The treatment of the esophageal cancer in octogenarian’s patients is controversial. This is a single- center, retrospective study with 79 patients. Patients were submitted to 20% neoadjuvant treatment, 24% up-front surgery, 15% definitive chemoradiotherapy, 34% palliative radiotherapy, and 6% base support care. Around 63% had completed the treatment in the neoadjuvant group. About 44% of all patients underwent surgical treatment, with 37% of major complications and 9% of mortality. Authors identified better overall survival in the curative intent treatment compared to the non-curative one.