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Li Lab finds intracellular copper disrupts apoptosis
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Copper levels increase in inflamed tissues and have been shown to promote colorectal cancer progression. Given that chronic inflammation is distinguished as a cancer risk factor,
Xiaoxia Li, PhD, a researcher at Cleveland Clinic Lerner Research Institute and member of the
Case CCC's Hematopoietic and Immune Cancer Biology Program, pursued better understanding of the elaborate relationship between inflammation and cancer and how, and why, copper becomes elevated in these conditions.
Her
team's investigations revealed that with the presence of the pro-inflammatory cytokine interleukin 17 (IL-17), expression of the STEAP4 protein increased. Increased STEAP4 allowed more copper to enter cells, ultimately decreasing cell death, possibly attributed to intracellular interactions between copper and the XIAP protein which inhibits apoptosis.
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Kattan listed as world's most-cited author in field of urological surgery
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A bibliometric analysis recently published in the International Journal of Surgery found articles authored by
Michael W. Kattan, PhD were most-cited in the field of urological surgery. Dr. Kattan is the Dr. Keyhan and Dr. Jafar Mobasseri Endowed Chair for Innovations in Cancer Research at Cleveland Clinic and a member of the
Case CCC's
Cancer Prevention Control & Population Research Program.
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Join Team Case CCC in VeloSano 2020!
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The Case Comprehensive Cancer Center (Case CCC) is honored to make its sixth appearance in
VeloSano, a year-round fundraising initiative and "Bike to Cure" weekend to support lifesaving cancer research. Our continuing goal is to bring sustainable funding to cancer research by enlisting the passion and energy of thousands of people who wish to give back... including
YOU! We raised nearly $94,000 in 2019 and every dollar goes directly toward cancer research. In our six years of participation, more than $1,000,000 of VeloSano fundraising totals have come back to the Case CCC to award researchers as pilot funding for cancer research projects.
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The Case CCC will provide complimentary registration fees and jerseys again this year. Contact team captains
Caroline El Sanadi or
Mary Wright for the registration fee waiver code to sign up! While registration is complimentary, all riders are responsible for meeting the minimum fundraising commitment associated with the
distance they ride. Fundraising can begin as soon as you register to ride and continues through October 1, 2020.
Registration is open now and information about volunteering for our cheer station and supporting our team through sponsorship will be available soon!
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Mon, Mar 9
Shared Resources Directors Meeting
12p WRB 1-422D
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Tues, Mar 10
Faculty Candidate Chalk Talk
4p WRB 3-136
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Weds, Mar 11
Disparities SPORE Meeting
5-7p WRB 2-136
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Thurs, Mar 12
D
evelopmental Therapeutics Journal Club
9a NE6-218
Immunology Journal Club
12p WRB 5-136
Molecular Biology and Microbiology Seminar
1p SOM W203
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Fri, Mar 13
Taussig Cancer Institute Grand Rounds
8a CA5-120
UH Seidman Grand Rounds
8a Wearn 137
Cancelled
: Cancer Center Seminar Series
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Mon, Mar 16
Cancer Center Research Chalk Talk
Sarah Markt, ScD, MPH
1p WRB 3-136
WRB Faculty Meetings with Stan Gerson
3:30p WRB
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Tues, Mar 17
Cancer Drug Discovery and Resistance
3p WRB 1-422D
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Weds, Mar 18
Biomedical Innovation & Entrepreneur Club
Alumni Career Panel
4-6p BRB 932
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Thurs, Mar 19
D
evelopmental Therapeutics Journal Club
9a NE6-218
Immunology Journal Club
12p WRB 5-136
Molecular Biology and Microbiology Seminar
1p SOM W203
Neil S. Cherniak, MD Lecture
Susan Redline, MD, MPH
4p Lecture
5p Reception
Robbins E501
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Fri, Mar 20
Taussig Cancer Institute Grand Rounds
8a CA5-120
UH HemOnc Grand Rounds
8a Wearn 137
Cancer Center Seminar Series
Omar Mian, MD, PhD
12p WRB Auditorium
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Cancer Center Seminar Series
March 6, 12p
Tinkham Veale University Center Ballroom
Our weekly seminar series will take place at noon today as part of the 4th Annual Cancer Disparities symposium and features
Lucio Miele, MD, PhD.
All are welcome to attend the noon seminar, regardless of symposium registration.
Dr. Miele is professor and genetics department head at the Louisiana State University (LSU) School of Medicine, Director for Inter-Institutional Programs for the LSU Stanley Scott Cancer Center and Louisiana Cancer Research Consortium. He is also the Cancer Crusaders Endowed Professor in Cancer Research at LSU.
He will present, "Breast Cancer Health Disparities: Social Determinants Meet Biology" in the
Tinkham Veale University Center Ballroom.
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CANCELLED
: Cancer Center Seminar Series
March 13, 12p
WRB Auditorium
Next week's cancer center seminar has been cancelled due to our guest speaker's institutional travel restrictions.
Our series will resume on Friday, March 20.
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Join Us Today at the 4th Annual Cancer Disparities Symposium
March 6, 2020
Tinkham Veale University Center
The
4th Annual Cancer Disparities Symposium: Cultivating Science and Community Engagement to Address Cancer Health Disparities is taking place today! Join fellow researchers, physicians, and community leaders as we share cutting edge science and innovations in community engagement. Registration is available on-site.
The
symposium agenda features sessions on Cancer Disparities and Underserved Populations, such as sexual and gender minorities, Amish, and muslim women, Community Engagement and Support Programs, and Cancer Disparities Research and Community Engagement, plus invited presentations selected from standout abstract submissions. The final session of the day will be a multidisciplinary and thought-provoking panel discussion that will crystallize the energy and inspire us to continue toward the ultimate goal of health equity.
Attendees are eligible to receive six (6) continuing research education credits (CRECs) or six (6) continuing education contact hours (CECH) units of advanced level training in health education. Meals, materials, refreshments and parking will be provided.
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Core Facilities and Shared Resources Symposium
April 28, 2020
Linsalata Alumni Center, CWRU
Opening remarks from Provost Ben Vinson III will begin at 8:30 am. This opportunity for networking and discovery will feature:
- plenary talks from CWRU faculty from various schools/colleges
- breakout sessions celebrating how our cores create a continuum of discovery across multiple disciplines and providing administrative technical assistance about running a Core
- poster sessions showing the work our facilities make possible
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Call for Abstracts and Registration: Cancer Stem Cell Conference 2020
August 4-6, 2020
Tinkham Veale University Center
The Case Comprehensive Cancer Center and the National Center for Regenerative Medicine invite you to submit an abstract and register for CSC 2020!
Now in its fourth year, CSC 2020 will feature renowned thought leaders in the field of cancer stem cell research. This conference is guaranteed to offer cutting-edge keynote presentations from a variety of niches within the field. Join world-class investigators for this three-day summit and network with scientists and clinicians advancing cancer stem cell research and therapeutic applications.
The
Cancer Stem Cells Conference call for abstracts affords an exciting opportunity to highlight cancer stem cell focused research, providing a forum to showcase basic research, as well as novel technologies and translational therapeutic strategies. Basic science, clinical and translational researchers, as well as trainees, are invited to
submit abstracts by 5 pm EST, Friday, May 29, 2020.
Symposia topics include, but are not limited to: developmental biology, immune interaction, microenvironment, cellular metabolism, epigenetic regulation, druggable targets and emerging technologies.
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Save The Date: Great Lakes Breast Cancer Symposium 2020
October 4-6, 2020
Tinkham Veale University Center, CWRU
As host site for the 2020 Great Lakes Breast Cancer Symposium, the Case Comprehensive Cancer Center encourages you to mark your calendar for the symposium taking place October 4-6, 2020.
The symposium highlights ongoing basic, translational, clinical and population studies addressing the biological mechanisms, management and prevention of breast cancer. Researchers from participating institutions will share their exciting work with a goal to develop cross-institutional collaborations.
This year's event features two keynote speakers:
- Carlos Arteaga, MD, Director of the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center
- Helen Piwnica-Worms, PhD, Professor of Experimental Radiation Oncology at the University of Texas MD Anderson Cancer Center
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Additional Upcoming Events
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NCCN 2020 Annual Conference
March 20-22, 2020
Orlando, FL
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The National Comprehensive Cancer Network (NCCN) 2020 Annual Conference agenda includes 30 educational sessions featuring the latest advances in oncology care, including interactive patient case studies. Session topics include: HPV-Associated Cancers, Patient-Reported Outcomes, Clinical Trial Implementation, Value-Based Payment Models, Role of Biosimilars and more.
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AACR Cancer Disparities Progress Report Capitol Hill Day
March 25, 2020
Capitol Hill, Washington, DC
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On Wednesday, March 25, the AACR will be releasing a historic document, the inaugural “
AACR Cancer Disparities Progress Report 2020: Achieving the Bold Vision of Health Equity for Racial and Ethnic Minorities and Other Underserved Populations,” at a Congressional Briefing from noon until 1 p.m. on Capitol Hill. Those interested in participating must
register by March 13, 2020.
In conjunction with the Congressional Briefing, they will also be organizing a "Cancer Disparities Progress Report Capitol Hill Day," which will take place during the morning and throughout the afternoon on March 25. Additionally, we will be sponsoring a special Congressional reception on Tuesday, March 24 beginning at 5:30 pm. During the reception, they will honor the dedicated scientists who have led the development of the report, along with the distinguished Members of Congress who have prioritized the elimination of cancer disparities through their work on the Hill. Rooms are available at the
Hilton Washington DC National Mall, where the events will take place.
For additional information, please contact Jon Retzlaff, Chief Policy Officer and Vice President, Science Policy and Government Affairs at
jon.retzlaff@aacr.org or 202.898.6499.
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The Race
May 10, 2020
Legacy Village
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The Race is a 5K and one mile walk/run charity event that empowers children and their families to make a difference in the lives of those touched by breast cancer by raising awareness and money for innovative breast cancer research. The Race has been held each Mother's Day for the past sixteen years and to date, The Race, with help from friends, business associates and corporate sponsors, has raised over $1,250,000 for the fight against breast cancer. Proceeds from this year's event will once again benefit the
Case Comprehensive Cancer Center.
Participate in the 17th annual event as we work to eradicate breast cancer in our lifetime! Bring your family and make it a Mother's Day to remember. Race participants will receive t-shirts and everyone can enjoy refreshments, clowns, a bounce house, laser tag, face painting and more.
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Inaugural Tee Off 4 Cancer Golf Classic
June 27, 2020
Mallard Creek Golf Club
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The 2020 Tee Off 4 Cancer Golf Classic will take place Saturday, June 27 at Mallard Creek Golf Club in Columbia Station, Ohio. Proceeds benefit the labs of Drs.
Vinay Varadan at the Case Comprehensive Cancer Center and
Danny Welch at the University of Kansas Cancer Center.
Players may join the classic for $95 which includes golf, range balls, lunch and dinner, plus beer, water, soda and sports drinks throughout play. Sponsorship packages are also available.
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AACR Annual Meeting
April 24-29, 2020
San Diego Convention Center
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The American Association for Cancer Research (AACR) Annual Meeting program covers the latest discoveries across the spectrum of cancer research—from population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy—and highlights the work of the best minds in research and medicine from institutions all over the world.
This year's meeting will take place April 24-29, 2020 at the San Diego Convention Center in San Diego, CA.
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2020 NIMHD Health Disparities Research Institute
August 3-7, 2020
NIH Campus, Bethesda, MD
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The National Institute on Minority Health and Health Disparities (NIMHD) will host the Health Disparities Research Institute (HDRI) from August 3-7, 2020 at the NIH campus (Natcher, Building 45 conference center rooms). The HDRI aims to support the research career development of promising early-career minority health and health disparities research scientists and stimulate research in disciplines supported by health disparities science. Applications will only be accepted from extramural scientists who meet NIH’s
Early Stage Investigator (ESI) eligibility criteria.
The program will feature lectures, mock grant reviews, seminars, and small group discussions on research relevant to minority health and health disparities. It will also include sessions with NIH scientific staff engaged in related health disparities research across the various institutes and centers.
Extramural scientists, early in their careers with research foci in minority health and health disparities, are encouraged to apply to the institute.
Applications are now open and must be submitted via the HDRI application portal by
Monday, March 9, 2020 at 5pm EST; emailed applications will not be accepted. Applicants are encouraged to apply before the deadline since late submissions will not be accepted. Questions may be directed to
HDRI@nih.gov.
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Pre-application Deadline: April 23, 2020
The Department of Defense's Congressionally Directed Medical Research Program (CDMRP) in Ovarian Cancer Research recently announced the following FY20 award mechanisms:
- Clinical Translational Research Award
- Investigator-Initiated Research Award
- Ovarian Cancer Academy – Early-Career Investigator Award
- Pilot Award
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Deadline: April 29, 2020
National Comprehensive Cancer Network® (NCCN®) is pleased to announce that it is collaborating with Taiho Oncology, Inc., to offer a new opportunity for the design and performance of clinical and correlative studies of futibatinib, a fibroblast growth factor receptor antagonist, in the treatment of solid tumors.
The overall aim is to develop innovative studies to help determine the role of futibatinib in the treatment of a broader range of solid tumors. It is hoped that proposals submitted in response to this RFP will be useful in guiding further development of futibatinib. Correlative work to identify predictive markers and preclinical studies as detailed in the RFP are welcomed.
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Wall Street Journal - Feb 27, 2020
Cleveland Clinic’s Center for Clinical Artificial Intelligence is developing artificial intelligence systems to predict patient readmissions, refine chemotherapy treatments, and improve diagnostics and disease prediction.
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News 5 Cleveland - Feb 28, 2020
“Your own body will attack this tumor using your own immune system it allows your own immune system to recognize the tumor, attack the tumor, and theoretically gives you immunological memory, so if the tumor were to come back you would continue to attack it,” said
Andrew Sloan, MD. Dr. Sloan is a member of the
Case CCC's Developmental Therapeutics and Cancer Imaging Programs.
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Weekly NIH Funding Opportunities and Notices
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Notices
Funding Opportunities
Deadlines: June 24, 2020; June 24, 2021
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Use the button below to submit all your news, events, announcements and communications requests to the Case CCC Marketing and Communications team!
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