November/December 2021 NEWSLETTER
The Human Islet Research Network (HIRN) announces a new funding initiative to support investigators developing bold, innovative, and challenging projects that will catalyze the diabetes research field and provide important advances in topics of interest to the network. Applicants must propose aims focused on an original scientific idea or question that is distinct from current HIRN funded research. The scientific focus of application to the HIRN Catalyst program must fall within the purview of one (or more) of the current HIRN consortia.

Key Dates
Posted Date:   
Letter of Intent Due Date:         
Application Due Date:                
Scientific Review:                       
Start Date:                                                  
December 1, 2021
March 1, 2022
May 2, 2022  
May – July, 2022
August 1, 2022                
Save the Date: "mRNA Modifications in Islet Biology"
iiiiiiiiiiiiiiiiiiiiiiiiiiiiThursday, January 27, 2022 at 2:00 pm Eastern.

Reminder: The recordings from previous HIRN Monthly Webinars are available to view and download on our YouTube Channel.
The IIDP recently released to the research community their Stored Resources inventory of formalin-fixed pancreas tissue sections (histology slides) available for most islet isolations over the past 7 years and flash frozen islets from a limited number of islet isolations. The new Stored Resources view allows you to search their inventory by donor age, sex, BMI, race, and diabetes status as well as Phenotypic data availability. Learn more HERE.
dkNET Webinar
The  NIDDK Information Network (dkNET) is inviting you to join them for a webinar "Pancreatlas." Pancreatlas is an online resource that houses and links human pancreas imaging data with clinical data to facilitate advances in the understanding of diabetes, pancreatitis, and pancreatic cancer. Increasingly, human tissue phenotyping programs and projects are generating complex data from numerous imaging modalities, yet only a fraction are shared as static figures for publication.

Drs. Marcela Brissova, Dr. Jean-Philippe Cartailler, and Diane Saunders from Vanderbilt University will be presenting this webinar on Friday, January 28, 2022, 11 am - 12 pm Pacific. Learn more HERE.
The nPOD JDRF Group invites you to their upcoming annual meeting January 30 - February 2, 2022. They are monitoring the COVID situation and hoping to return to an in person meeting. Information will be posted soon with proposed program, abstract submission deadlines, registration and more. Learn more HERE.
NIDDK Exocrine/Endocrine Pancreas Workshop

The goal of this 1.5-day workshop will be to gather clinical and basic science investigators who are interested in diseases of the exocrine and/or endocrine pancreas and in achieving an understanding of how the two compartments interact in disease. This workshop will provide an opportunity for investigators in exocrine diseases to come together with those studying islets in diabetes as a means to foster interdisciplinary discussion and identify areas for advancement. Learn more HERE
Upcoming Collaborative Opportunity
The NIDDK Integrated Islet Distribution Program (IIDP) intends to announce a Request for Proposals (RFP) for Affiliated Islet Isolation Centers (IICs). The RFP will be issued on January 3, 2022, with applications due by the end of March 2022. Visit IIDP website for more information.
Announcing the New Funding Program from the Innovative Science Accelerator Program (ISAC)
Due date approaching (December 15, 2021):
The Innovative Science Accelerator (ISAC) Program supports truly innovative, disruptive, risky research to accelerate breakthrough discoveries. SAC provides:
  • Funding for small high-risk/high reward projects via a streamlined process to support cutting-edge research and accelerate true innovation in areas of science of interest to the Kidney-Urologic-Hematologic (KUH) research communities.
  • Collaboration and Events for researchers and trainees to efficiently exchange ideas and resources to accelerate innovation.
dkNET Funding Opportunity for Early Stage/New Investigators
Are you an early stage or new investigator seeking to apply computationally-intensive methods to diabetes, endocrinology, and metabolic disease research? Check out the dkNET New Investigator Pilot Program in Bioinformatics! The dkNET New Investigator Pilot Program is designed to: (i) facilitate the ability of Early Stage and New Investigators with computational and bioinformatics expertise to pursue research questions in diabetes, endocrinology, and metabolic diseases (DEMD), or (ii) allow Early Stage and New PIs currently pursuing DEMD-related research to explore incorporating computational, mathematical, statistical, and/or bioinformatics approaches into their research projects. Letter of Intent Due Date: January 28, 2022. Application Due Date: February 28, 2022. Learn more HERE.
RFA-DK-21-017: High-Resolution Exploration of the Human Islet Tissue Environment [HIRN Human Pancreas Analysis Consortium (HPAC)] (U01 - Clinical Trial Not Allowed)
  • Application due date: March 3, 2022

RFA-DK-21-030: New Investigator Gateway Awards for Collaborative T1D Research (R03 Clinical Trial Not Allowed)
  • Application due date:  June 1, 2022 and March 20, 2023 
  • Foreign applications allowed

F31 PAR-19-378: Bioinformatics Interdisciplinary Predoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases 
  • Application due date:  Standard dates apply 
  • Foreign applications allowed

F32 PAR-19-379: Bioinformatics Interdisciplinary Postdoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases 
  • Application due date:  Standard dates apply 
  • Foreign applications allowed

PAR-20-140: Catalytic Tool and Technology Development in Kidney, Urologic, and Hematologic Diseases (R21 Clinical Trial Not Allowed)
  • Application due date:  Standard dates apply
  • Foreign applications are allowed
Below is a summary of the most recent job postings by category (Faculty, Research Staff/Admin, Postdoc). Visit the HIRN Website for a full listing for job opportunities.
Program Director for Integrative Physiology of Human Diabetes
The National Institute of Diabetes and Digestive and Kidney Diseases is hiring a Program Director for Integrative Physiology of Human Diabetes. A scientist with strong managerial, communications and interpersonal skills, and experience in integrative physiology relevant to diabetes, is sought for the position of Program Director for Integrative Physiology in the Division of Diabetes, Endocrinology, and Metabolic Diseases (DDEMD) in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), at the National Institutes of Health. Research to be managed by the Director of DDEMD’s Integrative Physiology program is supported through multiple mechanisms, including regular research grants and cooperative agreements. Activities to be pursued include planning, establishing, and overseeing a wide range of goal-directed initiatives to expedite and enhance translational, pre-clinical and clinical research in diabetes. Apply HERE.
Program Officials
The National Institute of Diabetes and Digestive and Kidney Diseases is hiring program officials with expertise in translational research in any of the following four topic areas as they specifically relate to key questions in diabetes, endocrine or metabolic diseases:
·      Integrative physiology of human diabetes, including physiology of counter-regulatory responses to hypoglycemia, mechanisms involved in regulation of peripheral metabolism, autonomic nervous system regulation of glucose and lipid metabolism, and basic and clinical studies investigating effects of bariatric surgery on diabetes and diabetes-related outcomes;
·      Neuroscience of human behavior and behavior change, including brain and peripheral systems that impact the onset, severity or resolution of diabetes or obesity pathophysiology; 
·      Immune regulation and inflammation, including innate and adaptive immune mechanisms influencing peripheral insulin resistance in animal models and humans;
·      Precision medicine in diabetes and obesity.
The mission of the Division of Diabetes, Endocrinology and Metabolic Diseases is to support broad-based research programs focused on both basic and clinical research in the areas of type 1 and type 2 diabetes and other metabolic diseases. Apply Here
Staff Scientist
A staff scientist is sought to fill a position to work in the diabetes research and regenerative medicine laboratory of Dr. Jeffrey Millman at Washington University in St. Louis. The laboratory focuses on the generation insulin-producing pancreatic β cells for the study and treatment of diabetes. We have a wide diversity of projects involving stem cells differentiation, genetic engineering with CRISPR, disease modeling, transplantation into animal models of diabetes, biomedical engineering, bioinformatics, and single-cell sequencing technologies and has been very productive with publications in high impact journals. The ideal candidate would be able to provide high level support across multiple projects. Please send your CV, cover letter, and contact information with 3 references to
Physician Scientist
The University of Chicago's Department of Medicine is searching for full-time physician scientist faculty members at any rank. Appointees will maintain a productive research program and provide patient care directly. Other responsibilities will include teaching and supervision of trainees and students. We are interested in applicants in any area of scientific investigation and clinical subspecialty, and especially welcome those whose research focus more broadly is in the areas of immunology/inflammation, diabetes, obesity, metabolism, sleep disorders, or cancer biology. Prior to the start of employment, qualified applicants must: 1) have a medical doctorate or equivalent, and 2) hold or be eligible for medical licensure in the State of Illinois. Please send your CV, cover letter, and contact information with 3 references to Dr. Mirmira
Research Technician
A new Stem Cell and Genome Editing Core Facility situated within the Kieffer Research Group has an opportunity for a highly motivated and collaborative technician to support diverse regenerative medicine research initiatives. The candidate will assist with the day to-day operation of the Core, will generate human induced pluripotent cells (iPSCs), and will culture and differentiate human embryonic stem cells (ESCs) and iPSCs down pancreatic lineages. Please send your CV, cover letter, and contact information with 3 references to Dr. Tim Kieffer.
Postdoctoral Position
A postdoctoral associate position is available at the Diabetes Research Institute of the University of Miami. The main lines of research in the Beta Cell Regeneration Lab revolve around the development of regenerative strategies for type 1 diabetes, including stem cell differentiation into insulin-producing β-cells and islet regeneration. In particular, our current research is focused on the induction of human pancreatic ductal BMP-responsive progenitor cells, which we have identified and characterized by lineage tracing (Klein et al., Diabetes, 2015; Qadir et al.Cell Reports, 2018); single-cell RNAseq and transplantation of sorted populations (Qadir et al., PNAS, 2020); and organotypic culture (human pancreatic slices) techniques (Qadir et al.Nature Comms, 2020). Our seminal contribution to the development of the latter has enabled for the first time the real-time monitoring of β-cell regeneration in an in vitro setting that resembles the native organ. Interested applicants are encouraged to send a letter/statement of interests, CV, and contact information for 2-3 references to Dr. Juan Dominguez-Bendala.
Postdoctoral Position
The Department of Medicine at the University of Miami, Miller School of Medicine, has an exciting opportunity for a full time Postdoctoral Associate. This Postdoctoral Associate position will support Dr. Joao Pedro Werneck with his investigations that focus on implementing in vivo tools to understand the thyroid gland physiology and how exercise impacts human pancreatic islets. Interested applicants are encouraged to send a letter/statement of interests, CV, and contact information for 2-3 references to Dr. Joao Saar Werneck de Castro.
Postdoctoral Position
City of Hope has a postdoctoral position available in the laboratory of Dr. Komatsu / Dr. Kandeel in the Department of Translational Research & Cellular Therapeutics. They are seeking a creative, experienced and highly collaborative postdoctoral associate with a strong interest in the translational research in Type 1 diabetes. The research goal for this position is to establish the extrahepatic islet transplantation strategy in animal models that can be translated into the clinical. Several projects are ongoing with highly productive collaborators including extramural engineers. By integrating our broad knowledge of islet physiology with engineering approaches, we seek to develop novel strategy of islet transplantation. These projects are led by the principal investigator with extensive clinical experience as translational researches. The selected candidate will take initiative in developing the new islet transplantation approaches using animal islet transplantation models. Candidates with clinical experience, beta cell biology and/or molecular biology, are particularly welcome to apply. Interested applicants are encouraged to send a letter/statement of interests, CV, and contact information for 2-3 references to Dr. Hirotake Komatsu.
Postdoctoral Position
Benaroya Research Institute’s Center for Interventional Immunology seeking outstanding clinical investigator for faculty position as well as post-doctorate candidates or research fellows interested in clinical/translational research in type 1 diabetes and/or autoimmunity. Please send your CV, cover letter, and contact information with 3 references to Dr. Carla Greenbaum.
Postdoctoral Position
The MacDonald Lab at the University of Alberta in Edmonton, Canada is looking to fill two postdoctoral positions within one or more of the following areas: cell physiology, single-cell biology, cell imaging, electrophysiology, and computational biology. The positions will be held within the Department of Pharmacology and the Alberta Diabetes Institute (ADI), Canada’s largest stand-alone diabetes research centre. Successful candidates will have access to extensive resources for research through the MacDonald Lab, the ADI, and the University of Alberta Faculty of Medicine and Dentistry. This includes core facilities for molecular biology and biochemistry, sequencing and single-cell work, live-cell imaging, animal services, and more. Please send your CV, cover letter, and contact information with 3 references to
Postdoctoral Associate
The laboratory of Dr. Jeffrey Millman in the Division of Endocrinology, Metabolism, and Lipid Research at Washington University School of Medicine is searching for a postdoctoral associates to lead several new research projects in the lab. The objective of the Millman Lab is to generate and study stem cell-derived beta cells for use in diabetic disease modeling and cell therapy. The candidate must have a PhD in cell biology, biomedical engineering, or related fields and has demonstrated quality publication of their work. Please send your CV, cover letter, and contact information with 3 references to Dr. Jeffrey Millman.
Postdoctoral Position
Post-Doctoral Fellowship positions in the Kulkarni Lab at Joslin Diabetes Center, Harvard Medical SchoolTwo positions are available immediately for a period of 3 years each. For both positions applications are invited from individuals with a PhD or MD or MD PhD degrees. 1) The first position is for training in exciting projects focused on Metabolism such as defining pathways and identifying mechanisms that regulate pancreatic (endocrine and exocrine) biology including inter-organ cross-talk in the overall maintenance of glucose homeostasis. The projects will utilize including induced pluripotent stem cells, genetically engineered and humanized mouse models. Topics are flexible - some examples include growth factor (e.g. insulin/IGF-1) signaling, mRNA modifications and stem cell biology. Candidates should have a strong background in molecular biology, cell biology (stem/iPS cells) and biochemistry. It is an advantage if candidates have the ability to interrogate “omics” and sequencing datasets. Candidates should possess skills or be willing to learn handling human islets, in vivo animal studies, rodent islet isolation and immunostaining. 2) For the second position candidates with expertise in Bioinformatics will be especially relevant. Prospective candidates should have expertise in handling large ‘omics’ databases and be willing to work closely with other Fellows in the lab to assist in analyses of biological data from diverse projects. Candidates will also be encouraged to develop their own research interests. Applicants for both positions should provide a brief statement of research interests, CV, and the names of three references to Dr. Kulkarni.
Postdoctoral Position
The Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope is looking for a talented postdoctoral fellow. The collaborative laboratories of Drs. John Kaddis and Bart Roep are jointly seeking innovative postdoctoral candidates to conduct in-silico translational research in the field of type 1 diabetes (T1D). This individual will participate in one or more projects that examine the role of molecular, cellular, genetic, and epidemiological variation in T1D. This candidate will have an opportunity to work with specialists in the fields of immunology, diabetes, and data/computer science. Expertize in statistical methods for disease risk prediction and modeling, as well as clinical data, genome sequence, SNP array, “-omics”, and large-scale genetic association analysis is helpful. Experience with public databases/repositories is highly desired.  Necessary skills include those from bioinformatics, computer/data science, mathematics, software engineering, and computational biology. Please send your CV, cover letter, and contact information with 3 references to
Postdoctoral Position
The Department of Molecular & Medical Genetics at Oregon Health & Science University (OHSU) in Portland, Oregon, is seeking a highly motivated and enthusiastic post-doctoral fellow to study adeno-associated virus (AAV) and its application for human gene therapy in the lab led by Professor Hiroyuki Nakai, M.D., Ph.D. Specifically, the lab is looking for a post-doctoral researcher who can lead productively several projects including a multi-PI (MPI) NIH project " U01DK123608 (MPIs: Nakai, Grompe and Kay): Gene Therapy for Diabetes, " where we seek to develop clinically relevant novel AAV vectors and methods for in vivo regeneration of insulin-secreting beta cells in rhesus macaques and profoundly understand the mechanisms behind the technologies. The main research focuses of the Nakai lab are: (1) AAV vector biology - capsid assembly, genome packaging, and virus-host interactions in rodents and non-human primates; (2) AAV antigen-antibody interactions; (3) developing novel vectors by engineering of AAV capsids; and (4) preclinical studies of gene therapy for the treatment of various human diseases including type I diabetes. Please send a cover letter and C.V. to Dr. Hiroyuki Nakai.
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