February 13, 2019
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Effectiveness of Clinic-Based vs. OR-Based Debridement: Controlling Bacteria

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Study Cites Factors Linked with Increased Reoperation After Above-Knee Amputation
There is an increased chance for unplanned reoperation in patients who underwent above-knee amputation if they had prior revascularization, multiple indications for amputation and postoperative wound complications, according to a recently published study. Researchers performed a retrospective review of 155 patients who underwent a total of 185 above-knee amputations. Data on standard demographics, comorbidities, perioperative data and postoperative data were collected. Investigators also calculated Pearson x2 tests, Fisher exact tests and logistic regression models.

Ketoprofen 'A Huge Step Forward' for Treatment of Lymphedema Symptoms 
The anti-inflammatory drug ketoprofen appeared to effectively treat lymphedema symptoms and ease the burden of care, according to study results. “Ketoprofen restores the health and elasticity of the skin. ... I believe it will reduce recurrent infection [and] can also reduce swelling,” Stanley G. Rockson, MD, professor of cardiovascular medicine at Stanford University School of Medicine, said in a press release. “This new treatment does not cure lymphedema, but our studies show it has the capacity to make the illness more livable and more workable.”
Patients with IBD Receive Suboptimal Preventive Care Consultations
Despite existing guidelines for preventive care in patients with inflammatory bowel disease, providers fell short of expectations in consultations at a tertiary care center, according to a presenter at the Crohn’s & Colitis Congress. “Many of our IBD patients are at higher risk of things like infections, specific malignancies, metabolic bone disease and mental health disorders not only as a product of the disease itself, but also the therapies employed. What’s important to remember about these is many of them are preventable,” Amanda Lynn, MD, a gastroenterology fellow at Mayo Clinic, Rochester, said during her presentation.

UCI-Led Study Reveals How Blood Cells Help Wounds Heal Scar-Free
New insights on circumventing a key obstacle on the road to anti-scarring treatment have been published by Maksim Plikus, an associate professor in developmental and cell biology at the UCI School of Biological Sciences and colleagues in Nature Communications. The research team discovered that the natural scar-free skin repair process relies partially on assistance from circulating blood cells. The results point the way toward possible treatments for scar-free wound healing that target the body's own blood cells.

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