Question: The definition of progression on Form 2116 uses the wording 'definite increase' when referring to the size of an existing bone lesion. How do we report progression of disease for a Myeloma patient who has a 'slight increase'?
We consulted with CIBMTR's Myeloma expert who stated that a slight increase in the bone lesion alone would not count as progression. Below is an exerpt from the Form 2116 Manual that lists the requirements for reporting a patient's disease status as Progressive Disease:
Progressive Disease requires two or more of the following:
Progressive Disease reporting requires two consecutive assessments (by the same method) made at any time before classification as disease progression and/or the start of a new therapy.