newsletter masthead
May 14, 2018
MEMBER/CENTER HIGHLIGHTS
Tesar Receives Diekhoff Award for Mentoring
Paul Tesar headshot While earning an undergraduate degree in biology at Case Western Reserve, Paul Tesar had three outstanding scientific mentors whose influence he feels to this day.

Now, 15 years later, it's Tesar who's being recognized for inspiring and guiding students: He will be honored during commencement May 20 as one of two recipients of the 2018 John S. Diekhoff Award for Mentoring.

As an undergrad, Tesar's faculty mentors were Stephen Haynesworth, Arnold Caplan and Charles (Chuck) Rozek.

"Chuck, my advisor for my biology major, provided superb guidance, and when I joined the Haynesworth and Caplan labs in my freshman year, I immediately knew I wanted to do science as a career," said Tesar, member of the Case Comprehensive Cancer Center, Associate Professor of Genetics and Genome Sciences, and the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics at CWRU. more>
MARK YOUR CALENDARS
VeloSano 5: Get Involved! 
VeloSano logo Spring is here, and it's time to start building momentum for VeloSano 5! Remember, a ll of the funds raised through VeloSano support cancer research right here in Cleveland. 

Getting involved is easy. Your help and support is appreciated:
  • Join Team Case CCC as a rider from the 12 to 200-mile level. Case CCC Director, Dr. Stan Gerson, will be on the 100-mile route, and looks  forward to riding with you!
  • Raise funds as a virtual rider  on Team Case CCC by signing up and supporting all of us!
  • Join as a volunteer to help before and during the ride to keep us on track, hydrated and cheered on!
  • Come to team events and show your support: Happy Hours scheduled for the following times: 
    Thurs, May 24, 4-6p, TOLI
    Thurs, June 7, 4-6p, Washington Place 
    Fri, June 29, 5-8p, TOLI
Cancer Center Scientific Series: VeloSano Pilot Awardees
Jun 4, 2018, 5-7p  | Wolstein Research Bldg
VeloSano logo Join us for the next Cancer Center Scientific Series and hear updates from recipients of VeloSano pilot awards. Presentations will be followed by a reception. 

Mark Jackson, PhD
A high-throughput screen for inhibitors of cancer stem cell plasticity

Julian Kim, MD
Development of intravenously injectable β-glucan treatment for regulating granulocytic myeloid-derived suppressive cells

Shigemi Matsuyama, PhD
Development of new type of therapeutics selectively targeting Bax or Bak

Alvin Schmaier, MD
Tyrosine kinase inhibitors and cardiovascular events in CML

Zhenghe John Wang, PhD
Develop GPT2 inhibitors to target PI3KCA-mutated colorectal cancers 

Youwei Zhang, PhD
Roles of UbcH7 in tumorigenesis and therapy response 

Lan Zhou, MD, PhD
Mediates immune-suppressive microenvironment in serrated pathway of colon carcinogenesis 

CTTE header
Cell-Based Therapies & Tissue Engineering
May 22-24, 2018 | CWRU 

The  Skeletal Research Center and the  Department of Biology of  Case Western Reserve University are pleased to present the 17th annual short course, Cell-Based Therapies and Tissue Engineering.

This course is intended for graduate students, post-graduate students, and health science professionals who are interested in Tissue Engineering with emphasis on the principles and detailed protocols used or being modeled for direct clinical use.

A discounted rate is available to National Center for Regenerative Medicine (NCRM) members. Please contact Megan Kilbane ( megan.kilbane@case.edu) for discount code. 

CSC 2018 - web banner

Cancer Stem Cell Conference
Aug 6-8, 2018 | Tinkham Veale 

Call for Abstracts Deadline: May 15
Discounts for early registration through May 31

The Case Comprehensive Cancer Center (Case CCC) and National Center for Regenerative Medicine (NCRM) invite you to Cancer Stem Cell Conference (CSC 2018)! Now in it's third year, CSC 2018 will feature renowned thought leaders in the field of cancer stem cell research. This conference is guaranteed to offer cutting-edge keynote presentations from a variety of niches within the field. Join world-class investigators for this 3-day summit and network with scientists and clinicians advancing cancer stem cell research and therapeutic applications.

Conference Highlights
  • The agenda will integrate invited talks from thought leaders in the CSC field with short talks from early-stage investigators and trainees selected from submitted abstracts.
  • Pre-conference career development workshop for junior faculty and trainees
    • Meet the Editors: Natalie Cain, PhD (CellReports), Mark Landis, PhD (CancerDiscovery) and Teodoro Pulvirenti, PhD(JEM)
    • Discussion of NIH grants: Michael Espey, PhD (NCI) and Michelle McGuirl, PhD (NIH)
  • Young Investigator Awards available to support travel for senior trainees or junior faculty (less than 5 years from their first independent position). Submit your abstracts by May 15 to be eligible. 
  • Opportunity to share ideas with world-class investigators in stem cell research. 2016 CSC was attended by over 300 from 20 countries and 25 U.S. states. This year's conference is on track to attract a similar crowd of colleagues.
Keynote Speakers
  • Norman E. 'Ned' Sharpless, MD (NCI)
  • John S. Condeelis, PhD (Einstein)
  • Irving Weissman, MD (Stanford)
  • Zena Werb, PhD (UCSF)
A Blueprint to Beat Cancer: Free Webcast
May 24, 2018 | Live webcast
AICR logo The American Institute for Cancer Research (AICR) is hosting a 
webcast of its special event, A Blueprint to Beat Cancer, and launch of AICR's new expert report: Diet, Nutrition, Physical Activity, and Cancer: A Global Perspective.

A group of leaders in the field of public health, research, nutrition, and cancer, will discuss the new report and new 10 Recommendations for Cancer Prevention.

Pre-register to join the live webcast on May 24 from 8:30-10:30a ET. 
IN THE NEWS
MedPage Today - May 8, 2018
In finalizing its  draft recommendations  for prostate cancer screening in men ages 55 to 69, the U.S. Preventive Services Task Force (USPSTF) has put itself broadly in alignment with guidelines from other organizations...  In a  JAMA Oncology  [Misra-Hebert, JAMA Oncol, 2018] editorial that accompanied the USPSTF recommendations, Anita D. Misra-Hebert, MD, MPH, and Michael W. Kattan, PhD, Case Comprehensive Cancer Center, Cleveland Clinic in Ohio, noted that even with recommendations from the AUA and other cancer organizations, shared decision-making has not significantly increased for prostate cancer screening and there are obstacles in doing so.  "What the updated USPSTF recommendations for prostate cancer screening are asking of physicians is to take time to pause, explain what is currently known, understand patient preferences, and make the screening decision together," explained Misra-Hebert and Kattan. "It is clear that these types of conversations are a necessity to deliver optimal patient care even while there does not appear to be enough time or any specific incentives tied to engaging in these discussions."
Esquire - May 8, 2018
"PSA is specific to prostate diseases but not specific to prostate cancer," says Eric Klein, Case Comprehensive Cancer Center, chairman of the  Glickman Urological and Kidney Institute  at the Cleveland Clinic. 
Oncology Times - May 5, 2018
Dr. Brian Bolwell, chairman of Cleveland Clinic Taussig Cancer Institute and Deputy Director for the Cleveland Clinic, Case Comprehensive Cancer Center, shares how he uses the concept of contextual intelligence (CI) when approaching complex issues.
FUNDING OPPORTUNITIES
Prevent Cancer Foundation
Prevent Cancer FoundationDeadline: Jun 28, 2018
The Prevent Cancer Foundation is the only U.S. nonprofit organization solely devoted to cancer prevention and early detection. Since 1985, the Foundation has invested in cancer prevention and early detection research,  education, outreach and advocacy and has played a pivotal role in developing a body of knowledge that is the basis for important prevention and early detection strategies. 

  • Early career researchers at the instructor or assistant professor level
  • More-senior researchers who have shifted their area of interest toward primary and secondary cancer prevention/early detection
  • Researchers at any academic level who need seed funding to test an innovative hypothesis
  • Researchers from non-profit institutions (including academic institutions) are eligible to apply
    • Documentation must be included that proves tax-exempt status of the applicant organization or parent organization. Attach your organization's IRS determination letter or other official documentation verifying your status as a nonprofit, academic institution or government agency.
  • Awards are limited to postdoctoral level applicants ONLY. Therefore, only graduate students who will have their doctoral degree before the project start date are eligible to apply.
  • Postdoctoral researchers from non-profit institutions (including academic institutions) are eligible to apply. Researchers from for-profit institutions will not be considered.
    • Documentation must be included that proves tax-exempt status of the applicant organization or parent organization. Attach your organization's IRS determination letter or other official documentation verifying your status as a nonprofit, academic institution or government agency.
International Myeloma Foundation
Deadline: Aug 1, 2018
International Myeloma Foundation logo The International Myeloma Foundation funds several research grants including the Brian D. Novis Research Award. These grants are provided through donations from private individuals, and are presented annually by the International Myeloma Foundation. These awards go to researchers doing work in the field of multiple myeloma and related disorders including smoldering myeloma, MGUS (monoclonal gammopathy of undetermined significance) as well as immunoglobulin derived amyloidosis. This year's awards will be $50,000 each for the junior grant and $80,000 for the senior grant.

Junior Research Award
The qualifications for a candidate for the Brian D. Novis Junior Research Award include the following:
  • Completed postdoctoral studies or clinical fellowships no later than August 1 of the application year.
  • Ability to devote a minimum of 50% of his or her time to the research project during the Award year.
  • Ability to provide a completed application with evidence of a meritorious research project.
  • NIH, other foundations or similar funding agencies.
Senior Research Award
These awards are targeted to established investigators with a track record in myeloma or related disorders, and are designed for projects which represent a different focus, direction, or area of research from those in which they are currently funded.  In most cases, these awards will be for pilot projects to obtain sufficient funding for larger applications from NIH or similar larger funding agencies.

The qualifications for a candidate for the Brian D. Novis Senior Research Award include the following:
  • Ability to provide a completed application with evidence of a meritorious research project.
  • NIH, other foundations or similar funding agencies.
NIH BULLETIN- Notices and Funding Opportunities
rfas 
Notices
Additional Awards Eligible for PA-18-586 Research Supplements to Promote Diversity in Health-Related Research (Admin Supp)(NOT-OD-18-176) 

Program Announcements

Investigation of the Transmission of Kaposi Sarcoma-associated Herpesvirus (KSHV)(R01 Clinical Trial Optional)(RFA-CA-18-013)
Deadline: Aug 16, 2018

Investigation of the Transmission of Kaposi Sarcoma-Associated Herpesvirus (KSHV) (R21 Clinical Trial Not Allowed)(RFA-CA-18-014)
Deadline: Aug 16, 2018

Novel Genomic Technology Development (R01 Clinical Trial Not Allowed)(PAR-18-777)
Deadline: Oct 2, 2018; Oct 2, 2019; Oct 2, 2020

Novel Genomic Technology Development, (R21 Clinical Trial Not Allowed)(PAR-18-778)
Deadline: Oct 2, 2018; Oct 2, 2019; Oct 2, 2020

Novel Genomic Technology Development, (R43/R44 Clinical Trial Not Allowed)(PAR-18-779)
Deadline: Oct 2, 2018; Oct 2, 2019; Oct 2, 2020
IN THIS ISSUE
EVENTSevents
Mon, May 14
Genomic Medicine Institute
Hippokratis Kiaris, PhD Associate Professor, Director of the Peromyscus Genetic Stock Center, University of South Carolina
"Stressing the deer mice: Modeling the unfolding protein response in genetically diverse animals"
12p NE1-205 Cleveland Clinic

Cancer Impact Lecture Chalk Talk
Jun Wang, PhD
Associate Research Scientist, Immunobiology, Yale Cancer Center
"Target discovery for cancer immunotherapy"
12p NE6-218
Tues, May 15
Radiation Oncology Grand Rounds
Ehsan Malek, MD
Instructor, Hematology and Oncology, CWRU/UH
"TGF-β: An emerging therapeutic target in multiple myeloma"
8:10a Lerner B-151

Cancer Biology Seminar Series
HyeonJoo Cheon, PhD
Project Staff, Stark Lab,  Cancer Biology, Cleveland Clinic
"p53 mutation induces constitutive expression of interferon β, enhancing the resistance of cancer cells to DNA damage"
Anna Kondratova, PhD
Research Associate, Stark Lab,  Cancer Biology, Cleveland Clinic
"Stimulation of poly(ADP-ribose) synthesis by suppression of 2'-5'-oligoadenylate synthetase as an approach to chemotherapy"
2p NC1-202 Cleveland Clinic
Thurs, May 17
Developmental Therapeutics Journal Club
9a R4-013 Cleveland Clinic

Molecular Biology and Microbiology Seminar
1p SOM W203

Cowden Craft Series: Flight Night - Event to benefit the Meredith A. Cowden Foundation
6-10p Masthead Brewing
Fri, May 18
Taussig Cancer Institute Grand Rounds
David Palma, MD
London Health Sciences Center 
"The Oligometastatic State: Real entity, or fake news?"
8a CA5-120 Cleveland Clinic

Cellular and Molecular Medicine 
Paul R. Lockman, PhD Professor and Chair, Basic Pharmaceutical Sciences, Associate Center Director for Translational Research, West Virginia University Cancer Institute
"Brain metastases - Our advances and failures"
10a NC1-202 Cleveland Clinic

Case Gastrointestinal Cancers SPORE Retreat
8:15a Tinkham Veale University Center 
Registration
Mon, May 21
Genomic Medicine Institute
Hyunpil Lee, PhD
Eng lab, Genomic Medicine Institute, Cleveland Clinic
"Oligodendrocyte maturation and function in a murine model of PTEN-ASD"
12p NE1-205 Cleveland Clinic

Cancer Center Research Chalk Talk
Kishore Guda, PhD
Assistant Professor, Oncology, CWRU
1p WRB 3-136
Tues, May 22
Pharmacology Spring Seminar
Karen Knudsen, PhD
Director, Sidney Kimmel Cancer Center;  Hilary Koprowski Endowed Professor and Chair, Department of Cancer Biology;  Professor, Cancer Biology, Urology, Radiation Oncology, and Medical Oncology; Thomas Jefferson University
"Targeting DNA repair dysfunction in prostate cancer"
12p Wood Bldg, SOM331

17th Annual Short Course: Cell-Based Therapies & Tissue Engineering
May 22-24, 2018
CWRU
Details
Wed, May 23
17th Annual Short Course: Cell-Based Therapies & Tissue Engineering
May 22-24, 2018
CWRU
Details
Thurs, May 24
17th Annual Short Course: Cell-Based Therapies & Tissue Engineering
May 22-24, 2018
CWRU
Details

Developmental Therapeutics Journal Club
9a R4-013 Cleveland Clinic

Molecular Biology & Microbiology Seminar
1p SOM W203Case CCC 

VeloSano Happy Hour
4-6p TOLI (Tavern of Little Italy)
Fri, May 25
Taussig Cancer Institute Grand Rounds
8a CA5-120 Cleveland Clinic

ADDITIONAL UPCOMING SYMPOSIUMS & EVENTS
prev-funding
PREVIOUSLY ANNOUNCED OPPORTUNITIES

Deadline: Open

Deadline: Open

Deadline: Open
Case Comprehensive Cancer Center 
2103 Cornell Road, Ste 1422
Cleveland, OH 44106-7285