December 4, 2020
Member/Center Highlights
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American Society of Hematology Annual Meeting: Highlights from the Case CCC
The 62nd Annual American Society of Hematology (ASH) Meeting will take place virtually December 5-8, 2020. The Case Comprehensive Cancer Center has compiled a list of session chairs, presentations, abstracts and papers from Cleveland-based institutions including Cleveland Clinic, University Hospitals and Case Western Reserve University. We wish the best of luck to all presenters and attendees! 
San Antonio Breast Cancer Symposium: Highlights from the Case CCC
The 2020 San Antonio Breast Cancer Symposium will take place virtually December 8-11. Drawing an international audience of academic and private physicians and researchers, the symposium is designed to provide state-of-the-art information on the experimental biology, etiology, prevention, diagnosis and therapy of breast cancer and premalignant breast disease. The Case Comprehensive Cancer Center (Case CCC) has compiled a list of spotlight sessions and posters featuring Cleveland-based institutions including Cleveland Clinic, University Hospitals and Case Western Reserve University. We wish the best of luck to all presenters and attendees!
Phase 2 Clinical Trial for Patients with Recurrent Glioblastoma underway at University Hospitals
University Hospitals (UH) will be one of six research sites to initiate Phase 2 of a clinical trial of PVSRIPO in combination with pembrolizumab for patients with recurrent glioblastoma, one of the most aggressive tumor types. According to a release from clinical-stage biotechnology company Istari Oncology, Inc., PVSRIPO is a novel viral immunotherapy that activates a patient’s innate and adaptive immunity to facilitate a targeted anti-tumor immune response. The study seeks to determine whether PVSRIPO and pembrolizumab will be able to generate anti-tumor response in patients with rGBM, given their complementary mechanisms of action.
Andrew Sloan
“The Phase 1 trial of PVSRIPO yielded survival rates like we’ve never seen before,” said Andrew E. Sloan, MD, FACS, Director of the Brain Tumor & Neuro-Oncology Center and the Center of Excellence in Translational Neuro-Oncology at UH Seidman Cancer Center and UH Neurological Institute, and Professor and Vice Chairman, Department of Neurosurgery at Case Western Reserve University School of Medicine. Dr. Sloan is a member of the Case Comprehensive Cancer Center's Developmental Therapeutics and Cancer Imaging programs.
Cleveland Clinic enters License Agreement for Innovative Ovarian Cancer Vaccine
Anixa Biosciences, Inc., a biotechnology company focused on the treatment and prevention of cancer and infectious diseases, announced Monday that it has entered into a license agreement with Cleveland Clinic for exclusive, world-wide rights to an innovative ovarian cancer vaccine technology.
Cleveland Clinic immunologist Vincent Tuohy, PhD has been working on a method to vaccinate women against ovarian cancer and other gynecological malignancies. This development-stage vaccine targets the extracellular domain of anti-mullerian hormone receptor 2 (AMHR2-ED), that appears in many types of ovarian cancer. Dr. Tuohy is a member of the Case Comprehensive Cancer Center's Hematopoietic and Immune Cancer Biology Program.
Center for Immunotherapy & Precision Immuno-Oncology Seeking Faculty, Program Head and Postdoctoral Fellow
The Center for Immunotherapy and Precision Immuno-Oncology at Cleveland Clinic Lerner Research Institute is seeking qualified candidates for various roles. CITI has open full time positions at all academic levels for candidates who have expertise in immuno-oncology, immunotherapy, immunology, or immunogenomics. The center is also seeking a Program Head for Cell Therapy Developmental Therapeutics and Faculty in Immuno-Oncology focused on Cell Therapy, as well as a postdoctoral fellow in the laboratory of Timothy Chan, MD, PhD. CITI is also hiring a Research Department Analyst.
Depts. of Biomedical Engineering and Computer & Data Sciences Seeking Associate Professor in Artificial Intelligence & Medical Imaging
The Departments of Biomedical Engineering and Computer & Data Sciences in the Case School of Engineering at Case Western Reserve University (CWRU) are inviting applications for a mid-level (tenured/tenure-track) faculty position in the area of artificial intelligence and medical imaging. The successful candidate will be jointly appointed and will also be affiliated with the Center for Computational Imaging and Personalized Diagnostics (CCIPD).
Case CCC COVID-19 Resource Hub
The Case Comprehensive Cancer Center (Case CCC) has centralized COVID-19 related news, resources and funding opportunities for our cancer center community. Content is updated regularly.

To have a cancer-focused resource added to the page, please email cancer@case.edu.
What's Coming Up
Mark Your Calendar
Cancer Center Seminar Series
Friday, December 4, 2020, 12p via Zoom
Today's Cancer Center Seminar features Adam Bass, MD presenting, "Translating the Genome in Gastroesophageal Cancer" on behalf of the GI Cancer Genetics Program at noon.

Dr. Bass is Associate Professor of medicine at Harvard Medical School and Assistant Professor of medicine in the division of cellular and molecular oncology at Dana-Farber Cancer Institute. The overarching goal of his lab is to leverage the study the cancer genome to elucidate key biological processes and therapeutic vulnerabilities in carcinomas arising in the GI tract, especially stomach and esophageal carcinomas.
Cancer Center Seminar Series
Friday, December 11, 2020, 12p via Zoom

On Friday, December 11, our Cancer Center Seminar welcomes Mario Suvà, MD, PhD on behalf of the Molecular Oncology Program 12 pm ET.

Dr. Suvà is an associate professor of pathology and associate molecular pathologist at Massachusetts General Hospital. He is also an associated scientist at the Broad Institute of MIT and Harvard and Co-Leader of the Dana-Farber/Harvard Cancer Center Neuro-Oncology Program and Co-Leader of the Cancer Program at Harvard Stem Cell Institute.
Registration Now Open: Cancer Disparities Symposium (Virtual)
March 4-5, 2021

The Case Comprehensive Cancer Center Office of Community Outreach and Engagement is pleased to present the 5th Annual Cancer Disparities Symposium, Navigating Cancer Disparities: Lessons Learned and How to Move Forward.
Registration is now open for this multi-disciplinary event for researchers, clinicians, health professionals, community outreach groups, community-based organizations, patient advocates and trainees. Keynote presentations will be delivered by renowned disparities researchers and community leaders, and a poster session highlighting academic research and community programs will provide a showcase of the depth and depth of work happening in this field.

Though the symposium is happening virtually, attendees will experience the conference using Whova, our official web-based conference app, to view presentations and ask questions in real-time, as well as network with others behind the scenes.

Call for Abstracts
Multidisciplinary researchers, community agencies and organizations are invited to submit abstracts for presentation at the 5th Annual Cancer Disparities Symposium. Abstracts will be divided into two tracks: Scientific Research and Community Programs. Meritorious abstracts will be selected for pre-recorded presentations. Abstracts must be submitted electronically by 5 pm ET on Friday, January 22, 2021.
Keynote Speakers Announced
Otis W. Brawley, MD, an internationally-recognized expert in cancer prevention and control, will present the symposium's Scientific Keynote His work is focused on closing racial, economic and social disparities in prevention, detection and treatment of cancer in the United States and worldwide.

Worta McCaskill-Stevens, MD, a medical oncologist nationally known for her expertise in bringing clinical trials to the community will present the Community Keynote. Dr. McCaskill-Stevens is Chief of the Community Oncology and Prevention Trials Research Group, which houses the National Cancer Institute (NCI) Community Oncology Research Program (NCORP), a community-based clinical trials network launched in 2014.
Additional Upcoming Events
Association of Indian Physicians of Northern Ohio (AIPNO) 37th Annual Gala Event/8th Research Showcase Poster Competition
Saturday, December 5, 2020
AIPNO is a vibrant large non-profit organization in the state of Ohio founded in 1983 geared toward enhancing the quality of healthcare by fostering excellence and professionalism in the practice of medicine and supporting efforts to improve the availability of healthcare to underserved populations in Ohio and in India. The mission of AIPNO is to continue to enhance community involvement and coordinate with other local, national and international organizations through philanthropy, health care access and education.

AIPNO is for non-Indians as well. The AIPNO Annual Event and Conference is one of their most prestigious events and includes a Research Showcase (complimentary registration for poster presenters and winners awarded cash prizes). AIPNO fosters and encourages participation from high school students, medical students, residents, fellows, faculty, nurses, seasoned researchers, allied healthcare providers (nurses, therapists, etc.), community leaders, legislative leaders, philanthropic practitioners, dedicated donors and valued beneficiaries alike.

Questions? Contact Pam Pawelecki at admin@aipno.org.
22nd Annual Best of Radiation Oncology (Live Stream)
Saturday, December 5, 2020
This course, co-directed by Janice Lyons, MD and John Suh, MD will provide radiation oncologists, radiation physicists, nurses, and others with the most current data and information that have been presented at the national meetings.

Agenda
8:00am | Welcome / Introduction
John Suh, MD, FASTRO and Janice Lyons, MD

8:05am | Management of Breast Cancer
Chirag Shah, MD

8:30am | Management of CNS Tumors
Samuel Chao, MD

8:55am | Management of GI Tumors
Suzanne Russo, MD

9:20am | Management of Thoracic Malignancies
Gregory Videtic, MD, FASTRO

9:45am | Management of GU Tumors
Gordon Guo, MD

Break (10 minutes)
10:20am | Management of Head and Neck Tumors
Neil Woody, MD

10:45am | Management of GYN Tumors
Sudha Amarnath, MD

11:10am | Overview of Radiation Oncology at VA
Aryavarta Kumar, MD, PhD

11:35am | Adjourn

Please email Sheryl Krall at kralls2@ccf.org to register.
62nd ASH Annual Meeting and Exposition (Virtual)
December 5-8, 2020
Registration is open for the American Society of Hematology's all-virtual Annual Meeting and Exposition, taking place Saturday, December 5 through Tuesday, December 8. Attend the world’s most comprehensive hematology event of the year for an invaluable educational experience and the opportunity to review thousands of scientific abstracts highlighting updates on the most critical topics in hematology.


The schedule-at-a-glance and the preliminary schedule and program for the 62nd ASH Annual Meeting and Exposition are now available, and abstracts have been recently posted.
San Antonio Breast Cancer Symposium (Virtual)
December 8-11, 2020
The San Antonio Breast Cancer Symposium is designed to provide state-of-the-art information on the experimental biology, etiology, prevention, diagnosis, and therapy of breast cancer and premalignant breast disease, to an international audience of academic and private physicians and researchers.

The symposium is comprised of prestigious award lectures, educational sessions, career development forum, special global session, special session presented by Tigerlily Foundation & AACR, plenary lectures, mini-symposia, clinical, translational & basic science forums, work shops, case discussions and more! The schedule at a glance and daily schedule are now posted online.

Registration fees for the virtual symposium has been reduced.
NCCN Virtual Patient Advocacy Summit
December 10, 2020
Patients with cancer often have widely divergent care experiences from screening through survivorship. Differences in care delivery and outcomes may be due, in part, to varying patient needs and preferences according to age and stage of life; inconsistent implementation of guidelines, recommendations, and policies; and unintended age bias in health care.

The National Comprehensive Cancer Network’s® (NCCN®) Virtual Patient Advocacy Summit will provide an opportunity for a varied group of stakeholders including patients, caregivers, providers, patient advocacy organizations, policymakers, and industry to thoughtfully discuss the importance of providing quality, effective, efficient, and accessible cancer care across the patient lifespan.
Funding Opportunities
The Mary Kay Foundation is accepting applications for grants for translational research in ovarian, uterine, breast, or cervical cancer. Only one individual at Case Western Reserve University (including University Hospitals researchers with CWRU appointments) will be nominated to submit a full application. Case Comprehensive Cancer Center members who are appointed through UH or CWRU should apply to THIS internal competition. CCF applicants should apply internally here by Dec 1.

Grants up to $100,000 total costs ($86,956 direct costs with a 15% IDC rate), to be used over one or two years. PIs must have a full-time, independent, faculty appointment.

Case Comprehensive Cancer Center leadership will review all applicants. Selected nominees will work with their department research administrators and Case CCC administration to submit full applications to the sponsor before February 5, 2021.
White Paper LOI Deadline: March 26, 2021
Solicitation Response Deadline: July 23, 2021
Do you have a cancer technology idea that breaks convention? The NCI SBIR Development Center is proud to announce the launch of a new funding option for you. Say hello to the SBIR Phase I Concept Award.

This opportunity is designed for small businesses developing highly innovative and transformative technologies that have the potential to create new scientific paradigms, establish entirely new and improved approaches to significantly improve cancer research, prevention, detection and care in pediatric and/or rare cancers. The short proposal is intended to de-risk out of the box ideas – therefore review will focus heavily on innovation and preliminary data is NOT required.

You can learn more about the SBIR Phase I Concept Award during an informational webinar on Wednesday, December 16, 2020.

Interested small business offerors are requested to indicate their intent to propose by submitting a White Paper by March 26, 2021. This will allow the NCI to provide feedback on whether or not the proposed idea falls within the scope of what this solicitation is seeking. Details are included in the solicitation.

Responses to this solicitation are due by July 23, 2021, 5 pm ET. For more information about this program, please visit the program solicitation or contact Tiffany Chadwick.
In The News
Cincinnati Enquirer - November 23, 2020
Mark Cameron, PhD weighed in on whether or not he'd be participating in common holiday traditions this season as COVID-19 numbers rise in Ohio and across much of the United States. Dr. Cameron is an infectious disease expert and associate professor at Case Western Reserve University School of Medicine and member, Case CCC.
MSN via Cleveland.com - November 27, 2020
"We are in the unfortunate situation right now of having to choose between doing the things we’d all like to be doing and losing more of our neighbors and family members," said Johnie Rose, MD, PhD, assistant professor at Case Western Reserve University School of Medicine and member, Case CCC.
From The NIH
Weekly NIH Funding Opportunities and Notices
Notices





Funding Opportunities

Standard Dates Apply

Deadlines: June 8, 2021; November 17, 2021

Deadlines: June 8, 2021; November 17, 2021

Deadlines: June 8, 2021; November 17, 2021

Deadlines: June 8, 2021; November 17, 2021

Deadlines: June 8, 2021; November 17, 2021

Deadlines: June 8, 2021; November 17, 2021

Deadlines: June 8, 2021; November 17, 2021

Deadline: March 8, 2021
COVID-19 Funding Opportunities and Notices
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