November 13, 2020
Gmail users: to ensure you're always viewing the entire newsletter, check at the bottom of the email to see if the newsletter has been "clipped" and click "view entire message" if so.
Member/Center Highlights
Virtual VeloSano announces record participation and final fundraising results, Team Case CCC among top 20 fundraisers
Despite many obstacles this year, people from all over the world came together for Virtual VeloSano - driven by a common purpose and the ultimate goal to cure cancer. VeloSano participants, volunteers, donors and sponsors all rallied together to raise funds for a cause so close to our hearts.

Team Case Comprehensive Cancer Center raised a total of $36,065, once again earning a spot in the top 20 teams this year. We thank you for your generous support.

Grab a tissue, cowbell and your dancing shoes as you prepare to watch the Virtual VeloSano Bash video and celebrate this year's fundraising results... you may even see a few familiar faces!
Cancer centers launch virtual lecture series to continue collaborations during pandemic 
From the NCI Public Affairs and Marketing Network: With in-person oncology conferences canceled due to the COVID pandemic, many cancer researchers have tuned in to virtual meetings, such as the two-part American Association for Cancer Research (AACR) conference and the annual meeting of the American Society of Clinical Oncology (ASCO).

At Case Comprehensive Cancer Center in Cleveland, leadership transitioned their existing interdisciplinary seminar series to a virtual format on March 20, 2020. The seminars, which address cutting-edge clinical, translational and basic research topics in cancer, are available to internal and external audiences. Those who tune in live can also earn continuing medical education (CME) credit.

Kelsey Kirsch, department coordinator at Case, said it took about two weeks to transition the in-person seminars to virtual, a process that began around the same time as people began working from home. Kirsch noted attendance jumped in the spring with the virtual platform, among other observations.
Tune in to today's seminar featuring Tim Chan, MD, PhD
Dr. Chan is Director of the Center for Immunotherapy and Precision Immuno-Oncology at Cleveland Clinic and Co-Director of the National Center for Regenerative Medicine at Case Western Reserve University School of Medicine.

Researchers use “Big Data” approach to identify melatonin as possible COVID-19 treatment
Recently published findings from a Cleveland-Clinic led study suggest that melatonin may be viably repurposed as a treatment for the novel coronavirus, COVID-19. The researchers leveraged an artificial intelligence platform to measure the proximity between SARS-CoV-2 host genes/proteins and those linked with 64 other diseases where closer proximity indicates a higher likelihood of pathological associations between the diseases. (Zhou & Hou, 2020, PLoS Biol)
Feixiong Cheng, PhD, assistant staff in the Genomic Medicine Institute at Cleveland Clinic and lead author on the study, noted that the findings do not suggest people start taking melatonin without consulting their physician. “Recent studies suggest that COVID-19 is a systematic disease impacting multiple cell types, tissues and organs, so knowledge of the complex interplays between the virus and other diseases is key to understanding COVID-19-related complications and identifying repurposable drugs,” said Dr. Cheng. “Our study provides a powerful, integrative network medicine strategy to predict disease manifestations associated with COVID-19 and facilitate the search for an effective treatment.”

Dr. Cheng is a member of the Case Comprehensive Cancer Center's Cancer Prevention Control & Population Research Program. Case CCC members Timothy Chan, MD, PhD and Charis Eng, MD, PhD also contributed to the work alongside other collaborators.
Case CCC COVID-19 Resource Hub
The Case Comprehensive Cancer Center (Case CCC) has centralized COVID-19 related news, resources and funding opportunities for our cancer center community. Content is updated regularly.

To have a cancer-focused resource added to the page, please email cancer@case.edu.
What's Coming Up
Mark Your Calendar
Cancer Center Seminar Series
Friday, November 13, 2020, 12p via Zoom
Today's Cancer Center Seminar features Tim Chan, MD, PhD presenting, "Immunotherapy: Evolving Landscape of Mechanisms and Modalities" behalf of the Hematopoietic and Immune Cancer Biology Program at noon via Zoom.

Chan is Co-Director of the National Center for Regenerative Medicine at Case Western Reserve University School of Medicine. He is Chair and Founding Director of the Center for Immunotherapy and Precision Immuno-Oncology at the Cleveland Clinic, which focuses on immunotherapy research and developmental therapeutics. He is PI of a cancer genetics laboratory and is an expert in cancer biology and immunogenomics.

The Chan laboratory specializes in using genomic analysis to characterize the drivers of genetic programs underlying immunotherapy and oncogenesis. These approaches include large-scale analyses, functional genomics, immunogenomics, biochemical and molecular analyses, and mouse modeling. The lab has a special interest in deciphering the mechanisms underlying immunotherapy treatment response, resistance, and mechanisms.
Cancer Center Seminar Series
Friday, November 20, 2020, 12p via Zoom

Next week's Cancer Center Seminar is a special presentation of the Helen Moss Lecture and welcomes Heather Greenlee, ND, PhD, MPH, held virtually at 12 pm ET.

Dr. Greenlee is Associate Professor, Cancer Prevention Program, Public Health Sciences & Clinical Research Divisions at Fred Hutchinson Cancer Research Center.

Dr. Greenlee is a public health researcher and naturopathic physician who focuses on cancer prevention and control, cancer survivorship, obesity and cancer, and integrative medicine. She studies the effects of dietary change, physical activity and weight loss on cancer outcomes and designs lifestyle interventions to reduce cancer risk and better the life of cancer survivors, particularly in underserved populations. Dr. Greenlee also studies the use of integrative therapies such as acupuncture, massage, botanicals, vitamins/minerals and mind-body approaches to improve cancer symptoms, alleviate treatment side effects and improve survivors’ quality of life. She has helped create national guidelines on the use of integrative therapies during and after breast cancer treatment and was a co-investigator on the first large, randomized trial that showed acupuncture relieves joint pain caused by hormone-suppressing drugs in early-stage breast cancer patients. Dr. Greenlee also studies dietary and physical activity interventions among Latina breast cancer survivors; predictors of cardiovascular disease in breast cancer survivors; and the association between physical activity, the gut microbiome and risk of colorectal cancer.
Registration Opening Soon: Cancer Disparities Symposium (Virtual)
March 4-5, 2021

The Case Comprehensive Cancer Center Office of Community Outreach and Engagement is pleased to present the 5th Annual Cancer Disparities Symposium, Navigating Cancer Disparities: Lessons Learned and How to Move Forward.
This multi-disciplinary event will appeal to researchers, clinicians, health professionals, community outreach groups, community-based organizations, patient advocates and trainees. Keynote presentations will be delivered by renowned disparities researchers and community leaders, and a poster session highlighting academic research and community programs will provide a showcase of the depth and depth of work happening in this field.

Though this event is happening virtually, attendees will experience the conference using Whova, our official web-based conference app, to view presentations and ask questions in real-time, as well as network with others behind the scenes.

Call for Abstracts
Multidisciplinary researchers, community agencies and organizations are invited to submit abstracts for presentation at the 5th Annual Cancer Disparities Symposium. Abstracts will be divided into two tracks: Scientific Research and Community Programs. Meritorious abstracts will be selected for pre-recorded presentations. Abstracts must be submitted electronically by 5 pm ET on Friday, January 22, 2021.
Keynote Speakers Announced
Otis W. Brawley, MD, an internationally-recognized expert in cancer prevention and control, will present the symposium's Scientific Keynote His work is focused on closing racial, economic and social disparities in prevention, detection and treatment of cancer in the United States and worldwide.

Worta McCaskill-Stevens, MD, a medical oncologist nationally known for her expertise in bringing clinical trials to the community will present the Community Keynote. Dr. McCaskill-Stevens is Chief of the Community Oncology and Prevention Trials Research Group, which houses the National Cancer Institute (NCI) Community Oncology Research Program (NCORP), a community-based clinical trials network launched in 2014.
Additional Upcoming Events
Upcoming Policy Forums: Cost of Cancer, Tobacco
November 16 and November 19, 2020
More than 70,000 Ohioans will be diagnosed with cancer in 2020 and the decisions made in the statehouse or in the White House can be just as consequential for patients as the decisions made in their doctor’s office.

Join the American Cancer Society Cancer Action Network (ACS CAN) for a virtual, wide-ranging discussion about the public policies that affect the cost of, access to and delivery of cancer treatment on Monday, November 16 at 11:00 am. Register for the Virtual Cancer Policy Forum: The Cost of Cancer in Ohio.

On Thursday, November 19 at 11:30 am, ASC CAN is hosting the annual Northern Ohio Policy Forum, bringing together leaders from business, education, government and research communities. The 2020 event will discuss the toll of tobacco. Register for the 2020 Northern Ohio Policy Forum: The Toll of Tobacco.
Association of Indian Physicians of Northern Ohio (AIPNO) 37th Annual Gala Event/8th Research Showcase Poster Competition
Abstract Deadline: November 22, 2020
Event: Saturday, December 5, 2020
AIPNO is a vibrant large non-profit organization in the state of Ohio founded in 1983 geared toward enhancing the quality of healthcare by fostering excellence and professionalism in the practice of medicine and supporting efforts to improve the availability of healthcare to underserved populations in Ohio and in India. The mission of AIPNO is to continue to enhance community involvement and coordinate with other local, national and international organizations through philanthropy, health care access and education.

AIPNO is for non-Indians as well. The AIPNO Annual Event and Conference is one of their most prestigious events and includes a Research Showcase (complimentary registration for poster presenters and winners awarded cash prizes). AIPNO fosters and encourages participation from high school students, medical students, residents, fellows, faculty, nurses, seasoned researchers, allied healthcare providers (nurses, therapists, etc.), community leaders, legislative leaders, philanthropic practitioners, dedicated donors and valued beneficiaries alike.

Call for Posters
Are you a high school student, medical student, resident, fellow, faculty, nurse, seasoned researcher or allied healthcare provider (therapist, etc.), interested in presenting your case study or research? AIPNO will accept abstracts for poster presentations held virtually as part of the 8th Annual Research Showcase Poster Competition from 4-5 pm on Saturday, December 5, 2020. View abstract guidelines.

Questions? Contact Pam Pawelecki at admin@aipno.org.
NCCN Virtual Patient Advocacy Summit
December 10, 2020

Patients with cancer often have widely divergent care experiences from screening through survivorship. Differences in care delivery and outcomes may be due, in part, to varying patient needs and preferences according to age and stage of life; inconsistent implementation of guidelines, recommendations, and policies; and unintended age bias in health care.
The National Comprehensive Cancer Network’s® (NCCN®) Virtual Patient Advocacy Summit will provide an opportunity for a varied group of stakeholders including patients, caregivers, providers, patient advocacy organizations, policymakers, and industry to thoughtfully discuss the importance of providing quality, effective, efficient, and accessible cancer care across the patient lifespan.
Funding Opportunities
Full Application Deadline: November 23, 2020
The Case Comprehensive Cancer Center, with funds from its American Cancer Society Institutional Research Grant, will provide seed money to foster cancer research by junior faculty who have no current national grant support of their own. Investigators in the CWRU School of Medicine, University Hospitals of Cleveland, and Cleveland Clinic Lerner College of Medicine as well as in other schools and colleges affiliated with Case Western Reserve University are eligible. Grants, not to exceed $40,000, will be awarded to investigators who intend to gather preliminary data to be used in seeking future and independently funded programs.

Award Description
  • Pilot funding for cancer-related research with a basic, clinical, prevention & control, behavioral, health services, or epidemiological focus.
  • Up to $40,000 award
  • Grants will be awarded to junior investigators who intend to gather preliminary data to be used in seeking future and independently funded programs

Postdoctoral fellows, graduate students, research associates, and instructors within another PI’s laboratory are not eligible to apply for these research grants. The subject of the proposed research must be directly related to cancer. The principal investigator must be a full-time member of the faculty within 6 years of their first full-time independent faculty appointment (or equivalent).

Deadline: December 1, 2020
The Case Comprehensive Cancer Center requests applications for Cancer Data Sciences pilot projects. Cancer Data Sciences will serve as a discipline in the Case CCC to standardize and organize data for optimal use and leverage advanced analytic approaches to enable independent and synergistic research for basic, clinical, population and translation sciences. Pilot applications should focus on driving new analytical capabilities, developing novel algorithms in order to mine, organize, and standardize cancer data as well as utilizing data sciences approaches to extract knowledge from complex, multi-level cancer data for maximal impact.

Award Description
  • Four (4) awards each at a maximum of $45,000, for one year will be awarded, with the potential for a second year dependent on progress. 
  • Metrics and Milestones will be: novel algorithms to be disseminated to Cancer center members, standardized datasets to be available to Cancer center members, peer-reviewed publications, peer-reviewed meeting presentations and/or generation of pilot data for peer-reviewed funding. 
  • Open to Case Comprehensive Cancer Center members. 
LOI Deadline: December 7, 2020
Harrington Discovery Institute at University Hospitals and Case Western Reserve University School of Medicine have issued a call for proposals for the 2021 Harrington-MSTP (Medical Scientist Training Program) Scholar Award to help the next generation of physician-scientists advance their discoveries into breakthrough medicines. This program is a two-year scholarship for MSTP students at the School of Medicine whose work has been identified as innovative, creative and having potential to progress towards clinical application.

Through this award, Harrington Discovery Institute and the School of Medicine combine resources and capabilities to advance into new medicines the most promising research of Case MSTP students. Awardees will receive grant funding and dedicated therapeutic development support from Harrington Discovery Institute's Therapeutics Development team, who are pharma-experienced industry leaders with a track record of bringing drugs to market.
AACR
The Breast Cancer Research Foundation-AACR Career Development Awards to Promote Diversity and Inclusion represent a focused effort to encourage and support investigators from diverse backgrounds that are under-represented in cancer research and to foster their career advancement. This grant program also intends to build a more diverse and inclusive future for breast cancer research. Eligibility is limited to members of racial or ethnic groups that have been shown to be underrepresented in the biomedical workforce who are junior faculty who, at the start of the grant term, will have completed their most recent doctoral degree or medical residency within the past 11 years.

Proposed projects must be basic, translational, clinical, epidemiological, population health, and/or community-based cancer research projects designed to accelerate the discovery, development, and application of new agents to treat breast cancer. Research that aims to advance the science of understanding cancer health disparities in racial and ethnic minorities that has relevance to breast cancer will also be considered.

The grants provide $150,000 over two years for expenses related to the research project.
In The News
World Health - November 5, 2020
Using data from electronic health records, Nathan Berger, MD, of Case Comprehensive Cancer Center, found that half of younger adults with colorectal cancer were overweight and 17% were obese. Unhealthy diets have become more common in past decades, the researchers pointed out. And the number of children and adults who are overweight or obese continues to climb.
BGR - November 11, 2020
“Large-scale observational studies and randomized controlled trials are critical to validate the clinical benefit of melatonin for patients with COVID-19, but we are excited about the associations put forth in this study and the opportunity to further explore them,” said Cleveland Clinic's Feixiong Cheng, PhD, member. Case CCC.
From The NIH
Weekly NIH Funding Opportunities and Notices
Notices


Funding Opportunities

Deadline(s): January 26, 2021; May 26, 2021; September 28, 2021; January 26, 2022; May 26, 2022; September 27, 2022; January 26, 2023; May 26, 2023; September 26, 2023

Deadline(s): January 26, 2021; May 26, 2021; September 28, 2021; January 26, 2022; May 26, 2022; September 27, 2022; January 26, 2023; May 26, 2023; September 26, 2023
COVID-19 Funding Opportunities and Notices
Have something to share?
Use the button below to submit all your news, publications, events, announcements, lab openings and communications requests to the Case CCC Marketing and Communications team! We are here to help.