Case CCC News - May 31, 2019

May 31, 2019

MEMBER/CENTER HIGHLIGHTS

50 Days Until "Bike to Cure" Weekend: Team Case CCC Prepares for VeloSano 6

As the weather heats up, training rides are well under way for members of the Case Comprehensive Cancer Center's VeloSano team of employees and friends who have joined the movement to raise money for the cause. 100% of the money the team raises will support lifesaving cancer research in Northeast Ohio's top-tier hospitals and research institutions and researchers and trainees who participate in VeloSano are eligible to apply for special funding opportunities.

To-date, Team Case CCC has 47 members who are committed to cancer research, prevention, treatment and cures and have raised $17,860 and counting!

Getting involved is easy!

RIDE with us during Bike to Cure Weekend July 19-21. Jerseys will be provided by the Case CCC. Contact team captains Caroline El Sanadi or Mary Wright for our registration waiver code.
DONATE to any rider on our team or to the team as a whole.
VOLUNTEER for our cheer station and keep everyone motivated as they ride. Friends, families and children are welcome to join in the fun!
PARTY with us at the Tavern of Little Italy for our Fundraiser Bash next Friday, June 7 from 5-8 pm. Tickets are $40 and include 2 drink tickets, 1 raffle ticket, food, live entertainment and valet parking.

American Society of Clinical Oncology Annual Meeting 2019: Highlights from the Case Comprehensive Cancer Center
The 2019 American Society of Clinical Oncology (ASCO) Annual Meeting will take place today through Tuesday, June 4, 2019 in Chicago, IL.

The Case Comprehensive Cancer Center (Case CCC)

has compiled a list of presentations, session chairs,

oral abstract sessions,

posters and abstracts from Cleveland-based institutions including Cleveland Clinic, University Hospitals Cleveland Medical Center and Case Western Reserve University. We wish the best of luck to all presenters and attendees and safe travels to Chicago! Read highlights>

The Case CCC is also glad to share your takeaways on social media; simply tag us on Twitter @CaseCCC! Get ready for the weekend with the ASCO Social Media Guide to #ASCO19!

Two-year Master's Level Program Focuses on Regenerative Medicine and Entrepreneurship

The RGME is the first two-year master's level program in Ohio focused on Regenerative Medicine and Entrepreneurship.

Students enrolled in the RGME program will have access to cutting-edge clinical and research facilities along with small biotechnology companies within the network of the National Center for Regenerative Medicine (NCRM).

This unique, interdisciplinary program will provide a rigorous educational pathway targeting individuals seeking the advanced skills and training required to excel in the unique workforce necessary to support the exponential growth and application of the field of regenerative medicine. The Master's program in RGME will train individuals to work in academic, commercial, and clinical settings to support cellular manufacturing, biotechnology innovation, legal and compliance, financial analyst and venture capital, and business development activities taking advantage of our strengths across the disciplines of regenerative medicine as a whole. Program details>

MARK YOUR CALENDARS

Race for the Place 2019

Sunday, June 2 | Beachwood Place

Celebrating 20 years of serving our community, The

Gathering Place is hosting its annual " Race for the Place" 5K and 1-mile run/walk at Beachwood Place on National Cancer Survivors Day, Sunday, June 2. Proceeds from Race for the Place help support their free programs and services. The schedule for Sunday's event is as follows:

7:30 am Race Day Registration

8:00 am Celebration Village Opens

8:45 am Survivor Ceremony

9:00 am 5K and 1 Mile Begin

10:30 am Awards Ceremony

The Gathering Place is a caring community that supports, educates and empowers individuals and families currently coping with the impact of cancer in their lives through programs and services provided free of charge. Join or give to Team Case CCC>

ASCO Review

June 26 | InterContinental Hotel & Conference Center

Don't forget to register for the ASCO Review course by 5:00 PM EST, Monday, June 24. The ASCO Review will be held Wednesday, June 26, 2019 at the InterContinental Hotel & Bank of America Conference Center.

The course will provide practicing hematologists, medical oncologists, radiation oncologists and oncology nurses with current data and information that is being presented at the meeting. Free registration includes syllabus, continental breakfast, breaks and lunch. Register now>

FUNDING OPPORTUNITIES

VeloSano Catalyst Fellowship

Deadline: 5 pm, June 7, 2019

With the generous support from VeloSano Bike to Cure

2018, the Case CCC is providing funding for Case CCC Trainee Associate Members to perform their "dream experiment."

The experiment should catalyze highly innovative and impactful projects and help strengthen fellowship and career development grant applications. The intent of the award is to support a single or limited set of innovative experiments, not for general laboratory supplies/projects or maintenance of the trainee's project. Eligibility and application instructions>

Opportunities for Drug Discovery Pilot Projects
Deadline: Open until 5 projects awarded

To improve the discovery and advancement of Case CCC logo

innovative cancer therapeutics, the Case Comprehensive Cancer Center is providing seed funding for the development of drug screening assays within the Small Molecule Drug Development Shared Resource (SMDD). This RFA is open to all Case CCC Members and applications will be accepted immediately on a rolling basis until all pilot award slots (5) are filled.

Assay development within the SMDD will transpire in two distinct phases:

Phase I: Assay Development

Up to 5 projects will be selected for assay development within the SMDD in collaboration with Yuriy Federov, Managing Director of the Shared Resource.
Potential drug targets must be justified and functionally validated by the PI.
Assay development can transpire over a period of one year.
The award will cover up to $10,000 of SMDD facility services for each awardee. Funds will be distributed directly to SMDD.

Phase II: High-throughput Screening

Based on potential screening robustness, up to 2 projects (from the group of Phase I awardees) will be selected for high-throughput library screening within the SMDD.
Phase II funds (up to $50,000 per awardee) will be allocated for expenses occurred for high-throughput screening within SMDD, and for laboratory-based validation analyses.

Award Description

Up to 5 research projects will be funded for Phase I, with 2 research project moving forward for Phase II. Total funds committed to this RFA are $150,000.
Each Phase I research project can request services of up to $10,000 for one year, while selected Phase II research projects can request services of up to $50,000 for one year.

Funding Criteria

Open to all Case CCC members
Potential drug targets must be justified and supported by compelling validation studies to be deemed responsive for this RFA
While investigators can be collaborators on multiple applications, only one application will be accepted per lead PI

View application instructions and apply>

Opportunities for Pilot Projects from Cancer Innovation Award
Deadline: June 28, 2019

The Case Comprehensive Cancer Center is providing

seed funding for highly innovative and impactful proposals that will generate key data for larger, nationally competitive grants.

Projects must be transformative in nature and may focus on technology development, innovative biological or therapeutic questions, novel concepts in catchment-based research, or topics that have the potential to overturn dogma. Investigators should submit novel ideas that are high risk and exceptionally innovative.

This RFA is open to all Case CCC Members. Proposals cannot be concurrently funded by other sources or by the Cancer Center.

Award Description

Up to 4 research projects will be funded. Total funds committed to this RFA are $300,000.
Each research project can request a budget of up to $75,000 for one year.
Research projects should be completed within one year.
Funds must be expended within the 12 month funding period as cost extensions will not be granted.

Funding Criteria

Strong investigative teams of Case Comprehensive Cancer Center members.
Projects must be highly innovative and potentially transformative to be deemed responsive to this RFA.
All materials to complete the project (IRB, bio-samples, reagents, mice imaging data) should be in-hand or readily available. Collection of new patient cohorts as the primary focus of the work is not responsive to this RFA.
Projects must have a high likelihood of subsequent national-level funding.
While investigators can be collaborators on multiple applications, only one application will be accepted per lead PI. And PIs are allowed one award per year (i.e., no concurrent awards).
All funds for shared resources must involve Case CCC facilities unless the use of a shared resource(s) at another NCI-funded institution is sufficiently justified.

View application instructions and apply>

Quality of Care & Clinical Care Pathways in Unresectable Stage III/Stage IV NSCLC Research Opportunity

Deadline: July 9, 2019

National Comprehensive Cancer Network® (NCCN®) is NCCN logo

pleased to announce that it is collaborating with AstraZeneca Pharmaceuticals (AstraZeneca) to offer a new opportunity to improve patient care and outcomes in advanced non-small cell lung cancer (NSCLC). The Request for Proposals (RFP) outlines the scope and process that will be followed for the submission of Letters of Intent (LOI).

The intent of this RFP is to encourage NCCN Member Institutions to submit LOIs describing concepts for developing, implementing, and evaluating health care provider performance and/or health care quality improvement initiatives to enhance patient care and outcomes in unresectable stage III NSCLC patients and stage IV NSCLC patients receiving first line therapy. Log in to the NCCN Oncology Research Program site to view grant opportunities>

NCCN views this collaboration with AstraZeneca as clear recognition of the advantages offered to NCCN Member Institutions through the NCCN Oncology Research Program. Questions regarding this RFP, may be directed in writing to Nicole Kamienski, Research Study Associate, Oncology Research Program at [email protected].

IN THE NEWS

AI has potential to disrupt and transform cancer care, center director says

Healio - May 24, 2019

Director of the Cleveland Clinic's Center for Clinical Artificial Intelligence Aziz Nazha, MD elaborates on a computer model at that allows them "to push the envelope of these technologies in health care."

NIH BULLETIN - Notices and Funding Opportunities

Notices
Notice of Correction to RFA-CA-19-033 "Improving Outcomes for Pediatric, Adolescent and Young Adult Cancer Survivors (U01 Clinical Trial Required)"

Notice of Special Interest for Small Business in Genomic Medicine Research

Funding Opportunities

Implementation of U.S. Food Safety Modernization Act - Identifying, Researching, and Implementing Alternative Methods to Expand the Reach across the Global Supply Chain (U01) - Clinical Trials Not Allowed(RFA-FD-19-022)

Deadline: July 29, 2019

Renewal Application: Critical Path Public Private Partnerships (U18) Clinical Trials Optional(RFA-FD-19-027)
Deadline: July 29, 2019

Cigar Tobacco Reference Products Program (UC2) Clinical Trials Not Allowed(RFA-FD-20-002)

LOI Deadline: June 21, 2019

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EVENTS

Fri, May 31

Cancelled due to ASCO: Taussig Cancer Institute Grand Rounds

2019 ASCO Annual Meeting

May 31-June 4

Chicago, IL

Sun, June 2

Race for the Place

7:30a Beachwood Place

National Cancer Survivors Day

Mon, June 3

UH HemOnc Recruitment Seminar

Frank Cackowski, MD, PhD

Rogel Cancer Center

Ann Arbor, MI

9a Lakeside 3 Albert Waldo Conf. Rm

Thurs, June 6

Developmental Therapeutics Journal Club

9a N E 6-218

Molecular Biology and Microbiology Seminar

1p SOM W203

Fri, June 7

Taussig Cancer Institute Grand Rounds

Monica Conces, MD

Alok Khorana, MD

Brian Rini, MD

Manasa Vulchi, MD

Cleveland Clinic

"ASCO Oral Presentations"

8a CA5-120

Team Case CCC VeloSano Fundraiser Bash

Details & Tickets

5-8p Tavern of Little Italy

Mon, June 10

Shared Resources Directors Meeting

12p WRB 1-422D

Genomic Medicine Institute

Scott Lundy, MD, PhD Eng Lab

"The Microbiome of Male Infertility"
Nick Sarn
Eng Lab
"Decreased Nuclear Pten Increases Microglia Activation and Synaptic Pruning in a Murine Model with Autism-like phenotype"

12p NE1-205