RECENTLY RELEASED: PANC-DB v2.0 |
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PANC-DB data portal is the canonical central source for Human Pancreas Analysis Program (HPAP) raw data, methods, and experimental metadata. The latest version of PANC-DB, called version 2.0, was released in May 2022. In this new version, we aimed to enable researchers to intuitively search, download, and visualize diverse data collected by HPAP. One of the HPAP’s unique features is deep molecular and functional characterization of different tissues and cell types from healthy and diabetic donors. This in turn creates a challenge to effectively model the data from disparate molecular and cellular experimental assays. To address this unmet need, we created new structured data models, and used them to equip PANC-DB 2.0 with two new data query functionalities.
The first new feature, called Data Download Matrix, provides a concise overview of all data availability by tissue and / or cell type. A researcher can use demographics and medical covariates to filter donors and then directly select data from available assays and tissues for download. Data Status Matrix is the second new feature implement in PANC-DB 2.0. Since not all assays can always be performed on every donor due to biological and technical reasons, we designed Data Status Matrix to communicate data availability state with PANC-DB users. Using this new feature, researchers can peruse whether data from a particular assay is available for a donor, or the experiment is in progress (in the sequencing queue, being analyzed, etc.) or will not be available (for example, due to insufficient islets). Together, this detailed information clarifies the extend of HPAP progress.
Since its launch, PANC-DB has served as a portal to share HPAP data with the research community. We have now expanded the role of PANC-DB as a data analysis platform by introducing the first interactive data analysis portal for pancreatic single-cell RNA-seq data. To provide this one-of-a-kind capability, we have collected, harmonized, and processed transcriptomic data of more than 270,000 cells from more than 70 donors. The result of this massive single-cell transcriptomic analysis is provided as commonly used data files for download. We also implemented CellxGene, developed by the Chan Zuckerberg Initiative, to allow researchers to visualize and examine gene expression at the level of an entire dataset or a particular subset of cells or donors, which can in turn help define stages and/or subtypes of diabetes.
PANC-DB’s new interactive analysis capability allows researchers to interactively track and select cells for several analyses including, but not limited to, filtering cells by donor types and other covariates, visual and quantitative examination of genes, and performing differential expression and other comparative studies. Taken together, PANC-DB 2.0 offers new capabilities enabling the diabetes research community to explore HPAP data more effectively, while offering a model for open-access data sharing.
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thesugarscience: D-Challenge |
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The D-Challenge is a community-based research challenge designed to uncover novel and compelling hypotheses about the biology, etiology, treatment of sequelae of Type 1 Diabetes, using the rich ecosystem of on-line tools and data findable through dkNET.
Deadline to register your team: August 1, 2022
Weekly data bootcamps: August 5 - October 8, 2022
Submit Hypothesis: October 14, 2022
Live Hypothesis Pitch/Awards: October 21, 2022
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NIDDK Exocrine/Endocrine Pancreas Workshop
The goal of this 1.5-day workshop will be to gather clinical and basic science investigators who are interested in diseases of the exocrine and/or endocrine pancreas and in achieving an understanding of how the two compartments interact in disease. This workshop will provide an opportunity for investigators in exocrine diseases to come together with those studying islets in diabetes as a means to foster interdisciplinary discussion and identify areas for advancement. This meeting will be held June 29-30, 2022 at the Natcher Conference Center on the NIH Campus.
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PAN3DP Conference
The PAN3DP conference is proud to present a range of speakers from Canada, Europe, Israel, the UK and the United States. Members of the PAN3DP Consortium will also discuss their work towards creating 3D-bioprinted pancreatic tissue as part of the PAN3DP project. This meeting will be held July 19-20, 2022 at Bush House in London. Learn more HERE.
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IIDP Islet Award Initiative
The Integrated Islet Distribution Program (IIDP) is now accepting applications for the next funding cycle of the Islet Award Initiative (IAI). For this application round only, the IAI eligibility criteria have been expanded to include all islet researchers with an unfunded human islet pilot project, regardless of previous experience working with human islets. Deadline June 15th. Learn more HERE.
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The Innovative Science Accelerator Program (ISAC) new funding program.
The ISAC Program supports truly innovative, disruptive, risky research to accelerate breakthrough discoveries.
ISAC provides:
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Funding for small high-risk/high reward projects via a streamlined process to support cutting-edge research and accelerate true innovation in scientific areas of interest to the Kidney-Urologic-Hematologic (KUH) research communities.
- Collaboration and Events for researchers and trainees to efficiently exchange ideas and resources to accelerate innovation.
Applications can be submitted to the ISAC web portal at any time. The review of submitted applications will occur three times a year and provide a quick turnaround from review to award.
- Application Final Submission: Aug 15, Dec 15
- Peer Review: Sept, Jan
- Notification of Award: Oct, Feb
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NIH FUNDING OPPORTUNITIES |
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RFA-DK-21-030: New Investigator Gateway Awards for Collaborative T1D Research (R03 Clinical Trial Not Allowed)
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Application due date: June 1, 2022 and March 20, 2023
- Foreign applications are not eligible
F31 PAR-19-378: Bioinformatics Interdisciplinary Predoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases
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Application due date: Standard dates apply
- Foreign applications eligible
F32 PAR-19-379: Bioinformatics Interdisciplinary Postdoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases
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Application due date: Standard dates apply
- Foreign applications eligible
PAR-20-140: Catalytic Tool and Technology Development in Kidney, Urologic, and Hematologic Diseases (R21 Clinical Trial Not Allowed)
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Application due date: Standard dates apply
- Foreign applications are eligible
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Below is a summary of the most recent job postings by category (Faculty, Research Staff/Admin, Postdoc). Visit the HIRN Website for a full listing for job opportunities.
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Associate Program Officers
The Helmsley Charitable Trust seeks two Associate Program Officers who will work closely with and report to the T1D Program Officers within evolving grant portfolios that aim to identify biomedical interventions to delay and prevent the disease. The Associate Program Officer will be responsible for substantive programmatic support of the following: review and response to scientific proposals, conducting due diligence for potential grants, managing and writing grant recommendations, monitoring progress of existing grants, keeping up to date on relevant scientific and clinical developments, and supporting new strategy development. The Associate Program Officer will help manage all administrative components of the grantmaking process, especially tasks associated with managing grant lifecycles, monitoring progress of grantees, tracking program budgets, ensuring accurate payment and accounting of grants, helping to plan and execute program-related meetings, and maintaining positive and proactive communication with grantees. Some travel, both domestic and international, is required for meetings with potential and current grantees, as well as to relevant conferences. Apply HERE.
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Faculty Recruitment
The University of Alabama at Birmingham* (UAB) and the UAB Comprehensive Diabetes Center (UCDC) are leading the recruitment of up to 10 investigators for a major strategic portfolio increase across basic, translational, clinical, and population science research efforts in diabetes. Recruitment is for tenured, tenure-track, and non-tenure-earning faculty applicants with an MD, PhD or MD/PhD at all ranks and includes academic appointment in one or more of 27 academic departments across the Heersink SOM. All applications will be considered, but priority will be given to those with the following focus areas in diabetes and metabolism research:
· single-cell biology
· epigenetics
· bioinformatics
· investigator-initiated clinical trials
· adult or pediatric longitudinal diabetes
· studies
· medical informatics
· precision diabetes
· translational type 1 and type 2 diabetes
· research
· population health research in diabetes
Interested candidates should send their CV, cover letter, and contact information with 3 references to Dr. Carter.
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Physician Scientist
The University of Chicago's Department of Medicine is searching for full-time physician scientist faculty members at any rank. Appointees will maintain a productive research program and provide patient care directly. Other responsibilities will include teaching and supervision of trainees and students. We are interested in applicants in any area of scientific investigation and clinical subspecialty, and especially welcome those whose research focus more broadly is in the areas of immunology/inflammation, diabetes, obesity, metabolism, sleep disorders, or cancer biology. Prior to the start of employment, qualified applicants must: 1) have a medical doctorate or equivalent, and 2) hold or be eligible for medical licensure in the State of Illinois. Please send your CV, cover letter, and contact information with 3 references to Dr. Mirmira.
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Animal Research Specialist
Animal physiology enthusiasts with animal care experience and an interest in regenerative medicine are encouraged to apply for a position as Animal Research Specialist in the laboratory of Dr. Juan Alvarez at the University of Pennsylvania Perelman School of Medicine. The Alvarez lab works at the interface of Circadian Rhythms and Diabetes. We ask how circadian & metabolic rhythms shape pancreatic islet maturity, using mice and human stem cell-derived islet organoids as model systems. The ideal candidate will support in vivo and ex vivo studies characterizing glucose homeostasis and pancreatic islet function and have an interest to grow in the position as a profession, assuming increasing levels of responsibility. College degree and experience in mouse colony management and timed mating are required. For application instructions please contact Dr. Alvarez.
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Project Manager
A multidisciplinary team at Vanderbilt seeks a Project Manager to coordinate multiple aspects of the Pancreatlas™ imaging resource, a public platform created to bring together imaging data from human pancreas samples to accelerate diabetes-related research. The candidate will oversee project operations, including maintaining documentation and organizational structures, leading regular meetings and establishing milestones, developing data visualization and metadata fields for new data types, identifying potential connections and collaborators, and creating written communications for conferences, meetings, or general publicity within the research community. The candidate will also provide biological expertise for data curation and publication. For more information and official job posting, contact Dr. Diane Saunders.
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Data Curator
The Powers & Brissova Research Group seeks a Data Curator to lead data and metadata curation for human pancreas and islet phenotyping projects. As a member of a multidisciplinary research team, the candidate will coordinate and maintain project timelines, assess and continually improve on best practices for local metadata/data storage and annotation, and assist group members with data analysis, visualization, and sharing. These responsibilities will include supporting the Pancreatlas™ imaging resource, a public platform created at Vanderbilt to bring together imaging data from human pancreas samples to accelerate diabetes-related research. The candidate will assist contributors with submitting and publishing imaging and other data types, including integrating existing metadata ontologies and identifying opportunities for cross-referencing with different scientific programs. The candidate will also use their knowledge of data structures to assist database developers in building a graph database and visualization tools connecting imaging and omic resources. For more information and official job posting, contact Dr. Marcela Brissova.
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Postdoctoral Position
The Evans-Molina lab in the Wells Center for Pediatric Research in the Department of Pediatrics and the Center for Diabetes and Metabolic Diseases at the Indiana University School of Medicine (IUSM) is seeking a highly motivated post-doctoral fellow to join our vibrant and diverse research team. The overall goal of the Evans-Molina lab is to define the molecular and signaling pathways in the pancreatic β cell that contribute to type 1 and type 2 diabetes. Much of this work is focused on the regulation of calcium homeostasis within the secretory pathway of the pancreatic β cell and testing how loss of calcium within this compartment leads to endoplasmic reticulum and Golgi stress and impaired proinsulin processing. The successful applicant for this position will have a Ph.D. degree and a background in laboratory-based investigation. Applicants for the position should provide a brief statement of research interests, CV, and the names of three references to Dr. Carmella Evans-Molina.
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Postdoctoral Position
Indiana Biosciences Research Institute is offering Postdoctoral positions to study the protection of antigen-specific monoclonal antibodies and engineered T cells against type 1 diabetes, supported by federal and local fundings. Candidates must have Ph.D. and/or M.D. degrees in immunology, biology, or a related field. Candidates with expertise and skills in Immunology, autoimmune disease, and diabetes are strongly encouraged to apply. In this position, you will work in a collaborative and interdisciplinary team to study immune interventions using both animal models and human samples. Candidates will also be encouraged to develop their own research interests. Interested candidates should send their CV, cover letter, and contact information with 3 references to Dr. Li Zhang.
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Postdoctoral Position
The University of Zurich and ETH Zurich is looking for a postdoctoral fellow to characterize the phenotypic and functional changes that occur in islets and their surrounding environment in the natural history of T1D. The project is embedded in an exciting multi-laboratory collaboration that will generate functional, single-cell genomics and imaging mass cytometry data from cultured pancreas slices. The selected candidate will use imaging mass cytometry (IMC) to analyze pancreas slices from human donors with T1D. Machine learning approaches and systems biology analyses will be used to integrate the different types of data and correlate phenotypic changes with functional measurements performed on the same slices. In this position you will work in a collaborative and interdisciplinary team to study immune cells and pancreatic islet and exocrine cells in human pancreas slices. You will develop novel single-cell approaches to integrate functional, genomics and imaging mass cytometry data. A highly motivated Ph.D. or M.D.-Ph.D. level researcher with a passion for science who would like to work in a collaborative multidisciplinary research environment that combines tissue biology, computational biology, systems biology and biomedicine. Applicants for the position should provide a brief statement of research interests, CV, and the names of three references to Dr. Bodenmiller.
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Postdoctoral Position
The Department of Molecular & Medical Genetics at Oregon Health & Science University (OHSU) in Portland, Oregon, is seeking an enthusiastic and highly motivated post-doctoral fellow to study adeno-associated virus (AAV) and its application for human gene therapy in the lab, led by Professor Hiroyuki Nakai, M.D., Ph.D. Specifically, the lab is looking for a post-doctoral researcher who can effectively lead several projects, including a multi-PI (MPI) NIH project " U01DK123608 (MPIs: Nakai, Grompe and Kay): Gene Therapy for Diabetes." We seek to develop clinically relevant novel AAV vectors and methods for in vivo regeneration of insulin-secreting beta cells in rhesus macaques and understand the mechanisms behind the technologies. Interested applicants are encouraged to send a cover letter and C.V. to Dr. Hiroyuki Nakai.
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Postdoctoral Position
Rutgers, the State University of New Jersey, is seeking a Postdoctoral Fellow for the Child Health Institute of New Jersey. The position is available in El Ouaamari’s laboratory to investigate the role of the peripheral neurons in the regulation of systemic energy homeostasis in the context of obesity and diabetes. Self-driven, creative, resourceful and independent candidates with a PhD in neuroscience or neurobiology are encouraged to apply. Prior postdoctoral experience in neuroscience or related fields is preferred. Successful applicants will develop a research project focused on understanding how peripheral neurons control glucose and lipid homeostasis—with the long-term goal of identifying high-value biological data that can be harnessed to design neuromodulation-based strategies to counter obesity and diabetes. The candidate must be skilled in using in vitro and in vivo techniques for manipulating and monitoring neuronal activity and should have strong records of productivity and achievement. Preference will be given to applicants who have experience in islet biology as well. The successful candidate will also contribute to the training of undergraduate and graduate students and work closely with the PI on preparation and submission of research/review articles and grants. Interested candidates should send their CV, a one-page summary of their past research and future research interests, and the contact information for 2-3 references directly to
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Postdoctoral Position
Post-Doctoral Fellowship position in the Kulkarni Lab at Joslin Diabetes Center, Harvard Medical School. One position is available immediately for a period of 3 years each. Applications are invited from individuals with a PhD or MD or MD PhD degrees. Candidates with expertise in Bioinformatics will be especially relevant. Prospective candidates should have expertise in handling large ‘omics’ databases and be willing to work closely with other Fellows in the lab to assist in analyses of biological data from diverse projects focused on Metabolism. These include but are not restricted to defining pathways and identifying mechanisms that regulate pancreatic (endocrine and exocrine) biology and inter-organ cross-talk in the overall maintenance of glucose homeostasis. Other projects include induced pluripotent stem cells, genetically engineered and humanized mouse models. Candidates will also be encouraged to develop their own research interests. Applicants for the position should provide a brief statement of research interests, CV, and the names of three references to Dr. Kulkarni.
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Postdoctoral Position
The Diabetes Institute at the University of Florida (UFDI) is recruiting up to two new Postdoctoral Research Associate positions. Our type 1 diabetes program recognized, at an international level, for outstanding research, training, and clinical care. It is well-funded by a series of individual, programmatic, and training level (T32, F, K) grants supported by numerous federal (NIH) and foundational agencies. Our research programs are broad in their scope, highly interdisciplinary, and translational. Faculty affiliated with the UFDI are engaged in innovative and cutting edge research in the areas of autoimmunity, genetics, metabolism, pathology, cell biology, microscopy, and imaging. Candidates should submit a curriculum vitae, NIH Biosketch/personal research statement (one-two pages), and three letters of recommendation. Three letters of reference should be sent directly to Dr. Todd Brusko.
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Postdoctoral Position
The Freyberg laboratory is offering Postdoctoral positions to study roles of dopamine in pancreatic hormone secretion and in diabetes. Candidates must have Ph.D. and/or M.D. degrees. Previous experience with molecular biology, mammalian cell and pancreatic islet culture, fluorescence microscopy is also preferred but not required, although candidates with experience in these skills are strongly encouraged to apply. Training in more advanced techniques is a key aim of the postdoctoral position; the biggest requirement is the enthusiasm and ambition of the candidate to make important contributions to our understanding of dopamine actions in metabolism. Interested candidates should send their CV, a one-page summary of their past research and future research interests, and the contact information for 2-3 references directly to Dr. Zachary Freyberg.
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Postdoctoral Position
The laboratory of Dr. Leonardo Ferreira in the Department of Microbiology and Immunology and the Hollings Cancer Center at the Medical University of South Carolina is searching for a postdoctoral fellow to lead regulatory T cell (Treg) research projects in the lab. The objective of the Ferreira Lab is to design and develop engineered immune cell therapies for autoimmune disease and aging. The candidate must have a PhD in biology, immunology, or a related field, and have demonstrated quality publication of their work. Please send your CV, cover letter, and contact information with three references to
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Postdoctoral Position
Benaroya Research Institute’s Center for Interventional Immunology seeking outstanding clinical investigator for faculty position as well as post-doctorate candidates or research fellows interested in clinical/translational research in type 1 diabetes and/or autoimmunity. Please send your CV, cover letter, and contact information with 3 references to Dr. Carla Greenbaum.
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Postdoctoral Position
The Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope is looking for a talented postdoctoral fellow. The collaborative laboratory of Dr. John Kaddis is seeking innovative postdoctoral candidates to conduct in-silico translational research in the field of type 1 diabetes (T1D). This individual will participate in one or more projects that examine the role of molecular, cellular, genetic, and epidemiological variation in T1D. This candidate will have an opportunity to work with specialists in the fields of immunology, diabetes, and data/computer science. Expertise in statistical methods for disease risk prediction and modeling, as well as clinical data, genome sequence, SNP array, “-omics”, and large-scale genetic association analysis is helpful. Experience with public databases/repositories is highly desired. Necessary skills include those from bioinformatics, computer/data science, mathematics, software engineering, and computational biology. Please send your CV, cover letter, and contact information with 3 references to
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