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Non-coding DNA located outside chromosomes may help drive glioblastoma
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From
The Daily: A paper published yesterday in
Cell could explain why drugs will often work for some cancer types, but not others. “We’ve been targeting the cancer-causing gene for therapy, but it turns out we should also think about targeting the switches that are carried along with it,” said co-senior author Peter Scacheri, the Gertrude Donnelly Hess Professor of Oncology at Case Western Reserve University School of Medicine and member of the
Case Comprehensive Cancer Center.
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Tesar Named One of Crain's Cleveland Business' Forty under 40
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This week,
Crain's Cleveland Business announced their 2019 Class of "Forty under 40" engaged in helping others and bettering the community through their jobs and volunteer efforts. The Case Comprehensive Cancer Center extends congratulations to member
Paul Tesar, PhD for joining this year's class of Northeast Ohio leaders.
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Don't Forget: Submit an Abstract, Apply for Travel Scholarship for the 4th Annual Cancer Disparities Symposium by December 3
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The
4th Annual Cancer Disparities Symposium is a premier event for presenting cutting-edge cancer disparities science and related community programs and services. The Office of Cancer Disparities Research will divide abstracts into two tracks:
Scientific Research
and
Community Programs and Services. Scientific Research abstracts are encouraged from multidisciplinary researchers that are focused on various aspects of health disparities and/or community-focused science. Community programs and service abstracts are encouraged from organizations that provide programs and services that benefit the community. Meritorious abstracts will be selected for oral presentation.
Abstracts must be submitted electronically by 5p EST on Tuesday, December 3, 2019. Students who submit an abstract prior to registration are able to register for free!
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Cancer-focused Summer Undergraduate Research Program (CanSUR) Student Stories
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Now available: read what students in the inaugural class of the Cancer-focused Summer Undergraduate Research (CanSUR) Program had to say about the experience.
Applications for the 2020
CanSUR Program are being accepted through January 15 with priority acceptance decisions made on a rolling basis. Faculty interested in mentoring students next summer are encouraged to reach out to Education Program Manager, Gena Richmann at
gnb15@case.edu.
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Recommended Reading: A long and winding R0(ad)1
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Cleveland Clinic's
Jacob Scott, MD, DPhil, reflects on 4 years and 6 submissions that led to his first funded R01. Dr. Scott is a member of the Case Comprehensive Cancer Center's Developmental Therapeutics Program.
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Mon, Nov 25
Cleveland Clinic Children's Pediatric Lecture Series
Gregory H. Reaman, MD
8a R3-002/003
Cancer Center Research Chalk Talk
Bill Schiemann, PhD
1p WRB 3-136
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Tues, Nov 26
Cancer Impact Lecture
1p NE1-205
DNA Damage and Repair Working Group
3p WRB 3-136
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Thurs, Nov 28
CWRU Closed for Thanksgiving
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Fri, Nov 29
CWRU Closed for Thanksgiving
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Mon, Dec 2
Cancer Center Research Chalk Talk
1p WRB 3-136
Tumor Immunology and Immunotherapy Meeting
4p CA5-124
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Tues, Dec 3
Immuno-Oncology Seminar Series
1p NE1-205
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Weds, Dec 4
Cancer Microbiome Focus Group
12p NB5-09
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Thurs, Dec 5
D
evelopmental Therapeutics Journal Club
9a NE6-218
Immunology Journal Club
12p WRB 5-136
Molecular Biology and Microbiology Seminar
1p SOM W203
CPC Program Meeting
5p CA5-124
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Fri, Dec 6
Taussig Cancer Institute
Grand Rounds
Pradnya Patil, MD
8a CA5-120
Cancer Center Seminar Series
Mahmoud Ghannoum, PhD, MBA
12p WRB Auditorium
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Cancer Center Seminar Series
November 22, 12p
WRB Auditorium
Today's Cancer Center Seminar features
Michael Rape, PhD, the K. Peter Hirth Chair of Cancer Biology and professor of cell and developmental biology at the University of California, Berkeley. He is also a Howard Hughes Medical Institute Investigator. Dr. Rape will present, "Ubiquitin Signaling in Development and Disease" at noon in the Wolstein Research Building Auditorium.
Michael Rape, PhD is a pioneer in uncovering molecular mechanisms of cell fate determination, using posttranslational modification with ubiquitin as his starting point. His work revealed new ubiquitin chain types, essential ubiquitylation enzymes and substrates, as well as mechanisms of ubiquitylation that are essential for human development and disease.
Most recently, his lab discovered quality control of protein complex composition, which is essential for nervous system development and maintenance. His work led to the first prospective development of a molecular glues targeting E3 ligases, which greatly helped in opening up the ubiquitin system for drug discovery. To advance new ubiquitin-focused approaches in drug discovery, Dr. Rape co-founded Nurix Therapeutics.
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Cancer Center Seminar Series
December 6, 12p
WRB Auditorium
While there is no Cancer Center Seminar next week due to the holiday, our series will resume on Friday, December 6 with
Mahmoud Ghannoum, PhD presenting, "Bacteriome-Mycobiome Interactions: Impact on Health and Disease."
Dr. Ghannoum is professor of dermatology at Case Western Reserve University (CWRU) School of Medicine and a member of the Case CCC's Hematopoietic and Immune Cancer Biology Program. Presently, he is Director of the CWRU/University Hospitals Center for Medical Mycology. In that capacity, he established a multidisciplinary Center of Excellence that combines basic and translational research investigating medically important fungi from the test tube to the bedside. More recently, he pioneered studies on the fungal communities residing in our body and coined the term ‘Mycobiome”.
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Research Ethics Theatre:
Miss Evers' Boys
+ Panel Discussion
December 19, 1:30-4:45p
WRB Auditorium
Join the Office of Research and Technology Management to view the film
Miss Evers’ Boys, a movie based on the true story of the US Public Health Service Untreated Syphilis Study conducted at Tuskegee from 1932 until 1972. Following the movie, our special guest, Dr. David Hodge, Associate Professor, National Center of Bioethics in Research and Health Care at Tuskegee University, will join CWRU panelists to discuss the ethical issues with the study.
Attendees are eligible to receive 6 CRECs.
Panelists include:
- Suzanne Rivera, PhD, MSW, Vice President for Research and Technology Management (moderator)
- Monica Webb Hooper, PhD, Professor, Case Comprehensive Cancer Center, CWRU
- Jackson Wright, MD, PhD, Emeritus Professor of Medicine, CWRU
- David Hodge, PhD, DMin, MTS, MEd, Associate Professor, National Center of Bioethics in Research and Health Care at Tuskegee University
Some attendees may find the contents of the film and the discussion unsettling.
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4th Annual Cancer Disparities Symposium
March 6, 2020
Tinkham Veale University Center
The Case Comprehensive Cancer Center Office of Cancer Disparities Research will present the
4th Annual Cancer Disparities Symposium
: Cultivating Science and Community Engagement to Address Cancer Health Disparities on March 6, 2020.
The
agenda is now posted and will feature sessions on Cancer Disparities and Underserved Populations, Community Engagement and Support Programs, and Cancer Disparities Research and Community Engagement, plus invited presentations selected from standout abstract submissions. Keynote talks from
Robert T. Croyle, PhD from the National Cancer Institute and
Lucio Miele, MD, PhD from Louisiana State University cap-off the day's innovative agenda.
Travel Scholarships
New for 2020, a limited number of Travel Scholarships are available to provide travel support to the symposium.
Application details>
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Additional Upcoming Events
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Cleveland Clinic Children's Pediatric Lecture Series
November 25, 8a
Cleveland Clinic R3-002/003
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Join Cleveland Clinic Children's for "The Science of Pediatric Blood & Cancer" Lecture Series featuring
Gregory H. Reaman, MD presenting, "Pediatric Cancer Drug Development: The Road Well Traveled by the Therapeutic Orphans - Construction Ahead."
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ASH Review
January 22, 2020 5:15-6:45p
Intercontinental Hotel, Cleveland
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This course will provide hematologists, medical oncologists, radiation oncologists and nurses with current data and information on topics presented at the American Society of Hematology 61st Annual Meeting in Orlando on December 7-10, 2019.
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2020 Multidisciplinary Head and Neck Cancer Update
February 14-15, 2020
Fort Lauderdale, FL
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This course will provide practicing physicians, residents, fellows, and nurses in medical oncology, otolaryngology, radiation oncology, and head and neck surgery with a contemporary update of management strategies of head and neck cancer using a multidisciplinary approach. Lecture and panels will provide a forum for discussion of updated therapies and new treatment innovations.
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NCCN 2020 Annual Conference
March 20-22, 2020
Orlando, FL
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Deadline: December 6, 2019
ACES+, the continuation of the NSF-ADVANCE Award, will offer Advance Opportunity Grants. All faculty members are eligible to apply for these grants, which provide small amounts of supplemental support for current or proposed projects and activities where funding is difficult to obtain through other sources.
Examples of funding support include:
- Seed funding for unusual research opportunities or training;
- Grants to support writing of books;
- Travel grants to explore new techniques or attend advanced training courses; and
- Child care to attend a professional meeting or conduct research at another institution.
The Opportunity Grant Faculty Oversight Committee selects the recipients. Preference will be given to applicants who have not previously received an opportunity grant, and successful applicants will receive notice the first week in March.
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Deadline: December 16, 2019
Alex's Lemonade Stand Foundation (ASLF) is currently accepting applications for their 3-year, $150,000 Young Investigator Grants, awarded to research scientists in the early stages of their careers such as postdoctoral or clinical fellows. Outstanding mentorship and demonstration of a career plan that shows commitment to pediatric cancer investigation are critical components of a successful application.
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HealthImaging - Nov 1, 2019
“In short, we’re probably overtreating patients,”
Anant Madabhushi, PhD professor of biomedical engineering at Case Western’s School of Engineering, said in a statement. “That goes against prevailing wisdom, but that’s what our analysis is finding.” "This could be a tool for determining who really needs the radiation, or who needs the gene test, which is also very expensive,” Madabhushi concluded.
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Bustle - Nov 12, 2019
"A plant-based diet has a number of benefits, including a reduction in risk of death from ischemic heart disease — a restriction in blood supply to tissues, causing a shortage of oxygen," said
Mahmoud Ghannoum, PhD, director of the Center for Medical Mycology at Case Western Reserve University. Dr. Ghannoum is a member of the
Case CCC's Hematopoietic and Immune Cancer Biology Program.
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Weekly NIH Funding Opportunities and Notices
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Notices
Funding Opportunities
Deadline: February 26, 2020
Deadline: February 26, 2020
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Use the button below to submit all your news, events, announcements and communications requests to the Case CCC Marketing and Communications team!
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