Issue #12
Photo: UCSF Dentistry Dean Michael Reddy (center in doorway) and Associate Dean Eunice Stephens (right) provide UCSF leaders with a tour of the command center set up to support Dentistry’s launch of the Epic electronic health record last December.
UCSF Sees Benefits and Possibilities After Integrating Dental and Medical Records

The Next Horizon: Precision Oral Health
The vast amounts of data – past, current, and future – integrated into UCSF's electronic health record system hold potential for research that will discover connections between oral health and medical health. Data driven patterns from the health records will lead to new discoveries, connections and, ultimately, better, precise care and outcomes for the patient.
UCSF is First in California to Provide Drug-Gene Testing

Precision Medicine Milestone Will Result in Smarter Prescribing
UCSF Health was the first hospital system in California, and one of only a few nationwide, to offer pharmacogenetic testing. The testing program will provide critical clues about a patient’s unique genetic makeup, enabling pharmacists to tailor medications and dosages accordingly.

"Our vision is to deliver on the promise of precision medicine for all patients we and our partners serve,” stated Russ Cucina, UCSF vice president of Genetic and Genomic Services and program co-lead.
Precision Medicine News
Newborn Screening is Biggest Factor in ‘Bubble Baby Disease’ Survival in Last 40 Years
UCSF Pediatrics Professor Jennifer Puck, MD, has spent decades pushing for universal newborn screening to detect severe combined immune deficiency (SCID), a rare and deadly genetic disorder. Her grit was affirmed by a Lancet study directly showing that, by enabling earlier treatment, newborn screening was the most significant factor in improving survival outcomes in children with SCID over the last 40 years. Read more
Evolution Pt.1: How Our Ancestry Is Revolutionizing Precision Medicine
Tony Capra, PhD, weighs in on this podcast: Science has come to learn that one treatment plan or medication won’t work the same for every patient; every dosage and application needs to be tailored specifically for each person to have the best results. Listen here
TRANSPERS publishes first systematic assessment on payers’ evidence needs for coverage of “liquid biopsy” screening tests
Published in Health Affairs Scholar: Emerging & Global Health Policy, Trosman et al report results from the first systematic assessment on the perspectives and evidence needs of U.S. private payers on insurance coverage and future clinical adoption of multicancer early detection (MCED) tests. MCED tests have been named a top technology trend, and MCED tests are already on the market. Read more
TRANSPERS study finds insurer coverage remains variable for ctDNA use in cancer management
Circulating tumor DNA testing for cancer patients (ctDNA) is increasingly part of clinical care for initial targeted therapy, identifying therapeutic resistance, and measuring minimal residual disease after treatment. However, in a new study TRANSPERS collaborators found that insurer coverage remains variable. The study in the Journal of the National Comprehensive Cancer Network, reviewed private and Medicare coverage policies for ctDNA testing. Among 57 private policies, 89% specified a policy for at least one clinical indication, with coverage for ctDNA for initial treatment selection most common (69%). Read more
Awards and Honors
Tippi MacKenzie won the Erich Saling Perinatal Prize from the World Association of Perinatal Medicine given biennially to the best scientist in perinatal medicine. MacKenzie co-directs the UCSF Center for Maternal-Fetal Precision Medicine.
November 7, 2023
Save the date: Toward Algorithmic Justice in Precision Medicine, a workshop, will convene health system professionals, biomedical investigators, AI tool developers and community members, to consider systemic flaws in data collection, datasets, and AI tools, and how resultant algorithmic injustices can be uncovered and addressed, enabling equitable advances in precision medicine. Details here
October 5, 2023
The annual UCSF Health Equity and Anti-Racism Research (HEAR) Symposium showcases research and action to advance health equity and anti-racism. The purpose is to inspire future collaborations and research direction by highlighting the breadth and depth of health equity, health disparities and anti-racism research. Learn more
November 30 - December 1, 2023
Personalized Medicine’s 20th Anniversary: From Promise to Practice
January 24 - 26, 2024
Save the date: Precision Medicine World Conference (PMWC): Details here
February 15 - 17, 2024
2024 AAAS Annual Meeting will be held in Denver Colorado with the themes "Toward Science Without Walls" - it will explore the consequences of barriers that currently fragment our community, separating us by discipline, approach, institution, nation, access, wealth, seniority, race, and gender. The meeting will consider solutions, and envision a seamless ecosystem that would drive more innovative, equitable, rapid, open science and technology. Learn more
Office of Science Policy and Strategy
NASEM Report and Recording Available: "Toward Equitable Innovation in Health and Medicine: A Framework"
An ad hoc committee developed a cross-sectoral governance framework for considering potential benefits and risks that emerging science, technology, and innovation in health and medicine can bring to society, with a focus on equity. The study's work was also informed by prior work of the National Academy of Medicine's standing Committee on Emerging Science, Technology, and Innovation. Watch the report release webinar in which study co-chairs Keith Yamamoto (UCSF Vice Chancellor for Science Policy and Strategy / Director, UCSF Precision Medicine) and Keith Wailoo (Henry Putnam University Professor of History and Public Affairs at Princeton University) describe the report's key messages and recommendations. Read the Press Release & Full Report
Science editorial: Embed equity throughout innovation
Keith Yamamoto, Victor Dzau, and Keith Wailoo also provide perspective in Science on the NASEM report. Read here
Inaugural Spring 2023 Science Policy Minicourse - A Success!
This spring minicourse, developed in collaboration with the UCSF SPG and inspired by UC Riverside’s Science to Policy Program, focused on teaching graduate student scientists two core competencies: (1) knowledge of the policymaking process and (2) rhetorical skills for communicating with a variety of audiences, with special attention given to how these skills can be used in advocacy and social justice work. See highlights @SPGatUCSF
Science Technology Action Committee
It is critical to ensure that Congress doesn’t let the debt ceiling deal’s spending constraints preclude extension in FY24 of sustained bipartisan support for federal funding of science and technology (S&T) – investment in S&T innovation and training is essential to advance discovery and development, and to maintain US global leadership. See STAC Full Statement
UCSF and Coalition for Life Sciences (CLS) Science Fair on Capitol Hill
The Capitol Hill Life Science Fair and reception is a unique opportunity not only to showcase fun and interactive science but to make a strong case for federally funded research.

“The annual Congressional Life Science Fair, organized by the Coalition for the Life Sciences (CLS) and held in the Rayburn House Office Building on Capital Hill, is a great opportunity for investigators from universities, research institutes and companies to present hands-on demonstrations of scientific research to members of Congress and their staffs," said Keith Yamamoto. 
From left to right: Dan Karmlic, Daniel Sprague, Representative Anna Eshoo (CA-16), Elysse Philips, Sneha Rao
At this year’s event, on July 19, the UCSF Office of Science Policy and Strategy was proud to send three teams of trainees, staff and faculty to spend the day visiting congressional offices, and then to exhibit and explain their outstanding research at the Science Fair. No other institution presented more than one project.
From left to right: Elysse Phillips, Keith Yamamoto, Sneha Rao
American Society for Microbiology

Open science enables and empowers a global and diverse community to participate in and contribute to science. Keith Yamamoto shares thoughts on revisions to current systems and 3 approaches to make the adoption of open science more equitable in “Open Science: Steps Toward Equitable Access in Microbiology” by Rachel Burckhardt, Ph.D. Read here
North Carolina State Podcast: What if Service Was Your Main Focus?

Listen to this podcast featuring Keith Yamamoto sharing his path at UCSF, science policy and public service in a special NC State podcast series. Listen here
Radiation Effects Research Foundation

Keith Yamamoto serves on the Board of Councilors of RERF and attended the latest 2023 meeting. The principal focus of RERF’s research program is to study radiation effects in the survivors of the atomic bombings of Hiroshima and Nagasaki. Learn more
Promoting Equitable and Inclusive Implementation of Open Scholarship Policies: A Workshop

Keith Yamamoto delivered the welcoming remarks in this workshop that explored the implications of new policies and practices intended to advance open scholarship, particularly the August 2022 memorandum of the Office of Science and Technology Policy on Ensuring Free, Immediate, and Equitable Access to Federally Funded Research. Learn more
The Elements of Precision Medicine
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