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The DIRECTION-GD study is evaluating an investigational medication called YB-101. YB-101 is a monoclonal antibody (a kind of protein made by your immune system). The study drug is a monoclonal antibody, a type of protein created in a laboratory. Researchers want to learn whether YB-101 helps restore normal thyroid function and reduces the symptoms of Graves’ Disease.
You may be able to take part if you:
- are 18 years of age or older
- have a diagnosis of Graves’ Disease with or without Thyroid Eye Disease, and
- weigh at least 32 kg (71 pounds).
Note: Additional criteria apply.
Participants who are medically eligible will be randomly assigned to receive either YB-101 or placebo during the treatment period. The study drug and placebo are given as an injection just under the skin.
The study lasts up to 10 months, with a 24-week treatment period followed by a safety follow-up period. If you take part in the study, you will be provided with all study treatment, examinations, and medical care related to the study without charge. Assessments and procedures that are part of the standard of care for your condition may not be covered by the study.
Email vl@yarrowbioscience.com for more information or review additional details at Clinicaltrials.gov Study Details | NCT07682896.
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