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King of Prussia’s commercial market continued its momentum in the second quarter of 2025, with notable changes across several sectors. This quarter, we adjusted the life sciences category to include all property types related to life science uses, not just R&D spaces. This expanded definition now covers office, industrial and flex properties occupied by life sciences companies. As a result, vacancy and inventory figures for life sciences and other categories shifted slightly.


Class A office vacancy rose to 12.8%, ending a seven-quarter streak below 10%, while total inventory held steady at 4.4M SF across 45 properties. Class B vacancy increased to 14.3% and Class C rose to 12%. Overall, the combined office vacancy rate for spaces over 10K SF increased to 13.3%. The total office vacancy rate, which includes owner-occupied spaces but excludes properties under 2K SF, increased to 11.8%, encompassing 8M SF across 171 properties.


The industrial sector remained strong, with vacancy rising slightly to 3.7% across 7.6M SF. Flex vacancy increased to 12.8% across 2M SF, reflecting consistent demand for spaces that blend office, light industrial and showroom functions. Retail continued to perform well with a stable vacancy rate of 2.3%, supported by a diverse mix of shopping, dining and entertainment options.


The medical sector experienced an increase in vacancy to 19.7% across 495K SF. Life sciences, under the new broader definition, recorded a vacancy rate of 7.7% across 2.3M SF. With 2.8M SF total, the King of Prussia/Valley Forge submarket continues to lead as a premier hub for life sciences activity in the region.

 

King of Prussia’s commercial real estate market continues to attract investment and new opportunities, reinforcing its position as a top-performing submarket in the Philadelphia region.

Qi Guo

Manager of Research & Data Analytics

King of Prussia District

Featured Business

Ecolab Life Sciences Expands in King of Prussia with New Lab and Resin Launch

Ecolab Life Sciences, a division of global hygiene and water treatment leader Ecolab Inc., has expanded its presence in the biopharmaceutical sector with the launch of a new Bioprocessing Applications Laboratory in King of Prussia. According to Twin Cities Business, the lab is housed within a 74K SF facility originally opened by Purolite in 2022. The site now serves as the headquarters for Ecolab’s Life Sciences division and employs approximately 75 people. Ecolab acquired Purolite in 2021 for $3.7B.

 

Announced on May 14, 2025, the new lab is designed to support the development of purification processes for biologic therapies, offering advanced technical services to help clients improve process efficiency, regulatory compliance and scalability across production stages.

 

Following the lab opening, Ecolab introduced Purolite AP+50, a next-generation resin aimed at reducing costs and improving operational efficiency in antibody manufacturing. According to Contract Pharma, the resin offers high dynamic binding capacity and manufacturing consistency through Ecolab’s proprietary jetted bead technology.

 

Together, the new lab and resin reinforce Ecolab’s commitment to advancing biopharmaceutical innovation and becoming a global technical partner to the life sciences industry.


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Valley Forge Casino is Spending Big in the Fight to be PA's Top Gambling Destination

Netflix House at King of Prussia Mall will have Mini-Golf, Virtual Reality Games, and a 'Wednesday' Themed Carnival

Industry Spotlight

King of Prussia/Valley Forge Life Sciences Submarket: The Largest Life Sciences Submarket in the Greater Philadelphia Region


With its strategic location at the crossroads of Southeast Pennsylvania's most traveled highways, King of Prussia is not only a premier shopping and business hub but also a leader in the region's life sciences market. The King of Prussia/Valley Forge submarket boasts 2.8M SF of life sciences space, leading the region with 41.2% of the total suburban inventory.

“At 2.8M SF, the King of Prussia/Valley Forge submarket is the largest life sciences location in the Philadelphia region. We are enormously proud that so many pioneering and innovative companies call KOP home,” said Eric Goldstein, President & CEO of King of Prussia District. As of Q2 2025, UMT/KOP is home to 17 life sciences properties spanning 2.3M SF, with a 7.7% vacancy rate.

 

Explore our life sciences portfolio and see what is driving growth in the region through our newly released Life Sciences Story Map.


Survey

KOP Data Dashboard: We'd Love to Hear Your Input!


Since its launch in January 2025, the KOP Data Dashboard has attracted over 10,000 views from users around the world. We’d love to hear your input via a brief 5-minute survey to help us enhance your experience and ensure the dashboard continues to meet your needs.


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Sales


Merion Henderson Mob LLC

700 S. Henderson Rd.

$11.825M


Braefield Enterprises Incoporated

771 5th Ave.

$5M


625 Clark Ave.

Suite 18

$514K


Leasing


3300 Horizon Dr.

92,000 SF


511 Fehely Dr.

32,400 SF


2900 Horizon Dr.

8,002 SF

1005 W. 9th Ave.

4,202 SF


150 S. Warner Rd.

3,946SF


1000 Continental Dr.

3,632 SF


700 S. Henderson Rd.

3,459 SF


660 American Ave.

2,183 SF


660 American Ave.

1,500 SF


700 S. Henderson Rd.

821 SF



* Commercial Office

* Industrial/Flex

* Retail

* Medical

Not a complete listing. All sales and leasing info from CoStar.

King of Prussia District is a 501(c)3 that accelerates economic growth by making King of Prussia vibrant, attractive and prosperous. This mission and our core values –progressive, determined and fun – drive the work that we do every day across five programs. 

 


Learn more at visitkop.com

DISCLAIMER

All information obtained using CoStar Analytics and field checked for accuracy by King of Prussia District. Vacancy rates are calculated using existing, non-owner occupied commercial buildings in Upper Merion Township only, over 10,000 SF, Class A, B, and C plus retail, industrial and flex. King of Prussia District uses "Direct % Vacant Available" in its vacancy reporting. All industrial and flex statistics are NNN.

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