February 19, 2021
Member/Center Highlights
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University Hospitals is first in Cleveland to offer new targeted therapy for brain tumors
From University Hospitals: A University Hospitals Cleveland Medical Center neurosurgeon is among the first in the region to begin offering GammaTile® Therapy, a new approach to treating brain tumors. GammaTile Therapy is an FDA-cleared, Surgically Targeted Radiation Therapy (STaRT) that is designed to delay tumor regrowth for patients with brain tumors while protecting healthy brain tissue. University Hospitals Seidman Cancer Center is the first to offer this to patients with brain tumors in Cleveland.
Andrew Sloan, MD, Director of the Brain Tumor Program, said, “GammaTile has the potential to allow patients to have their radiation and surgery simultaneously, allowing patients to get back to their families and their lives several months earlier than with other methods.” Dr. Sloan is a member of the Case Comprehensive Cancer Center's Developmental Therapeutics and Cancer Imaging Research Programs.
University Hospitals Seidman Cancer Center welcomes new Chair of Radiation Oncology, Daniel E. Spratt, MD effective May 1
University Hospitals (UH) Seidman Cancer Center President and Scientific Director Theodoros Teknos, MD, this week announced Daniel E. Spratt, MD, will join the UH Seidman Cancer Center team and hold the Vincent K. Smith Chair in Radiation Oncology, effective May 1.

Dr. Spratt joins UH from the University of Michigan in Ann Arbor, where he was a tenured Professor, held the Laurie Snow Endowed Research Professorship and was the Associate Chair for Clinical Research in Radiation Oncology. He served as both the Director of the Spine Oncology Program and Co-Chair of the Genitourinary Clinical Research Team for the Rogel Cancer Center.
Scott elected to American Society for Clinical Investigation
Please join the Case Comprehensive Cancer Center in extending congratulations to Cleveland Clinic's Jacob Scott, MD, DPhil on his recent election to the American Society for Clinical Investigation (ASCI), which recognizes outstanding scholarly achievement among physician-scientists.

Dr. Scott will be officially inducted, along with 79 other nominees across the breadth of academic medicine in April during the AAP/ASCI/APSA Joint Meeting.
Trainee Spotlight: Marissa Scavuzzo chosen for prestigious Howard Hughes Medical Institute’s Hanna H. Gray Fellowship
Marissa Scavuzzo, PhD, a postdoctoral research fellow in the lab of Paul Tesar, PhD, was selected as one of 21 scientists to receive the Howard Hughes Medical Institute (HHMI) Hanna H. Gray Fellowship. The highly competitive program, supports talented early-career scientists, specifically outstanding women and underrepresented researchers, providing up to $1.4 million to each Fellow for up to eight years of postdoc training and research during their early careers as independent faculty.

“The track record for Dr. Scavuzzo’s career development remains incredible and places her among an esteemed few, which I applaud her for and want many more at our School of Medicine to follow,” said Stan Gerson, MD, the CWRU School of Medicine's interim dean and director of the Case Comprehensive Cancer Center. “Her individual work will facilitate her emergence as an independent investigator and add to our cohort of young accomplished women in biomedical research.”

Please join us in congratulating Dr. Scavuzzo on this distinguished accomplishment!
Youth Engaged in Science program kicks off "Learn to Beat Cancer" virtual education program for middle school students
The Youth Engaged in Science (YES) Program, led by Nathan A. Berger, MD, kicked off its spring session with a new "Learn to Beat Cancer" cohort this past Saturday. Eight middle school students, their families and a middle school teacher joined a Zoom-based virtual classroom, where they learned the basics of "What is Cancer" from Case Western Reserve University med students.

This first meeting offered a basic introduction to cell biology, cell division, mutations, cancer progression, a brief discussion of cancer risk factors and a brief discussion of cancer-related careers. The group will meet weekly from 11 am-12 noon on Saturdays until May, attending successive workshops that will increase their knowledge about cancer, introduce them to strategies for risk reduction and disparity elimination, and hopefully, excite them about the possibility of pursuing careers in cancer research.

New students are welcome to participate. For more information or to sign up, contact Rachel Perovsek at rkp16@case.edu.
Explore racial inequality in American healthcare through common reading discussion during upcoming Cancer Disparities Symposium
Just Medicine front cover
Attendees of the 5th Annual Cancer Disparities Symposium, "Navigating Cancer Disparities: Lessons Learned and How to Move Forward" will have the opportunity to participate in an in-depth discussion of the book Just Medicine: A Cure for Racial Inequality in American Health Care by Dayna Bowen Matthew.

In the book, Matthew explores how health disparities in the American health care system arise from unconscious racial and ethnic biases and provides solution-oriented road maps for a way forward.

The virtual symposium is taking place March 4-5, 2021. Register today to join the conversation.
What's Coming Up
Mark Your Calendar
Cancer Center Seminar Series
TODAY, February 19, 2021, 12p via Zoom
Today's Cancer Center Seminar features Thomas LaFramboise, PhD presenting, "Roles of Mitochondrial DNA Mutations in Cancer: Controversies and Emerging Insights" on behalf of the GI Cancer Genetics Program at noon via Zoom.

Dr. LaFramboise is an associate professor of Genetics and Genome Sciences and member, of the GI Cancer Genetics Program at Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine.

The LaFramboise laboratory develops computational methodologies and applies them to large, complex genomic data sets derived from patients with cancer and other diseases. In the cancer realm, the laboratory has projects in both germline and somatic genetics/genomics, as well as recent work on the role of the microbiome in myeloid malignancy. Dr. LaFramboise’s work has been funded by grants from the American Cancer Society, National Cancer Institute, National Library of Medicine, and National Science Foundation.
Cancer Center Seminar Series
Friday, February 26, 2021, 12p via Zoom
Next week's Cancer Center Seminar features Michele Cote, PhD, MPH presenting, "Beyond Obesity: The Increasing Incidence and Epidemiology of High Grade Endometrial Cancers" on behalf of the Cancer Prevention, Control & Population Research Program.

Dr. Cote is a professor in the department of oncology at Wayne State University School of Medicine and Associate Center Director for Cancer Research Career Enhancement at Karmanos Cancer Institute.
Secure your access today: 5th Annual Cancer Disparities Symposium (Virtual)
March 4-5, 2021

In less than 2 weeks, The Case Comprehensive Cancer Center Office of Community Outreach and Engagement is pleased will present the 5th Annual Cancer Disparities Symposium, Navigating Cancer Disparities: Lessons Learned and How to Move Forward.
About the Symposium
This multi-disciplinary event will appeal to researchers, clinicians, health professionals, community outreach groups, community-based organizations, patient advocates and trainees. Keynote presentations will be delivered by renowned disparities researchers and community leaders, and a poster session highlighting academic research and community programs will provide a showcase of the depth and breadth of work happening in this field.

Though the symposium is happening virtually, attendees will experience the conference using Whova, our official web-based conference app, to view presentations and ask questions in real-time, as well as network with others behind the scenes.

Session topics include:

  • COVID-19 and cancer disparities
  • Improving the participation of minority and underserved populations in cancer clinical trials
  • Interplay of biology and social determinants of cancer disparities
  • The many pains of cancer: physical, emotional and financial

The symposium agenda is updated and available online.

Plus, attendees will have the opportunity to participate in an in-depth discussion of the book Just Medicine: A Cure for Racial Inequality in American Health Care by Dayna Bowen Matthew.
Keynote Speakers
Otis W. Brawley, MD, an internationally-recognized expert in cancer prevention and control, will present the symposium's Scientific Keynote His work is focused on closing racial, economic and social disparities in prevention, detection and treatment of cancer in the United States and worldwide.


Worta McCaskill-Stevens, MD, a medical oncologist nationally known for her expertise in bringing clinical trials to the community will present the Community Keynote. Dr. McCaskill-Stevens is Chief of the Community Oncology and Prevention Trials Research Group, which houses the National Cancer Institute (NCI) Community Oncology Research Program (NCORP), a community-based clinical trials network launched in 2014.
Additional Upcoming Events
Management of Checkpoint Inhibitor-Related Toxicity Virtual Updates
March 5, 2021
The goal of the program is to bring together a multidisciplinary group of clinicians to share expertise and improve the care of patients receiving immune checkpoint inhibitor therapies.

Specialists in dermatology, endocrinology, gastroenterology, oncology, internal medicine, rheumatology/ immunology, nurses, nurse practitioners, physician assistants and residents/ fellows are invited to attend.
4th Annual International PTEN Symposium
Monday, March 15, 2021
The Genomic Medicine Institute and Center for Personalized Genetic Healthcare at Cleveland Clinic invite you to join the virtual 4th Annual International PTEN Symposium: From Patient-Centered Research to Clinical Care. They are planning an engaging day with an emphasis on advances in the diagnosis, management and treatment of patients with PTEN Hamartoma Tumor Syndrome (PHTS).

Pier Paolo Pandolfi, MD, PhD, FRCP, senior scientist at the Renown Institute for Cancer and honorary professor of molecular biology at the University of Turin, will deliver the morning keynote address. Neil Friedman, MBChB, pediatric neurologist and director of quality, outcomes, and innovation at Barrow Neurological Institute at Phoenix Children’s Hospital, will deliver the afternoon keynote address on the neurological spectrum of PHTS. Other topics include hormone use and high-risk patients, gynecological cancer risks, updates on PTEN clinical trials, and autism. Please refer to the symposium agenda for more details about this year’s speakers and topics.
NCCN Virtual Annual Conference
March 18-20, 2021
In response to the ongoing COVID-19 pandemic, the National Comprehensive Cancer Network (NCCN) has transitioned the NCCN 2021 Annual Conference to a to a live virtual format.

Designed to meet the needs and improve the competence and performance of the interprofessional oncology care team, including physicians, nurse practitioners, nurses, physician assistants, pharmacists, and other relevant health care professionals who manage the care of patients with cancer, this three-day virtual event will offer more than 35 educational sessions covering a range of topics such as:

  • Updates to NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) 
  • New and emerging therapies, controversies in treatment, and best practices in the delivery of oncology care  
  • Issues surrounding HPV vaccination  
  • Racial disparities in guideline-adherent cancer care  
  • Effects of the pandemic on cancer care  
  • Best practices for incorporating patient-reported outcomes into oncology care

Throughout this three-day virtual event, educational sessions will include a mix of challenging case reviews, interactive polling, and moderated Q&A providing participants the opportunity to reinforce knowledge and develop strategies for the management of a variety of cancers.
AACR
AACR Annual Meeting 2021
April 10-15 and May 17-21, 2021 | Virtual
The AACR Annual Meeting program covers the latest discoveries across the spectrum of cancer research—from population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy—and highlights the work of the best minds in research and medicine from institutions all over the world.
AACI Clinical Research Innovation 13th Annual Meeting
July 13-15, 2021

Save the date! The 13th Annual AACI Clinical Research Innovation (CRI) Meeting will be held July 13-15, 2021. Information about the meeting format, abstract submissions, and registration will be made available in early 2021.
VeloSano logo
VeloSano 8 Bike to Cure Weekend
July 16-18, 2021
We are looking ahead with optimism to VeloSano 8 (2021), with a goal of providing opportunities to reunite our VeloSano community in a variety of safe and meaningful ways!

VeloSano's hope is to offer options for anyone to participate in any way they are most comfortable - whether riding with us during "Bike to cure" weekend July 16-18; riding virtually, or by choosing your own activity to participate anytime, anywhere as a Virtual Fundraiser.
Funding Opportunities
Deadline: April 19, 2021

National Comprehensive Cancer Network® (NCCN®) is pleased to announce a collaboration with Puma Biotechnology to offer a new grant opportunity for NCCN Member Institution faculty. This research grant will support the conduct of clinical and correlative studies to evaluate the effectiveness of neratinib in the treatment of breast, gastrointestinal (GI), lung and certain neurological cancers. It is anticipated that proposals submitted in response to this RFP will be useful in guiding further clinical development of neratinib. Clinical studies with correlative endpoints are encouraged.

Please direct questions regarding this RFP to Nicole Kamienski at kamienski@nccn.org with the subject line, “Puma Neratinib 2021 Project.”
LOI Deadline: August 2, 2021

Black in Cancer aims to strengthen the network between black people in the cancer space whilst highlighting black excellence in cancer research and medicine.
In pursuit of this mission, Black in Cancer will be highlighting Black excellence in the field of cancer research by awarding a postdoctoral fellowship to an outstanding member of the cancer research community who embodies the principles of the organization. The goals of this award are to advance innovative strategies that will lead to preventions, treatments, or cures for cancers of all types, promote research into disparities in cancer outcomes in the Black community, and increase Black representation in the cancer research community.

The Black in Cancer Postdoctoral Fellowship will provide up to three years of financial support for an ambitious scientific project, including one in its early stages and/or not currently supported by grants from the NIH, NSF, DoD, or other government agencies. In an effort to help the awardee achieve success in a tenure-track position, the fellowship can also be used to provide funding that bridges this transitional stage of an academic career. The award will provide $75,000 per year while the awardee is a trainee but will increase to $100,000 per year if/when the awardee accepts an academic tenure-track position.
In The News
Cleveland Clinic ConsultQD - January 25, 2021
"The world of cancer care is indeed very different than when many of us joined the field years ago, and the possibilities are striking and extraordinarily promising for our patients," writes Brian Bolwell, MD, Chair of Cleveland Clinic Taussig Cancer Institute and Deputy Director for Cleveland Clinic at the Case CCC.
Columbus Dispatch- February 11, 2021
“There's no argument with the logic of these curfews," said Mark Cameron, PhD, an immunologist at Case Western Reserve University and a member of the Case CCC. "...It’s not the cure-all for the transmissions, but it’s one of several tools being applied."
From The NIH
Request for Information (RFI) regarding opportunities for new national programs at the National Cancer Institute’s (NCI) Frederick National Laboratory for Cancer Research
NCI has released a Request for Information (RFI) seeking input from the cancer research community on the most important needs and promising opportunities in cancer research that are difficult to address on an individual scale but could be tackled through the NCI Frederick National Laboratory for Cancer Research. This is part of a planning effort to identify unique, large-scale programs of national significance that the FNLCR could support in the interest of the entire cancer research community.

Email responses to RFI_NewNationalPrograms@nih.gov and place "RFI Response" in the subject line. Responses will be accepted through February 19, 2021.
Weekly NIH Funding Opportunities and Notices
COVID-19 Funding Opportunities and Notices
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