Community Recommendations on Cryo-EM Data Archiving and Validation | |
|
In a paper at IUCrJ, Gerard J. Kleywegt et al. follow up on a workshop that was held in 2020 at EMBL-EBI (Hinxton, UK) to "discuss data requirements for the deposition and validation of cryoEM structures, with a focus on single-particle analysis. The paper describes the workshop's motivation and history, the topics discussed, and the resulting consensus recommendations. Some challenges for future methods-development efforts in this area are also highlighted, as is the implementation to date of some of the recommendations." Some key topic areas discussed include:
- Brief history of archiving for macromolecular crystallography (MX), NMR and 3D electron microscopy (3DEM)
- Why there is a need for validation and how its applicable to 3DEM
- Types of validation reports
- Recommendations to the wwPDB/EMDB on archiving and deposition
- And more
| |
New Low Profile Lid For Cryo-EM Grid Boxes | | |
|
|
One of the new products we've added is a Low Profile Lid for cryo-EM grid boxes. The low thickness of the lid means you can stack 2 grid boxes and lids in 1 pocket of a cryo-EM grid storage puck, doubling your storage capacity!
It is made of anodized aluminum and is screwed on and off of the grid box with a hex key/allen wrench (sold separately). The anodized aluminum is highly robust, and is less susceptible to static electricity than plastic lids.
| |
2024 ACA Annual Meeting In Denver | | |
|
|
The 2024 ACA Annual Meeting is July 7th to the 12th in Denver, Colorado. It will feature numerous sessions, workshops, vendor exhibitors and a transactions symposium.
We will be there exhibiting our latest tools and instruments for crystallography and cryo-EM. If you are attending the annual meeting, we invite you to stop by our booth and chat with us.
| |
Sentinel G2 Watchdog Beamstop Kit | | |
|
|
The Sentinel™ G2 Watchdog Beamstop kit provides real-time X-ray beam monitoring and dosing information without interfering with diffraction data collection.
It includes an improved scintillator material (GAGG:Ce), increasing light yield and responsiveness, as well as a new high-tolerance Tungsten housing with precision dimensions, enabling smaller custom designs.
| |
Ludo Frevel Crystallography Scholarship Winners | | |
|
|
The ICDD has announced the winners of the 2024 Ludo Frevel Crystallography Scholarship. The scholarship is designed to encourage promising graduate students to pursue crystallographically oriented research.
The ICDD will present each winner with a check for $2,500 to assist in continuing studies in their selected fields of crystallographic research. Learn more about the winners and this scholarship by clicking the button below.
| |
The Neutrons in Structural Biology - Challenges & Opportunities workshop is June 10-12 in Arlington, VA. The workshops goal is to garner support for the construction of the macromolecular neutron diffraction beamline EWALD at ORNL’s 2nd Target Station. We are a proud sponsor of the workshop. | |  |
The 2024 French Association of Crystallographers Congress (AFC 2024) is July 2-5 in Montpellier, France. The meeting features 14 thematic group sessions, plenary conferences, micro symposiums, poster sessions, exhibitor booths, AFC satellite, prize program and much more. We are a proud sponsor of AFC 2024. | | |
Events, Workshops and Conferences | | |
|
|
If you are looking for more events visit our events page. It lists conferences, workshops, symposiums, user meetings and more.
Topics include structural biology, material science, crystallography, cryo-EM, beamline research and more.
| |
Industry Resources and News | |
|
Here is a small selection of industry resources and news for your browsing.
- Paper at Acta Cryst D, Deep residual networks for crystallography trained on synthetic data - Learn More
- Paper at Nature, Fragment library screening by X-ray crystallography and binding site analysis on thioredoxin glutathione reductase of Schistosoma mansoni - Learn More
- Paper at Acta Cryst D, From femtoseconds to minutes: time-resolved macromolecular crystallography at XFELs and synchrotrons - Learn More
- Paper at IUCrJ, Data reduction in protein serial crystallography - Learn More
- Paper at Acta Cryst F, High-resolution double vision of the allosteric phosphatase PTP1B - Learn More
- From CCDC, Online Platforms for Crystal Structures Exploration - Learn More
- Editorial at Acta Cryst F, Shaping the future of Acta Crystallographica F: unveiling our vision - Learn More
- From James Holton at Berkeley Lab - The UNTANGLE Challenge - Build a model that scores better - Learn More
- Paper at Paper at Acta Cryst D, A web-based dashboard for RELION metadata visualization - Learn More
- Preprint at bioRxiv, EMinsight: a tool to capture cryoEM microscope configuration and experimental outcomes for analysis and deposition - Learn More
- From IUCrJ, Community recommendations on cryoEM data archiving and validation - Learn More
- From the Staff at IUCr, two videos on the use of RELION - Learn More
- From CCDC, Small Molecule FDA Novel Drug Approvals Increase by Over 50% in 2023 - Learn More
- Pre-registration for the Beamline for Schools physics competition ends on April 10th. There is still time to register - Learn More
- 2024 marks 20 years of Lightsources.org - Learn More
- Cornell High Energy Synchrotron Source (CHESS) has been awarded nearly $20 million from the U.S. National Science Foundation to build a new precision X-ray beamline for research on biological and environmental systems - Learn More
- Paper at Synchrotron JSR, Finback: a web-based data collection system at SSRF biological macromolecular crystallography beamlines - Learn More
- Find beamline proposal deadlines from around the world at Lightsources.org - Learn More
| | |
|
|
A reminder that Our New Lab Program is available for those planning a new lab or are expanding their lab. It offers special discounts, startup bundles, and expert support and service.
If you are starting or expanding your lab contact us and we'll explain the program in detail. Or if you know someone who is starting or expanding their lab please share this information with them.
| |
Have your lab be the first to know. Follow us on social media! | | | | |
