HIRN Network


May

2025 NEWSLETTER

HIRN HIGHLIGHTED IN THE "NIH RECORD"

The HIRN was profiled in the May 9th issue of the NIH Record, a biweekly newsletter for NIH employees. The scientific advancements and accomplishments of the network as well as the January 2025 Annual Meeting were profiled. View article HERE.

NIDDK 75th ANNIVERSARY COLLECTION

In celebration of National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 75th anniversary, a collection of review articles and commentaries are posted online at Diabetes and Diabetes Care. The series illustrates important scientific and medical progress in understanding, preventing, and treating diabetes.


IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIView all articles HERE


IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIThe HIRN specific article can be found HERE  

NOMINATIONS FOR DIABETES TRAILBLAZERS

Nominate someone for the 2025 class of WIELD Diabetes Trailblazers!


Criteria: Women who exemplify excellence in their contributions to obesity, metabolism, diabetes, or endocrinology as well as excellence in mentoring and service to the scientific community should be nominated! Nominees should be Full or Emeritus Professors (or industry equivalent), with >150 publications and an H- or I-Index > 60 or hold an executive leadership in industry. Self-nominations are accepted! 


Nominations due: May 30, 2025


For more information click HERE and submit nomination HERE.

NIH FUNDING OPPORTUNITIES

RFA-DK-26-009: New Investigator Gateway Awards for Collaborative T1D Research (R03 Clinical Trial Not Allowed)


The New Investigator Gateway Award in T1D Research is designed to support a robust pipeline of innovative projects and talented new investigators in T1D research. Embedding awardees within an established scientific framework in each of these consortia will provide unique opportunities for New and Early Stage Investigators to increase their understanding of key questions in the field, to network, and to establish unique and potentially long-lasting collaborations that will propel their careers forward. Bringing New and Early Stage Investigators into existing collaborative research networks also will benefit the networks by infusing new ideas and perspectives. *Foreign applications not allowed.


Application due dates:

  • June 26, 2025
  • March 6, 2026

AMERICAN DIABETES ASSOCIATION (ADA) AWARDS

2025 Pathway to Stop Diabetes® Awards:

The Pathway program aims to attract outstanding early-career scientists in the field of diabetes research and accelerate their progress by providing resources and support for conducting transformative science. The call for nominations will prioritize investigators across the spectrum of diabetes research, spanning basic science through public health research and implementation science. The ideal applicant will propose innovative research with the goal of improving the lives of people at risk for diabetes or living with the disease—and the pathway to this impact is clear.  


The ADA will accept up to two nominations per institution with one nomination spanning basic through preclinical research and the other spanning clinical through public health research. The Pathway award will provide substantial support of up to $1.625 million to exceptional early-career diabetes researchers and those established in other fields who are interested in applying their expertise to diabetes research. For more information on this opportunity, please visit HERE.


Application Submission Deadline: July 23, 2025

Award Notification Date: November 17, 2025

Earliest Award Start Date: January 1, 2026

2025 Postdoctoral Fellowship Awards: 

The American Diabetes Association® (ADA) is committed to nurturing the next generation of leaders in diabetes research, which is why we are pleased to announce that the application period of the Postdoctoral Fellowships Awards is now open! This award recognizes and supports outstanding researchers in their pursuit of innovative and impactful research projects. As there is a pressing need for more talented, early-stage investigators to join the field of diabetes research and tackle these challenges, postdoctoral training is an essential step in launching a successful research career and making significant contributions to the field. 


The call for applications aims to support exceptional training opportunities that will enable fellows to make significant advances in scientific research and contribute to the ADA's mission to prevent and cure diabetes and to improve the lives of people affected by diabetes. This funding opportunity is open to all areas of diabetes research spanning basic, clinical, and translational research; epidemiology; health services research; and public health. For more information on this opportunity, please visit HERE.


Application Submission Deadline: July 23, 2025

Award Notification Date: November 14, 2025

Earliest Award Start Date: January 1, 2026

HELMSLEY FUNDING OPPORTUNITY

The Leona M. and Harry B. Helmsley Charitable Trust’s (Helmsley) Type 1 Diabetes (T1D) Program currently has an open request for proposals to fund T1D innate immunity projects. The Helmsley T1D Program aims to support the discovery and development of new therapies to prevent or delay T1D and the identification and validation of biomarkers to predict disease initiation and progression.


T1D is a complex autoimmune disease where insulin-producing beta cells in the pancreas are targeted by immune cells. The predisposing factors, triggers, and other elements that affect disease pathogenesis in humans are not yet fully identified. Understanding these drivers of disease could lead to discoveries of new drug targets, guide intervention strategies to halt the disease, or improve prediction of disease development.


To date most T1D preclinical and clinical research has focused on the role T cells play in disease pathogenesis. However, innate immune cells are the first and most abundant type of immune cells in the pancreas, especially in individuals with T1D. Moreover, data, mostly generated from animal experiments, suggests that these cells might play different roles in T1D: from activating T cells and/or recruiting them to the pancreatic islets, to promoting inflammation or inducing immune tolerance. However, what leads to an increase in innate immune cells in the pancreas during T1D, its significance, and what role these cells play in disease in humans is not yet fully understood.


Learn more HERE


Full grant proposal due: July 30, 2025

Funding start date: February 2026

HIRN FUNDING

The Human Islet Research Network (HIRN) announces new funding initiatives to support the use of existing HIRN datasets and resources to explore unique and innovative hypotheses designed to accelerate breakthroughs and advances in type 1 diabetes (T1D) research. The Human Islet Research Network (HIRN) Data Scholars Award (DSA) Program provides:


  • Funding for data-science centered or driven projects submitted via a streamlined process to the HIRN Human Islet Research Enhancement Center (HIREC). Projects will use existing datasets from HIRN and related T1D partner programs and/or resources to design studies or create resources that are responsive to specific initiatives in this announcement.


  • Opportunities to collaborate with HIRN investigators and programs and efficiently exchange ideas and resources to accelerate innovation in T1D research.

 

Depending on the initiative (there are currently two opportunities), awardees will receive either $50,000 or $1,000. Learn more HERE

 

KEY DATES

Application Due Date:                November 1, 2025  

Scientific Review:                        December 2025

Start Date:                                    February 2026 

UPCOMING MEETINGS

Come see a demo of PanKbase at the 85th Scientific Sessions of the American Diabetes Association (ADA) June 20th-23rd!


PanKbase will be at the 85th Scientific Sessions of the ADA as part of the NIDDK Data Science Corner. If you are coming to ADA, stop by PanKbase, booth 1047, to learn more about the platform and meet the PanKbase team. Daily demos will explore our single cell browser, T1D differential gene expression browser, PanKgraph, and more highlighting the utility of PanKbase. Visit us to discover new features, ask questions, and give us feedback. We look forward to interacting with the diabetes community.  


Follow PanKbase on social media for additional updates of the platform, including Bluesky, LinkedIn, X.


PanKbase now has a YouTube channel. Videos on YouTube will introduce users to the PanKbase and PanKgraph platforms. Currently, these are in the works but subscribe and check back periodically for new content and tutorials guiding users through our features. We’re adding content on a rolling basis.  

The 2025 Rachmiel Levine-Arthur Riggs Diabetes Research Symposium will be held in Pasadena, California from November 14-17, 2025. This year’s symposium will highlight the latest developments in type 1 diabetes research and provide opportunity for trainees to present and receive awards. For more information, scan the QR code below or learn more HERE.

JOB OPPORTUNITIES

Below is a summary of the most recent job postings by category (Faculty, Research Staff/Admin, Postdoc). Visit the HIRN Website for a full listing of job opportunities.

LEADERSHIP/FACULTY

The Leuven Diabetes Lab is seeking an ambitious Principal Investigator with a strong background in immunology or beta-cell biology to join, and ultimately take over, leadership of the lab, currently headed by Prof. Chantal Mathieu and managed by Dr. Conny Gysemans. The lab’s mission is to advance the understanding and treatment of type 1 diabetes through innovative research, spanning beta-cell preservation, immune modulation, and translational approaches.


As part of this position, candidates may be eligible for enhanced ERC funding, recently expanded to support top global researchers relocating to Europe, making this a unique opportunity for outstanding scientists from the US or other countries to establish a high-impact research program in a world-class environment. Join us in shaping the future of type 1 diabetes research and working toward a world without type 1 diabetes. Interested candidates should send a CV and brief description of research interests to

Dr. Chantal Mathieu and Dr. Conny Gysemans.

Assistant or Associate Professor

The University of Florida Diabetes Institute (UFDI), associated with the Department of Pathology, Immunology, and Laboratory Medicine, is seeking applicants for a full-time tenure-track faculty position at the rank of Assistant or Associate Professor. We are seeking candidates with a strong publication record and history of NIH or foundation grant funding in the area of diabetes research or its complications. Individuals who apply for this position should submit a cover letter, a summary statement outlining the focus and future vision for their research program. The applicant will need to provide at least three letters of recommendation from senior scientists. The letters of reference may be uploaded or sent directly to the Director of the UFDI and search committee chair, Dr. Todd Brusko.

POSTDOCTORAL

Postdoctoral Position

The Wortham lab at the University of Colorado Anschutz Medical Campus is recruiting a postdoctoral trainee to study how nutrient metabolism impacts regulation of the epigenome to mediate functional adaptations by pancreatic beta cells. Successful candidates will employ combinations of stable isotope tracing, single cell genomics, and physiological studies in mouse models of diabetes and in primary human islets. Trainees in the lab will benefit from strong technical support including animal surgery, tagging, and genotyping, as well as computational analysis. This position will provide opportunities for career development activities pursuant to the trainee’s goals including presentations at regional and national conferences, collaborations within and beyond CU Anschutz, networking opportunities, and focused training in scientific communication including grantsmanship, manuscript preparation, and public speaking. Prior experience in mouse genetics and strong written communication skills are required. A background in genomic dataset analysis is preferred. Interested candidates should send a CV and brief description of research interests to Dr. Matthew Wortham.

Postdoctoral Position

We are seeking highly motivated, detail-oriented, and collaborative individuals with excellent writing and verbal communication skills to join our research team. Experience in animal physiology, molecular biology, and cell biology are desired. Additional experience in transcriptomics, metabolomics, or bioinformatics are desirable, but not required. A recent PhD in biology or a related field is required. Projects in the laboratory are centered on elucidating the molecular and transcriptional mechanisms involved in the regulation of beta cell proliferation and mitochondrial metabolism, delta cell function, islet paracrine signaling, and stem cell-derived islet generation. 

Interested applicants please send a cover letter and curriculum vitae, including the names of three references, to: Dr. Richard Cox.

Postdoctoral Position

The Integrative Immunology and Cell Design Laboratory at Penn Medicine is seeking postdoctoral fellows to investigate the molecular mechanisms underlying T cell antigen recognition in autoimmunity, cancer, and infectious diseases. Our research employs high-throughput antigen discovery, single-cell genomics, and synthetic biology to map T cell specificity using platforms such as TScan-I (Cell, 2019), TScan-II (Cell, 2023), and TCR-MAP (Nature Biotechnology, 2024). Successful candidates will join a multidisciplinary team to advance our understanding of T cell-mediated immune surveillance and tolerance while contributing to translational research. Interested applicants should send a cover letter, CV, and reference contacts to: Dr. Mohammad Haj-Dezfulian.

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