May 28, 2021
Member/Center Highlights
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Researchers Identify New Drug Target for Treating Aggressive Prostate Cancer
According to new findings published in Science Translational Medicine, researchers in Lerner Research Institute’s Department of Cancer Biology have identified a promising drug target for treating and preventing drug-resistant prostate cancer.

The team, led by Nima Sharifi, MD, reports that inhibiting the protein H6PD significantly reduced tumor sizes and improved progression-free survival among human-derived preclinical models of drug-resistant prostate cancer. They found that H6PD levels were significantly enriched in biopsied patient tumors, as well, suggesting it can be targeted in patients.
American Society of Clinical Oncology Annual Meeting 2021: Highlights from the Case CCC
The American Society of Clinical Oncology (ASCO) Annual Meeting will be held virtually again this year, June 4-8, 2021. The meeting will feature a dynamic program of educational and scientific sessions, showcasing what is possible when the cancer care community comes together to advance cancer research, treatment, and patient care. On-demand content and presentations will be available beginning at 9:00 am ET on Friday, June 4, while a scheduled broadcast experience featuring 48 high-impact sessions with real-time engagement and live Q&A is planned for all registrants.

The Case Comprehensive Cancer Center has compiled a list of ancillary educational events, oral abstract sessions, poster and poster discussion sessions, as well as publication-only abstracts from Cleveland-based institutions including Case Western Reserve University, University Hospitals, Cleveland Clinic and The MetroHealth System.
Julie DeJager named Deputy Associate Director for Administration
We are pleased to announce Julie DeJager, MA, as the Deputy Associate Director for Administration for the Case Comprehensive Cancer Center.

As the Deputy Associate Director, Julie is responsible for developing implementation strategies, advising on matters of operational feasibility, providing programmatic and developmental research support, and overseeing activities of the Cancer Center Support Grant (CCSG). Working directly with John Pounardjian, MBA, Associate Director for Administration, she will provide organizational oversight for research space, shared resources, research programs, CCSG funds, pilot grants, various national activities, information services, and other operational activities of the Cancer Center. Julie will work with administrators across the consortium institutions to implement seamless administrative services to achieve the goals and strategies of the Case CCC.

Julie has been part of the Cancer Center administration team since 2013. She has extensive experience with grants management, process development and data collection, serving as Manager of Research Administrative Operations for the Cancer Center prior to being named Deputy Director. Please join us in congratulating Julie on her new role!
Trainee Spotlight: Kincaid receives AACR Meritorious Achievement Award, graduates with honors this weekend
The Case Comprehensive Cancer Center extends congratulations to Jack Kincaid, a trainee in the lab of Nathan A. Berger, MD, as he received the AACR Meritorious Achievement Award at the AACR Undergraduate Student Caucus and Poster Competition (USCPS) held during the Annual Meeting of the American Association for Cancer Research (AACR).

His poster, reporting the effects of sex and obesity on latency of Acute Promyelocytic Leukemia (APL) highlights the likelihood that APL will join a list of 13 other malignancies formally labeled as obesity-associated cancers. Currently, only one hematologic malignancy, multiple myeloma, is formally identified as obesity-associated. The research, with Dr. Berger and Berger Lab Senior Research Assistant & Manager Anne Baskin, revealed how obesity and obesogenic diets accelerated the development of APL, with males demonstrating earlier development of the disease and provided a robust model to study mechanisms by which sex impacts leukemia latency.
National Cancer Institute Requests for Information: Enhancing Cancer Health Disparities Research and Diversity and Inclusion in the Cancer Research Workforce
NCI Logo
The National Cancer Institute (NCI) Equity and Inclusion Program seeks actionable recommendations to enhance cancer health disparities research and diversity and inclusion in the cancer research workforce through the following two Requests for Information (RFIs).

Jennifer Cullen, PhD, MPH (jxc1650@case.edu) and Erika Trapl, PhD (erika.trapl@case.edu) are coordinating a response on behalf of the Case Comprehensive Cancer Center, and welcome your feedback and comments.

Webinar: Master of Science in Regenerative Medicine and Entrepreneurship (RGME)
The Master of Science in Regenerative Medicine & Entrepreneurship is the first two-year master's level program in Ohio focused on Regenerative Medicine and Entrepreneurship. Students enrolled in the RGME program will have access to cutting-edge clinical and research facilities along with small biotechnology companies within the network of the National Center for Regenerative Medicine (NCRM).

RGME students are trained in academic, commercial and clinical settings to support cellular manufacturing, biotechnology innovation, legal compliance, financial analysis, venture capital, and business development activities, all while taking advantage of our strengths across the disciplines of regenerative medicine as a whole.

Join RGME program director Tracey Bonfield, PhD on Wednesday, June 23, 2021 from 1-2 pm ET for a webinar to discover how a graduate degree in regenerative medicine, combined with entrepreneurship, can change lives.
What's Coming Up
Mark Your Calendar
Register Today for the Annual Scientific Retreat
July 22-23, 2021 | Virtual
The 2021 Annual Scientific Retreat for members and trainees is scheduled for July 22-23! As you may know, this is one of the few times a year our entire center is able to enjoy the company of one another and collaborate.

This year's virtual retreat features an expanded agenda that mirrors our prior in-person retreats, highlighting research across each of our scientific programs.

The retreat will begin Thursday with an address from Director Stan Gerson, MD, followed by TED-style Talks from Diana Bilimoria, PhD, Daniel E. Spratt, MD, and Serpil Erzurum, MD. Registration for the retreat is now open.
Zihai Li
Keynote
Zihai Li, MD, PhD will present the retreat keynote on Friday, July 23. Dr. Li is the founding director of the Pelotonia Institute for Immuno-Oncology and the Klotz Chair in Cancer Research at The Ohio State University.
Register today for VeloSano 8!
Bike to Cure Weekend | September 10-12, 2021
We are looking ahead with optimism to VeloSano 8 with a goal of providing opportunities to reunite our VeloSano community in a variety of safe and meaningful ways!

VeloSano is offering options for anyone to participate in any way they are most comfortable - whether riding with us during "Bike to Cure" weekend September 10-12; riding virtually, or by choosing your own activity to participate anytime, anywhere as a Virtual Fundraiser.

The Case Comprehensive Cancer Center, Team Case CCC, will be joining VeloSano again this year and providing complimentary registration and jerseys for its riders. Please contact team captains Caroline El Sanadi or Mary Wright for the registration waiver or code with any questions!
Save the Date: Great Lakes Breast Cancer Symposium
October 25-26, 2021 | Virtual
Save the date for the Great Lakes Breast Cancer Symposium, to be held virtually October 25-26, 2021!

This annual symposium highlights ongoing basic, translational, clinical and population studies addressing the biological mechanisms, management and prevention of breast cancer. Researchers from participating institutions will share their exciting work with a goal to develop cross-institutional collaborations.

Though this event is happening virtually, attendees will experience the conference using Whova, our official web-based conference app, to view presentations and ask questions in real-time, as well as network with others behind the scenes.
Helen Piwnica Worms
Keynote
Helen Piwnica-Worms, PhD, will deliver a keynote at the symposium. Dr. Piwnica-Worms is Professor, Department of Experimental Radiation Oncology, Division of Radiation Oncology and Senator AM Aiken Jr. Distinguished Chair at University of Texas MD Anderson Cancer Center.

Registration and call for abstracts for this symposium will open June 2021.
Additional Upcoming Events
2021 Race for the Place
June 6, 2021 | Virtual
Race for the Place in support of The Gathering Place, takes place the first Sunday in June on National Cancer Survivors Day. The Race, a 5K and 1 Mile walk, is a wonderful celebration of cancer survivors and an opportunity to raise money to support the free programs and services provided at The Gathering Place to help children, teens, adults, individuals, families and friends cope while on the cancer journey.

Registration is now open!
NCCN Policy Summit: Defining the "New Normal"
June 15, 2021 | Virtual
Registration is now open for the next National Comprehensive Cancer Network (NCCN) policy summit: Defining the "New Normal" - 2021 and the State of Cancer Care in America Following 2020, held virtually Tuesday, June 15, 2021.

This FREE online program will explore how national health and sociopolitical events in 2020 will impact future cancer care delivery in the United States. Convening a group of diverse speakers and panelists, the virtual summit will discuss the influence of watershed events including the COVID-19 pandemic, post-election landscape, and national conversations of racial inequity on cancer care. Learn more about upcoming NCCN summits.
AACI Clinical Research Innovation 13th Annual Meeting
July 13-15, 2021 | Virtual
Registration is now open for the 13th Annual AACI CRI Meeting, Adapting Clinical Trials Offices for 2021 and Beyond which will be held virtually July 13-15. The program will provide panel discussions with content experts and breakout sessions for our members and abstract winners and runners-up will be acknowledged in poster sessions.

More information, including the program and registration, is now available on the CRI meeting website.
Midwest Melanoma and High Risk Skin Cancer Symposium
July 16, 2021 | Live Stream 8a-1:15p ET
This half day CME accredited symposium is specifically designed to provide those who have skin cancer management interests the latest advances in prevention, surveillance, and local-regional and systemic therapies.

This activity will bring together an audience of medical oncologists, radiation oncologists, surgeons, dermatologists, nurses, and other health care providers to discuss management of these patients.

Click here to view the symposium agenda. Registration includes access to presentations for 3 months after program.
National Cancer Institute Logo
NCI Drug Development Workshop Series: How to Advance A Therapeutic Candidate from Bench to Bedside
July 23, 2021 - December 10, 2021
This workshop being sponsored by the Developmental Therapeutics Program at the NCI will entail a series of 10 webinar-based lectures held Friday afternoons (12-2:30 pm ET) July 23, 2021 through December 10, 2021. The goal of this workshop is to provide researchers with an interactive setting in which they will gain an understanding of product development considerations for anti-cancer therapeutics, to facilitate successful translation from preclinical to clinical studies.

This workshop is specifically designed for researchers who are interested in learning about key activities that are needed to take their discoveries from the lab to the clinic. Junior faculty and trainees are encouraged to attend.

Workshop topics will encompass key IND-enabling activities and milestones, regulatory considerations, as well as contemporary first-in-human trial design, available NCI translational resources, insights from the private sector for entrepreneurial purposes, and case studies. Each session includes facilitated questions and answers (Q&A) to engage audience in the discussion.

Session recordings will be made available to the public at the registration site. Registration is not required for accessing the recordings. Please note that while you may register for one or multiple sessions, attendance for all sessions is encouraged to gain the maximal learning and benefit.

8th Annual Genetics Education Symposium
September 30, 2021 | Live Stream 8a-4:45p ET
This accredited program, presented by Cleveland Clinic’s Genomic Medicine Institute (GMI) and the Center for Personalized Genetic Healthcare (CPGH), will provide the opportunity to review the latest advances in genetics and genomics. GMI and CPGH will provide state-of-the-art information to healthcare providers treating patients with hereditary cancer syndromes.

Expert Cleveland Clinic and guest faculty will present case- and research-based presentations highlighting the integration of genetics and genomics into clinical practice.

Invited are practitioners and healthcare professionals seeking to learn the latest developments in medical genetics, especially providers in Hematology/Oncology, Genetics, Internal Medicine and Subspecialties, Pediatrics, and Nursing. Trainees and students with an interest in expanding their knowledge of genomic medicine and related topics are also encouraged to attend.

Funding Opportunities
With the generous support from VeloSano Bike to Cure 2020, the Case Comprehensive Cancer Center (Case CCC) is providing seed funding for innovative and impactful proposals that will generate key data for larger, nationally competitive multi-investigator/team grants (MPI R01, P01, U01, SPORE, etc.). The Case CCC has recently undertaken a reorientation of its scientific programs, and this award will provide funds for each of our six scientific programs. Program Leaders will select the award aligned to their program, and therefore will not serve as project PI. Projects must be focused on the establishment or support of a collaborative effort by a team of 2 or more independent investigators from the case Case CCC research program. The goal is to submit a federal team science grant application.
The Vilcek Foundation is currently seeking young foreign-born applicants for the 2022 Vilcek Prizes for Creative Promise in Biomedical Science. The Vilcek Foundation a nonprofit foundation dedicated to raising awareness of immigrant contributions to the arts and sciences in the United States.

Immigrant biomedical researchers are encouraged to apply. Applicants should have been born outside of the United States and be 38 years of age or younger. Three winners will each receive a $50,000 unrestricted cash prize and be honored at an awards ceremony in New York City in April 2022.
The Nature Research Awards for Inspiring Women in Science - Science Outreach Category, is presented for initiatives that support girls or young women to engage with, enjoy and study STEM subjects OR to increase the retention of women in STEM careers. STEM includes natural sciences, technology, engineering, mathematics and medicine. These initiatives can be run by an individual or academic, educational, charitable, governmental or corporate entity.

NRA is seeking initiatives that have either:
  • encouraged girls or young women to engage with and study natural sciences, technology, engineering, mathematics and medicine OR
  • increased retention of women in STEM careers, with a focus on providing tools to support women through their career progression in a STEM discipline.

Entries will have shown exceptional vision, insight and/or imagination and demonstrated that they encourage, support or promote the interest of girls and/or women in STEM.
In The News
Cleveland.com - May 20, 2021
Mark Cameron, PhD, associate professor at the School of Medicine, noted that Ohio is among the top states for distributing vaccines, but ranks lower in the number of people vaccinated. Dr. Cameron is a member of the Case CCC.
University Hospitals - May 2021
Painter Mark Krieger’s cancer journey has been inspired by the example of a father who fought through daily struggles as a double amputee and by 32 years teaching art to middle-school children. Mark was diagnosed and treated for liposarcoma at University Hospitals Seidman Cancer Center, one of Case CCC's clinical partners.
From The NIH
Weekly NIH Funding Opportunities and Notices
COVID-19 Funding Opportunities and Notices
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