News and Updates from the Case Comprehensive Cancer Center
FEBRUARY 14, 2020
Member/Center Highlights
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Kishore Guda
Potential Breakthrough in the Search for New Treatment Options for Esophageal Cancer Patients
Kishore Guda, DVM, PhD, an associate professor of oncology at Case Western Reserve University School of Medicine, has been awarded $200,000 by The DeGregorio Family Foundation and the Price Family—partnering with the Savone Family and The Esophageal Cancer Awareness Association.

This award will support Dr. Guda's research at the Case Comprehensive Cancer Center on establishing a deeper understanding of the TGFbeta cellular pathway and its impact on the development of esophageal adenocarcinoma (EAC).
Read the full release
Oversight Hearing on DOE's Role in Advancing Biomedical Sciences (EventID=110447)
Chance Testifies Before US House on Synchrotron Facilities, Cancer-related Discoveries and Drug Development
Earlier this month, Mark Chance, PhD, visited Washington DC to testify before the US House of Representatives Committee on Appropriations and report on synchrotron facilities at Case Western Reserve University (CWRU).
The oversight hearing on the Department of Energy's role in advancing biomedical sciences, presented Dr. Chance alongside Narayanan 'Bobby' Kasthuri, MD, PhD of the Argonne National Laboratory and The University of Chicago and Harold Varmus, MD of Weill Cornell Medicine and former Director of the National Institutes of Health and National Cancer Institute.

Dr. Chance is Vice Dean for Research at the CWRU School of Medicine, Director of the Center for Proteomics and Bioinformatics and a member of the Case Comprehensive Cancer Center (Case CCC) GI Cancer Genetics Program. In his testimony, which begins around 25:12 in the video above, he states simply, "DoE science facilities are critical to America's basic biomedical science, drug and device development, and public health goals of the nation with positive effects on the health and welfare of all Americans and saving many lives." Dr. Chance goes on to inform the Subcommittee on Energy and Water Development, and Related Agencies on the role of synchrotrons in drug development, where more than 90 percent of structures have the drug target solved at beamlines.
Read witness testimonies from Drs. Chance, Varmus and Kasthuri
Work from Madabhushi's Group Featured in 2019 Research Highlights for the Epidemiology and Genomics Research Program
Each year, the Epidemiology and Genomics Research Program (EGRP) Research Highlights showcases a selection of research publications supported by grants in the EGRP grant portfolio. For the second year in a row, work from Anant Madabhushi, MS, PhD's group has been selected for the showcase. Dr. Madabhushi is Director of the Center for Computational Imaging and Personalized Diagnostics at CWRU and a member of the Case CCC's Cancer Imaging Program.

This year's highlighted work is, " Changes in CT Radiomic Features Associated with Lymphocyte Distribution Predict Overall Survival and Response to Immunotherapy in Non-Small Cell Lung Cancer" published by a multi-disciplinary team from Case Western Reserve University, University Hospitals, Cleveland Clinic, Weill Cornell Medicine, Maimonides Medical Center, Hospital of the University of Pennsylvania and New York University. Case CCC Developmental Therapeutics Program member Pingfu Fu, PhD, associate professor of Population and Quantitative Health Sciences at CWRU, also co-authored the work.
Join Team Case CCC in VeloSano 2020!
The Case Comprehensive Cancer Center (Case CCC) is honored to make its sixth appearance in VeloSano, a year-round fundraising initiative and "Bike to Cure" weekend to support lifesaving cancer research. Our continuing goal is to bring sustainable funding to cancer research by enlisting the passion and energy of thousands of people who wish to give back... including YOU! We raised nearly $94,000 in 2019 and every dollar goes directly toward cancer research. In our six years of participation, more than $1,000,000 of VeloSano fundraising totals have come back to the Case CCC to award researchers as pilot funding for cancer research projects.
The Case CCC will provide complimentary registration fees and jerseys again this year. Contact team captains Caroline El Sanadi or Mary Wright for the registration fee waiver code to sign up! While registration is complimentary, all riders are responsible for meeting the minimum fundraising commitment associated with the distance they ride. Fundraising can begin as soon as you register to ride and continues through October 1, 2020.

Registration is open now and information about volunteering for our cheer station and supporting our team through sponsorship will be available soon!
Learn more about VeloSano 7 and joining or supporting Team Case CCC
What's Coming Up
Mon, Feb 17
Genomic Medicine Institute Seminar
12p NE1-205
Details

Wolstein Research Building Faculty Meetings with Stan Gerson
3:30p WRB
Tues, Feb 18
Dept of Pathology Seminar
Mark Jackson, PhD
12p WRB Auditorium

Cancer Drug Discovery and Resistance
3p WRB 1-422D

Pavey Family Designated Professorship Ceremony
Mark Griswold, PhD
4:30p WRB
Weds, Feb 19
Biomedical Innovation and Entrepreneur Club
4-6p BRB 932
Details
Thurs, Feb 20
D  evelopmental Therapeutics Journal Club
9a NE6-218

Molecular Biology and Microbiology Seminar
1p SOM W203

Reception Celebrating Monica Webb Hooper, PhD
4-6p WRB Rear Lobby
Fri, Feb 21
Taussig Cancer Institute Grand Rounds
8a CA5-120

Cancer Center Seminar Series
David Chambers, DPhil
12p WRB Auditorium
Mon, Feb 24
BME Guest Seminar
Gertraud Orend, PhD
11a NC1-202
Details

Cancer Center Research Chalk Talk
1p WRB 3-136
Tues, Feb 25
DNA Damage and Repair Working Group
3p NB5-09
Thurs, Feb 27
D  evelopmental Therapeutics Journal Club
9a NE6-218

Immunology Journal Club
12p WRB 5-136

Molecular Biology and Microbiology Seminar
1p SOM W203
Fri, Feb 28
Taussig Cancer Institute Grand Rounds - CCF Only
8a CA5-120

Cancer Center Seminar Series
Sudha Chakrapani, PhD
12p WRB Auditorium
Case CCC Calendar
LRI Calendar
Mark Your Calendar
Cancer Center Seminar Series
February 14, 12p
WRB Auditorium



Our weekly seminar series features Jan Grimm, MD, PhD at noon today in the auditorium of the Wolstein Research Building.

Dr. Grimm is Associate Attending at Memorial Hospital, Associate Professor, Cornell Radiology and Gerstner Graduate School of Biomedical Sciences, and Associate Member of the Molecular Pharmacology Program at Memorial Sloan Kettering Cancer Center.

He will present, "Imaging with the Speed of Sound and Light" on behalf of the Cancer Imaging Program.
Watch live at noon
Cancer Center Seminar Series
February 21, 12p
WRB Auditorium



Next week's cancer center seminar will be presented by David Chambers, DPhil on behalf of the Cancer Imaging Program.

Dr. Chambers is Deputy Director for Implementation Science at the National Cancer Institute, National Institutes of Health.

He will present, "Advancing the Science of Implementation in Cancer: An NCI Perspective" at noon in the WRB Auditorium.
View the Seminar Series schedule
Pavey Family Designated Professorship Ceremony
February 18, 4:30p
Wolstein Research Building

Join President Barbara R. Snyder to celebrate the generosity of the Pavey Family and the appointment of Mark Griswold, PhD as the Pavey Family Designated Professor of Innovative Imaging - Revolutionizing the Worlds of Education and Medicine.

A ceremony will take place on Tuesday, February 18 at 4:30 pm in the Wolstein Research Building with a reception to follow. Dress is business attire and complimentary valet parking will be available off of Circle Drive.
Monica Webb Hooper
Farewell Reception for Monica Webb Hooper, PhD
February 20, 4-6p
Wolstein Research Building Rear Lobby

Join us on Thursday, February 20 for a farewell reception celebrating Monica Webb Hooper, PhD, Case Comprehensive Cancer Center Associate Director for Cancer Disparities Research, and her appointment as Deputy Director of the National Institute on Minority Health and Health Disparities.
3 Weeks Away: 4th Annual Cancer Disparities Symposium
March 6, 2020
Tinkham Veale University Center, CWRU

The   4th Annual Cancer Disparities Symposium : Cultivating Science and Community Engagement to Address Cancer Health Disparities is less than one month away! Don't miss the opportunity to join researchers, physicians, and community leaders as we share cutting edge science and innovations in community engagement.

The symposium agenda is now posted and features sessions on Cancer Disparities and Underserved Populations, such as sexual and gender minorities, Amish, and muslim women, Community Engagement and Support Programs, and Cancer Disparities Research and Community Engagement, plus invited presentations selected from standout abstract submissions. The final session of the day will be a multidisciplinary and thought-provoking panel discussion that will crystallize the energy and inspire us to continue toward the ultimate goal of health equity.

Robert T. Croyle, PhD of the National Cancer Institute will deliver the day's Plenary Address and and Lucio Miele, MD, PhD from Louisiana State University is this year's Distinguished Scientific Keynote speaker.

Attendees are eligible to receive six (6) continuing research education credits (CRECs) or six (6) continuing education contact hours (CECH) units of advanced level training in health education. Meals, materials, refreshments and parking will be provided.
Register now for the Cancer Disparities Symposium
Research ShowCASE 2020
April 17, 9a-3p
Veale Convocation Center

CWRU faculty, staff and students by presenting your work at Research ShowCASE 2020. The event will provide an opportunity for CWRU researchers to display your research in a traditional scientific poster or other creative means. We encourage University Hospitals, Cleveland Clinic, MetroHealth Medical Center and the Louis Stokes Cleveland VA Medical Center researchers to participate.

In addition to the opportunity to display and share your work, undergraduate and graduate students, professional students and postdoctoral scholars are encouraged to participate in the research competition, which will include having your presentation evaluated and feedback provided. Cash prizes will be awarded to winning entries.

In order to display your work at Research ShowCASE, you will need to submit an online abstract describing your research. If you are a student or post-doc, your faculty adviser will need to approve your submission. 

Abstract Deadlines:
Graduate and professional students, post-docs, faculty, staff and affiliates: February 16, 2020

Undergraduate and high school students: March 20, 2020
High school, graduate and professional student, faculty, staff and affiliate submissions
Undergraduate submissions
Registration Opening Soon: Cancer Stem Cell Conference 2020
August 4-6, 2020
Tinkham Veale University Center

The Case Comprehensive Cancer Center and the National Center for Regenerative Medicine invite you to save the date for CSC 2020!

Now in its fourth year, CSC 2020 will feature renowned thought leaders in the field of cancer stem cell research. This conference is guaranteed to offer cutting-edge keynote presentations from a variety of niches within the field. Join world-class investigators for this three-day summit and network with scientists and clinicians advancing cancer stem cell research and therapeutic applications. 

Registration and abstract submission will open soon!
Sign up to receive updates on #CLECSC2020
Save The Date: Great Lakes Breast Cancer Symposium 2020
October 4-6, 2020
Tinkham Veale University Center, CWRU

As host site for the 2020 Great Lakes Breast Cancer Symposium, the Case Comprehensive Cancer Center encourages you to mark your calendar for the symposium taking place October 4-6, 2020.

The symposium highlights ongoing basic, translational, clinical and population studies addressing the biological mechanisms, management and prevention of breast cancer. Researchers from participating institutions will share their exciting work with a goal to develop cross-institutional collaborations.

This year's event features two keynote speakers:
  • Carlos Arteaga, MD, Director of the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center
  • Helen Piwnica-Worms, PhD, Professor of Experimental Radiation Oncology at the University of Texas MD Anderson Cancer Center
Sign up to receive symposium updates
Additional Upcoming Events
Management of Checkpoint Inhibitor-Related Toxicity Conference
March 6, 2020
InterContinental, Cleveland
Immune checkpoint blockade leads to a new spectrum of dysimmune toxicity requiring collaboration between oncologists, providers, and specialists to improve the understanding of the mechanism, diagnosis, and management of immune-related adverse events (irAEs). The goal of this conference is to bring together a multidisciplinary group of clinicians to share expertise and improve the care of patients receiving immune checkpoint inhibitor therapies.
Register for the conference by Wednesday, March 4
NCCN 2020 Annual Conference
March 20-22, 2020
Orlando, FL

The National Comprehensive Cancer Network (NCCN) 2020 Annual Conference agenda includes 30 educational sessions featuring the latest advances in oncology care, including interactive patient case studies. Session topics include: HPV-Associated Cancers, Patient-Reported Outcomes, Clinical Trial Implementation, Value-Based Payment Models, Role of Biosimilars and more.
Secure early-bird registration by Tuesday Feb 18
AACR Annual Meeting
April 24-29, 2020
San Diego Convention Center
The American Association for Cancer Research (AACR) Annual Meeting program covers the latest discoveries across the spectrum of cancer research—from population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy—and highlights the work of the best minds in research and medicine from institutions all over the world.

This year's meeting will take place April 24-29, 2020 at the San Diego Convention Center in San Diego, CA.

Final data for clinical abstract placeholders is due Thursday, February 20.
Register by February 21 to take advantage of the lowest rate
2020 NIMHD Health Disparities Research Institute
August 3-7, 2020
NIH Campus, Bethesda, MD
The National Institute on Minority Health and Health Disparities (NIMHD) will host the Health Disparities Research Institute (HDRI) from August 3-7, 2020 at the NIH campus (Natcher, Building 45 conference center rooms). The HDRI aims to support the research career development of promising early-career minority health and health disparities research scientists and stimulate research in disciplines supported by health disparities science. Applications will only be accepted from extramural scientists who meet NIH’s Early Stage Investigator (ESI) eligibility criteria.

The program will feature lectures, mock grant reviews, seminars, and small group discussions on research relevant to minority health and health disparities. It will also include sessions with NIH scientific staff engaged in related health disparities research across the various institutes and centers.

Extramural scientists, early in their careers with research foci in minority health and health disparities, are encouraged to apply to the institute.

Applications are now open and must be submitted via the HDRI application portal by Monday, March 9, 2020 at 5pm EST; emailed applications will not be accepted. Applicants are encouraged to apply before the deadline since late submissions will not be accepted. Questions may be directed to HDRI@nih.gov.
Learn more about the NIMHD Research Institute
Funding Opportunities
Funding Opportunity for Junior Faculty - Early Career Award
LOI Deadline: March 16, 2020

The Case Comprehensive Cancer Center, with funds from its American Cancer Society Institutional Research Grant, will provide seed money to foster cancer research by junior faculty who have no current national grant support of their own. Investigators in the CWRU School of Medicine, University Hospitals of Cleveland and Cleveland Clinic Lerner College of Medicine as well as in other schools and colleges affiliated with Case Western Reserve University are eligible. Grants, not to exceed $40,000, will be awarded to investigators who intend to gather preliminary data to be used in seeking future and independently funded programs.

Award Description
  • Pilot funding for CANCER-RELATED research with a basic, clinical, prevention and control, behavioral, health services or epidemiological focus.
  • Up to $40,000 award.
  • Applications accepted for general cancer-related projects and for special interest projects in adolescent-and-young-adult cancer research.
View previously announced funding opportunities
In The News
“Virtual Biopsies” May Soon Make Some Invasive Tests Unnecessary
Leapsmag - Jan 31, 2020
University Hospitals urologist Lee Ponsky, MD says a combined MRI and computerized tool would be, "the closest to a crystal ball that we can get" in detecting and grading prostate cancer. Anant Madabhushi, MS, PhD, director of the Center for Computational Imaging and Personalized Diagnostics at CWRU also weighs in. Both Dr. Ponsky and Dr. Madabhushi are members of the Case CCC.
ASCO’s Inaugural Breakthrough Global Summit Showcased Evolving Technologies Poised to Revolutionize Cancer Care
ASCO Post - Feb 10, 2020
"We investigate how to use computer algorithms to interrogate the radiographic and pathology images to tease out the features and backgrounds the human eye may not be able to visually appreciate," said Anant Madabhushi, MS, PhD at the ASCO Breakthrough Global Summit in October 2019.
From The NIH
Weekly NIH Funding Opportunities and Notices
Notices
Request for Information (RFI): Inviting Comments and Suggestions on a Framework for the NIH-Wide Strategic Plan for FYs 2021-2025

Notice of Correction and Clarification to PAR-18-947 "Integrating Biospecimen Science Approaches into Clinical Assay Development (U01)"

Notice of Intent to Publish a Funding Opportunity Announcement for Metastasis Research Network (U54 Clinical Trial Not Allowed)

Notice of Special Interest (NOSI): Dissemination and Implementation Science for Cancer Prevention and Control in Low Resource Environments

Funding Opportunities
Research Centers in Minority Institutions (RCMI) (U54)- Clinical Trials Optional(RFA-MD-20-006)
Deadline: April 14, 2020 
View this week's bulletin
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