November 6, 2020
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Member/Center Highlights
Case CCC Researchers receive NCI support to assess patient and provider perceptions of cannabis use during treatment
A team of Case Comprehensive Cancer Center (Case CCC) researchers were recently awarded $150,000 by the National Cancer Institute (NCI), as a supplement to the Cancer Center Support Grant, to survey cancer patients and oncology healthcare providers about the use of cannabis products during treatment.

Richard T. Lee, MD, the Helen Moss Foundation-Schoff Family Professor of Integrative Oncology at Case Western Reserve University School of Medicine, Director of the Supportive and Integrative Oncology Program at University Hospitals Seidman Cancer Center and member of the Case CCC’s Developmental Therapeutics Program will lead the project. Lee is joined in the assessment by Case CCC experts in survey-based research Jennifer Cullen, PhD, MPH and Erika Trapl, PhD, and physicians Samir Abraksia, MD (South Pointe Hospital Cleveland Clinic) and Michael Harrington, MD (Case Western Reserve University and MetroHealth Cancer Center).
Richard T. Lee, MD
Using an in-person survey and a follow-up phone interview for patients and the team aims to recruit 1,000 participants among five recruitment sites, which will provide diversity in practice types in the Cleveland metropolitan area and of patients from each location. Researchers will assess the prevalence and patterns of cannabis use among patients receiving cancer treatment and intend to describe patients’ perceptions of both the harms and benefits related to such use. They will also study patients’ impressions of communication patterns regarding cannabis use with their cancer team. Additionally, an email questionnaire for oncology healthcare providers will help investigators describe oncology providers’ perceptions, education and self-described practice patterns, including communication, about cannabis use with their patients.

Indicating that peer-reviewed literature regarding medical cannabis is scarce, the team believes the information captured by this project will ground further research into cannabis utilization by patients and facilitate the development of useful clinical communication strategies for healthcare providers relevant to the use of cannabis by cancer patients.
Cancer Metabolism Shared Resource in development
The Cancer Center will soon offer investigators isotope tracing capability through the new Cancer Metabolism Shared Resource (SR) in development. Isotope tracing analysis allows investigators to monitor pathway activities, which cannot be attained by measuring the metabolites' cellular concentrations. The facility is led by Masaru Miyagi, PhD, an expert in developing analytical methods for proteome profiling, protein structural characterization, and metabolite analysis. The facility is located in the Department of Pharmacology, School of Medicine Wood Building 1st Floor (W146).
Masaru Miyagi, PhD
The Cancer Metabolism SR offers a full-service option, including the extraction and mass spectrometry analysis of metabolites, mass spectrometry data analysis, and results reporting; a self-service option is also available. Services to be provided by this emerging shared resource complement the targeted metabolomics services currently offered by the Metabolomics Shared Resource at the Cleveland Clinic.

Though we anticipate tracing analysis service services will be available by January 2021, contact Dr. Miyagi (mxm356@case.edu or 216.368.264) now to discuss your projects so he can start prepping during the ramp-up phase.
Madabhushi joins FDA Network of Digital Health Experts
The Case Comprehensive Cancer Center extends congratulations to Anant Madabhushi, PhD, as he recently joined the US Food and Drug Administration's Network of Digital Health Experts (NoDex).

In this role, he will help advance digital health and artificial intelligence tools in medicine, supporting the FDA's mission to promote and protect public health.
Jackson Lab seeking postdoctoral fellows
The lab of Mark Jackson, PhD at the Case Comprehensive Cancer Center is looking to fill postdoctoral positions studying the breast cancer microenvironment and immune interactions. Their research focuses on triple negative breast cancer (TNBC). Postdoctoral fellows will benefit from career and mentoring opportunities available the Case CCC (including opportunities for pilot funding, grant-writing courses, and teaching and mentoring experience in our CanSUR Summer Undergraduate Research Program).
5th Annual Cancer Disparities Symposium
Navigating Cancer Disparities: Lessons Learned and How to Move Forward

The Case Comprehensive Cancer Center Office of Community Outreach and Engagement is pleased to present the 5th Annual Cancer Disparities SymposiumNavigating Cancer Disparities: Lessons Learned and How to Move Forward.

This multi-disciplinary event will appeal to researchers, clinicians, health professionals, community outreach groups, community-based organizations, patient advocates and trainees. Keynote presentations will be delivered by renowned disparities researchers and community leaders, and a poster session highlighting academic research and community programs will provide a showcase of the depth and depth of work happening in this field.

Though this event is happening virtually, attendees will experience the conference using Whova, our official web-based conference app, to view presentations and ask questions in real-time, as well as network with others behind the scenes.
Scientific Keynote Speaker Announced
Otis Brawley
Otis W. Brawley, MD, internationally-recognized expert in cancer prevention and control, will deliver the scientific keynote address at the 5th Annual Cancer Disparities Symposium. His work is focused on closing racial, economic and social disparities in prevention, detection and treatment of cancer in the United States and worldwide. Dr. Brawley is the Bloomberg Distinguished Professor of Oncology and Epidemiology at Johns Hopkins University, and leads a broad interdisciplinary research effort on cancer health disparities at the Johns Hopkins Bloomberg School of Public Health and Kimmel Cancer Center.
Call for Abstracts

Multidisciplinary researchers, community agencies and organizations are invited to submit abstracts for presentation at the 5th Annual Cancer Disparities Symposium. Abstracts will be divided into two tracks: Scientific Research and Community Programs.

Meritorious abstracts will be selected for pre-recorded presentations.

Abstracts must be submitted electronically by 5 pm ET on Friday, January 22, 2021.
Now Open: Applications for 2021 Cancer-focused Summer Undergraduate Research (CanSUR) Program
Launched in 2019, the Cancer-focused Summer Undergraduate Research Program, CanSUR, supports 32 undergraduates for a 10-week period (June through August) each summer. Undergraduates will be accepted from colleges and universities from across the country to work with one of 82 Case Comprehensive Cancer Center (Case CCC) researchers.

This year, 32 exceptional undergraduates from over 200 applications and 77 schools were selected for the program, but in the interest of public safety in the face of the pandemic, the summer 2020 program was canceled.

The Case Comprehensive Cancer Center's Office of Cancer Training, Education and Research is hopeful that the 10-week summer program for 2021 will take place and will accept applications through January 15, 2021.

Questions about CanSUR? Please contact Education Program Manager Gena Richmann at gnb15@case.edu.
Case CCC COVID-19 Resource Hub
The Case Comprehensive Cancer Center (Case CCC) has centralized COVID-19 related news, resources and funding opportunities for our cancer center community. Content is updated regularly.

To have a cancer-focused resource added to the page, please email cancer@case.edu.
What's Coming Up
Mark Your Calendar
Cancer Center Seminar Series
Friday, November 6, 2020, 12p via Zoom
Today's Cancer Center Seminar welcomes Jennifer Adair, PhD presenting, "Delivering on the Promise of Gene Therapy: Translating Accessible Treatments," at noon via Zoom on behalf of the Developmental Therapeutics Program.

Dr. Adair is Associate Professor, Stem Cell and Gene Therapy Program, Clinical Research Division at Fred Hutchinson Cancer Research Center. She is also Research Associate Professor in the Department of Medical Oncology at University of Washington and holds the Fleischauer Family Endowed Chair in Gene Therapy Translation.

She joined Fred Hutch in 2008 where she translated multiple clinical trials for blood stem cell gene therapy for diseases including glioblastoma, Fanconi’s anemia, primary immunodeficiencies and HIVunder Dr. Hans-Peter Kiem. She transitioned to faculty in 2013 andis currently an Associate Professor in the Stem Cell and Gene Therapy Program at Fred Hutch and a Research Associate Professor in Medical Oncology at the University of Washington.The ultimate goal of her laboratory is to develop new clinical methods and technologies to make gene therapy affordable and accessible to patients worldwide. Jennifer was named an Outstanding New Investigator by the American Society of Gene and Cell Therapy, where she serves as an elected Board Member. Her lectures have been featured by TEDx, GeekWire and AAAS. In 2020, Jennifer was honored as the Fleischauer Family Endowed Chair in Gene Therapy Translation. She has more than 40 peer-reviewed publications and is an inventor on seven patents.

Cancer Center Seminar Series
Friday, November 13, 2020, 12p via Zoom

Next week's Cancer Center Seminar features guest speaker Tim Chan, MD, PhD presenting virtually at 12 pm ET on behalf of the Hematopoietic and Immune Cancer Biology Program.

Chan is Co-Director of the National Center for Regenerative Medicine at Case Western Reserve University School of Medicine. He is Chair and Founding Director of the Center for Immunotherapy and Precision Immuno-Oncology at the Cleveland Clinic, which focuses on immunotherapy research and developmental therapeutics. He is PI of a cancer genetics laboratory and is an expert in cancer biology and immunogenomics.

The Chan laboratory specializes in using genomic analysis to characterize the drivers of genetic programs underlying immunotherapy and oncogenesis. These approaches include large-scale analyses, functional genomics, immunogenomics, biochemical and molecular analyses, and mouse modeling. The lab has a special interest in deciphering the mechanisms underlying immunotherapy treatment response, resistance, and mechanisms.
Biomedical Graduate Student Symposium (Virtual)
November 9-10, 2020
The Biomedical Graduate Student Symposium (BGSS) is a student-run event that celebrates student research in the School of Medicine at CWRU. This event will consist of student poster presentations, student oral presentations, and a keynote address from Dr. Yasmine Belkaid, National Institute of Allergy and Infectious Diseases (NIAID). BGSS will also partner with the Career Opportunities for Trainees Series (COTS) for a career panel (details and panelists to be announced).

Contact casebgss@gmail.com with any questions or concerns.
Additional Upcoming Events
NCCN 2021 Virtual Annual Conference: Call for Abstracts
Abstract Deadline: November 11, 2020
NCCN is now accepting abstracts for consideration to be presented during the NCCN 2021 Annual Conference General Poster Session to be held virtually Thursday, March 18 through Saturday, March 20, 2021. NCCN welcomes original abstracts from investigators in the general oncology community. Submissions will be accepted from academic institutions, teaching and community hospitals, or industry. Both NCCN and non-NCCN institutions may participate.

Research may fall into the general areas below:

  • Clinical Oncology (all phases)
  • Pre-Clinical Oncology
  • Epidemiology/Risks/Prevention
  • Correlative/Genomic
  • Best Practices in Implementation and Use of Clinical Practice Guidelines
  • Quality Improvement
  • Outcomes and Health Services Research
  • Bioinformatics/Information Technology Sciences
Sixth Computational Approaches for Cancer Workshop (CAFCW20)
Workshop: November 13, 2020
The National Cancer Institute Center for Biomedical Informatics and Information Technology and SC20 are seeking abstracts for presentations for the Sixth Computational Approaches for Cancer Workshop (CAFCW20). CAFCW20 is a workshop designed to bring together clinicians, cancer biologists, mathematicians, data scientists, computational scientists, engineers, developers, thought leaders, and anyone else interested in advancing computation to use in cancer care and research. This year’s topic is “AI and HPC: Overcoming Data Challenges in Cancer Research and Clinical Applications.”

A special emphasis for the CAFCW20 is the role of HPC and AI to address research challenges when data are limited by availability, variability and size. The workshop will be held in conjunction with SC20: The International Conference on High Performance Computing, Networking, Storage and Analysis in Atlanta, GA., on November 15.
Upcoming Policy Forums: Cost of Cancer, Tobacco
November 16 and November 19, 2020
More than 70,000 Ohioans will be diagnosed with cancer in 2020 and the decisions made in the statehouse or in the White House can be just as consequential for patients as the decisions made in their doctor’s office.

Join the American Cancer Society Cancer Action Network (ACS CAN) for a virtual, wide-ranging discussion about the public policies that affect the cost of, access to and delivery of cancer treatment on Monday, November 16 at 11:00 am. Register for the Virtual Cancer Policy Forum: The Cost of Cancer in Ohio.

On Thursday, November 19 at 11:30 am, ASC CAN is hosting the annual Northern Ohio Policy Forum, bringing together leaders from business, education, government and research communities. The 2020 event will discuss the toll of tobacco. Register for the 2020 Northern Ohio Policy Forum: The Toll of Tobacco.
NCCN Virtual Patient Advocacy Summit
December 10, 2020
Patients with cancer often have widely divergent care experiences from screening through survivorship. Differences in care delivery and outcomes may be due, in part, to varying patient needs and preferences according to age and stage of life; inconsistent implementation of guidelines, recommendations, and policies; and unintended age bias in health care. The National Comprehensive Cancer Network’s® (NCCN®) Virtual Patient Advocacy Summit will provide an opportunity for a varied group of stakeholders including patients, caregivers, providers, patient advocacy organizations, policymakers, and industry to thoughtfully discuss the importance of providing quality, effective, efficient, and accessible cancer care across the patient lifespan.
SGO 2021 Annual Meeting
EXTENDED ABSTRACT DEADLINE: November 6, 2020
Annual Meeting: March 20-23, 2021
The Society of Gynecologic Oncology (SGO) Annual Meeting on Women’s Cancer is a comprehensive forum for the subspecialty of gynecologic oncology. Whether you’re a physician, surgeon, researcher, allied health professional or a student in the field, you can join us to make the connections that will boost your career, see what’s new in gynecologic oncology science and research, and learn the best practices and techniques that can take your care to the next level.

The Call for Abstracts and Surgical Films for the SGO 2021 Annual Meeting on Women’s Cancer has been extended through November 6, 2020. Call for Late-breaking abstracts will be open December 1, 2020 through January 4, 2021.
Funding Opportunities
LOI Deadline: November 9, 2020
Full Application Deadline: November 23, 2020
The Case Comprehensive Cancer Center, with funds from its American Cancer Society Institutional Research Grant, will provide seed money to foster cancer research by junior faculty who have no current national grant support of their own. Investigators in the CWRU School of Medicine, University Hospitals of Cleveland, and Cleveland Clinic Lerner College of Medicine as well as in other schools and colleges affiliated with Case Western Reserve University are eligible. Grants, not to exceed $40,000, will be awarded to investigators who intend to gather preliminary data to be used in seeking future and independently funded programs.

Award Description
  • Pilot funding for cancer-related research with a basic, clinical, prevention & control, behavioral, health services, or epidemiological focus.
  • Up to $40,000 award
  • Grants will be awarded to junior investigators who intend to gather preliminary data to be used in seeking future and independently funded programs

Postdoctoral fellows, graduate students, research associates, and instructors within another PI’s laboratory are not eligible to apply for these research grants. The subject of the proposed research must be directly related to cancer. The principal investigator must be a full-time member of the faculty within 6 years of their first full-time independent faculty appointment (or equivalent).

The Case Comprehensive Cancer Center has been invited to nominate one investigator for the V Scholar Grant for Black/African American Cancer Researchers. This grant opportunity will be specifically for researchers who come from the Black/African American community, a minority group that is underrepresented in the scientific community. The V Scholar Award supports early tenure-track faculty by funding a range of projects from laboratory-based fundamental research through bench to bedside research. The total amount of the grant is $200,000, paid in two annual installments of $100,000. Only direct costs of the research are supported by this award.

SPECIAL FOCUS AREA: ANY area of adult cancer research.


Application Information
Submit a one-page specific aims response and biosketch by Tuesday, November 10, 2020 to casecccpilots@case.edu.
Deadline: December 1, 2020
The Case Comprehensive Cancer Center requests applications for Cancer Data Sciences pilot projects. Cancer Data Sciences will serve as a discipline in the Case CCC to standardize and organize data for optimal use and leverage advanced analytic approaches to enable independent and synergistic research for basic, clinical, population and translation sciences. Pilot applications should focus on driving new analytical capabilities, developing novel algorithms in order to mine, organize, and standardize cancer data as well as utilizing data sciences approaches to extract knowledge from complex, multi-level cancer data for maximal impact.

Award Description
  • Four (4) awards each at a maximum of $45,000, for one year will be awarded, with the potential for a second year dependent on progress. 
  • Metrics and Milestones will be: novel algorithms to be disseminated to Cancer center members, standardized datasets to be available to Cancer center members, peer-reviewed publications, peer-reviewed meeting presentations and/or generation of pilot data for peer-reviewed funding. 
  • Open to Case Comprehensive Cancer Center members. 
Next Quarterly Deadlines: November 15, 2020, February 15, 2021
Sanofi Genzyme is committed to making a positive impact in the areas of rare diseases, rare blood disorders, multiple sclerosis, oncology, and immunology.

To that end, the company welcomes applications for its Community Relations contributions program. With the goal of creating sustainable partnerships that have a lasting impact, the program provides support for nonprofit organizations focused on science education, access to health care, and other community needs, specifically in areas of the U.S. where Sanofi has a presence. The program only supports specific programs and initiatives and does not support general operating expenses or capital campaigns.
The American Brain Tumor Association seeks applications for their Discovery Grants from faculty who propose high-risk/high-impact projects with the potential to change current diagnostic or treatment paradigms for adult and pediatric brain tumor care.

ABTA Discovery Grants provide up to $50,000 in support over a one-year period.

  • Grants are intended to encourage the development of new approaches to the diagnosis and treatment of brain tumors leading to advancements in the understanding and treatment of brain tumors and increasing the potential for improving, extending, and ultimately, saving the lives of those living with a brain tumor diagnosis.
  • The funding mechanism specifically encourages novel research by allowing researchers to conduct the early scientific studies needed to secure additional/future funding for their projects.
  • Investigators from sciences outside traditional biological fields are encouraged to apply.

The ABTA seeks projects focused on all brain tumor types, benign or malignant, primary or secondary (metastatic), and that will have an impact on pediatric, adult, or both populations.
The American Society of Breast Surgeons Foundation awards grants for research projects and grants related to patient breast care and patient education each year.

The 2021 Call for Grant Proposals is now open! The society is accepting proposals for innovative patient breast care and patient education and research, and is also looking to support practicing physicians that display humanism in medicine. Please read these instructions on how to submit your grant proposal. 

Four grant categories are available:
  • Education ($5000)
  • Community Outreach ($5000)
  • Research ($5000)
  • Humanism in Medicine ($1000)
In The News
Medscape - October 30, 2020
"One of most interesting findings is that persistent symptoms do not correlate with PCR positivity, suggesting that symptoms are in many cases not due to ongoing viral replication," said Jonathan Karn, PhD, professor and chair of the Department of Molecular Biology and Microbiology at Case Western Reserve University School of Medicine. Dr. Karn is a member of the Case CCC.
Targeted Oncology - November 1, 2020
Shilpa Gupta, MD, leader, Bladder Cancer Program, Taussig Cancer Institute at Cleveland Clinic discusses the case of a 62-year-old man with bladder cancer. Dr. Gupta is a member of the Case CCC's Genitourinary Malignancies Program.
From The NIH
Weekly NIH Funding Opportunities and Notices
COVID-19 Funding Opportunities and Notices
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