Learn about the products that will improve your Cryo-EM workflow by simplifying the steps in grid preparation, allow you to take control of the variables influencing your grid quality, increase efficiency, and easily organize, track and ship your prepared grids.
Another MiTeGen Product Contributing Towards a Solution to Covid-19
This article at Nature,
Structural Plasticity of SARS-CoV-2 3CL Mpro Active Site Cavity Revealed by Room Temperature X-ray Crystallography, reports on "the room temperature X-ray structure of unliganded SARS-CoV-2 3CL Mpro, revealing the ligand-free structure of the active site and the conformation of the catalytic site cavity at near-physiological temperature. Comparison with previously reported low-temperature ligand-free and inhibitor-bound structures suggest that the room temperature structure may provide more relevant information at physiological temperatures for aiding in molecular docking studies."
Our MiTeGen room-temperature capillary setup was used in this study.
This is another example of how MiTeGen products are supporting researchers working on a solution to COVID-19.
The room-temperature capillary setup allows for room temperature diffraction screening and data collection. Go from a crystal in a drop to a crystal in the X-ray beam at room temperature quickly and easily. Collect room and low temperature data from the same crystal to evaluate your crystal and cryopreservation protocol.
New Product - Barcoded Autogrid Compatible Cryo Grid Box
We recently introduced the Barcoded Autogrid Compatible Cryo Grid Box. What makes these unique is the ability to add custom barcodes to them which allow you to easily track them and stay organized.
Structural Contributions to SARS-CoV-2 and the COVID-19 Pandemic
We are sponsoring the
Structural Contributions to SARS-CoV-2 and the COVID-19 Pandemic session on Tuesday August 4th. This session features six speakers covering such topics as structures of the main protease, curation of structures, vaccine targets & more.
Given the importance of structural biology and related fields, there are numerous job openings available. Listed below are some of the latest ones we are aware of:
Microscopist / Image Processor - Lead Discovery (LD) department in Pharma Research and Early Development (pRED), the research arm of Roche (Basel) is searching for a microscopist / image processor for its growing structural biology group.
Postdoctoral Scientist - The lab of Dr Satpal Virdee is searching for a postdoctoral scientist for work on a project involving definitive structural characterization of the large, multi-subunit E3 ligase complex centered on the unusual E3 machinery present within MYCBP2. Motivated candidates should ideally have recently carried out a PhD working in the area of structural biology with experience in cryoEM and/or crystallography.
Postdoctoral fellow - There is an opening for a postdoctoral fellow in the laboratory of H. Furukawa at Cold Spring Harbor Laboratory (CSHL) located in the suburb of New York City. The lab is interested in identifying and understanding molecular machinery involved in the brain physiology and neuron-cancer interfaces by a combination of biochemistry, cryo-EM/crystallography, electrophysiology, antibody engineering, reagent development, and more.
Postdoctoral position in X-ray crystallography, NMR, cryo-EM, single molecule tracking, cell biology is available in the lab of Dr. Kyung Lee at the NIH
2 Fully funded post doc positions are available at the Jovine Lab. These positions will use cryo-electron microscopy and cryo-electron tomography for visualizing the molecular basis of gamete recognition
A Research Technician position is available in the High Throughput Crystallization Laboratory (HTX Lab) at EMBL Grenoble, Grenoble, France
Industry Resources and News
Here is a small selection of hand picked industry resources and news for your browsing.
MDPI Special Issue "X-ray Diffraction Methods in Crystallography" edited by Prof. Stanko Popović and Prof. Željko Skoko is now open for submissions. Deadline is January 31st, 2021 - Learn More
Video series from Diamond Light Source illustrating how the XChem facility is using protein crystallography to study "main protease" (a.k.a. MPRO), a critical part of the molecular machinery that the virus builds to replace itself. - Learn More
Journal of Synchrotron Radiation as an open call for a new Main Editor to join leadership team - Learn More
EIPOD4 is a new international postdoctoral fellowship programme co-funded by Marie-Skłodowska Curie Actions. Designed to support the increasing diversity of career paths in Europe’s research landscape the programme offers an academic, industry and clinical track for fellows to choose from based on their research interests and career aspirations. - Learn More
Flashback To The Past - Real-Time Protein Crystal Growth on ISS
Flash back to the past - Our modular In Situ-1 crystallization plate floating aboard the International Space Station with the earth as a background! This was part of an experiment that "sought to demonstrate the feasibility of conducting protein crystal growth experiments in real time onboard the ISS."
