February 2015 Issue  

Clinical Trials Office, 

The Clinical Trials Office (CTO) provides assistance in the design, execution, and evaluation of veterinary clinical trials  using client-owned animals, with the overriding goal of advancing the diagnosis and treatment of disease in veterinary patients while enhancing the health of humans. Read More
In This Issue
Dogs with mast cell tumors

In dogs, mast cell tumors

(MCT) express a protein on the

surface of the cells called KIT, this protein is known to drive the uncontrolled growth of this cancer.

 Because of its ability to inhibit KIT function, anti-KIT monoclonal antibody is currently being investigated as a therapeutic option for treating tumors in which KIT plays an important role

The objective of this study is to assess changes in KIT expression and to assess response to therapy in dogs with MCT following administration of an anti-KIT monoclonal antibody. 

Do you want to know if your dog qualifies? Click here

Dogs with a cardiovascular disorder 

Myxomatous mitral valve degeneration (MMVD) is the most common cardiovascular disorder of dogs, which leads to progressive heart enlargement and heart failure.


Current techniques are unable to accurately predict which dogs will develop symptoms and how soon such symptoms may occur.


The purpose of this study is to evaluate measurements in dogs with mitral valve disease, with the expectation that dogs with more advanced disease will show greater abnormalities than dogs with mild disease. Read more

Dogs with environmental allergies

KIT is a protein expressed on the surface of mast cells that is critical for their normal growth, development, and survival. 

In dogs with atopic dermatitis (environmental allergies), mast cells that express KIT on their cell surface are over-activated and drive a perpetual itch-scratch cycle with associated inflammation. 

Anti-KIT monoclonal antibodies bind to KIT cellular receptors and prevent its' ability to promote the growth and activation of mast cells. The inhibition of KIT function with anti-KIT monoclonal antibodies is currently being investigated as a therapeutic option for the treatment of dogs with mild to severe atopic dermatitis. Read More
Upcoming Trials
Cats with Diabetes 
Diabetes Mellitus (DM) is a common disease of domestic cats.  Cats are diagnosed with DM only after clinical signs appear.  By this time, the management of the disease is difficult, costly, and often associated with life threatening complications. 

Cats with DM often are euthanized because of treatment difficulties for the owner. The purpose of this study is to evaluate potential candidate tests for diagnosis of DM before clinical signs appear.  

Do you want to know if your cat qualifies? click here
Meet Macy

This is Macy, one of our clinical trial patients. 

Kaleigh Peters will tell you that her dog Macy is a typical Doberman. "She's very smart," Kaleigh said, adding how the 8-year-old pup loves people, knows lots of tricks, is great with kids and was easy to train. 

Unfortunately, Macy has a history of chronic lameness that worsened after activity, causing her to limp. Concerned, Kaleigh scheduled an appointment for Macy with the Veterinary Medical Center's Orthopedic Service, where she was diagnosed with osteoarthritis. 

To read more about Macy click here 
The Ohio State University 
Clinical Trials Office � - Veterinary Medical Center 
601 Vernon L Tharp St, Columbus, OH 43210
Phone: 614-247-8706 | Email: cvm-clinicaltrials@osu.edu