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May 3, 2019
NATIONAL CANCER RESEARCH MONTH
May is National Cancer Research Month
This month, the Case Comprehensive Cancer Center (Case CCC) is supporting the global awareness campaign highlighting the importance of cancer research.

According to the American Association for Cancer Research (AACR), more than 16.9 million people in the United States and millions more worldwide are cancer survivors who are living with, through, and beyond their disease thanks to spectacular advances in cancer research.

This year's National Cancer Research Month theme is "Bringing Cancer Research to Life." Though significant strides have been made, the toll of cancer is still a growing public health challenge. We know that together, we can defeat cancer. 

You can join us in this campaign by sharing how you bring cancer research to life through your work by submitting a feature to the Case CCC communications team or engaging in the campaign on social media with hashtags #NCRM19 and #ResearchSavesLives. Don't forget to tag us @CaseCCC on so we can share as well!
MEMBER/CENTER HIGHLIGHTS
"The Race" 5K and 1-Mile Run Benefits Breast Cancer Research on Mother's Day, May 12
The 16th annual family-friendly "The Race" will take place this Mother's Day, Sunday, May 12, at Legacy Village in Lyndhurst. Registration begins at 7:30 am and the 5K starts at 8:30 am, followed by the 1-mile run at 9:30 am.

The goal of "The Race" is to empower children and 
their families to make a difference in the lives of those touched by breast cancer. Participants will receive a commemorative t-shirt and all guests will enjoy refreshments, bounce houses, laser tag, face painting and more. Prizes will be awarded to the team and school with the greatest participation, and well as the individual who raises the most money.

This year's event will honor two inspiring women and breast cancer survivors from Case Western Reserve University School of Medicine. Dean Pamela B. Davis, MD, PhD, who is a renowned physician researcher and the medical school's fearless leader, and associate professor Nicole Ward, PhD, who has obtained national and international recognition and funding for her dermatology research.

For the past 15 years, "The Race" has attracted thousands of participants each Mother's Day. Private donors cover the operating costs of the event, and 100 percent of participants' registration fees and donations will be given to the Case Comprehensive Cancer Center (Case CCC) in support of innovative breast cancer research.

"Our investigators are consistently working towards finding cancer cures, and thanks to 'The Race' they will be supported through availability of new pilot grant awards," said Case CCC Director Stan Gerson, MD. "It's inspiring to see cancer research advocates join together in our Cleveland community. The event organizers are bringing an engaged community to an exciting event that will benefit all individuals and families affected by cancer." more>
Ice Cream Sundae Bar Benefitting VeloSano Team Case CCC
May 3, 1-3p | BRB Lobby

The ice cream sundae bar is back today,
this time in the BRB lobby. Stop by between 1-3pm, and build your own sundae for just a $5 donation. Cash and Venmo will be accepted.
Scott Lab Recruiting Technician
The lab of Jacob Scott, MD, PhD in the Cleveland Clinic Lerner Research Institute's Theory Division is seeking a bachelor's or master's level lab technician to assist in studying cancer evolution and antibiotic resistance.  A great candidate would have (or almost have) a BS in an applied science, be curious, like working in teams, be inclusive and eager to work in a diverse community. The job will be mostly wet lab with some light management type work too.

In case you missed it, his Twitter sales pitch for the role was quite entertaining! Visit the lab website to learn more or contact Scott for more information.
MARK YOUR CALENDARS
19th Annual Jerome I. Kleinerman, MD Lecture in Pulmonary Pathobiology
May 3, 4p | WRB Auditorium

The Department of Pathology will be hosting The 19th Annual Jerome I. Kleinerman, MD Lecture in Pulmonary Pathobiology on Friday, May 3, 2019 at 4 pm in the Wolstein Research Building Auditorium.

Philip T. Cagle, MD, professor of pathology at 
the Weill  Medical School of Cornell University and S. Donald Greenberg Chair and Director of Pulmonary Pathology at Houston Methodist Hospital in Houston, TX, will be presenting, "Approach to the Lung Cancer Biopsy for Molecular Testing in the Context of the New Guidelines".

A wine reception will be held in the WRB lobby immediately following the lecture. All are welcome to attend.
Fellowship Writing 101
May 9, 12p | WRB 3-136

To help trainees prepare competitive applications, William Schiemann, PhD, Chair of the NCI fellowship review panel, will present "Fellowship Writing 101" on Thursday, May 9 in WRB conference room 3-136 at 12 pm.  Free lunch will be provided for those that RSVP to Damian Junk at  damian.junk@case.edu . An NCI-style review panel will include Case CCC Trainee Associate Members as reviewers to provide insight into the review process.
Cancer Center Seminar Series: "Prediction and Prevention of Treatment-Related Adverse Effects in Cancer Survivors"
May 10, 12p | WRB Auditorium

Our weekly seminar will be back next Friday in the Wolstein Research Building Auditorium. Join us at noon to hear Smita Bhatia, MD, MPH present, " Prediction and Prevention of Treatment-Related Adverse Effects in Cancer Survivors."

Dr. Bhatia is visiting us from the School of Medicine at the University of Alabama at Birmingham. There she is the Gay and Bew White Endowed Chair in Pediatric Oncology, professor of pediatric oncology, Vice Chair for Outcomes Research in the Department of Pediatrics, and Director of the Institute for Cancer Outcomes and Survivorship.

The Seminar Series  will  be
available to view via live stream. While we highly encourage you to attend in person to interact with our speakers and receive CME credit, we understand that may not always be possible. Presentations will not be recorded for later viewing, but you may watch the seminar in real time and ask questions via chat.  Watch live at noon>
Cancer Center Seminar Series: Special Presentation: Helen Moss Integrative Oncology Lecture
May 17, 12p | WRB Auditorium

The final weekly seminar of the 2018-2019 series will be held Friday, May 17 in the Wolstein Research Building Auditorium. Join us at noon to hear Peiying Yang, MS, PhD present, "Natural Products for the Development of Novel Anticancer Therapies. "

Dr. Yang is associate professor in the Department of Palliative, Rehabilitation and Integrative Medicine, Division of Cancer Medicine at The University of Texas MD Anderson Cancer Center. Her research examines the effects of traditional Chinese medicine, natural products and dietary supplements  for treatment or prevention of cancer and symptom management.
FUNDING OPPORTUNITIES
Opportunities for Pilot Projects in Catchment-Related Cancer and Risks
Deadline for specific aims: May 27, 2019
Deadline for full proposal: June 21, 2019

The Case Comprehensive Cancer Center is providing
Case CCC logo
seed funding for highly innovative and impactful laboratory-based proposals focused on catchment-related cancers and risks prevalent in underserved populations. Results from this pilot are expected to provide key findings to support larger, nationally competitive grants. Only members of the Molecular Oncology, GU Malignancies, Developmental Therapeutics, Hematopoietic and Immune Biology or Cancer Imaging Programs are eligible to serve as lead PIs for this pilot award. Attention to research relevant to our catchment area is a cross-cutting theme of the Case CCC scientific programs; thus projects aligned with the Center's strategic plan that focus on the major cancers of our catchment area, in particular those with excess incidence, morbidity, mortality or risks of cancers due to local environment, lifestyle, socioeconomic, special population factors will be prioritized. Collaborative, multi-investigator projects are particularly encouraged, especially those linking laboratory- and population-based researchers. more>
Doris Duke 2019 Sickle Cell Disease/Advancing Cures Award
Deadline: May 31, 2019


The Doris Duke Sickle Cell Disease/Advancing Cures
Doris Duke Charitable Foundation
award provides grants to advance curative approaches for sickle cell disease, including gene modification and drug therapies to restore hemoglobin function.

This award aims to support clinical research that will:
  • Advance gene therapies for sickle cell disease into the clinic, including gene addition and genome editing.
  • Build on globin regulatory mechanisms to restore red blood cell function.
  • Advance bone marrow transplant approaches to minimize toxicities and improve outcomes.
In keeping with the wishes expressed in Doris Duke's will, experiments that use animals or primary tissues derived from animals will not be supported by this program. The number of funded projects will depend on the number of meritorious applications received and their budgets. Flexible annual direct cost amounts of $150,000 - $300,000 will be considered, plus an annual 10% indirect cost allowance. View the complete RFA>

Doris Duke 2019 Physician Scientist Fellowship
Deadline: June 7, 2019


The Doris Duke Physician Scientist Fellowship program provides grants to physician scientists at the subspecialty fellowship level who are seeking to conduct additional years of research beyond their subspecialty requirement. The goal is to aid in the transition into a research faculty appointment.

The Physician Scientist Fellowship consists of $100,000 for annual direct costs plus $10,000 (10 percent) for annual indirect costs for one or two years, depending on the need of the applicant. The priority of the Physician Scientist Fellowship program is to fund outstanding individuals with excitement for clinical research careers, whose projects will address highly significant research questions and lead to career advancement. DDCF does not have funding priorities for this fellowship based on disease area or research type.  View the complete RFA>
Pediatric Brain Tumor Foundation Early Career Development Grants
Deadline: June 7, 2019


The Pediatric Brain Tumor Foundation's multi-year Early Career Development grants support rising stars in research, seeding the field for future pediatric brain tumor discovery. Recent awards have led to progress in medulloblastoma and neuro-epidemiology research and helped leverage additional research funding.

The goal of the PBTF's Early Career Development program is to support talented researchers in the field of pediatric brain tumors who are in the first five years of their first faculty position. The expectation is that this funding (up to $300,000 total over 3 years) will facilitate awardees' transition to becoming fully independent investigators. The research proposed for funding must focus on pediatric brain tumors. Projects may be discovery-oriented, translational or epidemiological in nature. more>
VeloSano Catalyst Fellowship
Deadline: June 7, 2019

With the generous support from VeloSano Bike to Cure 2018, the Case CCC is providing seed funding for Case CCC Trainee Associate Members to perform their "dream experiment." Up to 5 research projects may be funded at $10,000 per award which must be completed within 1 year.

The experiment should catalyze highly innovative and impactful projects and help strengthen fellowship and career development grant applications. The intent of the award is to support a single or limited set of innovative experiments, not for general laboratory supplies/projects or maintenance of the trainee's project.  more>
Opportunities for Developmental Research Proposals in Translational Cancer Disparities Research
Deadline:
 June 30, 2019

The Case Comprehensive Cancer Center's P20 SPORE
Case CCC logo
( Feasibility and Planning Study for the Development of Specialized Programs of Research Excellence to Investigate Cancer Health Disparities ) is providing seed funding for highly innovative disparities-focused proposals that will generate key data for a future P50 application under the umbrella of the National Cancer Institute (NCI) "Specialized Programs of Research Excellence (SPOREs)." The P20 pilot grants will support feasibility and planning activities to build comprehensive cancer health disparities research programs. All applications must propose translational research that will contribute to improved prevention, early detection, diagnosis, and/or treatment of cancers found to disproportionately affect populations who experience cancer health disparities. DRPs need not reach a human endpoint during the proposed project period, yet must have clearly defined translational potential. Proposals must clearly demonstrate the relevance to cancer outcome disparities. more>
IN THE NEWS
Health Imaging - Apr 18, 2019
"The idea is simple: assess digital images and determine which slides are worthy for analysis by a computer and which are not," said Anant Madabhushi, PhD, director of CWRU's Center for Computational Imaging and Personalized Diagnostics and member of the Case CCC's Cancer Imaging Program.

Getting to Know Our Patients
The New York Times - Apr 24, 2019
Mikkael Sekeres, MD, director of the leukemia program at the Cleveland Clinic, shares a trainee story in his latest contribution to the NY Times. Dr. Sekeres is the Deputy Associate Director for Clinical Research at the Case CCC.
NIH BULLETIN - Notices and Funding Opportunities
Notices
Notice of Correction in Expiration Date for PAR 18-331 "Simulation Modeling and Systems Science to Address Health Disparities (R01 Clinical Trial Not Allowed)"

Notice of Change to Key Dates in RFA-RM-19-005 " NIH Directors Pioneer Award Program (DP1 Clinical Trial Optional)"

Program Announcements
Lasker Clinical Research Scholars Program (Si2/R00 Clinical Trial Optional)(PAR-19-262)
Deadline: August 30, 2019

Imaging, Biomarkers and Digital Pathomics for the Early Detection of Premetastatic Aggressive Cancer (R01 Clinical Trial Optional)(PAR-19-264)
Deadlines: July 10, 2019; December 10, 2019; July 10, 2020; December 10, 2020; July 9, 2021; December 10, 2021
IN THIS ISSUE
EVENTSevents
Fri, May 3
Taussig Cancer Institute Grand Rounds
Laura Dawson, MD
Princess Margaret Cancer Center
"Increasing Role of Radiotherapy for Primary and Metastatic Liver Cancer"
8a CA5-120

*No Cancer Center Seminar Series*

2019 Great Lakes Breast Cancer Research Symposium
Columbus, OH
Details

$5 Ice Cream Sundae Bar VeloSano Fundraiser for Team Case CCC
1-3p BRB Lobby

19th Annual Jerome I. Kleinerman, MD Lecture in Pulmonary Pathobiology
Philip T. Cagle, MD
Professor of Pathology
Weill Medical School of Cornell University
S. Donald Greenberg Chair and Director, Pulmonary Pathology 
Houston Methodist Hospital
" Approach to the Lung Cancer Biopsy for Molecular Testing in the Context of the New Guidelines"
4p WRB Auditorium
Mon, May 6
Cancer Center Research Chalk Talk
1p WRB 3-136

Tumor Immunology and Immunotherapy
Adoro
12p CA4-124

Genomic Medicine Institute
Sara Akhavanfard, MD
Eng Lab
"The Genomic Landscape of Early-onset Solid Tumors in Children, Adolescents and Young Adults"
Rumana Akhter, PhD
Bekris Lab
"The Role of TREM2 in the Microglial Response to β-amyloid"
12p NE1-205
Thurs, May 9
Developmental Therapeutics Journal Club
9a N E 6-218

Fellowship Writing 101
Lunch provided for trainees that RSVP to damian.junk@case.edu
12p WRB 3-136

Molecular Biology and Microbiology Seminar
1p SOM W203
Fri, May 10
Taussig Cancer Institute Grand Rounds
8a CA5-120

UH Seidman Cancer Center Grand Rounds
8a Wearn 137

Cancer Center Seminar Series
Smita Bhatia, MD, MPH
Professor & Vice Chair of Outcomes for Pediatrics
Director, School of Medicine Institute for Cancer Outcomes and Survivorship
Associate Director for Outcomes Research of the UAB Comprehensive Cancer Center
Associate Director, Center for Outcomes and Effectiveness Research and Education
University of Alabama at Birmingham School of Medicine
"Prediction and Prevention of Treatment-Related Adverse Effects in Cancer Survivors"
12p WRB Auditorium
Mon, May 13
Shared Resources Directors Meeting
12p WRB 1-422D

Cancer Center Research Chalk Talk
1p WRB 3-136
Thurs, May 16
Developmental Therapeutics Journal Club
9a NE6-218

Molecular Biology and Microbiology Virology Journal Club
1p SOM W203
Fri, May 17
Taussig Cancer Institute Grand Rounds
8a CA5-120

Innovators in Biomedical Engineering Speaker Series
Herbert Levine, PhD
Professor, Physics and Bioengineering
Northeastern University
"What is Epithelial-Mesenchymal Plasticity and Why Is It Important for Metastasis?"
11a NE1-205

Cancer Center Seminar Series: Helen Moss Integrative Oncology Lecture
Peiying Yang, MS, PhD Associate Professor Department of Palliative, Rehabilitative and Integrative Medicine Division of Cancer Medicine 
The University of Texas MD Anderson Cancer Center
"Natural Products for the Development of Novel Anticancer Therapies"
12p WRB Auditorium
ADDITIONAL UPCOMING SYMPOSIUMS & EVENTS
prev-funding
PREVIOUSLY ANNOUNCED OPPORTUNITIES

Deadline: Open

Deadline: Open

Deadline: Open
Case Comprehensive Cancer Center