Question: How do I determine what is clinically significant to report on the Pre-TED?
The Data Management Manual for the Pre-TED (2400) defines the term clinically significant as, . . . conditions that are being treated at the time of pre-HCT evaluation, or are in the recipient's medical history and could cause complications post-HCT.
Diseases or organ impairments that are clinically significant to report are based on the HCT comorbidity index (HCT-CI) published by Dr. Sorror (Source: Blood, 2005 Oct 15;106(8):2912-2919).
Since our form revision release in October 2013, the co-existing disease/organ impairment questions were eliminated from the Baseline (2000) form and are only located on the Pre-TED now. Serious conditions that are clinically significant to report are asked about one-by-one in questions 97-133. Answer those questions prior to answering question 96. Any 'yes' to those questions will indicate answering a 'yes' to question 96 also.
If a recipient has a medical history of something other than those conditions listed in questions 97-133, (for example, hypertension) you do not need to report that on the Pre-TED in the "Other, specify" field any longer.