18 months

  • Available award: $180,000 for 18 months

Questions? Contact casecccpilots@case.edu or Julie DeJager Glavic at 216.368.5780.

In The News
SurvivorNet - July 31, 2020
“The immune response is actually heightened as the child is younger,” says Ted Teknos, MD scientific director of University Hospitals' Seidman Cancer Center and deputy director for University Hospitals at the Case CCC. “So if you’re vaccinated as a nine-year-old compared to an 11-year-old, your actual memory of that vaccine in your immune system is stronger — the effectiveness of the vaccine goes up.”
Elemental - August 6, 2020
“We declared victory at a plateau a couple months ago, and now we have a brand-new peak that has broken the previous record by twice the magnitude,” says Mark Cameron, PhD, an associate professor in the Department of Population and Quantitative Health Sciences at Case Western Reserve University School of Medicine and member, Case CCC.
From The NIH
Weekly NIH Funding Opportunities and Notices
COVID-19 Funding Opportunities and Notices
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