In This Issue:



🎈2025 Impact Report - A Defining Moment in JM

🎈Join Us for Our Biggest Season of Hope Yet

🎈Cure JM Funded NATA Project - A New Way to "Turn Off" Inflammation

🎈Your Research Participation Could Lead to Better Treatments

🎈Walk Strong Fall Schedule - Small Steps, Big Impact!

🎈Upcoming Regional Events, Training, and Online Events



For our complete listing of available resources, click here.

To learn more about our current research projects, click here.

To learn more about the Cure JM Foundation and how to join, click here.

As we open a new fiscal year, we are pleased to share the progress that you made possible over the last year. 2025 has been a defining year as we reached new levels of accomplishment and expanded our mission.

You are the power behind this progress and momentum.

Throughout this remarkable year, we've celebrated continued progress and reached new milestones. For 23 years, we have remained laser-focused on our mission to fund research that improves treatments and care while supporting families on this journey toward a cure.

As we look back on 2025 through our Impact Report, we are proud of the progress our Cure JM families and supporters made possible. The research and programs we funded over the past year are changing the trajectory for children and young adults.

Backed by funding from the Cure JM Foundation, scientists at the UK’s Nucleic Acid Therapy Accelerator (NATA) are creating tiny medicines that press the “quiet” button on the immune system’s mistaken alarm that causes myositis.

Think of your immune system like a safety alarm. Interferon beta is the warning that blasts when a virus shows up. It tells the immune system to wake up and get to work. In JM, sometimes that alarm gets stuck on even when there is no danger. A loud, nonstop alarm makes the immune system overreact. In juvenile myositis, that constant signal can inflame muscles and make kids feel weak, sore, and tired.

If the immune system “alarm” can be quieted, the immune system may calm down, and muscles, skin, and blood vessels may be protected. This is an early lab step, not a treatment for people yet, but it points toward a new way to help without heavy steroids.

This innovative research collaboration is a powerful example of your support leading to real-world impacts.

The season of "hope" is approaching, leading up to the biggest day of the year for Cure JM! Giving Tuesday, December 2, 2025, is a day of global generosity when billions of dollars will be donated to charity. 

As JM families, we want some of this powerful generosity to be directed at Cure JM to improve and empower the lives of our kids. Because JM is so rare, research is only made possible by families like yours, who deeply care about the futures of our kids.

Federal funding for rare disease research is more limited than ever before during these unprecedented cuts. Together, we must fight for continued progress through our own funding efforts.

Your participation in our holiday challenge helps us transform lives by turning hope into life-changing healing.



Watch this video message from Cure JM mom and Director of Family Engagement, Shannon Malloy. She explains how easy it is to join and why this special time of year is so critical to our success.

Learn more and join us at www.curejm.org/hopehero. 

For rare diseases like juvenile myositis, every patient and family who participates in research makes an enormous difference. Because the patient population is so small, progress depends on as many families as possible joining together to fuel discoveries. Your participation may help researchers discover better treatments and bring us closer to a cure.

Here are three important opportunities available now:

1. CAR-T Clinical Trial Now Open at Three Sites



Enrollment has begun for the first-ever CAR-T trial in juvenile myositis at:

• Children’s Hospital of Philadelphia (CHOP)
• UCSF Benioff Children’s Hospital
• University of Chicago Comer Children’s Hospital

Many additional sites are accepting adult patients. Please email clinicaltrials@cabalettabio.com to learn more.

This trial is a bold new chapter in JM care and may offer the potential for an “immune system reset.” Learn more here: 

2. Donate a Past Skin Biopsy for Research

If your child has ever had a skin biopsy, researchers are asking families to consider donating it for use in a new study. There are no additional tests performed. Donate the past biopsy by filling out this form - Skin Biopsy Donation Form

3. MyoRisk Study for Patients with Anti-Synthetase Autoantibodies

This study is currently enrolling patients who have tested positive for Jo-1 or other anti-synthetase autoantibodies within the first two years of diagnosis. Enrollment can be completed from home, without any travel. Click here for MyoRisk Study Info.

Families also explore additional opportunities to participate in clinical trials at Current Clinical Trials.

You can join the fight by taking important steps towards progress and a cure! Even small steps make a big impact!

Walk Strong events feature fun and friendship as our families celebrate the power of community and walk for progress. There is fun for the whole family, including children, teens, and young adults.

We'd like to thank all of our families and communities who are walking with us. Your steps propel our progress!

2025 Walk Strong events:  RSVP here to join a walk in your region!

• Boston, MA - Sunday, October 5th
• Houston, TX - Sunday, October 5th
• Austin, TX - Saturday, October 11th
• Nashville, TN - Saturday, October 18th
• Northern California - Saturday, October 18th

2025 Online Meetings, In-Person & Educational Trainings - Save The Dates!

We're excited to share upcoming regional and online events that support our community.

This updated page is your single stop for "being in the know" on upcoming chapter events, support meetings, educational training, and more happening in person and online.

October 2025 Online and In-Person Events:

• October 16th at 8:00 PM Eastern - "Cure Jm Dads' Connect Group" Register Now.

• October 18th at 12:00 PM Pacific - "Southern California Family Day" (In-Person Event) Register Now.

• October 23rd at 8:00 PM Eastern - "Monthly Cure Jm Grandparent Alliance Call" Register Now.



• October 27th at 8:00 PM Eastern - "Monthly Cure JM Moms' Connect Group" Register Now.

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