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June/July 2023 NEWSLETTER
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TIPS FOR THE NIH DATA SHARING MANDATE | |
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New Reoccurring Series
Tip #2: Utilizing dkNET to Navigate Data Sharing Mandate
Since the release of the data sharing mandate, dkNET has been actively making resources available to researchers in order to help navigate all the requirements of the mandate. Available through the dkNET website, resources can be found highlighting all available tools and templates addressing the mandate, along with direct web links to multiple YouTube videos and all webinars that have been held on the topic. Additionally, dkNET continues to create new webinar series, intended to help answer questions and assist researchers in creating plans in line with the data sharing mandate. Researchers also can find announcements of office hours held by dkNET to answer any questions regarding the mandate. Click HERE to access the dkNET website and view all available resources.
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NEW HPAP CITE-seq DATASET RELEASE | |
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The Human Pancreas Analysis Program (HPAP) performs deep phenotyping of the human endocrine pancreas to better understand the cellular and molecular events that precede and lead to beta-cell loss and/or dysfunction in diabetes. Type 1 Diabetes (T1D) is driven by the autoimmune destruction of pancreatic islet beta cells. Learning where this autoimmunity is coordinated can help inform therapeutic strategies to control the autoimmune process. Profiling immune cells that infiltrate islets would be invaluable to understanding how beta cell destruction occurs. However, human pancreatic samples demonstrating active infiltration and beta cell destruction are rare. Alternatively, pancreatic lymph nodes (pLN) provide a more accessible anatomical location to observe potential autoimmune coordination, and evidence from mouse models indicates that pLN play a significant role in autoimmune diabetes.
To profile the immune response throughout T1D onset and disease, lymphocytes from pLNs, mesenteric lymph nodes (mesLNs), and the spleen were collected from human T1D, auto-antibody positive (AAb+), and normal donors (NDs) enrolled in HPAP. Tissue immune cell identity, phenotype, and transcriptional status was analyzed using CITEseq. Lymphocytes from 20 pLN, 12 mesLN, and 18 spleen samples spanning 6 ND, 7 AAb+, and 7 T1D donors were processed through the CITEseq pipeline. Most donors in this cohort have matched tissues across anatomical sites for observing cross-tissue immune status comparison. The dataset provides one of the first and largest CITEseq datasets on human AAb+ and T1D samples publicly available. The dataset is publicly accessible from PANC-DB or from the Gene Expression Omnibus (GEO).
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The second annual meeting for American Association of Extracellular Vesicles (AAEV) will take place October 26 - 29, 2023 in Boston, MA. The purpose of the Association is to promote the development, dissemination, integration, and utilization of knowledge in the field of EV. The Association provides a platform for researchers to learn, disseminate, and network with EV researchers worldwide through Annual Conferences, peer-reviewed journal, initiatives, and industry partnerships. For more information, please click HERE.
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Save the Date: The A-BC Islet Workshop meeting organized by the University of Alberta and the University of British Columbia will be held in February 2024 in Silverstar, British Columbia (Canada).
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“The “R” in FAIR: Data Reuse” on July 13, 2023, will focus on what data contributors can do to increase the reusability of their data and how secondary use of shared data can advance scientific knowledge.
- Explain why data generators benefit by making research data available for reuse
- Identify how considerations for secondary analyses differ from analysis performed on primary data
- Learn about tools to help data generators increase the reusability of their data and how secondary researchers can find relevant data
For more information please click HERE.
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Microphysiological Systems (MPS) for Studying T2D, Obesity, and Their Complications
Dates: September 28, 2023 (Full Day), September 29, 2023 (Half Day)
Location: NIH Campus in Bethesda, MD (hybrid meeting - virtual available)
Purpose: Microphysiological systems (MPS) are in vitro systems that aim to recapitulate higher orders of cell/tissue organization than conventional two-dimensional static cultures and enable disease modeling and drug discovery studies. Advances in biomaterials, microfluidics, and tissue engineering allow for greater control of three-dimensional cell cultures containing multiple cell types and constituting more physiological tissue organization. The connection of chambers allows inter-organ crosstalk. The use of patient samples and human induced pluripotent stem cell–derived cells may someday enable patient-on-a-chip or clinical-trial-on-a-chip studies for many disease processes that are high priority for the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Challenges in this field of research include the need for multidisciplinary team science, evolving protocols for stem cell differentiation to obtain mature cell types, and balancing the system complexity with reproducibility and throughput. For more information please click HERE.
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NIH FUNDING OPPORTUNITIES | |
RFA-DK-23-014: NIDDK Catalyst Award (DP1 Clinical Trial Not Allowed)
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Application due date: September 29, 2023
- Foreign applications are not eligible
RFA-DK-22-037: Postbaccalaureate Research Education Program in Diabetes, Endocrinology and Metabolic Diseases (R25 – Independent Clinical Trial not Allowed)
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Application due date: October 25, 2023
- Foreign applications are not eligible
RFA-DK-23-019: Integration of Novel Measures for Improved Classification of Type 2 Diabetes (U01, Clinical Trials Not Allowed)
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Application due date: October 26, 2023
- Foreign applications are not eligible
RFA-DK-23-020: Integration of Novel Measures for Improved Classification of Type 2 Diabetes – Biostatistics Research Center (U01 Clinical Trial Not Allowed)
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Application due date: October 26, 2023
- Foreign applications are not eligible
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The American Diabetes Association (ADA) is pleased to announce the opening of a new nomination window for the Pathway to Stop Diabetes® research grants in 2023.
This call for nominations will prioritize translational applications that move knowledge and discovery gained from basic research to its eventual translation into patient and population benefit. The ideal applicant will propose innovative research that will be an important step towards our goal of improving the lives of people at risk of diabetes or living with the disease—and the pathway to this impact is clear. Our vision is to create a pathway to launch the next generation of trailblazers in diabetes research. Submission deadline is August 1, 2023. Learn more HERE.
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The IIDP is excited to announce two new funding opportunities available to IIDP investigators and centers as well as the general diabetes research community.
The Technology Resource Award (TRA) is intended to advance research of human islets and other non-islet pancreatic biomaterials (e.g. acinar, ductal tissues, lymph nodes, duodenum) by providing support for high-impact studies that will enhance services provided by IIDP to the human islet research community. Up to $150,000 will be available per award. Click here for information.
The Data Resource Trainee Scholar Award (DRTSA) is intended to advance research in human pancreas biology by providing trainees with support and access to detailed donor and islet data contained within the IIDP’s Research Data Repository (RDR) that will enable important secondary analyses to explore the relationships among donor characteristics, islet phenotyping, and genetic risk. Up to $10,000 will be available per award. Click here for information.
The application deadline for both programs is July 31, 2023 with an anticipated start date of October 1, 2023. The maximum duration of both programs is one year.
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ISAC INNOVATIVE SCIENCE ACCELERATOR PROGRAM | |
What is ISAC?
The Innovative Science Accelerator (ISAC) Program supports truly innovative, disruptive, risky research to accelerate breakthrough discoveries. ISAC provides:
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Funding for small high-risk/high reward projects via a streamlined process to support cutting-edge research and accelerate true innovation in areas of science of interest to the Kidney-Urologic-Hematologic (KUH) research communities.
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Collaboration and Events for researchers and trainees to efficiently exchange ideas and resources to accelerate innovation.
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Below is a summary of the most recent job postings by category (Faculty, Research Staff/Admin, Postdoc). Visit the HIRN Website for a full listing for job opportunities.
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Associate or Full Professor
The Department of Diabetes Immunology within the Arthur Riggs Diabetes & Metabolism Research Institute (AR-DMRI) at City of Hope has an opening at any professorial rank (Assistant/Associate or full professor). The successful candidate will be a scientist with interest in understanding islet autoimmunity and more broadly the disease pathogenesis at the preclinical and/or clinical levels and with the desire to translate promising insights into biomarkers, treatments and potential cures for type 1 diabetes. Interested Applicants for the position should send a CV, a brief statement of their research interests, and contact information for three references to Dr. Alberto Pugliese
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Assistant Professor
The Department of Biology at Indiana University Purdue University Indianapolis (IUPUI) invites applications for a tenure-track faculty position at the rank of Assistant Professor. Competitive salary and start-up funds are available. A Ph.D. and postdoctoral experience are required. Applicants must demonstrate the ability to initiate a research program that can attract external funding to sustain it, dedication to effective student mentoring and the ability to teach courses at the graduate and undergraduate levels. Candidates able to teach courses in microbiology, biochemistry and neuroscience are particularly welcome. Research strengths in the department span a range of topics in cellular, molecular, and organismal biology. Applicants for the position should provide a brief statement of research interests, CV and the names of three references to Dr. Mastracci.
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Senior Scientist
The Islet Cell Therapy and Stem Cell Biology group is looking for an in vitro biologist with training in human iPSC culture. This position will play a key role in establishing a new lab focused on developing the next generation of islet cell therapies and application of iPSC-derived platforms to novel target discovery and validation. Qualified individuals will have experience with human iPSC culture, gene editing, molecular biology and assay development, as well as broad experience in pancreas and islet biology. Applicants for the position should provide a brief statement of research interests, CV and the names of three references to Dr. Gopika Nair.
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Assistant or Associate Professor
The Barbara Davis Center for Diabetes (BDC) at the University of Colorado Anschutz Medical Campus is searching for an Assistant or Associate Professor. The person holding this position will develop and direct an independent, externally funded research program related to the development and/or investigation of the molecular and/or cellular mechanisms operative in human stem cell models related to understanding the etiology of Type 1 Diabetes or developing human stem cell derived therapies. This individual will be responsible for the daily management, supervision, training and evaluation of personnel (such as graduate students, postdoctoral fellows and professional research assistants) whose positions are funded by research grants on which s/he is the principal investigator. For more information and official job posting, please contact Dr. Lori Sussel.
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Research Associate II
A Research Associate II opportunity is immediately available for the highly motivated individual in the laboratory of Dr. Alberto Pugliese, MD in the AR-DMRI Department of Diabetes Immunology. The research is highly translational and primarily focused on human type 1 diabetes. Major ongoing projects are investigating miRNA biomarkers, pancreas pathology, and novel therapeutics, also in the context of the analysis of live pancreas tissue from organ donors obtained from the Network for Organ Donors with Diabetes (nPOD), of which Dr. Pugliese is Executive Co-Director, and in future clinical trials. Interested Applicants for the position should send a CV, a brief statement of their research interests, and contact information for three references to
Dr. Alberto Pugliese.
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Postdoctoral Position
A Postdoctoral Fellowship opportunity is immediately available for the highly motivated individual in the laboratory of Dr. Alberto Pugliese, MD in the AR-DMRI Department of Diabetes Immunology. The research is highly translational and primarily focused on human type 1 diabetes. The candidate will participate in several projects. Major ongoing projects are investigating miRNA biomarkers, pancreas pathology, and novel therapeutics, also in the context of the analysis of live pancreas tissue from organ donors obtained from the Network for Organ Donors with Diabetes (nPOD), of which Dr. Pugliese is Executive Co-Director, and in future clinical trials. Upcoming studies are projected to include the analysis of samples from patients with type 1 diabetes participating in clinical trials, with trials expected to start in late 2023 and 2024. Additional studies involve analysis of samples from recipients of pancreas-kidney transplant in the context of recurrent type 1 diabetes. Interested Applicants for the position should send a CV, a brief statement of their research interests, and contact information for three references to Dr. Alberto Pugliese.
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Postdoctoral Position
A Postdoctoral Fellowship position is available in the Department of Cell, Developmental and Integrative Biology (CDIB) at the University of Alabama at Birmingham (UAB). The position is available for a minimum period of two years. A major requirement will be expertise in molecular biology approaches and experience with CRISPR technology. The applicant will also be expected to have working knowledge of animal work (genotyping, islet and immune cells isolation); in vivo analyses (glucose tolerance and insulin sensitivity); in vitro assays with beta-cells and immune cells; Western blotting; immunofluorescence analyses; and proficiency with RT-qPCR protocols. Interested applicants please send a cover letter and curriculum vitae, including the names of three references, to Dr. Sasanka Ramandham.
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Postdoctoral Position
One postdoctoral fellow position is available at the ULB Center for Diabetes Research, Brussels, Belgium. We are looking for a highly motivated researcher to join the lab of Dr. Decio Eizirik. This lab aims to clarify the mechanisms of pancreatic beta cell dysfunction and death in type 1 diabetes mellitus, with focus on endoplasmic reticulum stress, alternative splicing and other mechanisms that may contribute to beta cell death and generation of neoantigens. Interested individuals are encouraged to provide a brief letter stating their accomplishments and interest in the lab’s research, curriculum vitae, and a list of three references to Dr. Decio Eizirik.
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Postdoctoral Position
The laboratory of Dr. Xuelin Lou at the Medical College of Wisconsin is seeking a highly motivated and creative Postdoctoral Fellow to lead exciting research projects on membrane trafficking in islet β cells. The ideal candidate will have a Ph.D. in Biology (or a related field) and quality publications. Experience in islet biology, or expertise in relevant research methods is highly desirable. Please send your cover letter, curriculum vitae, and the name/contact of three references to Dr. Xuelin Lou.
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Postdoctoral Position
The Khosravi Immunoengineering Lab in the Department of Immunology at the Mayo Clinic Arizona is seeking two Postdoc Research Fellows in the areas of autoimmunity and transplantation. The Immunoengineering Lab research focuses on developing and applying novel ways of inducing immune tolerance using integrated approaches that combine laboratory, clinical, and computational methods. The engineering of immune cells is an integral part of these novel methods. The focuses of current research projects: 1) to develop chimeric antigen receptor (CAR) Tregs with enhanced stability and functionality for inducing immune tolerance in transplantation and xenotransplantation; 2) to study Tregs in autoimmune diseases and apply engineering strategies to develop autologous Treg therapies for these patients. Please contact Dr. Mohsen Khosravi Maharlooei for more information.
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Postdoctoral Position
The Kravets Lab – “Pancreatic Islet Physics and Physiology” lab at the Department of Bioengineering and Department of Pediatrics of the University of California San Diego - is looking for a creative and highly motivated Postdoctoral Fellow to lead experimental and computational research projects. The successful candidate will have a PhD in Bioengineering, Biology, Biophysics, Mathematics, or related fields. Desired (but not required) skills: experience in animal work (mouse or zebrafish) and tissue culture, willingness to perform animal surgical procedures, MATLAB, C (or other languages), signal analysis. Interested applicants please send a cover letter and curriculum vitae, including the names of three references, to Dr. Vira Kravets.
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Postdoctoral Position
The Alvarez laboratory at the University of Pennsylvania Perelman School of Medicine seeks a creative, collaborative and highly independent postdoctoral fellow to lead new research projects. Our laboratory asks how circadian & metabolic rhythms impact islet cell maturity, aiming to build mature stem cell-derived organoids as human models of islet development & physiology and as diabetes cell therapy. We are unraveling genetic, chromatin, and translation circuits that govern islet maturity states in health and disease. Candidates must have quality first-author publications and a PhD in Biology, Bioengineering, or related fields. Computational/bioinformatics expertise is highly desirable. We embrace diversity, equity, and inclusion. Please send your CV, a brief statement of relevant research interests, and contact information for three references to Dr. Juan Alvarez.
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Postdoctoral Position
The University of Montreal, under the direction of Dr. Poitout, has a postdoctoral position available to decipher the mechanisms whereby very long-chain sphingolipids lead to reactive oxygen species production and cell-cycle activation in rodent and human beta-cells. Methodologies to be employed include rat and mouse islet isolations, adenoviral transduction of rodent and human islets, measurements of beta-cell proliferation by flow cytometry, assessment of hormone secretion in static incubations and perifusions, and islet transplantation studies. Interested applicants please send a cover letter and curriculum vitae, including the names of three references, to Dr. Vincent Poitout.
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Postdoctoral Position
The laboratory of Dr. Audrey Parent at the University of California, San Francisco is seeking postdoctoral fellows interested in developing immune evasion strategies for beta cell replacement therapy. Our research program is diverse, combining directed differentiation of human pluripotent stem cells into pancreatic beta cells and thymic epithelial cells with genome engineering approaches to study autoimmunity in humanized models. Selected candidates will work in a collaborative and interdisciplinary team and will be encouraged to develop their own research interests. Candidates must have a PhD in biology, immunology, or a related field. Applicants for the position should send a CV, a brief statement of their research interests, and contact information for three references to Dr. Audrey Parent.
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