ANNUAL MEETING: SAVE THE DATE
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The HIRN 2021 Annual Investigator Meeting will be held virtually on Tuesday, September 21 – Thursday, September 23, 2021 from
12:00 – 5:00 pm Eastern. We kindly ask that you please save these dates on your calendar.
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The Human Islet Research Enhancement Center (HIREC) will be hosting
a webinar on "From Donation to Automation: The Ins and Outs of
High-Throughput Islet Cell Culture."
Meeting Information:
Date/Time: Wednesday, April 28, 2021 at 11:00 AM PDT | 2:00 PM EDT
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We are updating the HIRN website and would like to display images from your HIRN Projects! Please email us images to include on the website.
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SenNet: Request for Information |
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HIRN now has a YouTube Channel. All of the publicly recorded videos from our Webinar & Tutorials will be posted on this channel to share with the research community. We encourage you to subscribe and to share an informational video you may have that you would like us to share profiling your HIRN research. |
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A successful proof of concept by the Kim lab (CTAR consortium), soon to appear in Nature Communications, marks another HIRN advance in exploiting CRISPR/Cas9 gene editing to answer important biological questions. Previously, several HIRN groups have contributed to improvements to the CRISPR/Cas9 technique and pioneered its usage for the engineering of beta cell lines and alpha cell lines. What the Kim lab recently demonstrated is a CRISPR/Cas9 strategy that can edit primary adult human islets, which should provide a great model system for later studies.
Their experiments, targeting both coding and non-coding regions, establish effectiveness and function as examples of how their lentiCRISPR-pseudoislet system can be applied. The first experiment removed PDX1 in primary beta cells within cultured pseudoislets without problematic side effects (off-target modifications). Given that PDX1 is a transcription factor important in beta cell function, this yields edited pseudoislets that could be assayed directly or transplanted to examine loss-of-function phenotypes. Their method to achieve loss-of-function was generalizable, as demonstrated by another experiment to remove a coding region of KCNJ11. The second set of experiments focused on non-coding variants that have been associated with diabetes risk but can be difficult to study functionally in cell lines. Using their lentiCRISPR technique, GWAS-linked variants in the KCNJ11-ABCC8 and the SIX2-SIX3 loci were modified to reveal regulatory interactions that other approaches had earlier failed to elucidate. Overall, the work by the Kim group shows how to wield CRISPR/Cas9 in a powerful system, and getting it to work on primary human islets should lead to excitement about what can be done next.
Contact us with a scientific highlight to profile in the newsletter
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Date: May 15, 2021
Time: 9:00 am - 12:30 pm CDT
This half-day program is designed for scientists/investigators, students and clinicians with an interest in diabetes. All are welcome, CME to be
offered, no registration fee. Learn more HERE.
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SUMMER STUDENT INTERNSHIP |
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dkNET Summer of Data Student Internship Program
*Deadline Extended to May 7
The 2021 dkNET Summer of Data Student Internship program provides students an opportunity to utilize the dkNET tools and resources in a research project and to provide feedback on their experience to the dkNET team. Don't miss this great opportunity to learn best practices to enhance rigor and reproducibility and learn the basics of good data management by following the FAIR (Findable, Accessible, Interoperable, Reusable) data principles! The program is a 6-week online program, and selected students will receive $1,000 awards. Research projects should be in the areas of the NIDDK including diabetes, obesity, nutrition, digestive, kidney, liver, urologic, endocrine, metabolic, bone, and blood diseases. Preference will be given to those projects that would most benefit from the types of services offered by dkNET, e.g., projects that involve antibodies, genetically modified organisms, and ‘omics’ data. The program is designed for both bench and bioinformatics scientists. No programming skills are required. For more information please click HERE.
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dkNET Webinar
The dkNET (NIDDK Information Network) is inviting you to join them for a webinar "Undiagnosed Diseases Network" on Friday, May 14, 2021, 11 am - 12:00 pm PDT. Presenter: Dr. Zhandong Liu. Register HERE.
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RFA-DK-21-005: Immune Cell Engineering For Targeted Therapy And Disease Monitoring in Type 1 Diabetes (R01 Clinical Trial Not Allowed)
- Application due date: June 22, 2021
RFA-DK-21-006: Development of New Technologies and Bioengineering Solutions for the Advancement of Cell Replacement Therapies for Type 1 Diabetes (T1D) (R01 Clinical Trial Optional)
- Application due date: September 20, 2021
PAR-20-140: Catalytic Tool and Technology Development in Kidney, Urologic, and Hematologic Diseases (R21 Clinical Trial Not Allowed)
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Application due date: Standard dates apply
- Foreign applications are allowed
F31 PAR-19-378: Bioinformatics Interdisciplinary Predoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases
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Application due date: Standard dates apply
- Foreign applications allowed
F32 PAR-19-379: Bioinformatics Interdisciplinary Postdoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases
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Application due date: Standard dates apply
- Foreign applications allowed
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Below is a summary of the most recent job postings by category (Faculty, Research Staff/Admin, Postdoc). Visit the HIRN Website for a full listing for job opportunities.
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Program Director for Diabetes Behavioral Science
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is seeking a clinical behavioral scientist to serve as Program Director for Diabetes Behavioral Science. The Program Director will play an active role in stimulating new research and managing ongoing grant portfolios focused on understanding the interaction between behavioral, psychological, and biological factors to inform development of more effective and targeted interventions to prevent and treat diabetes.
Program Director for Health Equity in Diabetes
Program Officials
The National Institute of Diabetes and Digestive and Kidney Diseases is hiring program officials with expertise in translational research in any of the following four topic areas as they specifically relate to key questions in diabetes, endocrine or metabolic diseases:
· Integrative physiology of human diabetes, including physiology of counter-regulatory responses to hypoglycemia, mechanisms involved in regulation of peripheral metabolism, autonomic nervous system regulation of glucose and lipid metabolism, and basic and clinical studies investigating effects of bariatric surgery on diabetes and diabetes-related outcomes;
· Neuroscience of human behavior and behavior change, including brain and peripheral systems that impact the onset, severity or resolution of diabetes or obesity pathophysiology;
· Immune regulation and inflammation, including innate and adaptive immune mechanisms influencing peripheral insulin resistance in animal models and humans;
· Precision medicine in diabetes and obesity.
The mission of the Division of Diabetes, Endocrinology and Metabolic Diseases is to support broad-based research programs focused on both basic and clinical research in the areas of type 1 and type 2 diabetes and other metabolic diseases. Apply Here
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Faculty Position
The Diabetes Clinical Research Program (DCRP) at Benaroya Research Institute at Virginia Mason (BRI) seeks to recruit outstanding applicants for a new faculty position. The appointment will be at the at the assistant, associate or full member level, commensurate with experience, training and achievement. The DCRP is an international leader in type 1 (autoimmune) diabetes research. We are looking for an investigator with strong interest in clinical research and clinical trials to take a leadership role within the DCRP and work on national, regional, and local projects in type 1 diabetes. Experience in epidemiology, clinical investigation and/or clinical trials preferred; however, applicants with related research experience will be considered including work outside of type 1 diabetes. Requires an MD and a license to practice medicine in US. Please send your CV, cover letter, and contact information with 3 references HERE.
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Research Scientist
The University of Chicago beta cell/diabetes research group under the direction of Dr. Raghu Mirmira has funded openings for several postdoctoral research scientists with interest in applying/learning cell biological techniques (immunoprecipitation, immunohistochemistry, confocal imaging), mouse genetic skills, human islet biology, and immunology and inflammation research. NIH-funded research projects in the Mirmira laboratory include the study of beta cell development and function, human islet gene regulation and mRNA translation, and islet cytokine signaling in the context of type 1 diabetes. Please send your CV, cover letter, and contact information with 3 references to Dr. Mirmira.
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dkNET Community Liaison
The NIDDK Information Network has an open position for a Community Liaison to provide community outreach and lead engagement with the scientific community. This position will support a range of activities linked to community-dkNET partnerships, researcher engagement and knowledge networking. The position will entail engaging with research scientists, students and trainees, government, industry and broader audiences through workshops, in-person outreach events, multimedia, social media and Web-based systems. dkNET was launched by the FAIR Data Informatics Laboratory at the University of California, San Diego to serve the needs of basic and clinical investigators in diabetes, digestive and kidney disease by addressing the challenge of connecting researchers to research resources, assisting researchers with rigor and reproducibility guidelines, supporting researchers in navigating new data sharing requirements, and providing tools in enabling data discovery and hypothesis generation. More information click HERE.
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Research Technician
A new Stem Cell and Genome Editing Core Facility situated within the Kieffer Research Group has an opportunity for a highly motivated and collaborative technician to support diverse regenerative medicine research initiatives. The candidate will assist with the day to-day operation of the Core, will generate human induced pluripotent cells (iPSCs), and will culture and differentiate human embryonic stem cells (ESCs) and iPSCs down pancreatic lineages. Please send your CV, cover letter, and contact information with 3 references to Dr. Kiefer.
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Postdoctoral Position
The Indiana Biosciences Research Institute (IBRI) Diabetes Center has a postdoctoral position available. We are looking for highly motivated researcher to join the IBRI in the lab of Dr. Decio Eizirik. This lab aims to clarify the mechanisms of pancreatic beta cell dysfunction and death in type 1 diabetes mellitus, with focus on endoplasmic reticulum stress, alternative splicing and other mechanisms that may contribute to beta cell death and generation of neoantigens. The selected candidate will participate in a team working with primary human and iPSC-derived islets, animal models of diabetes and human beta cell lines, and advanced molecular biology techniques. Interested applicants should send a letter/statement of interests, CV, and contact information for 2-3 references to Dr. Eizirik.
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Postdoctoral Position
A postdoctoral position is available in the group of Dr. Remi Creusot at the Columbia Center for Translational Immunology (CCTI), to participate in research investigating the pathophysiology and therapy of autoimmune diabetes. The research will focus primarily on two NIH-funded projects: one studying the development and function of autoreactive T cells in humanized mouse models and a collaborative project on engineered stromal cells to reestablish immune tolerance. Applicants should send a full CV, a one-page cover letter highlighting research interests and goals, and the name and contact details of 3 references directly to Dr. Creusot.
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Postdoctoral Position
A postdoctoral position is available in the laboratory of Dr. Douglas Melton at Harvard University. We seek a creative and highly collaborative PhD scientist with computational skills in single cell RNA-seq and/or ATAC-seq analysis (Trajectory inference, Multimodal analysis, Noise modeling, Entropy analysis). Research projects in the Melton laboratory include the study of human pancreatic islet development and dysfunction in the context of type 1 diabetes, using pluripotent stem cell-derived islets as a human model system. Interested applicants are encouraged to send their CV and names of 3 references to Dr. Pop.
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Postdoctoral Position
A Postdoctoral Fellow position is available at the intersection of Regulatory Genomics and Statistical Genetics in the laboratory of Dr. Steve Parker in the Departments of Computational Medicine & Bioinformatics and Human Genetics at the University of Michigan Medical School. The major goal of the lab is to generate mechanistic knowledge about how disease susceptibility is encoded in the non-coding portion of the genome (from GWAS), with a focus on diabetes and related traits. Interested applicants should send a letter/statement of interests, CV, and contact information for 2-3 references to Dr. Parker.
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Postdoctoral Position
Interested in small-molecule discovery and modulating beta-cell phenotypes? The Wagner lab in the Chemical Biology & Therapeutics Science (CBTS) Program at the Broad Institute, is accepting applications for postdoctoral fellow positions. We are looking for researchers interested in studying small molecule-mediated beta-cell survival. Candidates should have a strong record of productivity and publication in islet biology or chemical biology. Interested applicants should send a letter/statement of interests, CV, and contact information for 2-3 references to Dr. Wagner.
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Postdoctoral Position
The Montreal Diabetes Research Center at the University of Montreal, has two Postdoctoral positions available at the Rutter laboratory. The laboratory studies pancreatic beta cell biology and its perturbations in type 2 diabetes (Rutter et alDiabetologia, 63(10):1990-1998. doi: 10.1007/s00125-020-05205-5, 2020). The objectives of the two projects are to explore the role and regulation of interactions between beta cells within the pancreatic islet using live cell imaging and optogenetics (Project 1), and to understand how genomic variants associated with type 2 diabetes impact pancreatic beta cell function (Project 2). The successful applicants will hold a PhD or equivalent. Experience in islet biology and/or glucose homeostasis, calcium signaling and image analysis (Project 1) or CRISPR/Cas9 genome editing, culture of human-derived beta cells or directed differentiation of embryonic stem cells towards a beta cell fate would be advantageous. Candidates with experience in data analysis using R, MATLAB etc. are particularly welcome to apply. Please send a cover letter and curriculum vitae, including three references, to Dr. Rutter.
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Postdoctoral Position
A postdoctoral position is available in the Lab of Dr. Sangeeta Dhawan at the Beckman Research Institute at City of Hope, in Los Angeles county, CA to study pancreatic beta cell development and maturation. The candidate should have a PhD in molecular, cell, or developmental biology. Experience in genetic mouse models, islet biology, physiology, molecular biology, high throughput sequencing is desirable. The candidate should send a cover letter/statement of research interests, CV, and contact information for three references directly to Dr. Dhawan.
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Postdoctoral Position
The University of California, San Francisco are looking for recent PhD to pursue a career in science and biotechnology around modulation of immune cells to recognize and eliminate senescent cells. Senescent cells accumulate in many age related disease and in autoimmunity by evading immune surveillance. We are developing methods to tune the immune response to selectively eliminate senescent cells in a number of diseases associated with aging. People trained in my lab pursue careers in academia, biotech, venture funds or consultants for large firms. Some lab members take key technologies from the lab to begin start up companies. Please send cover letter and CV/resume to Dr.Bhushan.
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Postdoctoral Position
The laboratory of Dr. Amelia Linnemann at the Indiana University Diabetes Center has an opening for a PhD and/or MD postdoctoral research scientist with skills in cell/molecular biological techniques (immunoprecipitation, western blotting, cloning) and/or microscopy. Research projects in the Linnemann laboratory include the study of pancreatic islet dysfunction and cytokine signaling in the context of type 1 and type 2 diabetes, with a focus on autophagy and the antioxidant response. Interested applicants are encouraged to send an updated CV and names of 3 references to Dr. Linnemann.
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Postdoctoral Position
Pacific Northwest National Laboratory has a postdoctoral position available to join their multi-disciplinary team focused on mass spectrometry (MS) based omics analyses. This project is part of the Human Islet Research Network funded by the National Institute of Health. We are investigating the roles of alternative splicing in beta cell stress and development of type 1 diabetes. Interested candidates please send your CV, cover letter, and contact information with 3 references to Dr. Nakayasu.
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Postdoctoral Position
The University of Florida under the Stabler laboratory is seeking a creative and dedicated postdoctoral associate to join their team in working on translational research in Type 1 diabetes. The research goals for this position are in the translation of our bioactive scaffolds and coatings into preclinical models for validation and optimization. As a highly collaborative laboratory, the Associate will integrate as a part of our team, working together with members of the laboratory, as well as our extensive researcher network. The Associate will be expected to take a leadership role in the laboratory, directing research goals and timelines, mentoring students, and writing reports and publications. Interested candidates should submit a CV, a summary of future research interests and goals, and three references to Dr. Stabler.
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Postdoctoral Position
A postdoctoral research associate position is available in the Hughes Lab at the Washington University School of Medicine to study primary cilia in islet cells. The laboratory combines standard molecular and cell biology with advanced imaging techniques to explore novel roles of cilia in mouse and human islets. We have generated new cilia knockout mouse models with strong diabetic phenotypes and are looking for someone to lead the investigation of cilia-mediated signaling mechanisms in islet hormone secretion. For human studies, we have a funded project to image primary cilia in T1D pancreas which will generate important and clinically relevant findings in autoimmune diabetes. Interested candidates please email Dr. Jing Hughes. Please send your CV, cover letter, and contact information with 3 references to Dr. Hughes.
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Postdoctoral Position
Postdoctoral Scholar Positions in Microphysiological Systems (“Tissue Chips”) in the Hughes Lab. An NIH-funded postdoctoral position is available to work on the development of body-on-chip devices in the areas of pancreatic islets (Type 1 diabetes). The ideal candidate will have experience in cell culture, vascular biology, bioengineering (including COMSOL modeling), and microfluidic systems. Prior knowledge in the areas of diabetes would be an advantage, however, candidates with any combination of the above should consider applying. Please send your CV, cover letter, and contact information with 3 references to Dr. Hughes.
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Postdoctoral Position
The Arrojo e Drigo lab focuses on the mechanisms regulating post‐mitotic cell homeostasis and longevity. Many postmitotic cells can be as old as the organism, which makes them remarkably long‐lived. We study long‐lived cells in different organs and explore their developmental trajectory, structure‐function and aging patterns. Our lab uses a combination of single cell sequencing and high‐resolution light, electron and isotope microscopy platforms to overlay cell structure‐function with molecular identity, age and metabolism. Applications are invited for a postdoctoral position to study the physiology of long‐lived cells in the pancreas. Please send your CV, cover letter, and contact information with 3 references to Dr. Arrojo e Drigo.
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Postdoctoral Position
The Voight lab invites applications for a computational Post-Doctoral position at the University of Pennsylvania School of Medicine, within the Department of Systems Pharmacology and Translational Therapeutics and the Department of Genetics. The lab focuses on translating discoveries from human genetics data into insights about the biological basis and genetic architecture of human disease (ultimately toward developing new therapeutics targets for human disease), and understanding selection
during recent human evolution. The candidate will have a MD, PhD, or equivalent doctorate, with a strong background in one or more of the following areas: statistics, biostatistics, population genetics, human genetics, genetic epidemiology, computational biology and/or genomics, bioinformatics. Please send your CV, cover letter, and contact information with 3 references to Dr. Voight.
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Postdoctoral Fellows
The Powers & Brissova research group in the Vanderbilt Diabetes Center is seeking a postdoctoral fellows to study human pancreas and islet biology with a focus on gene expression and developmental biology of single cells. We are especially interested individuals with computational or informatics
expertise, multimodal, multiplex imaging experience, or live cell imaging experience. Please send your CV, cover letter, and contact information with 3 references to Dr. Powers.
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Postdoctoral Associate
The laboratory of Dr. Jeffrey Millman in the Division of Endocrinology, Metabolism, and Lipid Research at Washington University School of Medicine is searching for a postdoctoral associates to lead several new research projects in the lab. The objective of the Millman Lab is to generate and study stem cell-derived beta cells for use in diabetic disease modeling and cell therapy. The candidate must have a PhD in cell biology, biomedical engineering, or related fields and has demonstrated quality publication of their work. Please send your CV, cover letter, and contact information with 3 references to Dr. Millman.
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Postdoctoral Associate
Rutgers, the State University of New Jersey, is seeking a Research Associate for the Child Health Institute of New Jersey. The position is available in El Ouaamari’s laboratory to investigate the role of the peripheral neurons in the regulation of systemic energy homeostasis in the context of obesity and diabetes. Self-driven, creative, resourceful and independent candidates with a PhD in neuroscience or neurobiology are encouraged to apply. Prior postdoctoral experience in neuroscience or related fields is required. Please send your CV, cover letter, and contact information with 3 references to
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Postdoctoral Associate
The Long Lab is a translational immunology lab focused on better understanding underlying mechanisms of autoimmune disease, patient variability, and response to therapy. Currently, we are primarily focused on three, inter-related projects in the setting of T1D: 1) Causes and consequences of reduced response to IL-2, 2) Cellular definition and stability of CD8 T cell exhaustion associated with response to therapy, and 3) identification of biomarkers of disease severity. The Postdoctoral Research Associate conducts independent biomedical research relevant to defining mechanisms underlying CD8 T cell exhaustion in the context of type 1 diabetes (T1D). The Postdoctoral Research Associate is a team-player who welcomes challenges and wants to grow as a translational biologist. Requires a Ph.D. in Immunology or a related field and experience in tissue culture, cellular and molecular techniques. Please send your CV, cover letter, and contact information with 3 references to Dr. Long.
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Postdoctoral Position
The Department of Molecular & Medical Genetics at Oregon Health & Science University (OHSU) in Portland, Oregon, is seeking a highly motivated and enthusiastic post-doctoral fellow to study adeno-associated virus (AAV) and its application for human gene therapy in the lab led by Professor Hiroyuki Nakai, M.D., Ph.D. Specifically, the lab is looking for a post-doctoral researcher who can lead productively a newly funded multi-PI (MPI) NIH project ” U01DK123608 (MPIs: Nakai, Grompe and Kay): Gene Therapy for Diabetes, ” where we seek to develop clinically relevant novel AAV vectors and methods for in vivo regeneration of insulin-secreting beta cells in rhesus macaques and profoundly understand the mechanisms behind the technologies. The successful candidate will also contribute to the training of graduate, undergraduate, and high school students, as well as research staff. Please send a cover letter and C.V. to
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Research Associate II
The Arrojo e Drigo laboratory at Vanderbilt University, has a research assistant II position open. This position requires knowledge of laboratory procedures, record keeping, validated experience in animal handling and anatomy, animal colony management, and standard molecular biology procedures. The research assistant II will support ongoing experiments in animal procedures, molecular biology, cell culture and microscopy. Motivated individuals will have their own projects and perform animal-related research. Additional responsibilities will include maintenance of and management of transgenic animal colonies and genotyping. Please send your CV, cover letter, and contact information with 3 references to
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