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Compritol® 888 ATO is an atomised powder of glyceryl dibehenate ideal for lubrication. It complies to USP-NF, EP, ChP, FCC and is a GRAS ingredient.

Inert

  • Does not react with API or excipients
  • Lipid with less than 1% water
  • Very low level of impurity


Effective

  • Reduces friction
  • Avoids sticking
  • Maintains tablet properties (hardness, disintegration time, drug release)


Robust

  • Insensitive to mixing conditions
  • No difference between lab and pilot scale
  • Use level: 1 to 3%

Comparison of lubricant's behaviour during mixing

Compritol® 888 ATO


  • Spherical particles
  • No change in shape, size and specific surface area during mixing
  • Not affected by mixing time and speed
  • No risk of over lubrication

Magnesium stearate


  • Flake particles
  • Particles tend to split during mixing, creating new lubricant surfaces
  • Affected by mixing time and speed
  • Risk of over lubrication

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