Research catches up to world’s fastest-growing plant
Wolffia, also known as duckweed, is the fastest-growing plant known, but the genetics underlying this strange little plant’s success have long been a mystery to scientists. Now, thanks to advances in genome sequencing, scientists are learning what makes this plant unique—and in the process, discovering some fundamental principles of plant biology and growth. The work, detailed in Genome Research, has implications for designing entirely new plants that are optimized for specific functions, such as increased carbon storage to help address climate change.
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SCIENTIFIC UPDATES
Specific bacteria in the gut prompt mother mice to neglect their pups
As scientists learn more about the microorganisms that colonize the body—collectively called the microbiota—one area of intense interest is the effect that these microbes can have on the brain. A new study led by Salk scientists, published in Science Advances, has identified a strain of E. coli bacteria that, when living in the guts of female mice, causes them to neglect their offspring.
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Salk team reveals never-before-seen antibody binding, informing both liver cancer and antibody design
In structural biology, some molecules are so unusual they can only be captured with a unique set of tools. That’s precisely how a multi-institutional research team led by Salk scientists defined how antibodies can recognize a compound called phosphohistidine—a highly unstable molecule that has been found to play a central role in some forms of cancer, such as liver, breast cancer and neuroblastoma. The study was published in the Proceedings of the National Academy of Sciences.
IN THE NEWS
How to bury carbon? Let plants do the dirty work
Neuroscientist’s research helped unearth how human brains can make new cells
Reduced adult neurogenesis linked with Alzheimer’s disease
Study provides human data confirming potential of company’s proprietary compounds for prevention of dry AMD
The When of Eating: The Science Behind Intermittent Fasting
Weight Loss: The Ten-Hour Restricted Eating (TRE) Method
Salk Institute scientists awarded $1.2 million for study of brain aging and dementia
Modern AI has been influenced by how the brain works
Salk’s High School Science Week goes virtual
Panda lab postdoc Emily Manoogian [minute 3:50] comments in “Daylight Saving Is Literally Killing Us”
Social isolation and the brain

Professor Kay Tye shares insights about how social isolation affects the brain and impacts health, a timely topic given the COVID-19 pandemic.
FACULTY FOCUS
Salk Professors honored with endowed chairs
Professors Satchin Panda and Tatyana Sharpee have been recognized for their significant scientific contributions by being named to endowed chairs at the Salk Institute. Panda, holder of the Rita and Richard Atkinson Chair, studies the body’s circadian timekeeping system to better understand a wide range of health issues, including digestion, cancer, cognitive functions and more. Sharpee, holder of the Edwin K. Hunter Chair, uses advanced methods from information theory, mathematics and physics to chart the principles by which the brain manages energy and information, with implications for understanding psychiatric and neurodegenerative conditions as well as aging.
Season 3 of Where Cures Begin podcast
launched in February!
Tune in to Season 3 of Salk’s award-winning podcast, Where Cures Begin, underway now, where listeners can learn from Salk faculty on how hormone receptors are critical for health; the neuroscience of vision and architecture; how genes are controlled and why it matters; and why living in sync with your biological clock can improve your health. For more information or to tune in, visit: www.salk.edu/podcasts.
We'll begin to see almost every aspect of disease or physiology has some circadian component, and developing strategies where we can combine pharmacology or drugs with optimum circadian function will be the way forward for treating almost every single disease.
—Professor Satchin Panda
SPOTLIGHT
Salk scientists awarded $1.2 million by Larry L. Hillblom Foundation to study brain aging and dementia
A collaborative team of Salk scientists led by Professor John Reynolds will receive $1.2 million over four years as part of a Network Grant from the Larry L. Hillblom Foundation to examine aging across the life span, including age-related neurodegenerative diseases such as Alzheimer’s disease. The research will advance our understanding of aging mechanisms at the cognitive, genomic and cellular levels with potentially direct translatability to humans. Other members of the team include Salk President and Professor Rusty Gage, Staff Scientist Uri Manor, Senior Staff Researcher Courtney Glavis-Bloom, and Carol Marchetto, an assistant professor at the University of California San Diego.
Salk receives $1 million from BioMed Realty to support innovative cancer research and faculty
The Salk Institute received a matching $1 million gift from the BioMed Realty Management Team, led by President and CEO, Tim Schoen, Salk Trustee. The gift funded the recruitment of award-winning cancer researcher Christina Towers and supports the Salk Cancer Center. The challenge match will also support Salk’s Conquering Cancer Initiative, which is harnessing cutting-edge approaches to fight some of the deadliest cancers.
$200,000 gifted to Salk’s Harnessing Plants Initiative
Recently donors completed a matching challenge, gifting $200,000 to Salk’s Coastal Plant Restoration (CPR) program to address increasingly urgent needs to preserve some of the world’s largest carbon reservoirs and restore global wetland ecosystems. Kristy Kitzmiller, a founding member of the Harnessing Plants Initiative Advisory Committee, and her husband, Brandon Moran, generously pledged the initial $100,000 gift in June of 2019.
Salk awards 2021 Tang Fellowship
Helen McRae, a postdoctoral fellow in the lab of Professor Diana Hargreaves, was selected as the 2021 Salk Institute Tang Prize Foundation Fellow for her work on tumor-fighting macrophages.

The one-year Tang Prize Foundation Fellowship, created by Tony Hunter, is awarded through an internal competition to a postdoctoral fellow in their first or second year who is conducting a research project investigating the molecular basis of cancer.
Enjoy Salk architecture on your devices

Looking for a unique background image for your computer, Zoom meeting, iPad or phone?

This month’s image showcases the beautiful Salk courtyard.
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