SEPTEMBER 27, 2019
Director's Message
Last week, we sent you a Message from the Director titled, "Dilemmas in Cancer Decision-Making" following a Perspective shared in the NEJM. We have published the message on our website , including a PDF version of the Perspective for those of you who may have had trouble accessing the article.
Member/Center Highlights
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The Importance of Physician Scientists to the Future of Healthcare
This week, the New York Times featured an opinion piece written by three board members of the Physician-Scientist Support Foundation, including Mukesh Jain, MD, University Hospitals cardiologist, professor at Case Western Reserve University School of Medicine and member of the Case Comprehensive Cancer Center (Case CCC).
In the article, the authors list several examples of medical breakthroughs that were the result of the melding of clinical practice with basic science research. The Case CCC has an extensive history of supporting valuable laboratory research experiences necessary to cultivate successful physician-scientists.

The Case CCC has an extensive history of supporting valuable laboratory research experiences necessary to cultivate successful physician-scientists. What is it that makes bridging the gap between patient care and novel investigations so important?
Cleveland Clinic Appoints Jame Abraham as Department Chair of Hematology/Medical Oncology
The Case Comprehensive Cancer Center extends congratulations to Jame Abraham, MD as he was recently appointed Chair of the Hematology/Oncology Department at Cleveland Clinic.

Dr. Abraham directs the Breast Oncology Program at Taussig Cancer Institute and is co-director of the Cleveland Clinic Comprehensive Breast Cancer Program. He is also a member of the Developmental Therapeutics Program at the Case Comprehensive Cancer Center and professor of medicine at Cleveland Clinic Lerner College of Medicine. 
2019 Cancer Innovation Pilot Awardees Announced
The Case Comprehensive Cancer Center (Case CCC) has made pilot award selections following a recent RFA. Selected projects were recognized as highly innovative and impactful, and likely to generate key data for larger, nationally competitive grants. Investigators were permitted to submit transformative proposals for technology development, biological or therapeutic questions, novel concepts in catchment-based research, or topics with the potential to overturn dogma. Please join us in congratulating the awardees below.

Paul Fox, PhD: Regulation of PARP1 Function in Breast Cancer by a tRNA Synthetase

Efstathios Karathanasis, PhD : Immuno-nanoparticles for directing antitumor immunity against early metastasis

Fu-Sen Liang, PhD : The Next Generation CAR T Cells to Reduce Off-tumor irAE

Jacob Scott, MD, PhD : Probing heterogeneity underlying the evolution of TKI resistance with single cell RNA sequencing
Last Chance to Contribute to Team Case CCC's VeloSano 6 Fundraising
When VeloSano weekend 2019 came to a close, Team Case Comprehensive Cancer Center had already secured over $57,300 in donations and collectively covered more than 4,820 miles for cancer research right here in Cleveland!

To-date, our team of 90 riders has raised $68,550 and is in the top 15 fundraising teams of the year! Again, we would like to thank everyone who rode with us, volunteered, or supported our team through donations. Funds raised go directly to cancer research thanks to VeloSano's incredible partners. The team is able to continue to collect tax-deductible contributions through October 1, 2019 if you would like to show your support for this year's efforts.
What's Coming Up
Mark Your Calendar
Cancer Center Seminar Series
September 27, 12p
WRB Auditorium

Our interdisciplinary seminar series addresses cutting-edge clinical, translational, and basic research topics in cancer.

This week's seminar returns to the Wolstein Research Building Auditorium and features Carolyn Anderson, PhD presenting, "Theranostics Targeting Tumor Cells and Immune Cells."

Dr. Anderson is a professor of medicine at the University of Pittsburgh as well as Director of the Nuclear Molecular Imaging Lab and co-director of the In Vivo Imaging Facility at UPMC HIllman Cancer Center. Her research interests include the development and evaluation of novel radiometal-based radiopharmaceuticals for diagnostic imaging and targeted radiotherapy of cancer and other diseases.
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Stefanie Avril
Norma C. and Albert I. Geller Designated Professorship of Ovarian Cancer Research Celebration
October 3, 4:30p
Wolstein Research Building

A program and reception celebrating the appointment of Stefanie Avril, MD as the Norma C. and Albert I. Geller Designated Professor of Ovarian Cancer Research will be held Thursday, October 3, 2019 at 4:30 pm in the Wolstein Research Building.

Complimentary valet parking will be available on Circle Drive between Mayfield and Cornell roads.
Cancer Center Seminar Series
October 4, 12p
WRB Auditorium

Next Friday's seminar will feature Jacob Scott, MD, DPhil , presenting, "Cancer Evolution."

Dr. Scott is associate staff in the department of translational hematology and oncology research (THOR) and radiation oncology at Cleveland Clinic Lerner Research Institute and a member of the Case CCC's Developmental Therapeutics program.

His lab seeks to use a suite of mathematical and experimental models to deconvolute the complexity of the evolutionary process to increase efficacy of targeted therapies and radiation. This same knowledge can be further harnessed to understand the differences in disease progression and therapy response on a personalized basis, so that the right treatment can be given to the right patient at the right time.
Artificial Intelligence in Oncology Symposium
October 24, 2019
Tinkham Veale University Center

The Case Comprehensive Cancer Center and Center for Computational Imaging and Personalized Diagnostics at Case Western Reserve University (CWRU) will host the inaugural  Artificial Intelligence in Oncology Symposium : Advancements in Policy at CWRU on Thursday, October 24, 2019.

The symposium will bring together experts in AI and machine learning as well as clinical, industry and federal agency experts in pathology, radiology, oncology and immuno-oncology to speak on research developments, regulatory policy, reimbursement and ethics surrounding AI.

Symposium Highlights:
  • Focused panel discussions
  • Networking opportunities
  • Exhibitions available throughout the day

  • Sohrab Shah, PhD, Chief, Computational Oncology, Memorial Sloan Kettering Cancer Center

Seats are filling quickly, so don't wait!  A discount for students and trainees who wish to attend is available. We look forward to seeing you in October!
Early Bird Registration and Call for Abstracts: Innovators in AYA Cancer
November 14-15, 2019
Tinkham Veale University Center

The Angie Fowler Adolescent and Young Adult (AYA) Cancer Research Initiative of the Case Comprehensive Cancer Center invites you to attend Innovators in AYA Cancer: Driving Science and Policy toward a Brighter Future for Teens and Young Adults with Cancer this November at Case Western Reserve University.

Call for Abstracts
The Symposium will feature a poster session and Rising Star oral presentations. All students, postdocs, residents, fellows and faculty conducting research in AYA cancer are invited to submit abstracts. Monetary prizes will be awarded. Abstracts must be submitted electronically by Friday, October 18, 2019 at 5pm ET. Learn more>

Be sure to register by October 18, 2019 to secure our discounted early bird registration . A discount for students and trainees who wish to attend is available. We look forward to seeing you in November!
4th Annual Cancer Disparities Symposium
March 6, 2020
Tinkham Veale University Center

The Case Comprehensive Cancer Center Office of Cancer Disparities Research will present the   4th Annual Cancer Disparities Symposium : Cultivating Science and Community Engagement to Address Cancer Health Disparities on March 6, 2020. 

The symposium will feature keynote presentations by renowned disparities
researchers and community leaders, a poster session highlighting academic research and community programs, networking opportunities and an all-attendee forum.

Call for Abstracts
The   4th Annual Cancer Disparities Symposium is a premier event for presenting cutting-edge cancer disparities science and related community programs and services. The Office of Cancer Disparities Research will divide abstracts into two tracks:   Scientific Research   and   Community Programs and Services . Scientific Research abstracts are encouraged from multidisciplinary researchers that are focused on various aspects of health disparities and/or community-focused science. Community programs and service abstracts are encouraged from organizations that provide programs and services that benefit the community. Meritorious abstracts will be selected for oral presentation.  Abstracts must be submitted electronically by 5p EST on Tuesday, December 3, 2019.   Learn more>
Additional Upcoming Events
Cleveland Clinic Colorectal Oncology Conference
October 18-19, 2019, 8a-3:30p
Naples, FL
Discounted registration ends today!
Cleveland Clinic Breast Cancer Update: From Detection Through Treatment to Survivorship
November 13, 2019
Independence, OH
Funding Opportunities
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Deadline: October 15

Based on the success of efforts in 2016 and 2018, School leadership has recommended that the Core Facility/Shared Resource/Research Infrastructure RFI process be repeated in this fiscal year. The plan is to initiate and complete this new RFI review process by December 2019 to align with SOM budgeting process and development of upcoming Shared Instrument Grant applications.

Proposals must be partnered with an established Core Facility and director, or be proposing a new core facility with a nominated director.

This RFI process will consist of:
  1. Up to 2-page proposal submission (due October 15, 2019
  2. NIH-style review of proposals (November 2019); and
  3. Reporting on top-tier proposals to CWRU SOM leadership (December 2019).

All questions about the program should be directed to Matt DeVries ( ).

Click the button below to review proposal requirements and submit an application.
Deadlines Vary by Award

LOI Deadline: Friday, October 18, 2019
Up to $120,000 of seed funding for innovative and impactful proposals that will generate key data for nationally competitive MPI grants. Projects must be focused on the establishment or support of a collaborative effort by 2 or more independent investigators with the goal of submitting an MPI extramural grant application.

LOI Deadline: Friday, October 18, 2019
Up to $180,000 of seed funding for innovative and impactful proposals that will generate key data for nationally competitive multi-investigator/team grants (P01, U01, SPORE, etc.).

LOI Deadline: Friday, October 18, 2019
Up to $75,000 of seed funding for outstanding, independent junior faculty to aid in generating key data for nationally competitive grants, particularly the development of R01 and Scholar Awards.

Applications accepted and awarded on a rolling basis
$25,000 of seed funding to support the resubmission and/or competitive renewal efforts of strong grant applications that narrowly missed the payline at national funding agencies. Ideal candidates are those with R01 applications scored at the 20th percentile or better.
In The News
Politico - March 20, 2019
Hematologist-oncologist Aziz Nazha, MD leads the Cleveland Clinic's Center for Clinical Artificial Intelligence and is a member of the Case CCC's Hematopoietic and Immune Cancer Biology Program. His goal, he says, is for clinicians and data scientists to work together on deploying AI and health, so that clinicians can point out anomalies. Dr. Nazha also serves on the planning committee of the upcoming Artificial Intelligence in Oncology Symposium.
Health Imaging
University Hospitals Cleveland Medical Center recently ran a frozen section pilot study of a digital pathology solution. “We need greater efficiency so we can look at slides and make a diagnosis from anywhere,” said Hannah Gilmore, MD, division chief of anatomic pathology and director of breast pathology service at UHCMC. Dr. Gilmore is assistant professor of pathology at the CWRU School of Medicine and a member of the Case CCC's Molecular Oncology Program.
From The NIH
Weekly NIH Funding Opportunities and Notices

Funding Opportunities
LOI Deadline: October 13, 2019

Deadline: November 22, 2019

LOI Deadline: November 17, 2019

LOI Deadline: November 17, 2019

Deadlines: February 13, 2020, July 17, 2020, February 13, 2021
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