We are glad to introduce a new drug license out asset GIP/GLP-1/FGF21 Fusion Protein treating NASH, T2DM, and Hyperlipoidemia.The asset is looking for out-licensing andco-development.
Here are the details, please get in touch with us if you are interested.
GLP-1/GIP /FGF21 Fusion Protein
Project Profile
★Asset name: GLP-1/GIP /FGF21 Fusion Protein
★Asset type: Fusion Protein
★Indications: NASH, T2DM, Hyperlipoidemia
★Research phase: Preclinical
★Cooperation demands: License-out and co-development
Highlights
▶Clear MOA
Tirzepatide, dual GIP/GLP-1 receptor agonist synergize with metabolic actions improved the efficacy and maximized therapeutic benefits, but no significant change on decreasing the liver triglycerides and cholesterol.
There are currently no approved treatments for NASH. The rising global prevalence of obesity, metabolic syndrome, and T2DM has driven a sharp increase in non-alcoholic steatohepatitis (NASH), which suffered over 20 million patients.
Fibroblast growth factor 21 (FGF21) deficiency favors the development of steatosis, inflammation, hepatocyte damage, and fibrosis in the liver, whereas administration of FGF21 analogs ameliorates NASH by attenuating these processes.
Triple targets fusion protein, combining the activity of FGF21, GLP-1 and GIP, can reduce body weight & liver triglycerides /cholesterol, improve glucose control and treat NASH.
▶ Excellent pre-clinical results:
Candidate has much better data in T2D/obesity related data (FPG/body weight change), PLUS the very comparable result in NAS score with same dosage of AKR001.
Candidate is far better than Tirzepatide in reducing body weight and ALT & AST level in the same dosage.
30 nmol/kg of candidate is slightly better than AKR001 in liver CHOI and liver TG in same dosage and surpass the result of Tirzepatide.
Research Progress
▶ Apr. 2024 IND in China & Apr. 2024 Phase I in AU
Glad to have you aboard. We encourage you to reply this email directly if you have any license in or out requests.
