Advanced Computing Systems & Services: Adapting to the Rapid Evolution of Science and Engineering Research

Today’s research discoveries at the confluence of theoretical, experimental, and computational S&E are enabled by the continuing availability of an ecosystem of advanced computational resources. For nearly four decades, NSF has effectively supported the broad availability and innovative use of a diverse set of computational resources to accelerate fundamental advances in S&E.

These investments have spanned discipline-specific instruments and facilities; computational systems of varying capabilities and architectures optimized for different applications; virtual organizations for allocating resources and interfacing with users; human expertise in using, developing, deploying and operating resources; and the network backbone that connects and provides access to these resources.

Deadline: 2/21/2023

Strengthening the Cyberinfrastructure Professionals Ecosystem (SCIPE)

Advanced computing and data analytics are increasingly central to S&E innovation and economic prosperity. S&E researchers use advanced CI systems and tools in close collaboration with the expert CIP workforce as an interdependent ecosystem. Efficient and effective use of the advanced CI ecosystem by NSF programs can sometimes be limited by lack of availability of appropriate CIP expertise, gaps in specialty skills, organizational distance, or even simple unawareness of needs. For testbeds and novel CI paradigms, CIPs are often the only link between newly developed computing capabilities and the research community.

The SCIPE program addresses the growing need for CIP expertise, the need to address emerging CI requirements, and the need for organizational recognition and to establish career pathways for the CIP workforce that supports innovation, development, maintenance, and utilization of NSF’s advanced CI ecosystem by researchers and educators.

Deadline: 2/23/2023

Maintaining Immunity after Immunization (U01 Clinical Trial Not Allowed)

The goal of this Funding Opportunity Announcement (FOA) is to promote research to improve our understanding of how vaccines against infectious agents lead to durable protective immunity. This initiative will support studies that define components and mechanisms of the immune system that determine such durability.

Applications must propose the use of human cells/tissues to decipher the human response elicited through vaccination. Animal studies also may be included to elucidate mechanistic pathways not easily accomplished with human samples.

Deadline: 1/13/2023

Ryan White HIV/AIDS Program (RWHAP) Integrated HIV/AIDS Planning and Resource Allocation Cooperative Agreement

The Health Resources and Services Administration (HRSA) is accepting applications for fiscal year (FY) 2023 Ryan White HIV/AIDS Program (RWHAP) Integrated HIV/AIDS Planning and Resource Allocation Cooperative Agreement.

The purpose of this cooperative agreement is to provide technical assistance to RWHAP Parts A and B recipients and their planning bodies regarding: 1) the integration of HIV planning across systems of HIV prevention and care within their jurisdictions; and 2) the development, implementation, monitoring, evaluation, and improvement of Integrated HIV Prevention and Care Plans (Integrated Plans), including Statewide Coordinated Statements of Need (SCSN), submitted to HRSA and the Centers for Disease Control and Prevention (CDC) in response to legislative and programmatic requirements.

RWHAP Parts A and B recipients and planning bodies use Integrated Plans to better inform and coordinate HIV prevention and care program planning, priority setting, resource allocation, and continuous quality improvement efforts to meet the HIV service delivery needs within their jurisdictions.

Deadline: 1/19/2023

Large Scale Integrated Mapping and Molecular Profiling of Cell Ensembles and/or Cell-Types Mediating Opioid Action in the Rodent Brain (R01 - Clinical Trial Not Allowed

This funding opportunity announcement (FOA) aims to support complementary research programs that adopt innovative scalable technologies to inventory, register and profile cellular ensembles and/or cell-types that produce and/or respond to opioids in the rodent brain, or that are engaged during different stages of opioid use (acute, chronic, withdrawal, abstinence, relapse).

Emphasis is on approaches capable of integrating data generated through molecular profiling, at single-cell resolution, with other data modalities, such as cellular activity, connectivity and/or spatial localization, collected from the same cells or cell-types.

The overarching goal of the FOA is to deliver multimodal reference datasets that will constitute useful resources to the research community and will provide a foundational biological framework to advance the understanding and treatment of opioid-associated states.

Deadline: 2/2/2023

BRAIN Initiative: Brain-Behavior Quantification and Synchronization – Transformative and Integrative Models of Behavior at the Organismal Level (R34 Clinical Trial Not Allowed)

This Funding Opportunity Announcement (FOA) seeks applications with limited scope proposing a set of planning activities that will lay the groundwork for a scientific project aimed at integrating complementary theories and methods to 1) develop, validate, and apply cutting-edge tools and methods for minimally invasive, multi-dimensional, high-resolution measurement of behavior at the level of the organism, with synchronous capture of changes in the organism’s social or physical environment; and/or 2) develop computational methods that allow for integration of multidimensional behavioral and environmental data representing multiple timescales into a conceptual and/or computational model of behavior as a complex dynamic system, designed with the capacity to integrate synchronously recorded neural data and/or inform existing models of neurobehavioral function, such as those developed with the support of the NIH BRAIN Initiative. 

Deadline: 2/14/2023

Mechanistic links between diet, lipid metabolism, and tumor growth and progression (U01 Clinical Trial Not Allowed)

The purpose of this funding opportunity announcement is to request applications that propose mechanistic investigations of the links between diet, lipid metabolism and tumor growth and progression.

It is anticipated that this program will support fundamental studies designed to identify and define the molecular mechanisms through which lipid metabolism mediates tumor growth and progression, focusing specifically on the central role lipids play in linking diet with the biology of cancer; bridge the historically divided fields of nutrition and molecular metabolism; and stimulate research and tool development in this emerging area, which faces particular challenges because of the complexity of lipid biochemistry.

Deadline: 2/17/2023

Innovative Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R61 Clinical Trial Not Allowed)

Through this funding opportunity announcement (FOA), the National Cancer Institute (NCI) intends to accelerate the development of evidence-based cancer-related interventions that reflect the diversity of people, places, contexts, and settings in the United States.

Specifically, this FOA will support research that tests the impact of cancer-related interventions on cancer-related outcomes across the cancer control continuum using a pragmatic trial study design. This FOA will use the UG3/UH3 phased cooperative agreement mechanism.

Deadline: 3/1/2023

Climate Change AI Innovation Grants 2023

Artificial Intelligence (AI) and machine learning (ML) can help support climate change mitigation and adaptation, as well as climate science, across many different areas, for example energy, agriculture, forestry, climate modeling, and disaster response (for a broader overview of the space, please refer to Climate Change AI’s interactive topic summaries and materials from previous events).

However, impactful research and deployment have often been held back by a lack of data and other essential infrastructure, as well as insufficient knowledge transfer between relevant fields and sectors.

Deadline: 3/1/2023

Climate Program Office (CPO), Earth System Science and Modeling Research in support of the Disaster

Climate variability and change present society with significant economic, health, safety, and security challenges.

As part of the National Oceanic and Atmospheric Administration (NOAA) climate portfolio within the Office of Oceanic and Atmospheric Research (OAR), Climate Program Office (CPO), the Earth System Science and Modeling (ESSM) Division programs address climate challenges by managing competitive research programs that support high-priority science initiatives.

CPO/ESSM Programs advance our understanding of the Earth’s climate system and foster the application and use of this knowledge to improve the resilience of our Nation and its partners.

Deadline: 1/26/2023

Quality of Life Grants Program

As a pillar of the National Paralysis Resource Center, the Quality of Life Grants Program, pioneered by the late Dana Reeve, impacts and empowers people living with paralysis, their families and caregivers by providing grants to nonprofit organizations whose projects and initiatives foster inclusion, involvement and community engagement, while promoting health and wellness for those affected by paralysis in all 50 states and U.S. territories.

Deadline: 3/8/2023

NIDDK Investigator Award to Support Mentoring of Early Career Researchers from Diverse Backgrounds (K26 - Independent Clinical Trial Not Allowed)

The purpose of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Investigator Award to Support Mentoring of Early Career Researchers from Diverse Backgrounds is to provide protected effort and resources to established, NIDDK-funded, mentors to provide high quality mentoring to graduate students and postdoctoral fellows from diverse backgrounds, including those from underrepresented groups (see, e.g., Notice of NIH’s Interest in Diversity).

Program Directors/Principals Investigators (PD/PIs) (mentors) must be conducting research that falls within the missions of the NIDDK and such research programs should serve as the framework around which mentoring activities are constructed. PD/PIs/applicants must have a demonstrable track record of mentoring early career researchers from diverse backgrounds, including those from underrepresented groups.

Deadline: 2/28/2023