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January 25, 2019
MEMBER/CENTER HIGHLIGHTS
ENGAGE Summer Training Program
NCRM logo The National Center for Regenerative Medicine is accepting applications for the ENGAGE summer research training program. The program supports undergraduates and medical students interested in stem cell and regenerative medicine research. Students are provided opportunities for scientific growth by working with our renowned scientific investigators.

Applications must be received by Friday, April 26, 2019.  Learn more about the program and how to apply.
Gong Awarded $1.8M from NCI to Boost Hereditary Breast and Ovarian Cancer Research
A new five-year, $1.8 million award will allow  Zihua Gong, MD, PhD to work to better understand the mechanisms of resistance of PARP inhibitors (PARPi) that induce cell death in BRCA1 and BRCA2-deficient cancer cells associated with breast and ovarian cancer. Assistant staff in the Department of Cancer Biology at Lerner Research Institute, assistant professor of molecular medicine at CWRU and member of the Case CCC's Molecular Oncology Program, Gong and his team will continue to investigate protein regulations that mediate cancer cell's sensitivity to PARPi. more>
2019 Priorities for the Biden Cancer Initiative
The Biden Cancer Initiative has outlined its priorities for 2019 and will focus on creating action through its working groups: Clinical Trial Design and Enrollment, Data Sharing, Data Standards, Patient Navigation, Prevention and Access to Care. Below is a video from the Initiative that features key experts - including Case CCC director Dr. Stan Gerson who is a member of the Data Sharing Working Group - and reminds us of the importance of creating a more cohesive, comprehensive and timely approach to cancer prevention, detection, diagnosis, research, and care. As Dr. Gerson says in the video, "Vice President Biden realizes he's not asking us to discover more faster. He's asking us to use our information better."  If you have comments and suggestions on how we can achieve this, especially in data sharing, please send along to Dr. Gerson at  slg5@case.edu

Biden Cancer Initiative 2019
Ending cancer as we know it
Tenured Faculty Positions in Cancer Research
The Case Comprehensive Cancer Center
Case CCC logo
is currently  inviting applications for tenured 
faculty positions  at the level of Associate Professor or Professor.
NEWS FROM THE NCI
NCI's 2019 Plans: A conversation with the director
Jan 25, 12p | Your smartphone or computer

Join the National Cancer Institute for a live social media event with NCI Director Ned Sharpless, MD discussing NCI's budget and plans for Fiscal Year 2019 with Elizabeth Jaffee, MD, National Cancer Advisory Board Chair, and Dafna Bar-Sagi, PhD, Board of Scientific Advisors Chair.
The event will also feature a Q&A session and participants are encouraged to ask questions in the comments. To join the event, visit the NCI on Facebook , Twitter , or the Director's Twitter account today at noon  EST.
MARK YOUR CALENDARS
Cancer Center Seminar Series: "Iron and GBMs: Genetics, metabolism and sex"
Jan 25, 12p | WRB Auditorium

Today's seminar features  guest speaker 
James Connor, PhD  presenting  "Iron and GBMs: Genetics, metabolism and sex. " Dr. Connor is visiting from Penn State University where he is Distinguished Professor of neurosurgery, neural and behavioral sciences and pediatrics. He is also Vice Chair of Neurosurgery Research and Director for the Center for Aging and Neurodegenerative Diseases. Dr. Connor has a long-standing interest in brain iron metabolism. His research group was among the first to demonstrate the importance of iron in brain
development and for its particular role in myelination.
This seminar is presented by the Brain Initiative of the Case Comprehensive Cancer Center. 
10th Annual "Take A Bite Out of AYA Cancer" Fundraiser
Jan 26, 7p | Rocky River, OH

The Steven G. AYA Cancer Research Fund is hosting their 10th annual "Take A Bite Out of AYA Cancer" fundraiser on Saturday, January 26, 2019.  In honor of the anniversary, all attendees will be entered to win an iPad! The fund fuels AYA cancer research here in NE Ohio, wellness and social support programs, as well as advocacy and education.

What: Dinner, beer, wine, dancing, & raffles!
When: 7-11:30p
Where: St. Demetrios Cultural Center, 22909 Center Ridge Road, Rocky River, OH 44116
Tickets: $45,  click here to purchase.
Biochemistry Seminar Series presents the Merton F. Utter Distinguished Lecturer:
"Hypoxia, Metabolism, and Tumor Progression"
Jan 31, 4p | BRB 105 Auditorium

The Department of Biochemistry invites you to hear  Celeste Simon, PhD present "Hypoxia, metabolism and tumor progression" on Thursday, January 31 in the BRB Auditorium. Dr. Simon is  Scientific Director of the Abramson Family Cancer Research Institute and Professor in the department of cell and developmental biology at the University of Pennsylvania Perelman School of Medicine. Her laboratory studies cancer cell metabolism, tumor immunology, metastasis, and cellular responses to oxygen deprivation. A reception will follow in the BRB lobby.
Save Your Seat for the 3rd Annual Cancer Disparities Symposium
Mar 1, 2019 | Tinkham Veale University Center

The Office of Cancer Disparities Research at the  Case Comprehensive Cancer Center   invites you to be a part of the national discussion of cancer disparities research, collaboration and programming at the 3rd Annual Cancer Disparities Symposium on March 1, 2019. 

Registration
Registration includes access to all symposium sessions, materials, breakfast, lunch, refreshments during breaks and free covered parking.  Save your seat today!

Continuing Research Education Credits (CREC)
Attendees are eligible to receive six (6) continuing research education credits.

Disparities Banner 2019-final

2 019 Symposium Highlights
  • Eliseo J. Pérez-Stable, MD, Director, National Institute on Minority Health and Health Disparities (NIMHD), National Institutes of Health (NIH), will discuss cancer disparities research trends and funding opportunities. 
  • Rick Kittles, PhD, Associate Director of Health Equities at City of Hope, will give a research-focused presentation on cancer disparities research. 
  • An entire afternoon session is devoted to research aligned with abstract submissions; this includes oral presentations from selected abstracts, plus a poster session.
  • The audience for this symposium is diverse in background and field, allowing attendees to interact, network, and expand their knowledge and opportunities for collaboration.
CANCER CENTER PROFILE: TRAINEE
Molly Gallogly, MD, PhD
Dr. Gallogly is a Paul Calabresi Scholar in the Case Comprehensive Cancer Center 's Clinical Oncology Research Career Development Program (CORP).  Her research project investigates the efficacy and mechanisms of two cellular therapies (extracorporeal photopheresis and mesenchymal stem cell infusion) for the treatment of steroid-refractory and high-risk graft vs. host disease. Dr. Gallogly is a member of the Hematopoietic and Immune Cancer Biology Program of the Case CCC, and Assistant Professor in the Division of Hematology and Oncology at CWRU School of Medicine.

A native of Philadelphia, PA, Dr. Gallogly matriculated to Case Western Reserve University (CWRU) where she earned both her medical degree and a PhD in pharmacology. During her graduate training, she earned an individual NIH F30 training grant for her work in redox signaling. Dr. Gallogly completed her internal medicine residency at University Hospitals Cleveland Medical Center and remained there for her hematology/oncology fellowship, where she served as chief fellow and pursued basic science research in signaling pathways in c-myc-driven hematologic malignancies.  more>
FUNDING OPPORTUNITIES
Call for Projects: Alcohol and Tissue Injury
LOI Deadline: Feb 1, 2019

The NIAAA/NIH-funded P50 Northern Ohio Alcohol Center (NOAC) is seeking applications for basic/translational or clinical projects related to the pathophysiological effects of alcohol on health, including liver cancers. The Center seeks to expand the research community and to provide essential support necessary for a successful research application by Assistant to Full Staff/Professor.

Each award will provide $25,000 of direct cost support. A letter of intent comprising of no more than one half of one page to should include: Investigator(s); Title; Problem; Aims; Anticipated outcomes and conclusions.

Please email Letter of Intent to Thomas McIntyre by Friday, February 1. View the full call for projects and application details>
Coulter Award Program
Pre-Proposal Deadlines: Feb 28, 2019

The Case-Coulter Translational Research Partnership ( CCTRP) is pleased to launch the PY2019 Coulter Award program. The CCTRP awards funding at 2 levels, pilot and full projects.

Successful projects often focus on the development of prototype products, building relationships with companies, performing clinical feasibility studies, obtaining regulatory approval, and other activities that companies or business experts indicate are the essential last steps before a license can be negotiated or a startup launched. An overarching goal of the program is to foster research and development work likely leading to commercially relevant translational technologies within a three- to five-year horizon. Because the goals of all Coulter projects are to reduce market risk, all proposals are expected to reflect genuine business input, and all projects must include a "business advisor" as an important member of the decision-making team. View full proposal information>
The Role of Health Policy and Health Insurance in Improving Access to and Performance of Cancer Prevention, Early Detection, and Treatment Services
Deadlines: April 1 & October 15, 2019

The American Cancer Society is accepting proposals for ACS logo research projects that have the potential to generate new knowledge of the effects of the United States healthcare system on both access to and outcomes of cancer screening, early detection, and treatment services. ACS is keenly interested in supporting rapid-learning research on the effects of health policy changes on patients, providers, and health systems. This includes but is not limited to facilitators and barriers to care; unintended consequences; differential experiences of and outcomes for patients seeking or receiving care; best practice models for quality care; and economic Impact.

Not to exceed $200,000 per year for up to four years, awards are open to independent investigators of all stages of their career. View program guidelines and application instructions>
IN THE NEWS
Tivozanib Improves Progression-Free Survival in Renal Cell Carcinoma
Oncology Nursing News - Nov 24, 2018
"This profile suggests an important place for tivozanib in the evolving treatment paradigm for RCC and, taken together with early combination data, the need to study tivozanib further in combination with immunotherapies," said Brian Rini, MD, director of the Cleveland Clinic's Genitourinary Cancer Program and member, Case CCC.

Virtual Reality Gets Real In the Operating Room
Fortune - Jan 9, 2019
Mark Griswold, PhD, professor of radiology and member, Case CCC weighs in on how virtual technology lends a helping hand when teaching the next generation of doctors.

Game-changing new tool at University Hospitals helps detect breast cancer sooner
News 5 Cleveland - Jan 10, 2019
"We have a much better way of curing things if we find it very early," said Donna Plecha, MD on the "Fast MRI" that picks up 2.5 to 3 times more cancer than even the 3D mammogram University Hospitals has offered since 2011. Donna is a member of the Case CCC's Cancer Imaging Program.
NIH BULLETIN - Notices and Funding Opportunities
Notices
Notice of Intent to Publish the Reissuance of RFA-OD-18-002 "Tobacco Regulatory Science (R01 Clinical Trial Optional)"

The National Institutes of Health (NIH) Sexual & Gender Minority Research Office (SGMRO) Announces Pacific Regional Workshop on Sexual and Gender Minority (SGM)-Related Research

Requests for Applications

Program Announcements
Biology of Bladder Cancer (R01 Clinical Trial Optional)(PAR-19-168)

Biology of Bladder Cancer (R21 Clinical Trial Optional)(PAR-19-169)
IN THIS ISSUE
EVENTSevents
Fri, Jan 25
Cancer Center Seminar Series
James Connor, PhD
Distinguished Professor of Neurosurgery, Neural and Behavioral Sciences and Pediatrics
Vice Chair of Neurosurgery Research
Director, Center for Aging and Neurodegenerative Diseases
"Iron and GBMs: Genetics, metabolism and sex"
Penn State University
12p WRB Auditorium
Mon, Jan 28
Genomic Medicine Institute
Ritika Jaini, PhD
Eng Lab, Genomic Medicine Institute, Cleveland Clinic
"The tumor suppressor Pten regulates expression of the autoimmune regulator aire"
12p NE1-205

Cancer Center Research Chalk Talk
Susan E. Waltz, PhD
Professor, Department of Cancer Biology
Director, Cancer & Cell Biology Graduate Program
University of Cincinnati College of Medicine
Vontz Center for Molecular Studies
"The role of the Ron Receptor tyrosine kinase in breast cancer"
1p WRB 3-136
Thurs, Jan 31
Developmental Therapeutics Journal Club
9a N E 6-218

Molecular Biology and Microbiology Seminar
Sam Ogwang and PD/PI
Nguyen Lab, CWRU
1p SOM W203

Biochemistry Seminar Series Merton F. Utter Distinguished Lecturer
Celeste Simon, PhD
Scientific Director, Abramson Family Cancer Research Institute
University of Pennsylvania Perelman School of Medicine
4p BRB 105
Fri, Feb 1
Taussig Cancer Institute Grand Rounds
8a CA5-120

Cancer Center Seminar Series
Raghu Kalluri, MD, PhD
RE Bob Smith Distinguished Chair in Cancer Research
Professor and Chair, Department of Cancer Biology
Director, Metastasis Research Center
University of Texas MD Anderson Cancer Center
"Exploiting exosomes and tumor stroma for treatment of pancreatic cancer"
12p WRB Auditorium
Mon, Feb 4
Genomic Medicine Institute
Feixiong Cheng, PhD
Assistant Staff, Genomic Medicine Institute, Cleveland Clinic
"Network medicine: From cellular networks to precision medicine"
12p NE1-205

Cancer Center Research Chalk Talk
David Wald, MD, PhD
1p WRB 3-136

Tumor Immunology and Immunotherapy Meeting
4p WRB 1-422D
Tues, Feb 5
Power of Diversity Lecture
Estela Mara Bensimon, PhD
Dean's Professor in Educational Equity
Director of the Center for Urban Education
University of Southern California
"Reclaiming racial justice in equity"
4:30p Tinkham Veale University Center Ballroom A
Weds, Feb 6
Molecular Biology and Microbiology Seminar - Virology Journal Club
Angelica Cruz Lebron
Levine Lab, CWRU
12p WRT 206
Thurs, Feb 7
Developmental Therapeutics Journal Club
9a N E 6-218

Molecular Biology and Microbiology Seminar
Curtis Dobrowolski 
Karn Lab, CWRU
1p SOM W203
Fri, Feb 8
Taussig Cancer Institute Grand Rounds
8a CA5-120

UH Seidman Cancer Center Grand Rounds
8a Lerner Tower 2060

Cancer Center Seminar Series
Chuanyue Wu, PhD
Professor of Pathology
Lombardi and Shinozuka Experimental Pathology Research Chair
University of Pittsburgh School of Medicine
"Cell-matrix adhesion: Molecular basis, signaling and diseases"
12p WRB Auditorium
ADDITIONAL UPCOMING SYMPOSIUMS & EVENTS
prev-funding
PREVIOUSLY ANNOUNCED OPPORTUNITIES

Deadline: Open

Deadline: Open

Deadline: Open
Case Comprehensive Cancer Center