HIRN 2020
Annual Investigator Meeting
The HIRN 2020 Annual Investigator meeting will be held on Wednesday, September 30th - Friday, October 2nd at the Bethesda North Marriott in Bethesda, MD.
Abstracts due June 26
th
. Submit
HERE
and be sure to follow abstract guidelines.
New this year,
HIRN Scholarships
will be awarded to trainees who submit a highly scored abstract.
At this time, it is anticipated that the event will take place as planned. However, any changes in response to COVID‐19 will be circulated promptly. We will be monitoring the situation closely and keep you promptly informed of any changes that need to be made.
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COVID-19 Messages from our Partners
Since the global pandemic made it necessary to suspend distribution of human islets via our Integrated Islet Distribution Program (IIDP) as of last month, we have been closely monitoring nation-wide progress towards halting progression of COVID-19, development of critical testing, and official decisions and recommendations that affect our program. We have been working closely with our Islet Distributions Centers and their Organ Procurement Organizations (OPOs) on plans to safely begin islet isolations and distributions again with donors who have tested negative. We are developing a system for islet recipients to notify us as soon as they’re ready to receive islets and restart their research. Most importantly, we are continuing to keep our collaborators, researchers and staff safe, while looking towards the day when the important diabetes research that the IIDP supports is once again in full swing. Stay healthy out there!
Details for future plans concerning the IIDP suspension and reinstitution of the islet distribution program will be provided in the upcoming IIDP Newsletter to be published by the end of this month.
The Alberta Diabetes Institute IsletCore Program in Edmonton looks forward to getting back to work, and to supporting islet research across North America and internationally. Like many of our colleagues however, we remain closed for the time being. As always the safety of our staff and users is paramount. We are monitoring the situation closely and are committed to resuming our human islet isolation program and collaborative activities when it is safe to do so, pending institutional and provincial guidance.
JDRF Network for Pancreatic Organ Donors with Diseases (
nPOD
)
In our role as procurers and providers of tissues for a variety of research programs, we are taking the COVID-19 (Coronavirus) threat very seriously. We are in close contact with our Organ Procurement Organization (OPO) partners and will follow guidelines put forward by professional organizations in this area. Further, we will be working with our OPO partners as instructed to assure that viral screening methods, alongside laboratory values and donor history, will be used as a means to protect both our laboratory staff and research community from infection.
For nPOD we are implementing the following precautionary measures:
- Only accept donors with T1D or non-diabetic individuals with T1D-associated autoantibodies, based on current acceptance criteria, providing they have passed all screening procedures implemented by the above indicated organizations. The tissues will be processed according to standard nPOD SOPs.
- Will not conduct pancreatic islet isolation or generate pancreas slices.
- Frozen or fixed tissue/sample distributions to investigators will continue for donors that have been recovered before January 19, 2020, the date in which the first patient was identified in the United States. Samples from donors identified beyond this date will become available for distribution after testing negative for COVID-19.
Additionally, for research projects that utilize nPOD specimens the following precautions are in place:
HIRN/HPAP:
Effective immediately, nPOD will only refer donors to HPAP program with T1D or non-diabetic with T1D-associated autoantibodies, based on current acceptance criteria, providing they have passed the all screening procedures implemented by the aforementioned organizations. Additionally, HPAP leadership has, and will continue to work with its investigators, to assure that all appropriate safety procedures are followed and will continue to monitor the emerging situation.
HANDEL-P and HANDEL-I Programs:
Given the specialized nature of these tissues, the leadership of the HANDEL programs have decided to immediately suspend current procurement efforts. This suspension will continually be monitored and procurement reinstated at an appropriate time.
HubMAP:
Similar to the HANDEL programs, current procurement efforts have immediately been suspended. This suspension will continually be monitored and procurement reinstated at an appropriate time.
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Laurie Chaikind McNulty, LCSW-C
Kelly Donahue, PhD
Sharon Milgram, PhD
Michael Sheridan, PhD
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NIH Requests for Information (RFI)
NOT-RM-20-014
Request for Information: Challenges and Opportunities in Understanding Cellular Senescence and Senolytics
The NIH is considering the possibility of developing a Common Fund program to address the role of senescent cells in health and disease. In spite of the burgeoning efforts already in the field attempting to test therapies based on attacking senescent cells, it has become clear that many aspects of cell senescence research are currently in need of answers before the full potential of such therapies can be safely developed in humans. As part of the initial planning process, we are requesting input from the scientific community on the challenges in this field that can best be addressed through a concerted and coordinated effort.
- Application Due Date: May 15, 2020
NOT-DK-20-015
Request for Information: National Institute of Diabetes and
Digestive and Kidney Diseases (NIDDK) Strategic Plan
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) has issued a Request for Information (RFI) seeking public input for the development of an Institute-wide strategic plan. This overarching, 5-year trans-NIDDK Strategic Plan will complement our disease-specific planning efforts. A critical component of this strategic planning process is to seek input from the research and patient communities and others who have an interest in research within the mission of NIDDK.
- Application Due Date: May 18, 2020
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NIH Requests for Applications (RFAs)
PAR-20-140
Catalytic Tool and Technology Development in Kidney, Urologic, and Hematologic Diseases (R21 Clinical Trial Not Allowed)
- Application due date: Standard dates apply
- Foreign applications are allowed
RFA-DK-19-026
New Investigator Gateway Awards for Collaborative T1D Research (R03 Clinical Trial Not Allowed)
- Application due dates: March 25, 2020 and November 3, 2020
- Foreign applications not allowed
- Application due dates: June 10, 2020
- Foreign applications not allowed
RFA-DK-19-027
Support for Small Business Innovation Research (SBIR) to Develop New Technologies for Development and Integration of Novel Components for Open and Closed Loop Hormone Replacement Platforms for T1D Therapy (R43/R44 Clinical Trial Not Allowed)
- Application due dates: April 9, 2020 and October 3, 2020
- Foreign applications not allowed
F31 PAR-19-378
: Bioinformatics Interdisciplinary Predoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases
- Application due date: Standard dates apply
- Foreign applications allowed
F32 PAR-19-379
: Bioinformatics Interdisciplinary Postdoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases
- Application due date: Standard dates apply
- Foreign applications allowed
RFA-PAR-18-886
:
New Paradigms in Tissue Communication-from mediators to metabolic function (RC2 Clinical Trials Optional)
- Letter of Intent due: Six weeks prior to application due date
- Application due dates: October 31, 2019; June 2, 2020
- Foreign applications are not allowed
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Job Openings with Funding Agencies
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Program Administrator
Juvenile Diabetes Research Foundation (JDRF) is seeking a Program Administrator to become an essential member of the Core Program Team(s) (CPT) and charged with ensuring an administrative perspective is fully represented at the team level when rendering governance decisions around project-level reports and modifications. The Program Administrator operates with great latitude in a matrix team structure to ensure all program-related projects are administrated uniformly and in accordance with best practices. Their primary charge is to exercise discretion to oversee a portfolio of grants within JDRF Priority Area Program(s).
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Associate Program Officer
The Helmsley Charitable Trust seeks an Associate Program Officer who will work closely with the T1D Program Officers within an evolving grant portfolio that aims to identify biomedical interventions to delay and prevent the disease. The Associate Program Officer will be responsible for substantive programmatic support of the following: review and response to scientific proposals, due diligence tasks for potential grants, managing and writing grant recommendations, monitoring the progress of existing grantees, and research in support of new strategy development.
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Program Director
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is seeking a Clinical Health Psychologist to lead a program of behavioral research on diabetes within the Division of Diabetes, Endocrinology and Metabolic Diseases (DDEM). The DDEM supports and provides leadership for research on the causes, prevention and treatment of diabetes and its complications, as well as other endocrine and metabolic diseases.
Physician to Oversee Diabetes Clinical Studies
The NIDDK at the NIH is seeking a talented Physician (M.D. or equivalent) with expertise relevant to type 1 and/or type 2 diabetes research to manage clinical studies and trials related to the prevention and treatment of diabetes and its complications. This position offers unique and exciting opportunities to provide scientific leadership and to administer grants in support of diabetes research in the US.
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New Job Openings in Research & Academia
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Faculty Position
A 3-year PhD research scientist position is available at the
Institute of Physiology, Center for physiology and pharmacology, Medical University of Vienna
. The candidate will work on an international joint research project called “Beta-cells in diet-induced diabetes and remission (Austrian Science Fund FWF project I3787-B21 and Slovene Research Agency project N3-0116). Highly motivated students with a strong interest in physiology of pancreatic beta cells/computational biology are welcome to apply. Practical experience with electrophysiological techniques and computer coding (e.g. Python) will be considered as an advantage. The candidate should preferably hold a research-based master degree in neuroscience, biophysics or related disciplines and should be able to communicate in English at an advanced level.
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Faculty Position
The
Lilly Diabetes Center of Excellence (LDCE)
at the Indiana Biosciences Research Institute (IBRI) is recruiting promising young investigators to start their own independent laboratories under excellent research conditions. The LDCE is recruiting high-potential Principal Investigators (PIs) at the IBRI in Indianapolis, Ind., who are interested in pancreatic beta cell research, particularly related to iPSC-derived beta cells and the crosstalk between beta cells and the immune system in type 1 diabetes (T1D).
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Laboratory Assistant
One Laboratory Assistant position at the Indiana Biosciences Research Institute is available in the IBRI Diabetes Center. We are looking for highly motivated laboratory assistant to join the IBRI in the iPSC Core Facility coordinated by Dr. Decio Eizirik. This Core aims to differentiate pancreatic beta cells and other cell types departing from iPSC cells. The selected candidate will participate in a team working with iPSC derived beta cells, functional studies and advanced molecular biology techniques. The selected candidate will be motivated and take initiative in proposing and performing experiments, with support by Dr. Eizirik and other colleagues in the iPSC Core.
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Postdoctoral Position
The
laboratory
of Dr. Seung Kim at the Stanford University School of Medicine and the Stanford Diabetes Research Center has an immediate opening for a post-doctoral fellow to work on one or more projects involving organ regeneration and development, stem cells, and diseases like diabetes mellitus. Applicants with skills or interest in developmental biology, cell and stem cell biology, immunology, genetics, physiology and/or bioinformatics are especially encouraged to apply. Previous experience working with mice, mammalian cell culture, statistical and computational methods for analyzing genome-scale data sets or large imaging files is an asset, but not required.
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Current Job Openings in Research & Academia
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Faculty Position
The Department of Pathology, Immunology and Laboratory Medicine,
University of Florida Diabetes Institute
is seeking creative and highly motivated individuals for the position of Postdoctoral Associate under the direction of Dr. Todd Brusko. The Postdoc will be engaged in studying novel pathways regulating the differentiation and pathogenicity of T cells, the function of regulatory T cell biology in autoimmunity.
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Faculty Position
The
Diabetes Center of Excellence at the University of Massachusetts Medical School
invites applications for a SENIOR TENURED or JUNIOR TENURE-TRACK basic science or clinical investigator faculty position. The position will be highly competitive with regard to start-up funds, laboratory space (if needed) and salary. The Center seeks an individual of outstanding research potential relating to diabetes pathophysiology or treatment.
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Faculty Positions
The
University of California, San Diego
Department of Pediatrics
is recruiting
two tenure track faculty positions. An Associate or Full position in the area of basic biology of diabetes and metabolic disease. This is broadly interpreted to include individuals in the fields of cell biology, stem cells, immunology, genetics, or bioengineering, interested in studying disease-relevant mechanisms.
An Assistant position in the area of basic biology of diabetes and metabolic disease. This is broadly interpreted to include individuals in the fields of cell biology, stem cells, immunology, genetics, or bioengineering, interested in studying disease-relevant mechanisms.
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Faculty Position
The Diabetes Clinical Research Program (DCRP) at
Benaroya Research Institute
seeks to recruit outstanding applicants for a new faculty position. The appointment will be at the at the assistant, associate or full member level, commensurate with experience, training and achievement.
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The
University of Miami Miller School of Medicine
Department of of Microbiology and Immunology is accepting applications for Assistant and Associate Professor level for investigators with research interests related to immunotherapy of cancer, autoimmunity, or infectious diseases. Applicants should have a Ph.D., M.D. or equivalent, at least 3 years of postdoctoral training.
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Postdoctoral Position
Two postdoctoral fellow positions at the Indiana Biosciences Research Institute are available in the IBRI Diabetes Center. We are looking for highly motivated researchers to join the IBRI in the lab of Dr. Decio Eizirik. This lab aims to clarify the mechanisms of pancreatic beta cell dysfunction and death in type 1 diabetes mellitus, with focus on endoplasmic reticulum stress, alternative splicing and other mechanisms that may contribute to beta cell death and generation of neoantigens.
The selected candidate will participate in a team working with primary human and rodent islets, animal models of diabetes and human beta cell lines, and advanced molecular biology techniques. A strong understanding of beta cell biology and/or molecular biology is important. The selected candidate will be motivated and take initiative in proposing and performing experiments, with support by Dr. Eizirik and other colleagues in the lab.
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Postdoctoral Position
The Department of Molecular & Medical Genetics at Oregon Health & Science University (OHSU) in Portland, Oregon, is seeking a highly motivated and enthusiastic post-doctoral fellow to study adeno-associated virus (AAV) and its application for human gene therapy in the lab led by Professor Hiroyuki Nakai, M.D., Ph.D. Specifically, the lab is looking for a post-doctoral researcher who can lead productively a newly funded multi-PI (MPI) NIH project " U01DK123608 (MPIs: Nakai, Grompe and Kay): Gene Therapy for Diabetes, " where we seek to develop clinically relevant novel AAV vectors and methods for in vivo regeneration of insulin-secreting beta cells in rhesus macaques and profoundly understand the mechanisms behind the technologies.
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Postdoctoral Position
We are looking for recent Ph.D to pursue a career in science and biotechnology at the intersection of immunology and aging. People trained in my lab pursue careers in academia, biotech start-ups, venture funds or consultants for large firms. The long-term goal of my research is to understand the role of tissue secretory senescent cells in diseases such as autoimmunity, diabetes and diseases of aging.
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Applications are invited for prospective Post-Doctoral Fellows to train at the
Joslin Diabetes Center
, Harvard Medical School. Applications are invited from qualified individuals with a PhD or MD or MD PhD degrees and interested in working in the Kulkarni Lab on projects focused on defining pathways and mechanisms that regulate pancreatic (endocrine and exocrine) biology and interrogating inter-organ cross talk in the overall maintenance of glucose homeostasis.
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Postdoctoral position in the Lab of Dr. Sangeeta Dhawan at the
Beckman Research Institute
at
City of Hope
, in Los Angeles county, CA to study the epigenetic regulation of pancreatic beta cell mass. The candidate should have a PhD in molecular, cell, or developmental biology. Experience in genetic mouse models, islet biology, physiology, molecular biology, high throughput sequencing is desirable.
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Postdoctoral position in the Lab of Dr. Doris Stoffers in the
Institute for Diabetes, Obesity, and Metabolism
within the
Perelman School of Medicine
at the
University of Pennsylvania
. A PhD is required; experience in genetic mouse models, islet physiology, advanced molecular techniques, high throughput sequencing methodologies and bioinformatics, proteomics, metabolomics is helpful.
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Postdoctoral Position
The
Lab of Dr. Abdelfattah El Ouaamari
at
Rutgers University/Robert Wood Johnson Medical School
is recruiting self-driven, creative and organized candidates with a PhD in neuroscience, biochemistry or molecular and cellular biology. The candidate must possess skills in manipulating and assessing neuronal activity.
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