June 5, 2020
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Note: The first edition of today's newsletter incorrectly noted the deadline for the Rapid Response COVID-19 Related Pilot Funding Research Opportunity as July 15.
The submission deadline is June 15 .
Member/Center Highlights
Join Team Case CCC for Virtual VeloSano!
VeloSano is more than a fundraising event. It's more than simply a bike ride, and this year, it has gone virtual! VeloSano is a movement with the goal of bringing an entire community together to help one another. The Case Comprehensive Cancer Center (Case CCC) is honored to participate for its sixth year in a row. Together, our team of Case CCC employees and friends are once again joining the movement to raise money for the cause. Team Case CCC is made of passionate individuals who are committed to cancer research, prevention, treatment, and cures! 100% of the money we raise will support lifesaving cancer research in Northeast Ohio's top-tier hospitals and research institutions.

Virtual VeloSano has no fundraising minimums or registration fees and "riders" are able to track their participation in their favorite activity such as biking, hiking, swimming, even gardening any time between now and October 1. VeloSano's signature "Bike to Cure" weekend will still take place virtually, complete with a streaming Kickoff Party and more!

Although we won't be able to unite in person, the need to fund cancer research remains more important than ever. We look forward to seeing our team's virtual participation through photos and videos on social media using hashtag #TeamCaseCCC or tags to @caseccc as we train and rally together remotely. Our continuing goal is to bring sustainable funding to cancer research by enlisting the passion and energy of thousands of people who wish to give back…including YOU! We raised nearly $94,000 last year and our team's participation has collectively brought more than $1,500,000 back to the Case CCC for funding pilot research projects. We are truly grateful for your commitment to the cause and hope you will join or support our efforts this year!
Today: AACI/AACR Joint Virtual Day of Action
For a joint virtual day of action today, Friday, June 5, AACI and the American Association for Cancer Research (AACR) have drafted a letter for the associations' members to share with their representatives. The letter builds on AACI's previous request for increased funding for the National Institutes of Health (NIH) and the National Cancer Institute (NCI) in fiscal year (FY) 2021, with additional requests related to COVID-19.
Cleveland Clinic Abstract Awarded First Place for Presentation at AACI Clinical Research Innovation Annual Meeting
The Association of American Cancer Institutes (AACI) Clinical Research Innovation (CRI) Annual Meeting is being held virtually Tuesday July 7 - Wednesday July 8. The AACI CRI Steering Committee, with peer reviewer assistance, have selected three abstracts for formal presentation during a virtual session on Wednesday, July 8.

The Case Comprehensive Cancer Center extends congratulations to Kimberly Jenkins, Joshua Workman, Lindsey Mooney and Megan Kilbane from Cleveland Clinic Taussig Cancer Institute for their winning abstract, "Standardized and Personalized Training Results in Increased Job Satisfaction and a Reduction in Turnover."
All accepted program abstracts are now available for viewing in advance of the July meeting. A total of five abstracts [abstracts 24, 45, 46, 62, 70] were accepted from the Cleveland Clinic. Abstract 24, "Capturing Metrics for the First Stage of Protocol Review at a Consortium Cancer Center" is authored by the Case Comprehensive Cancer Center's Kevin Hoy, April Firstencel, John Pounardjian and Josephine Chan and Cleveland Clinic's Kimberly Jenkins, Lindsey Mooney, and Megan Kilbane.
Artificial Platelet Technology Developed in Sen Gupta Lab Licensed by Haima Therapeutics
From The Daily: Haima Therapeutics has executed an exclusive license agreement with Case Western Reserve University to research, develop and market artificial platelet technologies to treat patients with various bleeding disorders.

The core technologies were developed in the laboratory of Professor Anirban Sen Gupta, PhD a pioneering researcher in platelet-inspired technologies in the Department of Biomedical Engineering at the university’s Case School of Engineering. Dr. Sen Gupta is a member of the Case Comprehensive Cancer Center's Cancer Imaging Program.
SynthoPlate is a synthetic platelet techonology that can mimic natural platelets' ability to stop bleeding.
2020 CTSC Annual Pilot Award Recipients
The Case Comprehensive Cancer Center extends congratulations to three members who recieved three of seven annual pilot awards supported by the Clinical & Translational Science Collaborative (CTSC). Projects were selected for their potential for moving ideas and/or technologies towards patients. This includes drug and device development, interventions, and research methods and processes in the translational space, including implementation science.
Cleveland Clinic Lerner College of Medicine

“Correlation of Orthogonal Plasma Biomarkers to Improve Hepatocellular Carcinoma Detection and Prognosis”
Case Western Reserve University School of Biomedical Engineering

“Development of a Prostate Cancer Risk Stratification Nomogram Integrating Clinical Variables and MRI Derived Radiomic Signatures for Patients on Active Surveillance”
Louis B. Stokes VA Medical Center

“NeutroStat: Neutrophil-Targeted Nanomedicine for Treating Venous Thromboembolism (VTE)”
Gupta Lab seeking postdoctoral fellow
The Gupta Laboratory, in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute, has an immediate opening for a Postdoctoral Fellow. Individuals with demonstrable experience in mechanistic immunology research, B cell biology, mouse models of autoimmunity and/or inflammation and/or infection, and a strong record of publication are encouraged to apply. The successful candidate will design, implement and manage exciting research projects addressing the regulation of B cell antibody response during infection and inflammation.

Candidates must be proficient in immunological techniques (multicolor flow cytometry, ELISA), cell culture, and molecular biology methods (western blotting, quantitative PCR, lentiviral gene expression, and CRISPR/Cas9 gene modification). Prior experience in murine lung and colon isolation and analysis is an advantage, as is cellular imaging. Excellent verbal and written communication skills are essential. The appointee will be expected to take advantage of this career opportunity to further develop skills in manuscript publication and grantsmanship.

Applicants must have a PhD. or an MD/PhD degree in immunology, with strong motivation, a passion for science, ability to work as a team and design experiments independently, and a strong work ethic. Proficiency in spoken and written English is required. Send a cover letter describing research accomplishments, future interests and career goals, CV and contact information for 3 references to Dr. Neetu Gupta at guptan@ccf.org .
Members: How has your research been affected by COVID-19?
We are collecting stories on how labs have shifted in response to COVID-19. If you have changed your work patterns and made discoveries despite COVID-19, or are adjusting your research to assess COVID-19, we would like to hear from you.

Please send stories and comments to cancer@case.edu.

We appreciate you taking the time to share your stories with us. Please let us know if there is anything Cancer Center administration can do to assist you.
Case CCC COVID-19 Resource Hub
As the COVID-19 outbreak progresses, the Case Comprehensive Cancer Center (Case CCC) has centralized COVID-19 related news, resources and funding opportunities for our cancer center community. Content is updated regularly.

To have a cancer-focused resource added to the page, please email  cancer@case.edu.
What's Coming Up
Mark Your Calendar
Virtual Race for The Place 2020
Through June 7, 2020
Facebook and Instagram Live

The Gathering Place is hosting its annual "Race for the Place" 5K and 1-mile run/walk virtually through National Cancer Survivors Day, this Sunday, June 7. Proceeds from Race for the Place help support their free programs and services.

For the safety of participants and the community and in light of the ongoing concerns around COVID-19, The Gathering Place has made the decision to hold a virtual Race for the Place. They have compiled virtual race ideas and will host their Cancer Survivor Ceremony at 9:00 am Sunday, June 7 on Facebook and Instagram Live.

Race for the Place is a particularly important event for The Gathering Place. It is their only annual fundraiser and provides significant financial support to keep their programs and services free of charge to help individuals and families cope with the impact of cancer in their lives. COVID-19 has not stopped the needs of our participants and they continue to provide free programs every day through GoToMeeting, Zoom, the telephone and Facebook Live.

The Gathering Place is a caring community that supports, educates and empowers individuals and families currently coping with the impact of cancer in their lives through programs and services provided free of charge.
Save The Date: Virtual Annual Scientific Retreat (Members and Trainees Only)
July 23-24, 2020

The Case Comprehensive Cancer Center invites all members and trainees to mark their calendars for Thursday, July 23 and Friday, July 24, 2020 for our annual scientific retreat! This year's retreat will be held virtually.

Thursday's events are scheduled from 12-2:30pm including TED talks from prominent Cleveland researchers and a cancer center update from Director Stan Gerson, MD.

The retreat will continue on Friday at noon with a keynote presentation from Timothy Rebbeck, PhD, the Vincent L. Gregory, Jr. Professor of Cancer Prevention at the Harvard T.H. Chan School of Public Health and the Dana-Farber Cancer Institute. Dr. Rebbeck is founding director of the Zhu Family Center for Global Cancer Prevention at the Harvard TH Chan School of Public Health and leads the Cancer Outreach and Engagement activities for the Dana-Farber Harvard Cancer Center. Friday's agenda will conclude with research program breakout sessions.

Retreat registration and full agenda are forthcoming. Please contact Mary Wright ( maw143@case.edu) should you have any questions about the retreat.
Save The Date: Artificial Intelligence in Oncology Symposium 2020
October 19-20, 2020
Tinkham Veale University Center, CWRU

The second annual Artificial Intelligence in Oncology Symposium will bring together experts in AI and machine learning this October at Case Western Reserve University.

Geraldine McGinty, MD, MBA, FACR will present the symposium plenary, "Fostering a Strong Ecosystem for AI in Medical Imaging." Dr. McGinty is an internationally recognized expert in imaging economics, Chair of the American College of Radiology Board of Chancellors and Chief Strategy and Contracting Officer at Weill Cornell Medicine in New York City.

Additional keynotes in drug discovery, ethics & policy and pathology will be delivered by Russ Altman, MD, PhD of Stanford University, Vinay Prasad, MD, MPH of the University of California, San Francisco, and Yinyin Yuan, PhD of the Institute of Cancer Research, London. Learn more about AIO 2020 speakers.
Rescheduled: Great Lakes Breast Cancer Symposium
May 23-25, 2021
Tinkham Veale University Center, CWRU

Originally scheduled for October 4-6, 2020, the next Great Lakes Breast Cancer Symposium has been rescheduled for Sunday, May 23 - Tuesday, May 25, 2021.

The symposium highlights ongoing basic, translational, clinical and population studies addressing the biological mechanisms, management and prevention of breast cancer. Researchers from participating institutions will share their exciting work with a goal to develop cross-institutional collaborations.
Additional Upcoming Events
AACR Virtual Annual Meeting: Part II
June 22-24, 2020
The AACR Virtual Annual Meeting II, June 22-24, will feature the originally planned Opening Plenary Session that explores the range of impactful cancer research and clinical translation; award lectures from individuals who have made extraordinary contributions to the cancer field; a special talk from National Cancer Institute Director Ned Sharpless, MD; and thousands of proffered papers in minisymposia and on an e-poster platform.
AACR Virtual Meeting: COVID-19 and Cancer
July 20-22, 2020
This special AACR conference will focus on the presentation of emerging data in basic, clinical, and epidemiologic research related to COVID-19 and cancer. The program will feature a mix of keynote lectures and other invited presentations, short talks from highly rated abstracts, virtual posters, and forums that include panels of experts from various fields. It is anticipated that this must-attend virtual event will attract participants from across the international research community.

Submit an abstract by Tuesday, June 9. 
12th Annual AACI Clinical Research Innovation (CRI) Meeting
July 7-8, 2020
Registration is now open for the 12th Annual AACI CRI Meeting, Cancer Clinical Research: Focus on the Future.

Registration for the two-day, virtual meeting is free for AACI cancer center members and sustaining members. AACI is working to ensure that the online meeting, scheduled for July 7-8, will still deliver the innovative, quality education that its members have enjoyed at prior CRI annual meetings.

More information, including the program and registration, is now available on the CRI meeting website.
Funding Opportunities
Deadline: June 15, 2020*
*corrected deadline
The COVID Research Taskforce is pleased to announce a request for applications (RFA) for research pilot opportunities to support COVID-related research across the university and within our healthcare system partners.

Over $500,000 from the NORD Family Foundation and six funding groups across campus have supported this effort:

  • NORD Family Foundation
  • Case Comprehensive Cancer Center
  • Center for AIDS Research (CFAR)
  • Cleveland Brain Health Initiative
  • Clinical and Translational Science Collaborative (CTSC)
  • Digestive Health Research Center
  • Mary Ann Swetland Center for Environmental Health

In response to the SARS-CoV-2 pandemic, the COVID Research Taskforce recruited 268 faculty with diverse interests. This Rapid-Response COVID-19 Pilot Program was created to support this effort and new research initiatives that will make immediate progress towards reducing the harm to individuals, groups, and society from SARS-CoV-2 and the COVID-19 pandemic. Together the funding partners seek shovel-ready applications that address a wide range of COVID-related questions including understanding and advancing knowledge on fundamental virology, immunology, evolution, natural history and pathogenesis of SARS-CoV-2; barriers and challenges in testing, tracing, diagnosis and treatment; impact of the pandemic on vulnerable populations (e.g., cancer patients, those with chronic conditions), health care workforce, health care utilization and impact on physical and mental health of the community.

Projects focusing on the use of informatics and understanding disparities are encouraged.

The CTSC will oversee the application and review process, working closely with the Taskforce and each of the seven funding groups to identify the best projects that align with each of their funding requirements.
Internal LOI deadline: Sunday, June 21, 2020
The Case Comprehensive Cancer Center has been invited to submit applications from junior faculty for the Gabrielle's Angel Foundation 2020 Medical Research Awards. Gabrielle’s Angel Foundation funds cutting-edge research in the fields of leukemia, lymphoma, and related cancers of the blood.

The awards provide $75,000 of support per year over three years, not to exceed $225,000. Applications in conventional and integrative research are being accepted.

Interested candidates are asked to submit an LOI (including PI contact information and an abstract/project summary) and biosketch to casecccpilots@case.edu by Sunday, June 21, 2020. Contact casecccpilots@case.edu with questions.
In The News
Global Engage - May 27, 2020
Anant Madabhushi, PhD was interviewed by Life Sciences/Global Engage about knowledge sharing across the global science community. Madabhushi will be speaking at the 6th Digital Pathology & AI Congress: USA in November 2020. Dr. Madabhushi, member of the Case CCC's Cancer Imaging Program, is professor of biomedical engineering at CWRU and director of the university's Center for Computational Imaging and Personalized Diagnostics. He is also chair of the planning committee for the upcoming Artificial Intelligence and Oncology Symposium.
From The NIH
Weekly NIH Funding Opportunities and Notices

Funding Opportunities:
Deadline: March 17, 2021, March 17, 2022, March 17, 2023

Deadline: March 17, 2021, March 17, 2022, March 17, 2023  

Deadline: October 2, 2020 

Deadlines: August 3, 2020; March 8, 2021; November 2, 2021; August 1, 2022; March 13, 2023

Deadlines: August 3, 2020; March 8, 2021; November 2, 2021; August 1, 2022; March 13, 2023
COVID-19 Funding Opportunities and Notices
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