Minneapolis Heart Institute Foundation

Advanced Heart Failure Research

August 2025 Semi-Annual Update

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News & Accomplishments

Course on Management of Cardiogenic Shock & Heart Recovery

Hosted by MHI Advanced Heart Failure and Critical Care Cardiology teams
MHI faculty in cardiology, cardiac surgery, pharmacy, nursing, critical care, palliative care, and administration
Participants from 14 centers
Sponsored by J&J

First Half of 2025:

14 publications

10 Podium & Poster Presentations

HF RA & 2025 Interns

Melanie Sun, Research Associate

Melanie recently joined the team and will support HF investigator-initiated research projects. She was a 2024 Intern at MHIF.

Julia Harris, 2025 Intern

Mentor: Dr. Siu-Hin Wan

Project: Clinical and Echocardiographic Changes with Treatment for ATTR-CM

Pranoy Sangowdar, 2025 Intern

Mentor: Dr. Steve Bradley

Project: Initial diuretic dosing in the emergency department among patients admitted for heart failure

Study Spotlight: CORCINCH-HF

Description

Study evaluating the safety and efficacy of the AccuCinch Ventricular Restoration System in patients with HFrEF.

Enrolling Patients with:

LVEF ≥20% and ≤40%
LVEDD ≥ 55 mm
NYHA Class III, ambulatory IV, or II with HF hospitalization within 12 months
On stable GDMT

Principal Investigator:

Dr. Peter Eckman

Contact:

Kate Jappe

Kate.Jappe@allina.com

Phone: (612) 863-5855

Recruiting Studies

Surgical & VAD

Studies

Description

PI & Enrolling Sites

INNOVATE

BrioHealth Solutions

Safety and efficacy of the BrioVAD System vs. HeartMate 3 Left Ventricular Assist System

Dr. Benjamin Sun

ANW

OHP Registry ll

Transmedics

Clinical outcomes of heart transplant recipients that used the Organ Care Heart Perfusion System

Dr. Benjamin Sun

ANW

Interventional Heart Failure

ALLAY-HF

Alleviant Medical

No-implant interarterial shunt in patients with HFpEF

Dr. Peter Eckman

ANW & United

ALT-FLOW ll

Edwards Lifesciences

Transcatheter interarterial shunt in patients with HFpEF

Dr. Mike Samara

ANW

CorCinch-HF

Ancora Heart

AccuCinch Ventricular Restoration System in patients with HFrEF

Dr. Peter Eckman

ANW

GenePHIT/ASK-CHF 2

AskBio

Gene therapy trial for patients with non-ischemic NYHA Class III symptoms of Heart Failure

Dr. Jay Traverse

ANW

Outpatient & Drug

CONTEMP-ICD

U of Rochester

Benefit and risks of ICD implantation in patients with HF who have a low risk of sudden death

Dr. Mosi Bennett

ANW

Electrophysiology

AIM HIGHer

Impulse Dynamics

Cardiac contractility modulation in HFpEF

Dr. Mike Samara

ANW

Peripartum

REBIRTH

U of Pittsburgh / NIH

Impact of bromocriptine on clinical outcomes for peripartum cardiomyopathy

Dr. Retu Saxena

ANW

Pipeline Studies

FASTR ll

Reprieve Cardiovascular

Fluid management of acute decompensated heart failure subjects treated with Reprieve System

Dr. David Miranda

ANW

REDEFINE-HF

Colorado Prevention Center

Finerenone for the treatment of hospitalized patients with HFmrEF or HFpEF

Dr. Mosi Bennett

ANW

INTeGRATE

Abiomed

Initiation and titration of GDMT in HF cardiogenic shock with Impella 5.5 for cardiac recovery

Dr. Kasia Hryniewicz

ANW

TEAM-HF

Abbott

LVAD vs continued GDMT in non-inotrope dependent HF patients with refractory pulmonary hypertension secondary to LV heart failure

Dr. Mosi Bennett

ANW

ANW=Abbott Northwestern; GDMT=Guideline-Directed Medical Therapy; HFmrEF=Heart Failure with Mildly Reduced Ejection Fraction HF=Heart Failure; HFpEF=Heart Failure with Preserved Ejection Fraction; HFrEF=Heart Failure with Reduced Ejection Fraction; ICD=Implantable Cardioverter-Defibrillator; J&J=Johnson & Johnson; LVAD=Left Ventricular Assist Device; LVEDD=Left Ventricular End-Diastolic Diameter; LVEF=Left Ventricular Ejection Fraction; NIH=National Institutes of Health; NYHA=New York Heart Association; OHP=Organ Care Heart Perfusion System; PI=Principal Investigator; VAD=Ventricular Assist Device

For more information, please contact Julianne Feola at julianne.Feola@allina.com; Ph: (585)944-8268

Interested in clinical trials from our other areas of cardiovascular research? Visit mplsheart.org/archive for any recent emails you may have missed.