Notice of Special Interest (NOSI): Computational and Statistical Methods to Enhance Discovery from Health Data

Recent successes with the use of data-centric artificial intelligence (AI) methods such as deep learning (DL) are stimulating interest in harnessing large and complex digital health-related data sets to advance the goals of biomedical informatics research.

Applying AI methods to large-health related data sets are becoming increasingly important for discovering, diagnosing and predicting, with computational tools, the improvement of health-related outcomes and the reduction of healthcare costs.

Many human and non-human public datasets are becoming available that encourage the development of specialized tools and platforms that can be used in research.

However, recent work in identifying and addressing data problems, such as systematic biases, missing data, data set imbalance and blind spots in data, have highlighted an array of potential problems with fairness, accuracy, safety, and reproducibility of inferences and conclusions, leading to bias in the AI tools that are derived from the data.

Deadline: dependent upon opportunity

Using Innovative Digital Healthcare Solutions to Improve Quality at the Point of Care (R21/R33 - Clinical Trial Optional)

The Agency for Healthcare Research and Quality's (AHRQ) mission is to produce evidence to make health care safer, of higher quality, more accessible, equitable, and affordable, and to work within the U.S. Department of Health and Human Services and with other partners to make sure that the evidence is understood and used.

Deadline: 2/16/2023

Targeting Inflammasomes in Substance Abuse and HIV (R21 Clinical Trial Not Allowed)

The scientific objective of this Funding Opportunity Announcement (FOA) is to encourage research to explore mechanisms of inflammasome activation, humoral immune reaction and potential antibody-mediated enhancement, and their link to immune functions in people with HIV and substance use disorders (SUDs).

This FOA supports studies to either (1) elucidate the mechanisms of inflammasomes in virus and drug-induced immune activation, or (2) identify molecular markers and CNS immune cells associated with HIV-1 infection or disease progression among individuals with SUD.

Success of these projects may lead to development of novel therapies that target inflammasome activation or suppression to treat neuroinflammation and immune dysregulation aroused in these processes.

Deadline: 3/15/2023

Using Archived Data and Specimen Collections to Advance Maternal and Pediatric HIV/AIDS Research (R21 - Clinical Trial Not Allowed)

The purpose of this Funding Opportunity Announcement (FOA) is to utilize archived HIV/AIDS data and biospecimen collections to generate new research questions and findings related to epidemiology, pathogenesis, treatment, prevention, clinical manifestations, and HIV-associated co-infections in maternal, pediatric, and adolescent populations.



Deadline: 3/29/2023

Using Just-in-Time Adaptive Interventions to Optimize Established Adolescent Mental Health Treatments (R61/R33 Clinical Trial Required)

NIMH seeks applications for pilot research to develop and test just-in-time adaptive intervention (JITAI) augmentations to enhance the effectiveness and clinical potency of established adolescent mental health treatments.

An emphasis is placed on studies that are informed by developmental science and grounded in an empirical model of behavior change.

Support will be provided for up to two years (R61 phase) for milestone-driven testing, refinement, and/or validation of the intervention's impact on empirically supported, measurable target mechanisms and the possibility (contingent on meeting the R61 milestones) of up to 3 additional years of support (R33 phase) to replicate the target engagement findings in a larger sample and examine the relationship between the target mechanisms and clinical outcomes.

Deadline: 2/22/2023

Neuroscience Collaborations Vision Statements Call

The Simons Foundation’s mission is to advance the frontiers of research in mathematics and the basic sciences.

Co-founded in 1994 in New York City by Jim and Marilyn Simons, the foundation exists to support basic — or discovery-driven — scientific research undertaken in the pursuit of understanding the phenomena of our world.

Please contact your RAS unit *and* Lorena McLaren to inform them of your intent to submit.

Deadline: 3/8/2023

The Role of Health Policy and Health Insurance in Improving Access to and Performance of Cancer Prevention, Early Detection, and Treatment Services

There is a need for research that evaluates the impact of the many changes now occurring in the healthcare system with a particular focus on cancer prevention, control, and treatment.

Efforts focusing on improving access to care may also impact inequities that contribute to health disparities. Public health policy initiatives such as the federal and state marketplaces that have expanded insurance coverage, as well as Medicaid expansion in some states, create natural experiments ripe for evaluation.

Deadline: 4/1/2023

Development of Innovative Informatics Methods and Algorithms for Cancer Research and Management (R21 Clinical Trial Optional)

The purpose of this Funding Opportunity Announcement (FOA) is to invite exploratory/developmental research grant applications (R21) for innovative informatics methods and algorithms to improve the acquisition, analysis, visualization, or interpretation of data across the cancer research continuum including cancer biology, cancer treatment and diagnosis, early cancer detection, risk assessment and prevention, cancer control and epidemiology, and/or cancer health disparities.

As a component of the NCI's Informatics Technology for Cancer Research (ITCR) Program, the emphasis of this FOA is on supporting the development of novel informatics capabilities that involve a high degree of innovation that have the potential to accelerate or enhance research.

Please contact your RAS unit *and* Alison Thompson to inform them of your intent to submit.

Deadline: 6/13/2023

Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trial Not Allowed)

This funding opportunity announcement (FOA) is intended to support novel environmental health research in which an unpredictable event or policy change provides a limited window of opportunity to collect human biological samples or environmental exposure data.

The primary motivation of the FOA is to understand the consequences of natural and human-made disasters, emerging environmental public health threats, and policy changes in the U.S. and abroad.

A distinguishing feature of an appropriate study is the need for rapid review and funding, substantially shorter than the typical NIH grant review/award cycle, for the research question to be addressed and swiftly implemented.

Deadline: 2/27/2023

Organismal Response to Climate Change (ORCC)

Expanding Understanding and Improving Predictions of Life on a Warming Planet

The world is currently undergoing unprecedented changes in global climates across all biomes, with effects on nearly every life-form.

How organisms respond to these rapidly changing conditions will have large consequences for the distribution of species over space and time, the integrity and the composition of natural communities, the distribution and the yield of domesticated crops and animals, and the incidence and the severity of pathogen outbreaks.

Consequences such as these are already having major impacts on the world's food security, the bioeconomy, and the ecosystem services provided by living systems to humans.

Developing a comprehensive understanding of the mechanistic underpinnings of organismal response to climate change will improve our ability to predict and to mitigate maladaptive biological responses to rapidly changing environments and to facilitate organismal adaptation and persistence.

Most climate change studies to date have lacked integration between the study of organismal mechanisms involved in the response to changing climates and eco-evolutionary approaches.

Deadline: 11/16/2023

Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

The purpose of this Funding Opportunity Announcement (FOA) is to support studies that will identify, develop, and/or test strategies for overcoming barriers to the adoption, adaptation, integration, scale-up, and sustainability of evidence-based interventions, practices, programs, tools, treatments, guidelines, and policies.

Studies that promote equitable dissemination and implementation of evidence-based interventions among underrepresented communities are encouraged.

Conversely, there is a benefit in understanding circumstances that create a need to stop or reduce (“de-implement”) the use of practices that are ineffective, unproven, low-value, or harmful.

In addition, studies to advance dissemination and implementation research methods and measures are encouraged.

Applications that focus on re-implementation of evidence-based health services (e.g. cancer screening) that may have dropped off amidst the ongoing COVID pandemic are encouraged.

Deadline: 6/5/2023

Advancing Diversity and Inclusion

The Public Diplomacy Section (PD) of the U.S. Embassy in Luxembourg, U.S. Department of State administers a Public Diplomacy Grants Program. Awards are granted through project-specific Notice of Funding Opportunities (NOFOs). This notice is subject to availability of funding.

PD Luxembourg invites proposals for programs that promote bilateral cooperation and highlight shared values.

All programs must include an American perspective, societal or cultural element, or connection with American expert/s, organization/s, or institution/s in a specific field that will promote increased understanding of U.S. policies and perspectives.

Grants available through this program are intended to serve as one-time opportunities that can help launch projects that should be sustainable after the project period is over.

They CANNOT be used to support on-going operational costs, construction, scientific research, partisan political activity, trade activities, fund-raising campaigns, or commercial products. Further restrictions may apply.

Deadline: 5/15/2023