05/12/2023 Edition 95
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R&D and Training in Isotope Production |
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The mission of the DOE IP is to produce and distribute critical radioactive and enriched stable isotopes that are in short supply or not produced in the U.S. The DOE IP ensures national preparedness for isotope production and distribution by maintaining mission readiness of relevant national infrastructure and core competencies to ensure functionality even during times of national crisis; conducts advanced R&D to develop innovative technology and advanced radiochemical separations and purifications; and mitigates U.S. dependence on foreign supplies of isotopes to ensure robust domestic supply chains. The DOE IP incorporates core competencies of many scientific areas including, but not limited to nuclear and radiochemistry, nuclear physics, accelerator and nuclear reactor science, materials science and engineering, separations science, and nuclear data.
Applications responsive to this FOA will address one of the R&D topics described below, or strongly align with isotopes in the DOE IP mission space. Applications considered nonresponsive to this FOA by the Program Office may be rejected without further review. Data and/or technology resulting from proposed scopes of work should complement and not duplicate those that exist in the scientific community in general and DOE IP specifically. The R&D topics of highest interest to DOE IP under this FOA are:
- Novel or improved capabilities for inducing transmutation of atoms in targets to produce high priority radioisotopes, including isotopes not yet produced domestically, such as C14 and Ir-192;
- Research on particle beam sources and small, compact accelerators for production and distribution of isotopes;
- Development of novel or improved radioisotope generator systems, especially platform technologies having potential for applicability to multiple radioisotopes, and/or that offer improved efficiency and reliability;
- Techniques or concepts to efficiently recover critical isotopes (such as Ra-226, Sr-90, and Pm-147), or their complex mixtures, from energy or mining wastes, or fission/activation products in irradiated materials;
- Research and development of automation, advanced manufacturing, AI/ML and/or robotics that would lead to advancement of production and processing techniques, targetry, and/or enhancement of facilities to increase the efficiency and/or safety of radioisotope production and/or processing; and
- Development of concepts and/or techniques to produce enriched stable isotopes of hydrogen (H-2 or deuterium) and other isotopes relevant to advanced nuclear fission and fusion energy fuel cycles especially He-3, Cl-37, and Li-7.
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The objective of the Cybersecurity Innovation for Cyberinfrastructure (CICI) program is to advance scientific discovery and innovation by enhancing the security and privacy of cyberinfrastructure. CICI supports efforts to develop, deploy and integrate cybersecurity that will benefit the broader scientific community by securing science data, computation, collaborations workflows, and infrastructure. CICI recognizes the unique nature of modern, complex, data-driven, distributed, rapid, and collaborative science and the breadth of infrastructure and requirements across scientific disciplines, practitioners, researchers, and projects. CICI seeks proposals in three program areas:
- Usable and Collaborative Security for Science (UCSS): Projects in this program area should support novel and/or applied security and usability research that facilitates scientific collaboration, encourages the adoption of security into the scientific workflow, and helps create a holistic, integrated security environment that spans the entire scientific cyberinfrastructure ecosystem.
- Reference Scientific Security Datasets (RSSD): Projects in this program area should leverage instrumented cyberinfrastructure to capture metadata from scientific workflows and workloads as reference data artifacts that can help support reproducible security research, testing and evaluation.
- Transition to Cyberinfrastructure Resilience (TCR): Projects in this program area should improve the robustness, trustworthiness, integrity, and/or resilience of scientific cyberinfrastructure through testing, evaluation, hardening, validation, and technology transition of novel cybersecurity research. The TCR area further encourages transition activities that advance the deployment and use of reproducibility in CI, workflows, and data.
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Emerging Mathematics in Biology (eMB) |
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Supports research in mathematical biology that addresses significant biological questions by applying nontrivial mathematics or developing new theories — particularly from foundational mathematics, including artificial intelligence or machine learning.
The Emerging Mathematics in Biology (eMB) program seeks to stimulate fundamental interdisciplinary and potentially transformative research pertaining to the development of innovative mathematical/statistical/ computational theories, tools, and modeling approaches to investigate challenging questions of great interest to biologists and public health policymakers. It supports research projects in mathematical biology that address challenging and significant biological questions through novel applications of traditional, but nontrivial, mathematical tools and methods or the development of new theories particularly from foundational mathematics and/or computational/statistical tools, including Artificial Intelligence/Deep Learning/Machine Learning (AI/DL/ML).
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Specific Area of Interest: Projects that will be considered for Pfizer support will focus on improving the care, management, and outcomes of adult patients with migraine by supporting healthcare professional education on topics including:
- Unmet need and disease burden associated with migraine
- The role of CGRP in the pathophysiology of migraine
- CGRP receptor antagonists in the acute treatment of migraine and preventive treatment of episodic migraine
- The diagnosis and management of migraine by general practitioners and specialists (focus on acute treatment and prevention of episodic migraine)
- Raising awareness of opportunities to improve the quality of migraine treatment across diverse patient populations
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Specific Area of Interest: Projects that will be considered for Pfizer support will be Investigator Sponsored Research (ISR) in one or more of the following areas:
- Basic and clinical research to further characterize the various endotypes and phenotypes of patients with AA receiving ritlecitinib.
- Studies evaluating ritlecitinib in AA patients with skin of color, different ethnic groups, different age groups
- Prospective interventional studies involving AA patients who received ritlecitinib.
- Translational research regarding the role of JAK3 and TEC inhibition pathways in AA.
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Althea Sheets, Research, Scholarly, and Creative Activities Development Manager, Office of Sponsored Programs, [email protected], 702-895-1880
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