May 29, 2020
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Member/Center Highlights
ASCO Virtual Scientific Program 2020: Highlights from the Case CCC
The American Society of Clinical Oncology (ASCO) Annual Meeting will be held virtually in two parts this year. The Virtual Scientific Program is taking place today through Sunday, May 31, and the Virtual Education Program will be held August 8-10. Oral abstract, poster discussion and poster sessions as well as track-based Clinical Science Symposia, is available on-demand as of 8:00 am ET today. The virtual meeting will provide an engaging lineup of scheduled and on-demand scientific content offering the opportunity to learn and collaborate across a variety of approaches, disciplines, and specialties. Registrants will have exclusive access to hundreds of video and slide presentations, as well as discussant commentary for 180 days.
The Case Comprehensive Cancer Center (Case CCC) has compiled a list of plenary sessions, clinical science symposia, oral abstract sessions, poster and poster discussion sessions, as well as publication-only abstracts from Cleveland-based institutions including Cleveland Clinic, University Hospitals and Case Western Reserve University. Our highlight compilation has been updated online since originally published in last week's newsletter.
Team co-led by Eng finds gene inactivation of PTEN drives cancer predisposition
Charis Eng, MD, PhD
In a new study published in the New England Journal of Medicine, researchers led by Charis Eng, MD, PhD and Pier Paolo Pandolfi, MD, PhD, FRCP determined that mutations of the WWP1 gene may also drive cancers associated with PTEN hamartoma tumor syndrome (PHTS) in patients without PTEN gene mutations. ( Lee, NEJM, 2020)

"Our findings suggest that WWP1 mutations may account for at least some portion of the large percentage of these patients we see without PTEN mutations," said Dr. Eng. "Importantly, unlike PTEN, WWP1 and the cellular pathway it regulates are druggable targets, a fact that has important implications for cancer prevention and therapy and may open the door for future drug development studies."
Dr. Eng is the inaugural chair of the Genomic Medicine Institute and director of the Center for Personalized Genetic Healthcare at Cleveland Clinic. She also holds the Sondra J. and Stephen R. Hardis Endowed Chair in Cancer Genomic Medicine, is professor and vice chair of genetics and genome sciences at Case Western Reserve University and is a member of the Case Comprehensive Cancer Center’s Cancer Prevention, Control & Population Research Program. Dr. Pandolfi is professor of cancer biology and genetics at the University of Turin, Italy and Harvard Medical School.
Members: How has your research been affected by COVID-19?
We are collecting stories on how labs have shifted in response to COVID-19. If you have changed your work patterns and made discoveries despite COVID-19, or are adjusting your research to assess COVID-19, we would like to hear from you.

Please send stories and comments to

We appreciate you taking the time to share your stories with us. Please let us know if there is anything Cancer Center administration can do to assist you.
Prepare for dual delivery this fall with a summer camp offered by UCITE and [U]Tech’s Teaching and Learning Technologies
Cropped view of man listening music in earphones and using laptop in cafe
University Technology’s ([U]Tech) Teaching and Learning Technologies (TLT), in collaboration with University Center for Innovation in Teaching and Education (UCITE), will offer a six-week Dual Delivery Summer Camp starting June 1. Faculty and staff members are invited to participate in a summer of discovery and community as the university prepares for dual delivery in the fall.
Team Case CCC "rides" on into Virtual VeloSano 2020!
Originally scheduled for July 17-19, 2020 in Cleveland, OH, VeloSano 7 is evolving into Virtual Velosano to keep our community safe and healthy during the COVID-19 pandemic. While we won't be able to unite in person this summer, we will continue fundraising as the need for cancer research is more important than ever.

Our continuing goal is to bring sustainable funding to cancer research by enlisting the passion and energy of thousands of people who wish to give back... including YOU! We raised nearly $94,000 in 2019 and every dollar goes directly toward cancer research. In our six years of participation, more than $1,000,000 of VeloSano fundraising totals have come back to the Case CCC to award researchers as pilot funding for cancer research projects.
Case CCC COVID-19 Resource Hub
As the COVID-19 outbreak progresses, the Case Comprehensive Cancer Center (Case CCC) has centralized COVID-19 related news, resources and funding opportunities for our cancer center community. Content is updated regularly.

To have a cancer-focused resource added to the page, please email
What's Coming Up
Mark Your Calendar
Virtual Race for The Place 2020
May 29 - June 7, 2020
Facebook and Instagram Live

The Gathering Place is hosting its annual "Race for the Place" 5K and 1-mile run/walk virtually from today, Friday, May 29 to National Cancer Survivors Day, Sunday, June 7. Proceeds from Race for the Place help support their free programs and services.

For the safety of participants and the community and in light of the ongoing concerns around COVID-19, The Gathering Place has made the decision to hold a virtual Race for the Place. They have compiled virtual race ideas and will host their Cancer Survivor Ceremony at 9:00 am Sunday, June 7 on Facebook and Instagram Live.

Race for the Place is a particularly important event for The Gathering Place. It is their only annual fundraiser and provides significant financial support to keep their programs and services free of charge to help individuals and families cope with the impact of cancer in their lives. COVID-19 has not stopped the needs of our participants and they continue to provide free programs every day through GoToMeeting, Zoom, the telephone and Facebook Live.

The Gathering Place is a caring community that supports, educates and empowers individuals and families currently coping with the impact of cancer in their lives through programs and services provided free of charge.
Save The Date: Annual Scientific Retreat (Members and Trainees Only)
July 23-24, 2020

The Case Comprehensive Cancer Center invites all members and trainees to mark their calendars for Thursday, July 23 and Friday, July 24, 2020 for our annual scientific retreat!

We will once again host TED talks from prominent Cleveland researchers and highlight research from each of our scientific programs. As in past years, attendees will hear a cancer center update from Director Stan Gerson.

We are also looking forward to a keynote presentation from Timothy Rebbeck, PhD, the Vincent L. Gregory, Jr. Professor of Cancer Prevention at the Harvard T.H. Chan School of Public Health and the Dana-Farber Cancer Institute. Dr. Rebbeck is founding director of the Zhu Family Center for Global Cancer Prevention at the Harvard TH Chan School of Public Health and leads the Cancer Outreach and Engagement activities for the Dana-Farber Harvard Cancer Center.

Mindful that we must do everything we can to keep our cancer center community safe and healthy, we are planning an alternate abridged virtual agenda as we will not be able to gather in-person in July. Please save the dates at this time, and we will provide additional details of the retreat's format and agenda in the weeks to come.

Please contact Mary Wright ( should you have any questions about the retreat.
Save The Date: Artificial Intelligence in Oncology Symposium 2020
October 19-20, 2020
Tinkham Veale University Center, CWRU

The second annual Artificial Intelligence in Oncology Symposium will bring together experts in AI and machine learning this October at Case Western Reserve University.

Geraldine McGinty, MD, MBA, FACR will present the symposium keynote, "Fostering a Strong Ecosystem for AI in Medical Imaging." Dr. McGinty is an internationally recognized expert in imaging economics, Chair of the American College of Radiology Board of Chancellors and Chief Strategy and Contracting Officer at Weill Cornell Medicine in New York City.
Rescheduled: Great Lakes Breast Cancer Symposium
May 23-25, 2021
Tinkham Veale University Center, CWRU

Originally scheduled for October 4-6, 2020, the next Great Lakes Breast Cancer Symposium has been rescheduled for Sunday, May 23 - Tuesday, May 25, 2021.

The symposium highlights ongoing basic, translational, clinical and population studies addressing the biological mechanisms, management and prevention of breast cancer. Researchers from participating institutions will share their exciting work with a goal to develop cross-institutional collaborations.
Additional Upcoming Events
AACR Virtual Annual Meeting: Part II
June 22-24, 2020
The AACR Virtual Annual Meeting II, June 22-24, will feature the originally planned Opening Plenary Session that explores the range of impactful cancer research and clinical translation; award lectures from individuals who have made extraordinary contributions to the cancer field; a special talk from National Cancer Institute Director Ned Sharpless, MD; and thousands of proffered papers in minisymposia and on an e-poster platform.
AACR Virtual Meeting: COVID-19 and Cancer
July 20-22, 2020
This special AACR conference will focus on the presentation of emerging data in basic, clinical, and epidemiologic research related to COVID-19 and cancer. The program will feature a mix of keynote lectures and other invited presentations, short talks from highly rated abstracts, virtual posters, and forums that include panels of experts from various fields. It is anticipated that this must-attend virtual event will attract participants from across the international research community.

Submit an abstract by Tuesday, June 9. 
12th Annual AACI Clinical Research Innovation (CRI) Meeting
July 7-8, 2020
Registration is now open for the 12th Annual AACI CRI Meeting, Cancer Clinical Research: Focus on the Future.

Registration for the two-day, virtual meeting is free for AACI cancer center members and sustaining members. AACI is working to ensure that the online meeting, scheduled for July 7-8, will still deliver the innovative, quality education that its members have enjoyed at prior CRI annual meetings.

More information, including the program and registration, is now available on the CRI meeting website.
Funding Opportunities
In order to promote young scientists early in their career, SciLifeLab has engaged in a collaboration with AAAS and Science magazine to award an annual prize in the area of life science for the best PhD thesis work. The Prize, established in 2013, was created to recognize that global economic health is dependent upon a vibrant research community and we need to encourage our best and brightest to continue in their chosen fields of research. The international Prize is awarded annually to four young scientists for outstanding life science research for which he/she earned a doctoral degree in the previous two years. Each year, a Grand Prize winner is selected from the applicants to receive $30,000 in prize money. The three other category winners are awarded $10,000 each for their accomplishments.

The 2020 categories are:
Internal LOI deadline: Sunday, June 21, 2020
The Case Comprehensive Cancer Center has been invited to submit applications from junior faculty for the Gabrielle's Angel Foundation 2020 Medical Research Awards. Gabrielle’s Angel Foundation funds cutting-edge research in the fields of leukemia, lymphoma, and related cancers of the blood.

The awards provide $75,000 of support per year over three years, not to exceed $225,000. Applications in conventional and integrative research are being accepted.

Interested candidates are asked to submit an LOI (including PI contact information and an abstract/project summary) and biosketch to by Sunday, June 21, 2020. Contact with questions.
In The News
Science Daily - April 23, 2020
A new expert panel consensus statement published in the journals Radiology: Imaging Cancer, Chest and the Journal of the American College of Radiology provides guidance to clinicians managing lung cancer screening programs and patients with lung nodules during the COVID-19 pandemic.
"This document provides guidance that we hope will help with these decisions. It outlines acceptable variances from standard practice during the pandemic and provides items to consider that could influence the decisions for a given patient," said Cleveland Clinic's Peter Mazzone, MD, MPH. Dr. Mazzone is a member of the Cancer Prevention Control & Population Research Program at the Case CCC.
New York Times - May 26, 2020
"We may lose our window to intervene early, when cancer is still at an early stage, and eliminate it," says Mikkael Sekeres, MD, MS, illuminating the consequences of screenings postponed by COVID-19 in his latest essay for The New York Times. Dr. Sekeres is director of the leukemia program at Cleveland Clinic and Associate Director for Clinical Research at the Case CCC.
From The NIH
Weekly NIH Funding Opportunities and Notices
COVID-19 Funding Opportunities and Notices
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