Orange County's First West Nile Virus Human Infection of the Season Reported
August 8, 2018
A Tustin woman in her 70s was diagnosed this week with West Nile Virus (WNV) neuroinvasive disease. This is the first human WNV infection identified in Orange County this season.  Human infections have already been reported this season in the surrounding counties of Los Angeles, Riverside, and San Bernardino.
For Providers
  • Health care providers should consider WNV infection in patients with prolonged fever or acute neurologic illness.

  • Clinical Description: The incubation period is usually 2 to 6 days after a bite from an infected mosquito. Most symptomatic WNV cases have an acute febrile illness. Symptoms include fever, headache, malaise, arthralgia, or myalgia, and occasionally nausea, vomiting and/or a maculopapular rash. About 1 in 150 WNV-infected persons develops neuroinvasive disease, which can manifest as encephalitis, aseptic meningitis, acute flaccid paralysis, or transverse myelitis.

  • Testing for WNV: Testing for WNV should include serum WNV IgM and IgG, with CSF IgM when a lumbar puncture is performed. Because serum WNV IgM may be negative early in the course of disease, repeat serology may be indicated if initial testing was done within 8 days after the onset of illness.

  • Surveillance of West Nile Virus in the community: Report all WNV infections to Orange County Public Health by phone (714-834-8180) or fax (714-564-4050) within 1 working day. For more information on vector surveillance, please visit the OCMVCD web site at

  • Avoiding mosquito bites is the best way to prevent WNV infection:

  • Eliminate standing water which can serve as mosquito breeding sites around the home or workplace.

  • Ensure windows and door screens are in good repair.

  • Use an insect repellent containing active ingredients registered with the U.S. Environmental Protection Agency when outdoors. Active ingredients include DEET, picaridin, and oil of lemon eucalyptus. Natural bug sprays may not be effective against mosquitoes. For more information, visit
Contact Information
If you have any questions or concerns please contact the Epidemiology and Assessment Program at (714) 834-8180.
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