October 2016
Dear colleagues,

In the October issue of Discoveries, we share the latest in science at Sanford Burnham Prebys Medical Discovery Institute (SBP)—steps towards new treatments for Crohn’s and colitis, a major heart genetics investigation, possible ways to stop the anthrax toxin and insights into the mechanism of a rheumatoid arthritis drug.

We also highlight how we’re giving back— getting involved in the pancreatic cancer community, and opening the doors to our labs to give interested individuals a chance to interact directly with cancer researchers.

We welcome your feedback!

New therapeutic target for Crohn's disease

Research from the lab of Jorge Moscat, Ph.D., and Maria Diaz-Meco, Ph.D., professors in the NCI-designated Cancer Center, identifies a potential target for future drugs to treat inflammatory bowel disease (IBD). The study, published in Cell Reports, also highlights the importance of specialized protector cells in preventing inflammation, which increases risk for colon cancer.

Read more on Beaker >>

Select media coverage: ScienceDaily, IBD News Today

Science News
A genetic parts list for the heartbeat

67 genes influencing heart function were identified in a new meta-study to which Rolf Bodmer, Ph.D., director of the Development, Aging, and Regeneration Program, contributed. The findings, in the Journal of the American College of Cardiology, could help identify new therapeutic targets for a number of heart conditions.

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Select media coverage: Medical Daily,
Medical Xpress

The search for new anthrax treatments isn't over

An anthrax attack would be nearly as deadly today as it was in 2001, but research from the lab of Robert Liddington, Ph.D., professor in the Bioinformatics and Structural Biology Program, could lead to new antitoxins. Publishing in the Journal of General Physiology, they show how the bacterial toxin gets across cell membranes.

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Select media coverage:, Digital Journal

Rheumatoid arthritis drug works by restoring balance to immune cells

Scientists led by Salvatore Albani, M.D., Ph.D., an adjunct professor in the Immunity and Pathogenesis Program, show that hydroxychloroquine returns the manic, long-lived T cells that destroy the joints in rheumatoid arthritis to normal. The study, published in the European Journal of Immunology, could lead to better drugs for this common, disabling disease.

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Taking down an aggressive form of breast cancer

Triple-negative breast cancer, which disproportionately affects women under age 50, is treatable only with surgery, radiation and chemo. SBP's newest faculty member, Brooke Emerling, Ph.D., assistant professor in the Cancer Metabolism and Signaling Networks Program, aims to change that.

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Welcome to our newest and recently renewed President's Circle Members!

• Alexandria Real Estate Equities
• Lisa and Steven Altman
• Roberta and Malin Burnham
• Linda Chester and Kenneth Rind
• Isabel and Peter Dansky
• Connie K. Golden
• Paul and Susan Hering
• Reena and Samuel Horowitz
• Jeanne Jones and Don Breitenberg
• Douglas Manchester
• Retrophin, Inc.
• Edward R. Schulak
• Anthony Y. Sun
• Armi and Albert Williams

Please Donate
SBP in the Community
Fighting pancreatic cancer on two fronts

In addition to searching for cures for pancreatic cancer, which has one of the lowest survival rates of any cancer, scientists at SBP participate in fundraising and awareness events such as PurpleStride, a walk held on Oct. 2. PurpleStride funds research, advocacy and patient assistance.
Open house lets high schoolers see science in action

Teenager Rachel J. Lian got to see the beating heart of a live fruit fly under a microscope for the first time at the open house held by the NCI-designated Cancer Center on October 13. The event gave community members a chance to see SBP’s labs and learn how the environment and lifestyle affect cancer development. 
Read more on Beaker >>
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