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Dear Colleagues,
We’re pleased to bring you the June edition of Discoveries, with updates on research advances, new grants, recognition of our cutting-edge capabilities, and efforts to share our work with the community.
We welcome your feedback!
SBP Communications
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Study reveals protein that dials immune responses up and down
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Research led by Linda Bradley, Ph.D., has identified a new regulator of immune responses—a protein called PSGL-1. The findings, published recently in Immunity, open the door for a new approach to modulating T cell activity to treat infections, autoimmune diseases, and certain cancers.
Read more on Beaker >>
Select Media Coverage: ScienceDaily, Lupus News Today, Rheumatoid Arthritis News
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High levels of protein p62 predict liver cancer recurrence
New research from Jorge Moscat, Ph.D., and Maria Diaz-Meco, Ph.D., published in Cancer Cell in collaboration with UC San Diego, suggests that p62 could be used as a prognostic marker and potential therapeutic target for liver cancer.
Read more on Beaker >>
Select Media Coverage: Medical News Today,
ScienceDaily
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Blocking RANTES may slow growth of liver cancer
In a study published in Hepatology, the laboratory of Garth Powis, D.Phil., identified RANTES—a protein secreted by immune cells—as a new potential therapeutic target to treat liver cancer, the leading cause of cancer-related deaths worldwide.
Read more on Beaker >>
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Super-oncogenic protein that promotes development of melanoma
An international collaborative study led by Ze’ev Ronai, Ph.D., has identified a malicious form of a protein called ATF2 that drives the formation of melanoma. The findings, published in Cell Reports, may lead to novel therapies against these aggressive tumors.
Read more on Beaker >>
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Making ERK work as a therapeutic target for colorectal cancer
New research in Nature Communications, co-led by Petrus de Jong, M.D., Ph.D., postdoctoral associate in the laboratory of Garth Powis, D.Phil., points to a way to overcome the lack of efficacy of ERK1/2 inhibitors in treating colorectal cancer.
Read more on Beaker >>
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Francesca Marassi receives NIH Outstanding Investigator Award to study deadly pathogens
Francesca Marassi, Ph.D., has been awarded a $4 million grant to study how proteins on the surface of pathogens promote virulence by mediating first-line interactions with human host cells.
Read more on Beaker >>
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Cosimo Commisso explains cancer metabolism on NIH website
In a new article on the website for the National Cancer Institute’s RAS Initiative, Cosimo Commisso, Ph.D., discusses how the metabolism of cancer cells might vary in different parts of solid tumors.
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Sanford Burnham Prebys selected as designated center for Chemical Biology Consortium
Our institute has been chosen as a dedicated center for the NCI Experimental Therapeutics (NExT) Program Chemical Biology Consortium (CBC). The NExt Program supports discovery of drugs for targets with a clear path to the clinic or potential benefit to patients.
Kristiina Vuori, M.D., Ph.D., and Michael Jackson, Ph.D., will act as co-principal investigators.
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Welcome to our newest and recently renewed President's Circle Members!
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• Liz and Michael Copley
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Gigi and Edward * Cramer
• Barbara and Jim Dudl
• Anne L. Evans
• Lisa Haile
• Linda and David Hale
• Joye Blount and Jessie J. Knight
• Amy and Bill Koman
• Sue Raffee
• Peggy Walker-Conner
• Ellen G. Weinstein
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2016 Faculty Retreat highlights research advances, awards and promotions
The 2016 Faculty Retreat was held May 11-12 in beautiful Carlsbad, Calif. Special kudos to Duc Dong, Ph.D., for receiving this year's "WOW" award for best presentation about his novel approach to generate insulin-producing cells to treat diabetes.
Read more on Beaker >>
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Cancer survivors support our Cancer Center Open House
Our NCI-designated Cancer Center held an open house Thursday, June 9 to promote awareness of cancer research and to create dialog between our scientists and the community. The free event included laboratory tours and a reception where scientists were on hand to answer questions.
Read more on Beaker >>
Watch the KUSI video >>
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