September 4, 2020
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From the National Cancer Institute
NCI Annual Plan & Budget Proposal for Fiscal Year 2022
National Cancer Institute Logo
The National Cancer Institute (NCI) released their Fiscal Year 2022 Annual Plan and Budget Proposal.

Each year, developing this plan provides the NCI with a special opportunity to reflect on progress in cancer research and consider how best to direct NCI resources in the years ahead, on behalf of the American public. This plan focuses on the NCI's enduring top priority — accelerating cancer research — and features four special scientific topics: cancer drug resistance, molecular diagnostics for cancer treatment, obesity and cancer, and cancer survivorship.
Jacob Scott MD PhD
Pay special attention to the section on Cancer Drug Resistance, which features research by Jacob Scott, MD, DPhil into co-opting cell evolution to overcome treatment resistance in cancer.
SBIR/STTR Applicant Assistance Program
The Applicant Assistance Program (AAP) is accepting applications for those who are participating in the January 2021 SBIR/STTR application cycle.

This is a FREE program geared toward helping small businesses apply for Phase I Small Business Innovation Research (SBIR) or Small Business Technology Transfer (STTR) funding. AAP provides participants with services such as application needs assessment, mentoring, application preparation support, and application review. If you are interested, apply by Thursday, September 24, 2020 on the AAP Application Portal. Program eligibility is limited to small businesses who have not previously won an SBIR or STTR award from the NIH.

If you are interested in participating in AAP, an informational webinar will be held Tuesday, September 15, 2020 from 3-4 pm EDT. Topics to be covered include: SBIR/STTR program basic, eligibility criteria, AAP information and how to write an application for AAP.
Member/Center Highlights
Muzic Appointed Director of the Radiation Resources Shared Resource
Raymond F. Muzic, Jr, PhD has been appointed director of the Radiation Resources Shared Resource. Dr. Muzic is well suited to oversee the operations of the facility. He has a track record of collaborative, translational research with physicians from many departments and especially in Nuclear Medicine and Radiation Oncology. He works closely with the Radiation Safety Departments at Case Western Reserve University and University Hospitals (UH) and has been the chair of the UH Radiation Safety Committee for more than a decade.

As Director of the Quantitative Imaging Laboratory, Dr. Muzic’s research has two main areas. One is development and validation of imaging agents. The other is data analysis methods for quantitative physiological interpretation. In the latter, tools include pharmacokinetic modeling, optimal experiment design, and artificial intelligence. These are applied to support the first area and in application such as personalized dosing and assessing response to therapy.

Dr. Muzic is Professor in the Department of Radiology at CWRU and UH. He has close associations with the departments of Radiation Oncology and Biomedical Engineering and is a long-time member of the Case Comprehensive Cancer Center.
Round Robin Meeting: Cancer Data Sciences Pillar & Machine Learning Working Group
The Case CCC Cancer Data Sciences Leadership Team has partnered with the Case CCC Machine Learning working group to launch a round robin style meeting. This meeting will allow the participants to briefly present their research work and interests in order to facilitate collaboration across the community. Please fill out this form only once, although you may be included on multiple emails with this request.



Case CCC Cancer Data Sciences Leadership Team
Jill Barnholtz-Sloan, PhD, Case CCC Associate Director for Data Sciences
Paolo Caimi, MD
Vinay Varadan, PhD
Aziz Nazha, MD
Paola Saroufim, PharmD, MPH, MBA
Recommended Reading: Homozygous HSD3B1(1245C) inheritance and poor outcomes in metastatic castration-resistant prostate cancer with abiraterone or enzalutamide: what does it mean?
Nima Sharifi
In the August issue of Annals in Oncology, Nima Sharifi, MD published an editorial on two original studies from four international patient cohorts that builds upon mechanistic, translational and clinical work investigating castration-resistant prostate cancer (CRPC) at the Case Comprehensive Cancer Center (Case CCC). The international studies show poor CRPC outcomes for HSD3B1(1245C) inheritance with drugs abiraterone or enzalutamide. In his editorial, Dr. Sharifi explains what this might mean, including implications of androgen-driven intrinsic resistance in homozygous 1245C patients, a link to race-associated differences and the role for assessment in earlier disease.

Dr. Sharifi is Director of the Center for GU Malignancies Research at Cleveland Clinic Lerner Research Institute, professor of molecular medicine, and Co-Leader of the Case CCC's GU Malignancies Program.
Call for Abstracts: Biomedical Graduate Student Symposium
The Biomedical Graduate Student Symposium (BGSS) is a student-run event that celebrates student research in the School of Medicine at CWRU. BGSS organizers are now accepting abstracts for posters and oral presentations for the 2020 symposium, to be held November 9-10.

Download the abstract template form to submit your abstract by October 2 at 11:59 pm (no exceptions).

Cash prizes will be awarded to top student posters and oral presentations!

Abstract Submission Guidelines:
  • 300 words MAXIMUM, not including title, authors, or affiliations
  • Do not include figures or tables with your abstract
  • Please submit as a .doc or .docx file named lastname_firstname.doc(x), for example franklin_rosalind.doc(x)

This event will consist of student poster presentations, student oral presentations and a keynote address from Dr. Yasmine Belkaid, National Institute of Allergy and Infectious Diseases (NIAID). BGSS will also partner with the Career Opportunities for Trainees Series (COTS) for a career panel (details and panelists to be announced).

For more details please visit http://cwrubgss.wordpress.com or contact casebgss@gmail.com with any questions or concerns.
VeloSano 7 Fundraising Continues through October 1
To-date, the 44 members that comprise Team Case Comprehensive Cancer Center have raised $22,512 and counting for lifesaving cancer research at Cleveland's top-tier hospitals and research institutions. This is an increase in funds raised of over $2,600 over this time last week!

Despite the shift to Virtual VeloSano, our team pressed on and remained committed to participating in their chosen activities - biking, hiking, walking and yes, even gardening. Fundraising for this year's event will continue through October 1, 2020. Thank you to our committed team members, those who have donated to the cause and all who have cheered them on!
Cakes for Cancer: High school student creates cookbook to raise money for research
Chase Sloan, a 15-year-old sophomore at Hawken School and aspiring surgical oncologist, has always enjoyed cooking and baking. He hoped to one day create a cookbook, but that goal seemed far off until early March when the world was forced to essential shut down due to the COVID-19 pandemic. It was then that Chase found the time to compile his recipes and publish them as a new cookbook, Cakes for Cancer. The cookbook is available through Amazon as an e-book or paperback. Chase will donate 75% of the proceeds to the American Association for Cancer Research and St. Jude Children’s Research Hospital. 

The theme of the book was inspired by the recent loss of Anne Duli, a close family friend and long-time Associate Director for Administration for our Center, who passed away last summer following a long battle with breast cancer. Chase and his family spent much time at Anne’s home cooking dinner with her and her wife Ana, sharing recipes and stories. “Making food really brings people together. It makes people feel good,” said Chase. “I still go to Ana’s house weekly. We cook and talk about Anne. It has helped us both over the past year.”

Chase credits his parents, cancer researchers Drs. Jill Barnholtz-Sloan and Andy Sloan, with educating him first-hand on the value of research, and inspiring him to want to give back and change the world. "Cancer is such a power disease. It is indiscriminate. It doesn’t care if you have healthy habits. It can just come and wipe you out," said Chase. "I wanted to donate money to create a brighter future for better and more effective treatments."
Case CCC COVID-19 Resource Hub
As the COVID-19 outbreak progresses, the Case Comprehensive Cancer Center (Case CCC) has centralized COVID-19 related news, resources and funding opportunities for our cancer center community. Content is updated regularly.

To have a cancer-focused resource added to the page, please email cancer@case.edu.
What's Coming Up
Mark Your Calendar
Portrait of Jennie Cullen
Cancer Center Seminar Series
Friday, September 11, 2020, 12p via Zoom
Each Fall and Spring, the Case Comprehensive Cancer Center (Case CCC) hosts a weekly interdisciplinary seminar series addressing cutting-edge clinical, translational and basic research topics in cancer each Friday at 12 pm EST.

This series returns this Fall, beginning Friday, September 11 with Jennifer Cullen, PhD, MPH presenting, "History, Evolution, and Modern Opportunities in Cancer Population Sciences" on behalf of the Cancer Prevention, Control & Population Research Program. Dr. Cullen holds the The James T. Pardee - Carl A. Gerstacker Professorship in Cancer Research and is Associate Director for Cancer Population Sciences at the Case CCC.

Due to institutional health restrictions, the seminar will continue to be held available virtually via Zoom this semester. Attendees will be muted upon entry and are encouraged to submit questions via chat or audio when appropriate.

CME credit will still be available for those who attend seminars live via Zoom. Contact Kelsey Kirsch for more information.
VeloSano bike to cure logo
VeloSano Trainee Dream Experiment Awardee Symposium Thursday, September 17, 2020, 9a via Zoom
In 2019, the Case Comprehensive Cancer Center granted 8 trainees with VeloSano Trainee Dream Experiment Fellowships. Awardees will present their projects and outcomes to the cancer research community on Thursday September 17, 2020 at 9 am via Zoom.

Please join us via Zoom to see a brief presentation of their research projects and to ask questions. Click here to view a list of awardees and their projects.
Cancer Center Seminar Series
Friday, September 18, 2020, 12p via Zoom



Our weekly seminar series will host its first external speaker, Lorelei Mucci, MPH, ScD on Friday, September 18. Dr. Mucci is associate professor of epidemiology at the Harvard T.H. Chan School of Public Health and leader of the Cancer Epidemiology Program at Dana-Farber/Harvard Cancer Center.

She will present, "IRONMAN: Findings and Future Directions in a Global Registry of Men with Advanced Prostate Cancer" on behalf of the Cancer Prevention, Control, & Population Research Program.

Dr. Mucci's major research focuses on the epidemiology of prostate cancer risk and progression within cohorts of men from the United States and Scandinavia, with an emphasis on biomarker studies, including circulating markers, inherited genetic susceptibility markers, as well as tumor biomarkers. Two of her specific areas of research are patho-epidemiology and twin studies of cancer.
Registration Discount Extended: Artificial Intelligence in Oncology Virtual Symposium 2020
October 19-20, 2020

The second annual Artificial Intelligence in Oncology Symposium will bring together experts in AI and machine learning as well as clinical, industry and federal agency experts in pathology, radiology, drug discovery, and ethics and policy to speak on research developments, regulatory policy, reimbursement and ethics surrounding AI in oncology. For the health and safety of all attendees, this year's symposium will take place virtually.

Join us for four focused sessions, with international speakers and panel discussions providing unique perspectives on how AI and machine learning are impacting the major areas of radiology, pathology and -omics in the contexts of precision medicine approaches for characterizing tumors and predicting therapeutic response.

Beyond the science, attendees will be able to network and enjoy a special session highlighting some of the brightest rising stars in the field of AI in oncology, selected from abstract submissions. Submit your abstract by Friday, September 11!

Geraldine McGinty, MD, MBA, FACR will present the symposium plenary, "Fostering a Strong Ecosystem for AI in Medical Imaging." Dr. McGinty is an internationally recognized expert in imaging economics, Chair of the American College of Radiology Board of Chancellors and Chief Strategy and Contracting Officer at Weill Cornell Medicine in New York City.

Additional keynotes in drug discovery, ethics & policy and pathology will be delivered by Russ Altman, MD, PhD of Stanford University, Aashima Gupta, MS of Google, Vinay Prasad, MD, MPH of the University of California, San Francisco, and Yinyin Yuan, PhD of the Institute of Cancer Research, London. Learn more about AIO 2020 speakers.
Case Western Reserve University Case Comprehensive Cancer Center Logo in dark CWRU blue
Case CCC Fall Clinical Research Retreat
October 28, 2020, 5-7p via Zoom
The Case Comprehensive Cancer Center's Fall Clinical Research Retreat will be held virtually on October 28, 2020 from 5-7 pm.

The retreat theme is, "Immunotherapy in Cancer Research." The retreat will include a presentation by Leland Metheny, MD, Chair of the Case CCC Protocol Review and Monitoring Committee (PRMC) and a keynote presentation from Timothy Chan, MD, PhD, Director of Immunotherapy and Precision Immuno-Oncology at Cleveland Clinic.

Registration is required.
Biomedical Graduate Student Symposium (Virtual)
November 9-10, 2020
The Biomedical Graduate Student Symposium (BGSS) is a student-run event that celebrates student research in the School of Medicine at CWRU. This event will consist of student poster presentations, student oral presentations, and a keynote address from Dr. Yasmine Belkaid, National Institute of Allergy and Infectious Diseases (NIAID). BGSS will also partner with the Career Opportunities for Trainees Series (COTS) for a career panel (details and panelists to be announced).

Contact casebgss@gmail.com with any questions or concerns.
Additional Upcoming Events
NCCN Oncology Policy Virtual Summit
September 9, 2020
The Summit will explore diverse perspectives related to emerging models to drive down healthcare costs in the United States and their potential impact on access to high-quality cancer care. Major themes of the summit will include an overview of legislative and regulatory efforts to reduce health costs, the current state of value-based payment models, and the impact of these models on providers and patients with cancer. The summit will also explore the unique implications of policies intended to curb costs for rural and other underserved populations.

If you have any questions, please contact Terrell Johnson, Manager, Policy and Advocacy, johnson@nccn.org.
NCCN 2020 Virtual Congress: Hematologic Malignancies
October 9-10, 2020
Attend this NCCN virtual congress to hear from world-renowned experts in the management of Hematologic Malignancies present the latest treatment advances, updates to the standard of care as recommended in the NCCN Guidelines®, and unique and challenging patient cases.

Co-chaired by Ranjana H. Advani, MD, Stanford Cancer Institute, and Andrew D. Zelenetz, MD, PhD, Memorial Sloan Kettering Cancer Center, this virtual program features presentations and interactive discussions highlighting the treatment options and supportive care for a variety of hematological malignancies.

This program is approved for AMA PRA Category 1 Credit™ for physicians and will award contact hours for nurses, pharmacists, and other health care professionals.
NCCN 2021 Annual Conference: Call for Abstracts
Abstract Deadline: November 11, 2020
NCCN is now accepting abstracts for consideration to be presented during the NCCN 2021 Annual Conference General Poster Session at the Rosen Shingle Creek in Orlando, Florida on Thursday, March 18 and Friday, March 19, 2021. NCCN welcomes original abstracts from investigators in the general oncology community. Submissions will be accepted from academic institutions, teaching and community hospitals, or industry. Both NCCN and non-NCCN institutions may participate.

Research may fall into the general areas below:

  • Clinical Oncology (all phases)
  • Pre-Clinical Oncology
  • Epidemiology/Risks/Prevention
  • Correlative/Genomic
  • Best Practices in Implementation and Use of Clinical Practice Guidelines
  • Quality Improvement
  • Outcomes and Health Services Research
  • Bioinformatics/Information Technology Sciences
Sixth Computational Approaches for Cancer Workshop (CAFCW20)
Abstract Deadline: September 6, 2020
Workshop: November 13, 2020
The National Cancer Institute Center for Biomedical Informatics and Information Technology and SC20 are seeking abstracts for presentations for the Sixth Computational Approaches for Cancer Workshop (CAFCW20). CAFCW20 is a workshop designed to bring together clinicians, cancer biologists, mathematicians, data scientists, computational scientists, engineers, developers, thought leaders, and anyone else interested in advancing computation to use in cancer care and research. This year’s topic is “AI and HPC: Overcoming Data Challenges in Cancer Research and Clinical Applications.”

A special emphasis for the CAFCW20 is the role of HPC and AI to address research challenges when data are limited by availability, variability and size. The workshop will be held in conjunction with SC20: The International Conference on High Performance Computing, Networking, Storage and Analysis in Atlanta, GA., on November 15.
SGO 2021 Annual Meeting
Abstract Deadline: October 23, 2020
Annual Meeting: March 20-23, 2021

The Society of Gynecologic Oncology (SGO) Annual Meeting on Women’s Cancer is a comprehensive forum for the subspecialty of gynecologic oncology. Whether you’re a physician, surgeon, researcher, allied health professional or a student in the field, you can join us to make the connections that will boost your career, see what’s new in gynecologic oncology science and research, and learn the best practices and techniques that can take your care to the next level.

The Call for Abstracts and Surgical Films for the SGO 2021 Annual Meeting on Women’s Cancer is open through October 23, 2020. Call for Late-breaking abstracts will be open December 1, 2020 through January 4, 2021.
2020 Graft versus Host Disease Virtual Symposium
October 2, 2020
The Meredith A. Cowden Foundation has hosted the GvHD National Symposium since 2010, focusing on cutting edge research and new treatments.

Due to COVID19 and the restrictions related to this pandemic, and the potential risks for symposium participants who may already be immunocompromised, the Foundation has decided to postpone the annual in-person meeting.

To address the continuing need to serve the community, the Foundation has decided to host a short ‘virtual’ symposium on Friday, October 2, 2020. This free, 2-hour event will consist of a clinical presentation by Dr. Dan Couriel from the University of Utah, followed by a patient-centered Q&A panel hosted by the GvHD planning committee.
Funding Opportunities
Proposals accepted on rolling basis subject to funds availability

The Case Comprehensive Cancer Center (Case CCC) has budgeted funds for the conduct of early phase clinical trials of relatively short duration. The objectives are to identify and fund investigator-initiated trials, which meet the Cancer Center Support Grant and Case CCC requirements, entertain highly innovative and novel ideas, and which directly foster the mission of the Case CCC. These may be new trials under development or an existing investigator-initiated trial that is unfunded/underfunded. Priority will be given to trials that have been developed jointly between investigators at both hospital systems (University Hospitals and Cleveland Clinic), with planned accrual at both sites.
The NCI has announced a Request for Applications for the Predoctoral to Postdoctoral Fellow Transition (F99/K00) Award for 2020, to support outstanding PhD candidates as they complete their dissertation research training (F99 phase; 1-2 years) and transition to a mentored, cancer-focused postdoctoral career development research positions (K00 phase – up to 4 years).

The F99/K00 award is open to 3rd or 4th year PhD students, including F31 Fellowship applicants and current awardees (note that 3 rd or 4 th year students would have matriculated in 2017 or 2018). International students may also apply. Students Matriculated in a dual-degree program (e.g.) MD/PhD, DO/PhD, DDS/PhD, or DVM/PhD) are not eligible for the F99/K00 program. Projects must be clearly focused on cancer.

To apply for this award, an applicant must be nominated by their institution. As each institution is allocated only one nomination, the Case Comprehensive Cancer Center (Case CCC) requires potential applicants to assemble a pre-application.

Click here to download nomination application instructions. Contact Damian Junk at damian.junk@case.edu for additional information.
VeloSano logo
With the generous support from VeloSano Bike to Cure, the Case Comprehensive Cancer Center (Case CCC) is providing funding for Case CCC Trainee Associate Members to perform their “dream experiment.”

The experiment should catalyze highly innovative and impactful projects and help strengthen fellowship and career development grant applications. The intent of the award is to support a single or limited set of innovative experiments, not for general laboratory supplies/projects or maintenance of the trainee’s project.

Up to five (4) projects will be funded at $10,000/award. Research projects must be completed within one (1) year, with funds expended by June 30, 2021.
The Pancreatic Cancer Action Network (PanCAN) Career Development Award of $200,000 over two years supports junior faculty to conduct pancreatic cancer research and establish successful career paths in the field. Proposed research may be basic, translational, clinical or epidemiological in nature and must have direct applicability and relevance to pancreatic cancer. Special consideration will be given to understudied areas in pancreatic cancer research.

It is anticipated that three grants will be funded. Grant recipients not only receive financial support for their research, but also join the Community for Progress built by PanCAN. This mentorship program connects grantees with leading scientists in the field. Ongoing career support activities offer opportunities for education and professional development to help keep the community of researchers committed and involved. The Community for Progress is a growing, robust and collaborative research community that is dedicated to changing the course of history for pancreatic cancer.
In The News
MedNetNews - August 12, 2020
“[Prostate-specific antigen] screening has fallen out of favor in recent years for problematic reasons,” says Jonathan E. Shoag, MD, assistant professor of urology at University Hospitals Cleveland Medical Center and Case Western Reserve University. Dr. Shoag is a member of the Case Comprehensive Cancer Center.
News 5 Cleveland - August 26, 2020
“Clusters of infections can link together and become another outbreak," said Mark Cameron, PhD, an infectious disease researcher at CWRU. Dr. Cameron is a member of the Case CCC's Hematopoietic and Immune Cancer Biology Program.
From The NIH
Weekly NIH Funding Opportunities and Notices
COVID-19 Funding Opportunities and Notices
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