Climate Change AI Innovation Grants 2023

Artificial Intelligence (AI) and machine learning (ML) can help support climate change mitigation and adaptation, as well as climate science, across many different areas, for example energy, agriculture, forestry, climate modeling, and disaster response (for a broader overview of the space, please refer to Climate Change AI’s interactive topic summaries and materials from previous events).

However, impactful research and deployment have often been held back by a lack of data and other essential infrastructure, as well as insufficient knowledge transfer between relevant fields and sectors.

Deadline: 3/1/2023

Accelerating Innovations in Biomanufacturing Approaches through Collaboration Between NSF and the DOE BETO funded Agile BioFoundry (NSF-DOE/ABF Collaboration)

The National Science Foundation (NSF) and the Department of Energy’s Bioenergy Technologies Office (DOE BETO) recognize the critical roles that synthetic and engineering biology play in advancing the U.S. Bioeconomy.

To translate advances in synthetic and engineering biology into products and processes that will impact the U.S. bioeconomy, there is a need to accelerate innovation and adopt new biomanufacturing approaches.

The integrated Design-Build-Test-Learn (DBTL) capabilities of the DOE BETO funded Agile BioFoundry (ABF) offer a unique resource to the academic community to develop and implement innovative biodesign and biomanufacturing technologies and practices.

Deadline: 4/18/2023

Extracellular RNA carrier subclasses in processes relevant to Substance Use Disorders or HIV infection (R01- Clinical Trial Not Allowed)

The purpose of this FOA is to encourage research investigating the roles of extracellular RNA (exRNA) carrier subclasses in biological processes relevant to substance use disorders (SUDs) and/or HIV infection, latency, or pathogenesis in the CNS.

Applicants may propose to investigate biological mechanisms involving exRNA carrier subclasses, or propose to develop improved technologies to investigate extracellular vesicles or other exRNA carriers.

Deadline: 3/15/2023

Notice of Special Interest (NOSI): Pharmacogenomic Approaches to Enhancing HIV and Substance Use Disorder (SUD) Treatment Strategies, A jump into Precision Medicine

Variable responses to ART are due at least in part to human genetic variants that affect drug metabolism, drug disposition, and off-site drug targets. Defining effects of human genetic variants on HIV treatment toxicity, efficacy, and pharmacokinetics has far-reaching implications.

Substances of abuse (opioid, stimulants, nicotine, anxiolytics, alcohol, etc.) and its treatments (methadone, buprenorphine, extended naltrexone, etc.) may interact with ART, altering its bioavailability, its safety, and its efficacy.

It is known that nevirapine and efavirenz increase methadone clearance. New evidence demonstrates that variabilities in responses to ART depend in part on genetic variants for certain drugs of abuse and its therapies. For instance, a NR1I3 gene variant affected methadone clearance only in those taking efavirenz.

Two other genetic variants in the ABCB1 and CYP2B6 genes decreased methadone clearance. More research, though, is necessary to better understand the role of pharmacogenomics in people with HIV (PLWH) with substance use disorders (SUD).

Deadline: 6/5/2023

Dyadic Interpersonal Processes and Biopsychosocial Outcomes (R01 - Basic Experimental Studies with Humans)

This funding opportunity announcement (FOA) invites basic and/or methodological research projects that illuminate and/or measure independent and interdependent health-related effects within dyads across relationships and settings.

For the purpose of this FOA, a dyad is a unit of two individuals whose interactions and influences on one another are nested within larger social contexts and networks. Dyads are social relationships that extend beyond the individual and have strong bidirectional influences on physical and mental health.

For the purpose of this FOA, independent effects are those effects that affect each member of the dyad individually (i.e., by nature of being part of the dyad), whereas interdependent effects are those that affect one member of the dyad contingent upon the other member of the dyad (i.e., not only because the individual is part of a dyad but also because being part of the dyad has an effect on the other individual within the dyad as well).

Deadline: 3/5/2023

Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional)

The purpose of this Funding Opportunity Announcement (FOA) is to invite applications proposing research on current topics in Alzheimer's disease (AD) and its related dementias (ADRD).

Further information on the high-priority topics of interest will be announced through a series of Notices published subsequent to this FOA.

Deadline: 3/10/2023

Modular R01s in Cancer Control and Population Sciences (R01 Clinical Trial Optional)

This funding opportunity announcement (FOA) encourages applications for research in cancer control and population sciences.

The overarching goal is to provide support to promote research efforts on novel scientific ideas that have the potential to substantially advance cancer research in statistical and analytic methods, epidemiology, cancer survivorship, cancer-related behaviors and behavioral interventions, health care delivery, and implementation science.

Deadline: 3/7/2023

AHEAD (Advancing Head and Neck Cancer Early Detection Research) (U01 Clinical Trial Not Allowed)

The purpose of this Funding Opportunity Announcement (FOA) is to accelerate translation of research to improve early detection of head and neck cancers (HNC).

This FOA seeks applications that focus on early detection of HNC by applying molecular, cellular, and multi-omics signatures to clinical studies for differentiating benign from premalignant lesions, and identifying prognostic signatures on the transformation from premalignant to malignant lesions.

Better understanding of the molecular characteristics of dysplastic lesions and early recurrence are needed for improving lesion classification relevant to predicting cancer progression, which could have a significant impact on cancer prevention and treatment optimization.

AIDS Deadline: 3/14/2023

Research to Action: Assessing and Addressing Community Exposures to Environmental Contaminants (R01 Clinical Trial Optional)

This Funding Opportunity Announcement (FOA) encourages multidisciplinary projects to investigate the potential health risks of environmental exposures of concern to a community and to develop and implement an environmental public health action plan based on research findings.

Projects supported under this program will employ community-engaged research methods to conduct research and to translate research findings into public health action.

Deadline: 6/5/2023

Chronic, Non-Communicable Diseases and Disorders Across the Lifespan: Fogarty International Research Training Award (NCD-LIFESPAN) (D43 Clinical Trial Optional)

This funding opportunity announcement (FOA) encourages applications for the Chronic, Non-Communicable Diseases and Disorders Across the Lifespan: Fogarty International Research Training Award (NCD-LIFESPAN) D43 program for institutional research training programs in low-and middle-income countries (LMICs, as defined by the World Bank classification system).

Applications may be for collaborations between institutions in the U.S and an eligible LMIC or may involve just LMIC institutions if there is a previous track record of externally funded research and/or research training programs by the lead LMIC institution.

The proposed institutional research training program is expected to sustainably strengthen the NCD research capacity of the LMIC institutions, and to train in-country experts to develop and conduct research on NCDs across the lifespan, with the long-range goal of developing and implementing evidence-based interventions relevant to their countries.

Interdisciplinary research training that cuts across NCDs is encouraged.

Deadline: 7/13/2023

Providing Research Education Experiences to Enhance Diversity in the Next Generation of Substance Use and Addiction Scientists (R25 Clinical Trials Not Allowed)

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH.

The overarching goal of this R25 program is to support educational activities that encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in research.

To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on:

• Research Experiences
• Courses for Skills Development

Deadline: 3/15/2023

Leading Culture Change Through Professional Societies of Biology (BIO-LEAPS)

The Leading Culture Change through Professional Societies of Biology (BIO-LEAPS) program aims to advance diversity, equity, and inclusion in the biological sciences broadly by leveraging the leadership, broad reach, and unique ability of professional societies to create culture change in the life sciences.

The Directorate for Biological Sciences at the National Science Foundation (NSF BIO) recognizes that culture change in the biological sciences is an urgent priority because it is foundational to increasing diversity, equity, and inclusion in the discipline.

The culture of a scientific discipline — defined here as the shared values, norms, traditions, and practices — can be thought of as an emergent property that results from years of experiences and interactions among scientists, their institutions, their professional societies, and their networks.

It is increasingly recognized that the perceptions and attitudes of that culture can be quite variable for different individuals and are often negative for individuals historically excluded from the sciences (e.g., based on gender, gender identity, disability status, sexual orientation, ethnicity, race, the intersections of these, and others).

Therefore, this program is designed to foster the necessary culture change within biology to move towards an equitable and inclusive culture that supports a diverse community of biologists that more fully reflects the demographic composition of the US population.

Deadline: 7/3/2023