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June 7, 2019
MEMBER/CENTER HIGHLIGHTS
Cancer-focused Summer Undergraduate Research Program Kicks Off
If you noticed an extra buzz of energy in the Case Comprehensive Cancer Center this week, it is likely because we welcomed the inaugural class of the new Cancer-focused Summer Undergraduate Research (CanSUR) Program! A total of 32 undergraduates from across the country were selected from nearly 300 applications and we are excited to have these bright young minds training with our researchers. This week, the scholars were immersed in a thorough overview of cancer research, took a tour of Cleveland on Lolly the Trolley, went bowling together downtown and were introduced to the labs they'll be working in for the next 9 weeks. Thank you to each of the cancer center members that have graciously taken on the task of mentoring our CanSUR scholars - I am certain that their time with you is priceless as they prepare for the next step in their careers. I'm looking forward to seeing our scholars learn, grow and present their final research experience at the CanSUR symposium at the end of the summer!

Mark Jackson, PhD
Mark W. Jackson, PhD
Program Director, CanSUR Program
Case Comprehensive Cancer Center
Cleveland Researchers Test Novel Gene Therapy for Glioblastoma
The Case Comprehensive Cancer Center extends congratulations to Andrew E. Sloan, MD, Director of
Andrew Sloan
Andrew Sloan
the Brain Tumor & Neuro-Oncology Center and the Center of Excellence for Translational Neuro-Oncology (CETNO) at University Hospitals Cleveland Medical Center and Seidman Cancer Center and
Dr. Stan Gerson
Stan Gerson
Stan Gerson, MD, Director of the Case Comprehensive Cancer Center, as they were recently awarded a prestigious U01 grant from the National Cancer Institute to further study gene therapy.

The $2.7 million grant will further a gene therapy study focusing on the efficacy of chemotherapeutic agents  O-benzylguanine (BG) and temozolomide (TMZ) and repair enzyme MGMT, known to be an important prognostic indicator in glioblastoma multiforme (GBM), the dealiest form of brain cancer, among the most difficult cancers to treat. Read the full release>
Wanted: Post-doctoral Fellows
Postdoctoral scholar positions in cancer microenvironment and metastasis are available in the lab of Khalid Sossey-Alaoui, PhD  at the Division of Cancer Biology, MetroHealth Medical Center and Case Western Reserve University School of Medicine in Cleveland, OH.

Their research focuses  on the basic molecular mechanisms underlying cancer invasion and metastasis as well as interactions within the tumor microenvironment in major solid tumor cancers, with a focus on breast, prostate and brain cancers. Highly motivated cancer biologists with PhD, MD, or both degrees and a proven record of research creativity and productivity are welcome to apply. 

Working experience using transgenic/knockout and xenograft mouse models, cell signaling and basic molecular biology techniques is valuable; familiarity with CRSPR/Cas9, cancer stem cells, bioinformatics or drug discovery is a plus. Competitive salary and generous benefit package will be provided for qualified candidates. Case Western Reserve University is an equal opportunity employer.

Several positions are immediately available. Interested candidates should send their CV and contact information for three references to Dr. Sossey-Alaoui at kxs586@case.edu. View the full posting>
MARK YOUR CALENDARS
Team Case CCC Fundraiser Bash
June 7, 5-8p | Tavern of Little Italy
You're invited to party with the Case Comprehensive Cancer Center's VeloSano team today from 5-8pm at the Tavern of Little Italy! Tickets are $40 and include 2 drink tickets, 1 raffle ticket, food, live entertainment and valet parking. PLUS: Riders (existing and those who sign up at the event) will receive a $40 credit toward their fundraising goal when they attend Friday's Bash! Pay at the door or grab your ticket in advance>

To-date, Team Case CCC has  58 members who are committed to cancer research, prevention, treatment and cures and have  raised $21,025 and counting. We've grown by 11 members and raised $3,165 in the last week alone! 


Thank you, Team Case CCC sponsors!

Spangenberg, Shibley, & Liber Attorneys at Law Case Western Reserve University School of Medicine
Park Place Technologies Taft
Elephants and Tea Majic Family Fund
Rich & Erica Horvitz Keri Lab & Grimberg Lab
Solving Health Care Challenges with Machine Learning and Artificial Intelligence
June 11, 5-6:30p | Nord Hall, Room 356

The BrainX Community and Case School of Engineering's Center for Computational Imaging and Personalized Diagnostics (CCIPD) will host a session titled "Solving Health Care Challenges with Machine Learning and Artificial Intelligence" on Tuesday, June 11 at 5pm in Nord Hall room 356.

Ashish Khanna from the Wake Forest University School of Medicine, Rakesh Shiradkar, a research associate in the CCIPD and Sharona Hoffman, the Edgar A. Hahn Professor of Law and co-director of the Law-Medicine Center, will speak during the event.

They will discuss the multifaceted challenges facing health care and the promise of machine learning and artificial intelligence in solving them, as well as the ethical and legal issues with application of artificial intelligence in health care. Email kpg11@case.edu to RSVP for the session.

PRCHN Seminar Series
June 12, 12p | B-03, BioEnterprise Building

Case Western Reserve University's Prevention Research Center (PRCHN) hosts a monthly lunchtime research seminar series featuring local and national experts presenting research on public health, food policy, and related issues. Presentations keep the conversation growing in ways that continually seek to improve the way we understand and address health concerns in our community.

This month's seminar topic is, " Building a Cancer 
AACI Clinical Research Innovation Meeting
July 9-11 | Loews Chicago O'Hare Hotel

The 11th Annual AACI Clinical Research Innovation Meeting will be held July 9-11 at the Loews Chicago O'Hare Hotel. This year the meeting has been expanded to a three-day format and will begin on Tuesday, July 9 at 1:00 pm central and end on Thursday, July 11 at noon central. The program will provide opportunities for our members to network, expanded poster sessions, and panel discussions with content experts. The theme for this year's meeting is "Strategies to Maximize Innovation to Advance Cancer Clinical Research."

More information on the meeting, including the programabstracts and registration, is available on the AACI meeting website. Please note: regular registration rates end June 10.

The hotel block closes on Monday, June 10 and there are a limited number of rooms open. Reserve your room today.
FUNDING OPPORTUNITIES
VeloSano Catalyst Fellowship
Deadline: 5 pm, June 7, 2019

With the generous support from VeloSano Bike to Cure 2018, the Case CCC is providing funding for  Case CCC Trainee Associate Members  to perform their "dream experiment."

The experiment should catalyze highly innovative and impactful projects and help strengthen fellowship and career development grant applications. The intent of the award is to support a single or limited set of innovative experiments, not for general laboratory supplies/projects or maintenance of the trainee's project. Eligibility and application instructions>
Global Oncology Young Investigator Award (GO YIA): Implementation Science to Address Oncology Care in LMICs
Deadline: June 27, 2019

The Conquer Cancer Foundation's Global Oncology Young Investigator Award (GO YIA) provides research funding to early-career investigators to encourage and promote quality research in global oncology and to develop the next generation researchers to address global health needs. "Global oncology" is a term that generally refers to the application of the concepts of global health to cancer, and implies an approach to the practice of oncology that acknowledges the reality of limited resources in most parts of the world.  For purposes of this Request for Proposals (RFP), "global health" is described as an "area for study, research, and practice that places a priority on improving health and achieving health equity for all people worldwide." 

This Global Oncology YIA has been established in support of implementation science projects to address oncology care in low- and middle-income countries (LMIC). The goal is to develop a curriculum for Primary Care Physicians (PCPs) in adult oncology care and to scope out the resources required to do this in a sustainable way. The project needs to be a research exercise - identifying training models, researching their outcomes, analyzing the outcomes of those models to select the most effective curriculum, and also researching the cost of creating sustainable models where they currently do not exist.  The ideal grantee will have a mentor who is established, and will need to be within a team or be paired with a high-income institution working for a period of time in a lower resource setting. View the full proposal and application instructons>
Congressionally Directed Medical Research Programs
Pre-application deadline: September 17, 2019

The Department of Defense's Congressionally Directed CDMRP logo Medical Research Programs ( CDMRP   ) recently released additional funding opportunities. Click the program below to view award announcements and application instructions.  

Kidney Cancer Research Program (KCRP)
  • Concept Award
  • Idea Development Awards
  • Translational Research Partnership Award
IN THE NEWS
The Wall Street Journal - June 2, 2019
A study including Case CCC members Marcos de Lima, MD, Paolo Caimi, MD, Pingfu Fu, PhD,  Folashade Otegbeye, MD, MPH, Stan Gerson, MD, and Ehsan Malek, MD was featured among others in this article highlighting research that shows expansion of insurance coverage boosted rates of diagnosis. The study was also mentioned by The Washington Post and Everyday Health.

HemOnc Today - June 3, 2019
SurVaxM demonstrated encouraging efficacy and immunogenicity among patients with newly diagnosed glioblastoma, according to results of a multicenter, single-arm phase 2 clinical trial presented at the ASCO Annual Meeting. Cleveland Clinic's Manmeet Ahluwalia, MD, FACP discussed the study with HemOnc Today. Ahluwalia is a member of the Case CCC's Developmental Therapeutics Program.

HemOnc Today - June 5, 2019
"This is the first-ever national study in the U.S. of perioperative chemotherapy for resectable pancreatic cancer," said Cleveland Clinic oncologist and Case CCC member, Davendra Sohal, MD, MPH.
NIH BULLETIN - Notices and Funding Opportunities
Notices
Notice of Pre-Application Webinars for The Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network, Clinical Sites (RFA-HG-19-013), Enhanced Diversity Clinical Sites (RFA-HG-19-014), and Coordinating Center (RFA-HG-19-015)

Notice of Intent to Publish a Funding Opportunity Announcement for Specialized Centers of Excellence on Environmental Health Disparities Research (P50)

Funding Opportunities
Deadline: October 18, 2019 at 5pm
IN THIS ISSUE
EVENTSevents
Fri, June 7
Team Case CCC VeloSano Fundraiser Bash
5-8p Tavern of Little Italy
Mon, June 10
Shared Resources Directors Meeting
12p WRB 1-422D

Genomic Medicine Institute Seminar
Scott Lundy, MD, PhD Eng Lab  
"The Microbiome of Male Infertility"
Nick Sarn
Eng Lab
"Decreased Nuclear Pten Increases Microglia Activation and Synaptic Pruning in a Murine Model with Autism-like phenotype"
12p NE1-205
Tues, June 11
BrainX + CCIPD Seminar
Ashish Khanna, MD
Wake Forest University School of Medicine
Rakesh Shiradkar
Center for Computational Imaging and Personalized Diagnostics (CCIPD)
Sharona Hoffman, JD, LLM
Law-Medicine Center at Case Western Reserve University
"Solving Health Care Challenges with Machine Learning and Artificial Intelligence"
5p Nord Hall 356
Thurs, June 13
Developmental Therapeutics Journal Club
9a NE6-218

Molecular Biology and Microbiology Virology Journal Club
1p SOM W203
Fri, June 14
Taussig Cancer Institute Grand Rounds
Jaleh Fallah, MD
Jessica Geiger, MD
Nathaniel Rosko, PharmD
Davendra Sohal, MD
"ASCO Oral Presentations"
8a CA5-120

UH Seidman Cancer Center Grand Rounds
8a Wearn 137
Mon, June 17
Genomic Medicine Institute Seminar
Harpreet Kaur, PhD Kallianpur Lab 
"Plausible Role of the HFE (hemochromatosis) Gene in HIV-Associated  Neurocognitive Disorder"
Vijay Nagampali, PhD
Blackenberg Lab 
A Machine learning based approach for predicting aberrant activity of PI3K pathway in cancer"
12p NE1-205
Tues, June 18
Cancer Drug Discovery and Resistance 
3p WRB 1-422D
Weds, June 19
Biomedical Innovation & Entrepreneur Club:
Discussion and Networking Happy Hour
4-6p Sears think[box]
Thurs, June 20
Developmental Therapeutics Journal Club
9a N E 6-218

Molecular Biology and Microbiology Seminar
1p SOM W203
Fri, June 21
Taussig Cancer Institute Grand Rounds - CCF ONLY
James Kochenderfer, MD
National Cancer Institute
"Chimeric Antigen Receptor T-cell Therapy for Lymphoma and Multiple Myeloma"
8a CA5-120
ADDITIONAL UPCOMING SYMPOSIUMS & EVENTS
prev-funding
PREVIOUSLY ANNOUNCED OPPORTUNITIES

Deadline: Open

Deadline: Open

Deadline: Open
Case Comprehensive Cancer Center