The CDC’s Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States provides an up-to-date resource on the use of COVID-19 vaccines across the age spectrum as well as special situations.
The Pfizer-BioNTech COVID-19 vaccine for those 6 months through 4 years of age is supplied in a maroon capped vial with a label with a maroon border. Once received, frozen vials may be immediately transferred to the refrigerator [2ºC to 8ºC (35ºF to 46ºF)], thawed and stored for up to 10 weeks. Alternatively, frozen vials may be stored in an ultra-low temperature freezer at -90°C to -60°C (-130° to -76°F) for up to 12 months from the date of manufacture. The vaccine must be diluted prior to administration at a dose of 0.2ml (3µg) in a three dose primary series. The intervals between the 1st and 2nd doses are 3-8 weeks and at least 8 weeks, respectively. This vaccine may be co-administered with other routine vaccines.
The Moderna COVID-19 vaccine for those 6 months through 5 years of age is supplied in a dark blue capped vial with a label with a magenta border. Once received, vials should be stored frozen between -50°C to -15°C (-58°F to 5°F). The vials also may be stored refrigerated between 2°C to 8°C (36°F to 46°F) for up to 30 days. The vaccine is NOT diluted and is administered at a dose of 25µg (0.25 ml) in a two dose primary series. The interval between the doses is 4-8 weeks. This vaccine may be co-administered with other routine vaccines. In those who are moderately to severely immunocompromised, an additional primary dose should be administered at least 8 weeks after the 2nd dose.
Contraindications to vaccination are a history of severe allergic reaction after previous dose, or to a component of a COVID-19 vaccine, or known allergy to a component of a COVID-19 vaccine.
There is currently no recommendation for the administration of booster doses following receipt of the Pfizer BioNTech vaccine series in children 6 months through 4 years, or the Moderna vaccine series at 6 months through 5 years of age.