ICTR July 2018 Newsletter                             
In This Issue

  • New K Scholar Named
  • PhD in Clinical Investigation Accepts Students
  • Catalytic Seed Grant Funding Still Available
  • Meet New IRB Staff
  • Einstein-Montefiore Research in the Headlines
Introducing New ICTR K Scholar
We are pleased to announce one of this year’s ICTR Scholars. The  KL2 awards  provide support for mentored research career development to junior faculty who have recently completed professional training and who are commencing translational and/or clinical research.

Mentors: Michelle Gong / Tia Powell
Project title: Improving Quality of End of Life Care through Optimization of Mid-Level Provider Communication with Patient and Families in the Acute Care Setting
Clinical Investigation Graduate Program Summer 2018
Three new students were accepted into the Ph.D. in Clinical Investigation (PCI) program and will begin July 2018. The ICTR education program provides rigorous advanced training that prepares you for an independent research career in clinical and translational science. This PhD track prepares current students to conduct research that will improve the health and welfare of society using clinical and translational research methodology. PCI is offered for Ph.D. students enrolled in Einstein’s graduate division and for M.D./Ph.D. students in Einstein’s Medical Scientist Training Program (MSTP). To learn more about the PCI program, click here . From left to right:

Aakash Mahant 
Mentors: Johanna Daily / Betsy Herold
Project title: Neonatal Herpes Simplex Virus ( HSV) prevention through maternal vaccination with Δgd-2
Aniella Murphy
Mentors: Joan Berman / Johanna Daily
Project title: Test the ability of buprenorphine to inhibit HIV associated neuropathogenesis
Phillip Galbo
Mentors:  Deyou Zheng / XingXing Zang
Project information:   Abundance of tumor-infiltrating immune cells and tumor associated non-malignant cells as prognostic for GBM patient survival, state of disease, and disease management and new therapeutic direction for GBM
Seed Grant of of the Month
Welcome to a new item in the ICTR newsletter that features brief vignettes of the outcomes of our Pilot Project Program. First, some historical metrics—over the past decade the ICTR has awarded about $1.2 million in pilot and seed grants, with the remarkable result that subsequently the investigators submitted a total of 94 grants that ultimately generated about $20 million of extramural support , a nearly 17:1 return on investment. As importantly, these projects generated many new collaborations and innovations. To learn more and begin your application, click here .

For example, Dr. Aluko Hope, who focuses on integrating geriatric and palliative care principles into the care of critically ill older patients has recently been supported by a pilot award . Elderly adults are often admitted to ICUs. Although there are substantial data on the effect of acute illness on outcomes among critically ill adults, their health status before the critical illness may also be essential factor in their prognosis. Frailty is a syndrome that could affect an individual's resilience after critical illness, and has been associated with risk of disability, hospitalization, and death. A seed grant was awarded to Aluko Hope MD, MS to help him validate two novel approaches to identify frailty in critically-ill older adults. The first used the power of the EHR to diagnose frailty using clinical markers before ICU admission. The second uses a frailty assessment questionnaire. Investigators collected EHR-based measures to develop an algorithm to identify older adults at risk of adverse events in the ICU. Dr. Hope recently received a K01 grant from the NIH; he earned his MD and an MS in Epidemiology at another CTSA hub, the University of Pennsylvania School of Medicine. His Primary Care Internal Medicine Residency was at Columbia and he then trained in Pulmonary and Critical Care at Mount Sinai, both sister CTSA hubs in New York City.
Meet the New IRB Staff
The IRB facilitates excellence in human research by extending personalized guidance and support to the research community through timely and high quality service, education, review, and monitoring.

The IRB has some new faces! Meet some of the new staff below.

Heather Rose
Clinical Research Regulatory Specialist
Heather Rose is the Protocol Registration and Results Reporting System (PRS) administrator. Heather is responsible for ensuring compliance with laws and policies requiring registration of clinical trials on ClinicalTrials.gov and is available to assist investigators and research coordinators make required updates and corrections to their study records. Prior to joining Einstein, Heather worked for Vanguard Group Staffing and Staples.

Rui Ferreira, MA
Reliance Analyst
Rui is the primary point person for researchers utilizing Single IRB (sIRB) review for multisite research. Prior to joining the IRB, Rui served as an IRB Specialist/Liaison in the Columbia University Medical Center Human Research Protection Office. Rui has also worked as a senior clinical research coordinator at the Mount Sinai School of Medicine. He is a graduate of the New School for Social Research in New York. Mr. Ferreira is pictured above, left.
Leslie Johnson
IRB Project Coordinator
Leslie Johnson provides support to the IRB director, associate directors, and the expanding team of analysts. She handles all office matters, assists with iRIS support, and serves as the key point person for sIRB and iRIS 101 training registrations. Leslie previously worked in the Department of Pediatrics and has extensive healthcare and administrative experience. She earned her B.A. from Baruch College. Ms. Johnson is pictured above right.
NIH Single IRB Policy Reminder
On January 25 th 2018, the NIH Single IRB Policy went into effect. 

If you are preparing a new NIH application and your grant proposes use of a single IRB for non-exempt multi-site research , please complete an IRB Reliance Request Form .
Please note that the policy is applicable to new and competing renewal applications/ proposals for NIH funding. It is applicable to NIH-funded multi-site domestic studies involving non-exempt human subjects’ research, whether supported through grants, cooperative agreements, contracts, or the NIH Intramural Research Program. If Einstein or Montefiore is being proposed as one of the participating sites in any new NIH application by another applicant organization , you should also inform the IRB as soon as possible by completing an IRB Reliance Request Form . For more information on fulfilling the requirements of the NIH sIRB Policy, click here .

Feel free to contact the IRB at [email protected] with any questions.
Opportunities Available for Collaborative Rare Disease Research
The National Center for Advancing Translational Sciences (NCATS) has released two new funding opportunities in the Rare Diseases Clinical Research Network to support collaborative clinical research on rare diseases. NCATS is accepting applications for a Data Management and Coordinating Center and a Rare Diseases Clinical Research Consortia, with both due on October 9th, 2018. To read the announcement, click here .

In addition to funding opportunities, the 5th Conference on Clinical Research for Rare Diseases, hosted by the Rare Disease Clinical Research Network, will take place on October 4th, 2018 at the Hilton Rockville Hotel & Executive Meeting Center. To learn more about this conference, click here .
Research in the Headlines
Funding Opportunities
Spotlight on Success
Einstein-Montefiore investigators continue to succeed in obtaining funding. Some of these investigators with new grant awards are:

Praveen Ballabh MD , Professor, Departments of Pediatrics (Neonatology) and Neuroscience, Anjali Sharma MD , Associate Professor, Department of Medicine (General Internal Medicine), Kamran Khodakhah PhD , Professor, Departments of Neuroscience, Psychiatry and Behavioral Sciences, and Neurology, Ava Liberman MD , Assistant Professor, Department of Neurology, Thomas Ow MD , Assistant Professor, Departments of Otorhinolaryngology - Head & Neck Surgery and Pathology.
Harold and Muriel Block Institute for Clinical and Translational Research