Foralumab Clinical Update in Multiple Sclerosis; A Landmark Study with Intranasal Immunotherapy   Hosted by Tiziana Life Sciences (NASDAQ: TLSA)   Monday March 14, 2022 11:00 AM ET This webinar will feature presentations from Key Opinion Leaders (KOLs) Howard Weiner, MD (Harvard Medical School), Tanuja Chitnis, MD (Massachusetts General Hospital), Lawrence Steinman, MD (Stanford Medicine), and Tarun Singhal, MD (Brigham and Women’s Hospital) who will discuss the current treatment landscape in inflammatory neurodegenerative disease and the potential for new, locally acting therapies capable of crossing the blood-brain barrier, which poses a unique challenge for drug delivery to the central nervous system.     Tiziana is currently evaluating an innovative and proprietary formulation of foralumab, a fully human anti-CD3 antibody for intranasal administration to treat secondary progressive multiple sclerosis (SPMS).   Drs. Weiner, Chitnis, Steinman, and Singhal will discuss the potential of this breakthrough approach. A live question and answer session will follow.

IMPORTANT INFORMATION

Registration You are required to register in advance for the webcast. For those who are unable to listen at this time, a replay of the call will be available by clicking here. Q&A You may submit questions live during the event. Should you want to pre-submit your questions, please send them to [email protected].

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SPEAKER BIOGRAPHIES

Howard L. Weiner, MD Howard L. Weiner, MD is the Robert L. Kroc Professor of Neurology at the Harvard Medical School, Director and Founder of the Partners Multiple Sclerosis Center and Co-Director of the Center for Neurologic Diseases at the Brigham & Women’s Hospital. Dr. Weiner established the Partners Multiple Sclerosis Center at Brigham & Women’s Hospital in 2000 which combines clinical evaluation, MRI imaging and immune monitoring and is the first integrated MS center that brings these disciplines to the individual care of the MS patient. Dr. Weiner has pioneered the use of immunotherapy and the drug cyclophosphamide for the treatment of multiple sclerosis and has investigated immune abnormalities in the disease including the role of the innate immune system and regulatory T cells. He has also pioneered the use of the mucosal immune system for the treatment of autoimmune and other diseases, including ALS, Huntington’s disease, and stroke. Based on his work vaccines are being tested in multiple sclerosis, diabetes, and most recently in Alzheimer’s disease. He is also developing new therapeutic options for Neuromyelitis Optica (NMO). Dr. Weiner is the author of “Curing MS: How Science is Solving the Mystery of Multiple Sclerosis” that chronicles the history of MS, his 30+ years in the research and clinical treatment of MS, and details his “21 point hypothesis” on the etiology and treatment of multiple sclerosis. In 2004 Harvard Medical School honored Dr. Weiner with the establishment of the Howard L. Weiner Professor of Neurology Endowed Chair.

Tanuja Chitnis, MD Tanuja Chitnis, MD is the Director of the Mass General Brigham Pediatric MS Center at the Mass General Hospital for Children. She also sees adult patients with MS at the Brigham and Women's Hospital. She completed her medical training at the University of Toronto Medical School, her Neurology residency in Philadelphia, and a fellowship in Multiple Sclerosis and Neuroimmunology at the Brigham and Women's Hospital, Harvard Medical School. Dr. Chitnis has had a longstanding interest in Pediatric MS. She is the Chair of the International Pediatric MS Workgroup, and has written many publications and reviews related to multiple sclerosis. She is actively involved in several research projects to help to better understand and treat MS in children.

Lawrence Steinman, MD Lawrence Steinman, MD is a professor of Neurology and Neurological Sciences, Pediatrics, and Genetics. He also served as the Chair of the Stanford University Interdepartmental Program in Immunology from 2003-2011. Dr. Steinman's research focuses on what provokes relapses and remission in multiple sclerosis (MS), the nature of the molecules that serve as a brake on the brain inflammation, and the quest for a tolerizing vaccine for autoimmune diseases like type 1 diabetes and neuromyelitis optica. He has developed two antigen specific therapies, using DNA vaccines, for MS and type 1 diabetes. He was senior author on the seminal 1992 Nature article that reported the key role of a particular integrin in brain inflammation. This research led to the development of the drug Tysabri, which is used to treat patients with MS and Crohn's disease.

Tarun Singhal, MD Tarun Singhal, MD is the Director of PET Imaging Program in Neurologic Diseases at the Ann Romney Center for Neurologic Diseases at Brigham and Women’s Hospital and an Assistant Professor of Neurology at Harvard Medical School and in Boston, MA. Dr. Singhal completed his medical school at All India Institute of Medical Sciences and completed a nuclear medicine residency in India prior to coming to USA in 2006. He completed a post doctoral fellowship at Yale PET Center and Kettering PET center followed by neurology and nuclear medicine residency and fellowships at Harvard. He is board certified in neurology and nuclear medicine and on the Harvard faculty since 2014. Dr. Singhal has led several molecular imaging projects in the neuroscience field, including work on [C-11]Methionine PET in brain tumors, Norepinephrine Transporter imaging of the central nervous system, and now more recently neuroinflammation PET imaging in multiple sclerosis and related disorders. Dr. Singhal maintains an active clinical practice of seeing MS patients in addition to leading the PET Imaging program in Neurologic Diseases at Brigham and Women’s Hospital.

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